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Conserved domains on  [gi|837349810|gb|AKM78994|]
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hypothetical protein UY43_C0001G0247 [Candidatus Beckwithbacteria bacterium GW2011_GWC1_49_16]

Protein Classification

DMT family transporter( domain architecture ID 11430850)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 4-284 1.40e-11

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


:

Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 63.32  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   4 FLLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLPW---APAGFNSGLWLPIFLVGVYETFV-MLLLF 79
Cdd:COG0697    5 ILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLrgrRLPPLSRRDWLLLLLRGLLGLALaFLLFF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  80 YTMRIGDISVVFPITtGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAKTtkekIRQKTGLKKGALPAMLVAV 159
Cdd:COG0697   85 LALQYTPAALAALLL-ALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPG----GGGGGGSLLGDLLALLAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 160 GTGLYLFLVGLVARGSSWFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWqWILPAAFLDVLGFSFYNMVVVQAEVS 239
Cdd:COG0697  160 SWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLA-LLYLGLFGTALAYLLWFRALRRLGAS 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 837349810 240 YATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVILQL 284
Cdd:COG0697  239 RAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAAL 283
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 4-284 1.40e-11

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 63.32  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   4 FLLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLPW---APAGFNSGLWLPIFLVGVYETFV-MLLLF 79
Cdd:COG0697    5 ILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLrgrRLPPLSRRDWLLLLLRGLLGLALaFLLFF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  80 YTMRIGDISVVFPITtGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAKTtkekIRQKTGLKKGALPAMLVAV 159
Cdd:COG0697   85 LALQYTPAALAALLL-ALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPG----GGGGGGSLLGDLLALLAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 160 GTGLYLFLVGLVARGSSWFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWqWILPAAFLDVLGFSFYNMVVVQAEVS 239
Cdd:COG0697  160 SWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLA-LLYLGLFGTALAYLLWFRALRRLGAS 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 837349810 240 YATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVILQL 284
Cdd:COG0697  239 RAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAAL 283
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 46-282 6.04e-06

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 46.68  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  46 LLLLPWAPAGFNSGLWLPIFLVGVYETFVMLLLFYTMRIGDISVVFPITTGGYALVAFVLGWLFLHE-TTSLARILGML- 123
Cdd:cd23110   40 LVVFLFLGPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEwSGTGAKLLGLLa 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 124 --LVILGIVLVSAKTTKEKIRQKtGLKKGALPAMLVAVGTGLYLFLVGLVarGSSWFVTALGIRIAISLTALMLLLVKRv 201
Cdd:cd23110  120 laLIIIGVLLTSYTDKGSAKKSK-NQKKGLLILLLSTIGYWSYSAIPKLF--SVSGLAIFLPQALGMLLGALIYALFTR- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 202 SLKKLWQGVVWQWILpAAFLDVLGFSFYNMVVVQAEVSYATIMISAQSLITVLLGYFVLKEQVVRRQW----AGIFLAIG 277
Cdd:cd23110  196 KPKALKEKASWRNIL-TGLLWGIANLAYLLSAQANGVATAFTLSQLNVVISTLGGILILHEKKTKRELrftlIGLVLIVA 274


                 ....*
gi 837349810 278 GLVIL 282
Cdd:cd23110  275 GAVLT 279
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 5-133 1.00e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810    5 LLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLP--WAPAGFNSGLWLPIFLVGVYETFVM-LLLFYT 81
Cdd:pfam00892   5 LLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALftGGKLVIPLKSWLALLYLGVLGTFLGfLLYFYG 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 837349810   82 MRIGDISVVFPITTGgYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVS 133
Cdd:pfam00892  85 LKYVSASNASVITSL-SPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLIL 135
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 4-284 1.40e-11

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 63.32  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   4 FLLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLPW---APAGFNSGLWLPIFLVGVYETFV-MLLLF 79
Cdd:COG0697    5 ILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLrgrRLPPLSRRDWLLLLLRGLLGLALaFLLFF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  80 YTMRIGDISVVFPITtGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAKTtkekIRQKTGLKKGALPAMLVAV 159
Cdd:COG0697   85 LALQYTPAALAALLL-ALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPG----GGGGGGSLLGDLLALLAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 160 GTGLYLFLVGLVARGSSWFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWqWILPAAFLDVLGFSFYNMVVVQAEVS 239
Cdd:COG0697  160 SWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLA-LLYLGLFGTALAYLLWFRALRRLGAS 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 837349810 240 YATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVILQL 284
Cdd:COG0697  239 RAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAAL 283
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
4-135 1.96e-10

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 57.50  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   4 FLLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLPW-----APAGFNSGLWLPIFLVGVYETFVMLLL 78
Cdd:COG2510    3 LLLALLSAFFAGLTAIFAKIGLKGIDPNLATFIRTLVALIFLLLILLVtgklgELPELSPKSWLFLLLSGLATGLSWLFY 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 837349810  79 FYTMRIGDISVVFPITtGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAK 135
Cdd:COG2510   83 FRALKLGPASIVAPID-KLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSLK 138
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
44-282 5.47e-07

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 49.86  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  44 FFLLLLPWAPAGFNSGLWLPIFLVGVYETFVMLLLFYTMRIGDISVVFPITTGGYALVAFVLGWLFLHE-TTSLARILG- 121
Cdd:COG4975   42 FAIIVFLFVQPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEwTTTTAKVLGf 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 122 --MLLVILGIVLVSAKTTKEKIRQKTGLKKGALPAMLVAVGTGLYLFLVGLVARGSSWFVTALGIRIAISltalMLLLVK 199
Cdd:COG4975  122 laLILIIIGAVLTSYQDKKSSQESKKNLKKGLIALLISTIGYVLYVVIPRLFGVDGWSAFLPQAIGMLIG----ALILSL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 200 RVSLKKLWQGVVWQWILPAAFldvlgFSFYN--MVVVQAEVSYATIMISAQS--LITVLLGYFVLKEQVVRRQW----AG 271
Cdd:COG4975  198 KSKGSKFFEKKTYKNIITGLI-----WAIGNlfMLISAQANGVATGFSLSQMgvVISTLGGILILGEKKTKKEMiytiIG 272

                        250
                 ....*....|.
gi 837349810 272 IFLAIGGLVIL 282
Cdd:COG4975  273 LVLIVAGGILI 283
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
149-282 1.36e-06

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 46.72  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 149 KGALPAMLVAVGTGLYLFLVGLVARG-SSWFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWQWILPAAFLDVLGFS 227
Cdd:COG2510    1 SWLLLALLSAFFAGLTAIFAKIGLKGiDPNLATFIRTLVALIFLLLILLVTGKLGELPELSPKSWLFLLLSGLATGLSWL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 837349810 228 FYNMVVVQAEVSYATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVIL 282
Cdd:COG2510   81 FYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILL 135
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 46-282 6.04e-06

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 46.68  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  46 LLLLPWAPAGFNSGLWLPIFLVGVYETFVMLLLFYTMRIGDISVVFPITTGGYALVAFVLGWLFLHE-TTSLARILGML- 123
Cdd:cd23110   40 LVVFLFLGPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEwSGTGAKLLGLLa 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 124 --LVILGIVLVSAKTTKEKIRQKtGLKKGALPAMLVAVGTGLYLFLVGLVarGSSWFVTALGIRIAISLTALMLLLVKRv 201
Cdd:cd23110  120 laLIIIGVLLTSYTDKGSAKKSK-NQKKGLLILLLSTIGYWSYSAIPKLF--SVSGLAIFLPQALGMLLGALIYALFTR- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 202 SLKKLWQGVVWQWILpAAFLDVLGFSFYNMVVVQAEVSYATIMISAQSLITVLLGYFVLKEQVVRRQW----AGIFLAIG 277
Cdd:cd23110  196 KPKALKEKASWRNIL-TGLLWGIANLAYLLSAQANGVATAFTLSQLNVVISTLGGILILHEKKTKRELrftlIGLVLIVA 274


                 ....*
gi 837349810 278 GLVIL 282
Cdd:cd23110  275 GAVLT 279
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 5-140 1.05e-05

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 45.99  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   5 LLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLPWA--PAGFNSGLWLPIFLVGVYETFVMLLLFYT- 81
Cdd:COG0697  152 LLALLAALSWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTglPLPLSAAAWLALLYLGLFGTALAYLLWFRa 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 837349810  82 MRIGDISVVFPITTGGyALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAKTTKEK 140
Cdd:COG0697  232 LRRLGASRAAPLTYLE-PVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERRRA 289
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
61-132 2.47e-04

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 39.70  E-value: 2.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 837349810  61 WLPIFLVGVYETFVMLLLFYTMRIGDISVVFPITTGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLV 132
Cdd:COG2076   28 LLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 5-133 1.00e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810    5 LLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGIPFFLLLLP--WAPAGFNSGLWLPIFLVGVYETFVM-LLLFYT 81
Cdd:pfam00892   5 LLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALftGGKLVIPLKSWLALLYLGVLGTFLGfLLYFYG 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 837349810   82 MRIGDISVVFPITTGgYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVS 133
Cdd:pfam00892  85 LKYVSASNASVITSL-SPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLIL 135
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 149-282 1.74e-03

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 39.05  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810 149 KGALPAMLVAVGTGLYLFLVGLVARGSSWFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWQWILPAAFLDVLGFSF 228
Cdd:COG0697    3 RGILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 837349810 229 YNMVVVQAEVSYATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVIL 282
Cdd:COG0697   83 FFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLI 136
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 149-282 2.35e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 37.56  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  149 KGALPAMLVAVGTGLYLFLVGLVARGSSwFVTALGIRIAISLTALMLLLVKRVSLKKLWQGVVWQWILPAAFLDVLGFSF 228
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRIS-PLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 837349810  229 YNMVVVQAEVSYATIMISAQSLITVLLGYFVLKEQVVRRQWAGIFLAIGGLVIL 282
Cdd:pfam00892  81 YFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
5-140 3.29e-03

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 38.26  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   5 LLAFIAMVSLGVGWFFAARSSKDMDPLASMFMFQLVGipfFLLLLPWAPAG-----FNSGLWLPIFLVGVYETFV-MLLL 78
Cdd:COG5006  148 LFALGAAACWALYILLGRRVGARLPGLTGLALGMLVA---ALVLLPFGLPTagpalLDPPVLLLGLGVAVLSSVLpYSLE 224

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 837349810  79 FYTMRIGDISVvFPITTGGYALVAFVLGWLFLHETTSLARILGMLLVILGIVLVSAKTTKEK 140
Cdd:COG5006  225 MVALRRLPART-FGILMSLEPAVAALAGWLVLGEVLTPLQWLGIALVVAASAGATLTARRRP 285
Sugar_transport pfam06800
Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 ...
 54-282 8.27e-03

Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,


Pssm-ID: 429127 [Multi-domain]  Cd Length: 280  Bit Score: 37.25  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810   54 AGFNSGLWLPIFLVGVYETFVMLLLFYTMRIGDISVVFPITTGGYALVAFVLGWLFLHE-TTSLARILG---MLLVILGI 129
Cdd:pfam06800  48 PTLTLKIFIFGFISGAFWAFGQIGQFKSFKLVGVSKAMPISTGMQLVGTSLFGVFAFGEwSTIIQKILGflaLILIVIGI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837349810  130 VLVSAKTTKEKIRqKTGLKKGALPAMLVAVGTGLYLFLVGLVARG--SSWFVTALGIRIAISLTALMLLLVKRVslkklw 207
Cdd:pfam06800 128 YLTSWTEKKEAKS-ASNLKKGIIILLVSTIGYWGYVVLPQLFKVDglQAILPQAIGMVIGALIFALFHKTAFFE------ 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 837349810  208 qGVVWQWILPAAFldvLGFSFYNMVVVQAEVSYATIMISAQSLITV--LLGYFVLKEQVVRRQWagIFLAIGGLVIL 282
Cdd:pfam06800 201 -KVTYLNIIPGLF---WAIGNLFMLISAQMVGVATGFSLSQLGVVIstIGGIFFLGEKKTKKEM--VFVIIGILLIV 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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