TP53, partial [synthetic construct]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
109-288 | 3.12e-95 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. : Pssm-ID: 176262 Cd Length: 179 Bit Score: 282.24 E-value: 3.12e-95
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P53_tetramer | pfam07710 | P53 tetramerization motif; |
319-358 | 1.70e-13 | ||||
P53 tetramerization motif; : Pssm-ID: 462238 Cd Length: 42 Bit Score: 64.23 E-value: 1.70e-13
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TAD2 | pfam18521 | Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ... |
35-59 | 1.81e-11 | ||||
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH. : Pssm-ID: 375947 Cd Length: 25 Bit Score: 58.22 E-value: 1.81e-11
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P53_TAD | pfam08563 | P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ... |
6-30 | 1.66e-08 | ||||
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence. : Pssm-ID: 462520 Cd Length: 25 Bit Score: 49.86 E-value: 1.66e-08
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Name | Accession | Description | Interval | E-value | ||||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
109-288 | 3.12e-95 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 282.24 E-value: 3.12e-95
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P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
99-289 | 1.98e-83 | ||||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 252.59 E-value: 1.98e-83
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P53_tetramer | pfam07710 | P53 tetramerization motif; |
319-358 | 1.70e-13 | ||||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 64.23 E-value: 1.70e-13
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TAD2 | pfam18521 | Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ... |
35-59 | 1.81e-11 | ||||
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH. Pssm-ID: 375947 Cd Length: 25 Bit Score: 58.22 E-value: 1.81e-11
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P53_TAD | pfam08563 | P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ... |
6-30 | 1.66e-08 | ||||
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence. Pssm-ID: 462520 Cd Length: 25 Bit Score: 49.86 E-value: 1.66e-08
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Name | Accession | Description | Interval | E-value | ||||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
109-288 | 3.12e-95 | ||||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 282.24 E-value: 3.12e-95
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P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
99-289 | 1.98e-83 | ||||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 252.59 E-value: 1.98e-83
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P53_tetramer | pfam07710 | P53 tetramerization motif; |
319-358 | 1.70e-13 | ||||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 64.23 E-value: 1.70e-13
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TAD2 | pfam18521 | Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in ... |
35-59 | 1.81e-11 | ||||
Transactivation domain 2; This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH. Pssm-ID: 375947 Cd Length: 25 Bit Score: 58.22 E-value: 1.81e-11
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P53_TAD | pfam08563 | P53 transactivation motif; The binding of the p53 transactivation domain by regulatory ... |
6-30 | 1.66e-08 | ||||
P53 transactivation motif; The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence. Pssm-ID: 462520 Cd Length: 25 Bit Score: 49.86 E-value: 1.66e-08
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Blast search parameters | ||||
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