NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|908268857|gb|AKT05363|]
View 

nonstructural protein NS3-4A, partial [Hepacivirus hominis]

Protein Classification

polyprotein( domain architecture ID 19614656)

partial polyprotein such as hepatitis C virus polyprotein, containing NS3 protease, helicase, and NS4

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 336-460 2.31e-44

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd18806:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 145  Bit Score: 155.50  E-value: 2.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 336 IEEVALGSEGEIPFYGKAIPIaqLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSV---IPTAGDVVVCATD 412
Cdd:cd18806    1 IEDVALEIPGRIWFYGKAWIT--IYGGKTVWFVHSKKKGNEIAACLSGLGKNVIQLYRKLDDTEypkIKTIDWDFVVTTD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 908268857 413 ALMTG*TGDFDSVIDCNVAVEQYVDFSLDPTFsIETRTAPQDAVSRSQ 460
Cdd:cd18806   79 ISEMGANFDADRVIDCRTCVKPTILFSGDFRV-ILTGPVPQTAASAAQ 125
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 198-340 3.27e-38

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd17931:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 151  Bit Score: 138.84  E-value: 3.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 198 QVGYLHAPTGSGKSTKVPAAYVAQGYN----VLVLNPSVAATLGFGSFMSrayGIDPNIRTGTRTITTGAK--LTYSTYG 271
Cdd:cd17931    2 QLTVLDLHPGAGKTTRVLPQIIREAIKkrlrTLVLAPTRVVAAEMYEALR---GLPIRYRTGAVKEEHGGNeiVDYMCHG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 908268857 272 KFLaDGGCSGGA---YDVIICDECHAQDATSILGIGTVLDQAETaGVRLTVLATATPPGSITVPH---SNIEEVA 340
Cdd:cd17931   79 TFT-CRLLSPKRvpnYNLIIMDEAHFTDPASIAARGYIHTRVEM-GEAAVIFMTATPPGTVTPFPqsnHPIEDFE 151
HCV_NS4a pfam01006
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 632-685 4.15e-20

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


:

Pssm-ID: 366414  Cd Length: 55  Bit Score: 84.05  E-value: 4.15e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 908268857  632 STWVLLGGVLAALAAYCLSVGCVVIVGHIELGGKP-ALVPDKEVLYQQYDEMEEC 685
Cdd:pfam01006   1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKPpAVVPDREVLYQQGEEMEEC 55
 
Name Accession Description Interval E-value
SF2_C_viral cd18806
C-terminal helicase domain of viral helicase; Viral helicases in this family here are ...
 336-460 2.31e-44

C-terminal helicase domain of viral helicase; Viral helicases in this family here are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350193 [Multi-domain]  Cd Length: 145  Bit Score: 155.50  E-value: 2.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 336 IEEVALGSEGEIPFYGKAIPIaqLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSV---IPTAGDVVVCATD 412
Cdd:cd18806    1 IEDVALEIPGRIWFYGKAWIT--IYGGKTVWFVHSKKKGNEIAACLSGLGKNVIQLYRKLDDTEypkIKTIDWDFVVTTD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 908268857 413 ALMTG*TGDFDSVIDCNVAVEQYVDFSLDPTFsIETRTAPQDAVSRSQ 460
Cdd:cd18806   79 ISEMGANFDADRVIDCRTCVKPTILFSGDFRV-ILTGPVPQTAASAAQ 125
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 198-340 3.27e-38

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 138.84  E-value: 3.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 198 QVGYLHAPTGSGKSTKVPAAYVAQGYN----VLVLNPSVAATLGFGSFMSrayGIDPNIRTGTRTITTGAK--LTYSTYG 271
Cdd:cd17931    2 QLTVLDLHPGAGKTTRVLPQIIREAIKkrlrTLVLAPTRVVAAEMYEALR---GLPIRYRTGAVKEEHGGNeiVDYMCHG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 908268857 272 KFLaDGGCSGGA---YDVIICDECHAQDATSILGIGTVLDQAETaGVRLTVLATATPPGSITVPH---SNIEEVA 340
Cdd:cd17931   79 TFT-CRLLSPKRvpnYNLIIMDEAHFTDPASIAARGYIHTRVEM-GEAAVIFMTATPPGTVTPFPqsnHPIEDFE 151
HCV_NS4a pfam01006
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 632-685 4.15e-20

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


Pssm-ID: 366414  Cd Length: 55  Bit Score: 84.05  E-value: 4.15e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 908268857  632 STWVLLGGVLAALAAYCLSVGCVVIVGHIELGGKP-ALVPDKEVLYQQYDEMEEC 685
Cdd:pfam01006   1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKPpAVVPDREVLYQQGEEMEEC 55
DEXDc smart00487
DEAD-like helicases superfamily;
191-329 4.23e-12

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 65.59  E-value: 4.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857   191 PAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYN-----VLVLNPSVAATLGFGSFMSRA-----------YGIDPNIRT 254
Cdd:smart00487  18 EALLSGLRDVILAAPTGSGKTLAALLPALEALKRgkggrVLVLVPTRELAEQWAEELKKLgpslglkvvglYGGDSKREQ 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857   255 GTRTITTGAKLTYSTYGKF---LADGGCSGGAYDVIICDECH----AQDATSILGIGTVLDQAetagvRLTVLATATPPG 327
Cdd:smart00487  98 LRKLESGKTDILVTTPGRLldlLENDKLSLSNVDLVILDEAHrlldGGFGDQLEKLLKLLPKN-----VQLLLLSATPPE 172


                   ..
gi 908268857   328 SI 329
Cdd:smart00487 173 EI 174
Flavi_DEAD pfam07652
Flavivirus DEAD domain;
284-335 3.67e-05

Flavivirus DEAD domain;


Pssm-ID: 400138 [Multi-domain]  Cd Length: 146  Bit Score: 44.25  E-value: 3.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 908268857  284 YDVIICDECHAQDATSILGIG---TVLDQAETAgvrlTVLATATPPGSIT-VPHSN 335
Cdd:pfam07652  94 YEVIIMDEAHFTDPASIAARGyisTLVELGEAA----AIFMTATPPGTSDpFPESN 145
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
356-414 1.67e-04

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 44.75  E-value: 1.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 908268857 356 IAQLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSV--------IptAGDV-VVCATDAL 414
Cdd:COG0514  225 LKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEreanqdrfL--RDEVdVIVATIAF 290
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 355-396 2.41e-03

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 41.24  E-value: 2.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 908268857 355 PIAQL-------KGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLD 396
Cdd:PRK11057 223 PLDQLmryvqeqRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLD 271
 
Name Accession Description Interval E-value
SF2_C_viral cd18806
C-terminal helicase domain of viral helicase; Viral helicases in this family here are ...
 336-460 2.31e-44

C-terminal helicase domain of viral helicase; Viral helicases in this family here are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350193 [Multi-domain]  Cd Length: 145  Bit Score: 155.50  E-value: 2.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 336 IEEVALGSEGEIPFYGKAIPIaqLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSV---IPTAGDVVVCATD 412
Cdd:cd18806    1 IEDVALEIPGRIWFYGKAWIT--IYGGKTVWFVHSKKKGNEIAACLSGLGKNVIQLYRKLDDTEypkIKTIDWDFVVTTD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 908268857 413 ALMTG*TGDFDSVIDCNVAVEQYVDFSLDPTFsIETRTAPQDAVSRSQ 460
Cdd:cd18806   79 ISEMGANFDADRVIDCRTCVKPTILFSGDFRV-ILTGPVPQTAASAAQ 125
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 198-340 3.27e-38

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 138.84  E-value: 3.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857 198 QVGYLHAPTGSGKSTKVPAAYVAQGYN----VLVLNPSVAATLGFGSFMSrayGIDPNIRTGTRTITTGAK--LTYSTYG 271
Cdd:cd17931    2 QLTVLDLHPGAGKTTRVLPQIIREAIKkrlrTLVLAPTRVVAAEMYEALR---GLPIRYRTGAVKEEHGGNeiVDYMCHG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 908268857 272 KFLaDGGCSGGA---YDVIICDECHAQDATSILGIGTVLDQAETaGVRLTVLATATPPGSITVPH---SNIEEVA 340
Cdd:cd17931   79 TFT-CRLLSPKRvpnYNLIIMDEAHFTDPASIAARGYIHTRVEM-GEAAVIFMTATPPGTVTPFPqsnHPIEDFE 151
HCV_NS4a pfam01006
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 632-685 4.15e-20

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


Pssm-ID: 366414  Cd Length: 55  Bit Score: 84.05  E-value: 4.15e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 908268857  632 STWVLLGGVLAALAAYCLSVGCVVIVGHIELGGKP-ALVPDKEVLYQQYDEMEEC 685
Cdd:pfam01006   1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKPpAVVPDREVLYQQGEEMEEC 55
DEXDc smart00487
DEAD-like helicases superfamily;
191-329 4.23e-12

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 65.59  E-value: 4.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857   191 PAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYN-----VLVLNPSVAATLGFGSFMSRA-----------YGIDPNIRT 254
Cdd:smart00487  18 EALLSGLRDVILAAPTGSGKTLAALLPALEALKRgkggrVLVLVPTRELAEQWAEELKKLgpslglkvvglYGGDSKREQ 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857   255 GTRTITTGAKLTYSTYGKF---LADGGCSGGAYDVIICDECH----AQDATSILGIGTVLDQAetagvRLTVLATATPPG 327
Cdd:smart00487  98 LRKLESGKTDILVTTPGRLldlLENDKLSLSNVDLVILDEAHrlldGGFGDQLEKLLKLLPKN-----VQLLLLSATPPE 172


                   ..
gi 908268857   328 SI 329
Cdd:smart00487 173 EI 174
Flavi_DEAD pfam07652
Flavivirus DEAD domain;
284-335 3.67e-05

Flavivirus DEAD domain;


Pssm-ID: 400138 [Multi-domain]  Cd Length: 146  Bit Score: 44.25  E-value: 3.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 908268857  284 YDVIICDECHAQDATSILGIG---TVLDQAETAgvrlTVLATATPPGSIT-VPHSN 335
Cdd:pfam07652  94 YEVIIMDEAHFTDPASIAARGyisTLVELGEAA----AIFMTATPPGTSDpFPESN 145
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 360-413 4.34e-05

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 43.74  E-value: 4.34e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 908268857 360 KGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSVIPT------AGDV-VVCATDA 413
Cdd:cd18794   29 LGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDvqrkwlRDKIqVIVATVA 89
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
356-414 1.67e-04

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 44.75  E-value: 1.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 908268857 356 IAQLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSV--------IptAGDV-VVCATDAL 414
Cdd:COG0514  225 LKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEreanqdrfL--RDEVdVIVATIAF 290
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 356-396 5.71e-04

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 40.57  E-value: 5.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 908268857 356 IAQLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLD 396
Cdd:cd18787   22 LEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLS 62
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 355-396 2.41e-03

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 41.24  E-value: 2.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 908268857 355 PIAQL-------KGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLD 396
Cdd:PRK11057 223 PLDQLmryvqeqRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLD 271
ResIII pfam04851
Type III restriction enzyme, res subunit;
200-293 6.70e-03

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 38.04  E-value: 6.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908268857  200 GYLHAPTGSGK---STKVPAAYVAQGY--NVLVLNPSVA----ATLGFGSFMSRAYGI-DPNIRTGTRTITTGAKLTYST 269
Cdd:pfam04851  26 GLIVMATGSGKtltAAKLIARLFKKGPikKVLFLVPRKDlleqALEEFKKFLPNYVEIgEIISGDKKDESVDDNKIVVTT 105

                          90       100
                  ....*....|....*....|....*....
gi 908268857  270 YGKF-----LADGGCSGGAYDVIICDECH 293
Cdd:pfam04851 106 IQSLykaleLASLELLPDFFDVIIIDEAH 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH