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Conserved domains on  [gi|808181992|gb|AKD01685|]
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globulin-1, partial [Zea mays]

Protein Classification

cupin domain-containing protein( domain architecture ID 14388889)

cupin domain-containing protein similar to 7S seed storage proteins, such as cupincin, beta-conglycinin, vicilin, provicilin, canavalin, convicilin, and conglutin beta, and Ara h 1, a major peanut allergen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 116-226 6.16e-51

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380371  Cd Length: 178  Bit Score: 163.06  E-value: 6.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 116 EQGSLRVLRPFDEVSRLLRGIRDYRVAVLEANPRSFVVPSHTDAHCICYVAEGEGVVTTIENGERRSYTIKQGHVFVAPA 195
Cdd:cd02244    5 EAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVYRIPA 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 808181992 196 GAVTYLANTDGRKKLVITKILHTIS--VPGEFQ 226
Cdd:cd02244   85 GSTFYLVNTDENEKLRIIALFDPVNslTPGPFQ 117
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 116-226 6.16e-51

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 163.06  E-value: 6.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 116 EQGSLRVLRPFDEVSRLLRGIRDYRVAVLEANPRSFVVPSHTDAHCICYVAEGEGVVTTIENGERRSYTIKQGHVFVAPA 195
Cdd:cd02244    5 EAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVYRIPA 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 808181992 196 GAVTYLANTDGRKKLVITKILHTIS--VPGEFQ 226
Cdd:cd02244   85 GSTFYLVNTDENEKLRIIALFDPVNslTPGPFQ 117
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 118-205 1.78e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 59.99  E-value: 1.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992   118 GSLRVLRPFDevSRLLRGIrDYRVAVLEANPRSFVVPS-HTDAHCICYVAEGEGVVTTI-ENGERR-SYTIKQGHVFVAP 194
Cdd:smart00835  12 GRLREADPTN--FPALNGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVdPNGNKVyDARLREGDVFVVP 88

                           90
                   ....*....|.
gi 808181992   195 AGAVTYLANTD 205
Cdd:smart00835  89 QGHPHFQVNSG 99
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 147-212 6.79e-05

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 41.55  E-value: 6.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992  147 NPRSFVVPS-HTDAHCICYVAEGEG-VVTTIENGERRSY--TIKQGHVFVAPAGAVTYLANTDGRKKLVI 212
Cdd:pfam00190  41 APGGMNPPHwHPNATEILYVLQGRGrVGFVVPGNGNRVFhkVLREGDVFVVPQGLPHFQYNIGDEPAVAF 110
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
132-212 6.70e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 35.21  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 132 LLRGIRDYRVAVLEANPRsFVVPSHT-DAHCICYVAEGEGVVTTieNGERrsYTIKQGHVFVAPAGAV-TYLANTDGRKK 209
Cdd:COG1917   16 LADGEDELEVVRVTFEPG-ARTPWHShPGEELIYVLEGEGEVEV--GGEE--YELKPGDVVFIPPGVPhAFRNLGDEPAV 90


                 ...
gi 808181992 210 LVI 212
Cdd:COG1917   91 LLV 93
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 116-226 6.16e-51

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 163.06  E-value: 6.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 116 EQGSLRVLRPFDEVSRLLRGIRDYRVAVLEANPRSFVVPSHTDAHCICYVAEGEGVVTTIENGERRSYTIKQGHVFVAPA 195
Cdd:cd02244    5 EAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVYRIPA 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 808181992 196 GAVTYLANTDGRKKLVITKILHTIS--VPGEFQ 226
Cdd:cd02244   85 GSTFYLVNTDENEKLRIIALFDPVNslTPGPFQ 117
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 118-205 1.78e-11

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 59.99  E-value: 1.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992   118 GSLRVLRPFDevSRLLRGIrDYRVAVLEANPRSFVVPS-HTDAHCICYVAEGEGVVTTI-ENGERR-SYTIKQGHVFVAP 194
Cdd:smart00835  12 GRLREADPTN--FPALNGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVdPNGNKVyDARLREGDVFVVP 88

                           90
                   ....*....|.
gi 808181992   195 AGAVTYLANTD 205
Cdd:smart00835  89 QGHPHFQVNSG 99
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 147-218 4.07e-08

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 51.82  E-value: 4.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 147 NPRSFVVPSHTDAHCICYVAEGEGVV--------TTIENGERRS-------------YTIKQGHVFVAPAGAVTYLANtD 205
Cdd:cd02242   43 EPRGLLLPSYSNAPKLAYVLQGRGIVgvvfpgcpETFQSSQQSQgqgqrfrdqhqkvRRIRKGDVIAVPAGVVHWWYN-D 121

                         90
                 ....*....|...
gi 808181992 206 GRKKLVITKILHT 218
Cdd:cd02242  122 GDSDLVIVFLGDT 134
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 101-204 1.68e-05

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 43.35  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 101 PYVFDRRSFRRVVRSEQGSLRVLR----PfdevsrLLRGIRDYRVAVleaNPRSFVVP-SHTDAHCICYVAEGEGVVTTI 175
Cdd:cd20306    1 PHLFSLEDSNPFFESEGGSIRQATadqlP------VLKGLSIYRLRL---SPGGIREPhWHPNANELGYVISGEARVSIL 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 808181992 176 EN-GERRSYTIKQGHVFVAPAGAVTYLANT 204
Cdd:cd20306   72 DPtGSLDTFTVKPGQVVFIPQGWLHWIENV 101
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 147-212 6.79e-05

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 41.55  E-value: 6.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992  147 NPRSFVVPS-HTDAHCICYVAEGEG-VVTTIENGERRSY--TIKQGHVFVAPAGAVTYLANTDGRKKLVI 212
Cdd:pfam00190  41 APGGMNPPHwHPNATEILYVLQGRGrVGFVVPGNGNRVFhkVLREGDVFVVPQGLPHFQYNIGDEPAVAF 110
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 145-196 4.09e-04

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 37.56  E-value: 4.09e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 808181992 145 EANPRSFvvPSHTDAHCICYVAEGEGVVTTiENGErrSYTIKQGHVFVAPAG 196
Cdd:cd02227    6 ECTPGKF--PWNYDEDEFCYILEGEVRVTP-EDGE--PVTFKAGDLVVFPAG 52
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 141-206 4.48e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 34.77  E-value: 4.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 808181992 141 VAVLEANPRSFVVP-SHTDAHCICYVAEGEGVVTTienGERRSYTIKQGHVFVAPAGAVTYLANTDG 206
Cdd:cd02208    1 ISVVTLPPGTSSPPhWHPEQDEIFYVLSGEGELTL---DDGETVELKAGDIVLIPPGVPHSFVNTSD 64
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
132-212 6.70e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 35.21  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808181992 132 LLRGIRDYRVAVLEANPRsFVVPSHT-DAHCICYVAEGEGVVTTieNGERrsYTIKQGHVFVAPAGAV-TYLANTDGRKK 209
Cdd:COG1917   16 LADGEDELEVVRVTFEPG-ARTPWHShPGEELIYVLEGEGEVEV--GGEE--YELKPGDVVFIPPGVPhAFRNLGDEPAV 90


                 ...
gi 808181992 210 LVI 212
Cdd:COG1917   91 LLV 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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