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Conserved domains on  [gi|823332263|gb|AKI30770|]
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cytochrome c oxidase assembly protein, partial [Metrosideros vitiensis]

Protein Classification

cytochrome c oxidase assembly protein( domain architecture ID 756)

cytochrome c oxidase assembly protein is involved in the insertion of copper into subunit I of cytochrome C oxidase; similar to Ehrlichia ruminantium cytochrome c oxidase assembly protein CtaG

Gene Ontology:  GO:0005507

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CtaG_Cox11 super family cl01240
Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is ...
 1-38 3.86e-21

Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units. The C terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae. Met 224 is also thought to play a role in copper transfer or stabilising the copper site.


The actual alignment was detected with superfamily member pfam04442:

Pssm-ID: 470128  Cd Length: 148  Bit Score: 78.70  E-value: 3.86e-21
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 823332263    1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:pfam04442  67 LVFYTATNLSDRPIVGQATYNVTPGQAGAYFNKIECFC 104
 
Name Accession Description Interval E-value
CtaG_Cox11 pfam04442
Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is ...
 1-38 3.86e-21

Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units. The C terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae. Met 224 is also thought to play a role in copper transfer or stabilising the copper site.


Pssm-ID: 461313  Cd Length: 148  Bit Score: 78.70  E-value: 3.86e-21
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 823332263    1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:pfam04442  67 LVFYTATNLSDRPIVGQATYNVTPGQAGAYFNKIECFC 104
PTZ00128 PTZ00128
cytochrome c oxidase assembly protein-like; Provisional
 1-38 7.68e-19

cytochrome c oxidase assembly protein-like; Provisional


Pssm-ID: 185464  Cd Length: 232  Bit Score: 74.76  E-value: 7.68e-19
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 823332263   1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:PTZ00128 141 LAFYRAKNRSDKPVIGVATYHIAPPEAGLYFNKIQCFC 178
COX11 COG3175
Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, ...
 1-38 6.81e-17

Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442408  Cd Length: 189  Bit Score: 68.74  E-value: 6.81e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 823332263   1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:COG3175   98 TVFYEATNLSDRPIVGQAIPSVTPGQAGAYFNKIECFC 135
 
Name Accession Description Interval E-value
CtaG_Cox11 pfam04442
Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is ...
 1-38 3.86e-21

Cytochrome c oxidase assembly protein CtaG/Cox11; Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units. The C terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae. Met 224 is also thought to play a role in copper transfer or stabilising the copper site.


Pssm-ID: 461313  Cd Length: 148  Bit Score: 78.70  E-value: 3.86e-21
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 823332263    1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:pfam04442  67 LVFYTATNLSDRPIVGQATYNVTPGQAGAYFNKIECFC 104
PTZ00128 PTZ00128
cytochrome c oxidase assembly protein-like; Provisional
 1-38 7.68e-19

cytochrome c oxidase assembly protein-like; Provisional


Pssm-ID: 185464  Cd Length: 232  Bit Score: 74.76  E-value: 7.68e-19
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 823332263   1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:PTZ00128 141 LAFYRAKNRSDKPVIGVATYHIAPPEAGLYFNKIQCFC 178
COX11 COG3175
Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, ...
 1-38 6.81e-17

Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442408  Cd Length: 189  Bit Score: 68.74  E-value: 6.81e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 823332263   1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:COG3175   98 TVFYEATNLSDRPIVGQAIPSVTPGQAGAYFNKIECFC 135
PRK05089 PRK05089
cytochrome C oxidase assembly protein; Provisional
 1-38 2.57e-15

cytochrome C oxidase assembly protein; Provisional


Pssm-ID: 235341  Cd Length: 188  Bit Score: 64.53  E-value: 2.57e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 823332263   1 LAFYTAENRSSTPITGVSTYNVTPMKAAVYFNKIQCFC 38
Cdd:PRK05089  97 LVFYEAENLSDRPIVGQAIPSVTPGQAGAYFNKIECFC 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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