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Conserved domains on  [gi|920783348|gb|ALA39997|]
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transferrin binding protein A, partial [Actinobacillus pleuropneumoniae]

Protein Classification

lactoferrin/transferrin family TonB-dependent receptor( domain architecture ID 11493155)

lactoferrin/transferrin family TonB-dependent receptor similar to Neisseria meningitidis TbpA, an integral outer membrane protein component of the transferrin transport system that promotes iron release from transferrin

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TonB-tbp-lbp TIGR01776
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-924 0e+00

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


:

Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 1345.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348    1 MKNKLNLISLALLSLFAVQSY-----------AEQAVQLNDVYVTGTKKKaHKKENEVTGLGKVVKTPDTLSKEQVLGMR 69
Cdd:TIGR01776   4 KKHVLNLSILALSLLFATLSFqtadadsakdtANQAVYLDEITVTATKVA-HRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   70 DLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRS---SSGAINEIEYENLRSIQISKGASSS 146
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTSQGSRSgtaGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  147 EFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTHRDGKETKAHKDAESRS 226
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTKRRGKETKAHGDANKGV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  227 QNITRVGVETNELDTsnrytatTNNQHTygWFLIKDECPTLDCTPKQMARVTKDTpsfrsypEYTPEEKQAYENQKHITE 306
Cdd:TIGR01776 243 QSIDRLDAFEQKYDL-------RPPQGR--SFIVENECASLDCAPCAQYGYVYDN-------QLSDEEKAQVLASRYRHE 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  307 RLNAQDYTGEYRALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLLRtGRNWYpmnNAK 386
Cdd:TIGR01776 307 QVSAKDYTGENRLLPNPLDYRSDSWLAKLGYHLNNRHYVGGVLEDTKQRYDIRDMTEPAYLGLSDAVK-GRLKN---GGG 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  387 GLYRDNALDGVAIDyfteDGVKSSKGLRWAKARFIDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLREN 466
Cdd:TIGR01776 383 IYLGDNYLEGLNFN----AGPASFKGLRYARGKFFDERHTKRRYGLEYRYKNEDYDRWLDTAKLSLDKQKIELRSRLQEL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  467 NCSEYPTIDKNCRATLDKLWSSTKNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGT 546
Cdd:TIGR01776 459 HCSQYPKVDKNCRPSLDKPYSFYKNDRNHYKEKHNVIQAEFDKSFDLGGGRHHLNLLLGYDKFKSQLSRHDYRRQNAVGT 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  547 WHRIRGNGYKDTPYIYELKDQAIYSKNECDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRS 626
Cdd:TIGR01776 539 YESIRGDEPKQNPYKYRLGKATIVKNSLCRYSETNGYANCCEPRKIKGSNHYISLNDNFTIGKYVDLGLGGRYDKHNFKS 618

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  627 THRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPEKSLNQEVAAT 706
Cdd:TIGR01776 619 TDRLVYSGTYRNLSWNFGIVVKPTPFFSLSYRASTGFRVPSFYELYGERRGKASKKNVQQFLRTPDLKPEKSLNHEIGAR 698

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  707 FKGDFGVVEVSYFKNDYKQLIAPAERM--------HQTQSMINYFNVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAY 778
Cdd:TIGR01776 699 FKGDFGHLEVSYFRNRYKDMIAEAPETrtdneagqTYGYCDHNYHNAQNAVLKGINILGKLDLNGVASKLPDGLYSTLAY 778

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  779 SKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPDELRGNEQVGFAN-YERTATKKR 857
Cdd:TIGR01776 779 NRIKVKEVKNRAGRLDVRSPLLDAIQPARYVVGLGYDHPSQKWGINLTLTYSKAKNPDELAGTEYLGNGNvVKQTATKKL 858

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920783348  858 TRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQHTNVKDYARYAAPGRNYV 924
Cdd:TIGR01776 859 SRSWYTLDVTGYVNLKKNLTLRAGVYNLFNYRYTTWESVRQTASNAVNQHTGVSNYNRYAAPGRNYS 925
 
Name Accession Description Interval E-value
TonB-tbp-lbp TIGR01776
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-924 0e+00

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 1345.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348    1 MKNKLNLISLALLSLFAVQSY-----------AEQAVQLNDVYVTGTKKKaHKKENEVTGLGKVVKTPDTLSKEQVLGMR 69
Cdd:TIGR01776   4 KKHVLNLSILALSLLFATLSFqtadadsakdtANQAVYLDEITVTATKVA-HRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   70 DLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRS---SSGAINEIEYENLRSIQISKGASSS 146
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTSQGSRSgtaGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  147 EFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTHRDGKETKAHKDAESRS 226
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTKRRGKETKAHGDANKGV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  227 QNITRVGVETNELDTsnrytatTNNQHTygWFLIKDECPTLDCTPKQMARVTKDTpsfrsypEYTPEEKQAYENQKHITE 306
Cdd:TIGR01776 243 QSIDRLDAFEQKYDL-------RPPQGR--SFIVENECASLDCAPCAQYGYVYDN-------QLSDEEKAQVLASRYRHE 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  307 RLNAQDYTGEYRALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLLRtGRNWYpmnNAK 386
Cdd:TIGR01776 307 QVSAKDYTGENRLLPNPLDYRSDSWLAKLGYHLNNRHYVGGVLEDTKQRYDIRDMTEPAYLGLSDAVK-GRLKN---GGG 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  387 GLYRDNALDGVAIDyfteDGVKSSKGLRWAKARFIDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLREN 466
Cdd:TIGR01776 383 IYLGDNYLEGLNFN----AGPASFKGLRYARGKFFDERHTKRRYGLEYRYKNEDYDRWLDTAKLSLDKQKIELRSRLQEL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  467 NCSEYPTIDKNCRATLDKLWSSTKNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGT 546
Cdd:TIGR01776 459 HCSQYPKVDKNCRPSLDKPYSFYKNDRNHYKEKHNVIQAEFDKSFDLGGGRHHLNLLLGYDKFKSQLSRHDYRRQNAVGT 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  547 WHRIRGNGYKDTPYIYELKDQAIYSKNECDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRS 626
Cdd:TIGR01776 539 YESIRGDEPKQNPYKYRLGKATIVKNSLCRYSETNGYANCCEPRKIKGSNHYISLNDNFTIGKYVDLGLGGRYDKHNFKS 618

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  627 THRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPEKSLNQEVAAT 706
Cdd:TIGR01776 619 TDRLVYSGTYRNLSWNFGIVVKPTPFFSLSYRASTGFRVPSFYELYGERRGKASKKNVQQFLRTPDLKPEKSLNHEIGAR 698

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  707 FKGDFGVVEVSYFKNDYKQLIAPAERM--------HQTQSMINYFNVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAY 778
Cdd:TIGR01776 699 FKGDFGHLEVSYFRNRYKDMIAEAPETrtdneagqTYGYCDHNYHNAQNAVLKGINILGKLDLNGVASKLPDGLYSTLAY 778

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  779 SKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPDELRGNEQVGFAN-YERTATKKR 857
Cdd:TIGR01776 779 NRIKVKEVKNRAGRLDVRSPLLDAIQPARYVVGLGYDHPSQKWGINLTLTYSKAKNPDELAGTEYLGNGNvVKQTATKKL 858

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920783348  858 TRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQHTNVKDYARYAAPGRNYV 924
Cdd:TIGR01776 859 SRSWYTLDVTGYVNLKKNLTLRAGVYNLFNYRYTTWESVRQTASNAVNQHTGVSNYNRYAAPGRNYS 925
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 58-924 3.38e-82

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 278.18  E-value: 3.38e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  58 DTLSKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYsrsssGAINEIEYENLRSI 137
Cdd:cd01347    8 EDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSNYGRG-----VDLNTIPPELIERV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 138 QISKGASSSEFGSGSLGGSVQFRTKEVSDiiKPGQSWGLDTKSA--YSSKNQQWLNSLAFAGtHNGFDALVIYTHRDGKE 215
Cdd:cd01347   83 EVLKGPSSALYGSGAIGGVVNIITKRPTD--EFGGSVTAGYGSDnsGSSGGGGFDVSGALAD-DGAFGARLYGAYRDGDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 216 TKAHKdaesrsqnitrvgvetneldtsnrytattnnqhtygwflikdecptldctpkqmarvtkdtpsfrsypeytpeek 295
Cdd:cd01347  160 TIDGD--------------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 296 qayenqkhiterlnaqdytgeyrALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLlrT 375
Cdd:cd01347  165 -----------------------GQADDSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSL--G 219

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 376 GRNWYPMNNAKGLYRDNALDGVAIDYFTEDgvksskglrwakarFIDEWHTRdRLGALYRYTNQDGNRLIDRLSLSFDQQ 455
Cdd:cd01347  220 GGPSSNTNGDRDWDYRDRYRKRASLGLEHD--------------LNDTGWTL-RANLSYSYTDNDGDPLILNGGNNAAGG 284

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 456 KINLSTRlrenncseyptidkncratldklwsstkneQSSYEEKHDTIQLSLDKTVQTGLGKHQLnmLLGSDRFNSTLKr 535
Cdd:cd01347  285 DLGRSGY------------------------------SSERDTTQLGFDAGLNAPFGTGPVAHTL--TLGVEYRREELD- 331

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 536 heilsefsvgtwhrirgngykdtpyiyelkdqaiysknecdysgtiagradcatskIKGHNHYIAlrDNFAITKYLDIGL 615
Cdd:cd01347  332 --------------------------------------------------------EKQTALYAQ--DTIELTDDLTLTL 353

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 616 GYRFDKHKFRSTHRWA----NQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGamkgsSDAYQKTE 691
Cdd:cd01347  354 GLRYDHYDQDSKDTIAggttAKKSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHG-----GTAAVGNP 428

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 692 KLSPEKSLNQEVAATFK-GDFGVVEVSYFKNDYKQLIAPAERMHQTQSMINYFNVQDIKLDGINLIGKLDWNGVFdkipe 770
Cdd:cd01347  429 NLKPEKSKQYELGLKYDpGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASYDLTDGL----- 503

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 771 GIYTTLAYSKMRVKEVknyqgYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPDELRGNEQvgfanye 850
Cdd:cd01347  504 GLTGSYTYTDTEVKRT-----DGATTGNRLPGIPKHTANLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNT------- 571

                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 920783348 851 rtatkKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSslnaihqhtnvkDYARYAAPGRNYV 924
Cdd:cd01347  572 -----VKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYYTSLSVRGS------------GLYGYYGPGRTYY 628
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
28-905 1.75e-32

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 134.57  E-value: 1.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  28 LNDVYVTGTKkkAHKKENEVTGLGKVVkTPDTLSKEQVLGMRDLTRYDPGISVvEQGRGATTGYSIRGVD--RNRVGLAL 105
Cdd:COG1629    1 LEEVVVTATR--TDESLQDVPGSVSVI-SREQLEDQPATDLGDLLRRVPGVSV-TSAGGGAGQISIRGFGggGNRVLVLV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 106 DGLPQiqsyvsQYSRSSSGAINEIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTKevsdiiKPGQSWGLDTKSAYSSK 185
Cdd:COG1629   77 DGVPL------NDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTK------KPKDGKGGEVSASYGSY 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 186 NQQwLNSLAFAGTHNGFDALVIYTHRDGketkahkdaesrsqnitrvgvetneldtsnrytattnnqhtygwflikdecp 265
Cdd:COG1629  145 GTY-RASLSLSGGNGKLAYRLSASYRDS---------------------------------------------------- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 266 tldctpkqmarvtkdtpsfrsypeytpeekqayenqkhiterlnaqdytGEYRalpDPLKYKSDSWLVKLGYTFSPKHYV 345
Cdd:COG1629  172 -------------------------------------------------DGYR---DNSDSDRYNLRAKLGYQLGDDTRL 199

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 346 AGTYEHSKQRYDTRDMTYTAYWQPSDLLRTGRNWYPMNNAKGlyrdnaldgvaidyftedgvksskglrwakarfidewh 425
Cdd:COG1629  200 TLSASYSDSDQDSPGYLTLAALRPRGAMDDGTNPYSNDTDDN-------------------------------------- 241

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 426 TRDRLGALYRYTNQDgnrlidrlslsfDQQKINLSTRLRENncseyptiDKNCRATLDKLWSSTKN-EQSSYEEKHDTIQ 504
Cdd:COG1629  242 TRDRYSLSLEYEHLG------------DGLKLSASAYYRYD--------DTDLDSDFTPTPADGGTlEQTDFDNRTYGLE 301

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 505 LSLDKTVQTGlGKHQLnmLLGSDRFNSTLKRheilSEFSVGTWHRIRGNGYKDTPYIYELKDQAIYsknecdysgtiagr 584
Cdd:COG1629  302 LRLTYDLGFG-GKHTL--LVGLDYQRQDLDG----SGYPLDLGSGSLPTLTSGADDDGTTTSLALY-------------- 360

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 585 adcatskikghnhyiaLRDNFAITKYLDIGLGYRFDKHKFRSTHRWANQG------DYKNSAWNIGIVAKPTSFLSLSYR 658
Cdd:COG1629  361 ----------------AQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDsasgsrSYSAFSPSLGLTYQLSPNLSLYAS 424

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 659 ASSGFRVPSFQELFGLRYDGAMKGSSDayqktekLSPEKSLNQEVAATFKGDFGVV--EVSYFKNDYKQLIAPAERMHQT 736
Cdd:COG1629  425 YSRGFRAPTFGELYANGTDPYSVGNPD-------LKPETSTNYELGLRYRLLDGRLslSLALFYSDVDNEILSVPLPNDS 497

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 737 QSMINYFNVQDIKLDGINLigKLDWNgvfdkIPEGIYTTLAYSKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQ 816
Cdd:COG1629  498 GFSTYYTNAGKARSYGVEL--ELSYQ-----LTPGLSLNASYSYTDAKFDDDTDGSADLDGNRLPGVPPLTANLGLTYEF 570

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 817 PDeKWGVNLTMTHssgknpdelrgneqVGFANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESV 896
Cdd:COG1629  571 PG-GWSLGLGVRY--------------VGDRYLDDANTQGAPGGYTLVDLGAGYRFGDNLTLSLGVDNLFDKKYATSLSV 635


                 ....*....
gi 920783348 897 RQSSLNAIH 905
Cdd:COG1629  636 RASNVRGFL 644
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 414-923 3.45e-32

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 131.43  E-value: 3.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  414 RWAKARFIDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLRENNCSEYPT----IDKNCRATLDKLWSST 489
Cdd:pfam00593   1 GWQLSLDLLGDDTLLTLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRkrlsLGYDYDLGDGLSWLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  490 KNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGTWHRIRGNGYKDTPYIYelkdqai 569
Cdd:pfam00593  81 LRLGLRYSSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLDYRRLDDDA------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  570 ysknecDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRSTHRWANQGDYKNSA----WNIGI 645
Cdd:pfam00593 154 ------YDPYDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNGGGDNFSRSYsafsPRLGL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  646 VAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGamkGSSDAYQKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYKQ 725
Cdd:pfam00593 228 VYKPTDNLSLYASYSRGFRAPSLGELYGSGSGG---GGGAVAGGNPDLKPETSDNYELGLKYDDGRLSLSLALFYIDIKN 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  726 LIAPAERMHQTQSMIN-YFNVQDIKLDGINLIGKLD-WNGVFdkipegIYTTLAYSKMRVKEVKNYQGYmnirspLLDTI 803
Cdd:pfam00593 305 LITSDPDGPGLGGTVYtYTNVGKARIRGVELELSGRlWGLGL------SGGGYTYTDADDDADADDTGN------PLPNV 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  804 QPARYVVGVGYDQPDEKWGVNLTMTHSSgknpdelrgneqVGFANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVY 883
Cdd:pfam00593 373 PRHTANLGLTYDFPLGGWGARLGARYVG------------SGERRYGDAANTFKTPGYTLVDLSAGYRLNKNLTLRLGVN 440

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 920783348  884 NLMNYRYTTWESvrqsslnaihqhTNVKDYARYAAPGRNY 923
Cdd:pfam00593 441 NLFDKYYKRYYS------------SGGGNLGGYPGPGRTF 468
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 578-889 1.64e-05

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 48.60  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 578 SGTIAGRADCATSK-IKGHNHYIAL--RDNFAITKYLDIGLGYRFDKH-KFRSthrwaNQGDYKNSAWNIGivakptSFL 653
Cdd:PRK13528 403 DGDIGGISGSAADRsSKNKSEISALyvEDNIEPVPGTNLIPGLRFDYHsEFGS-----NWSPSLNLSQELG------DYF 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 654 SLSYRASSGFRVPSFQE-----LFGLRYDGAMKG--SSDAY-QKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYK- 724
Cdd:PRK13528 472 KVKAGIARAFKAPNLYQssegyLLYSRGNGCPKDitSGGCYlVGNKNLDPEISVNKEIGLEFTVDDYHASVTYFRNDYQn 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 725 QLIAPAERMHQTQSminyfnvqdikldGINLigkLDWNGVFDKIPEGIYTTLAYSKMrvKEVKNYQ---GYMnIRSPLLD 801
Cdd:PRK13528 552 KIVAGDDVIGRTAS-------------GAYI---LQWQNGGKAVVEGLEGNLLVPLM--KDRLNWNtnaTYM-ITSEQKD 612

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 802 TIQP----ARYVVGVGYD-QPDEKWGVNLTMTHSSGKNP---DELRGNEQVGFANYERTAtkkrtrsWHTFDLTGYITPW 873
Cdd:PRK13528 613 TGNPlsviPKYTINSTLDwQITQALSANVNWTLYGKQKPrthAESRSEETGGLSGKELGA-------YSLVGVNVNYDIN 685

                        330
                 ....*....|....*....
gi 920783348 874 KHTTVRAGVYNLMN---YR 889
Cdd:PRK13528 686 KNLRLNVGVSNLFDkqiYR 704
 
Name Accession Description Interval E-value
TonB-tbp-lbp TIGR01776
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-924 0e+00

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 1345.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348    1 MKNKLNLISLALLSLFAVQSY-----------AEQAVQLNDVYVTGTKKKaHKKENEVTGLGKVVKTPDTLSKEQVLGMR 69
Cdd:TIGR01776   4 KKHVLNLSILALSLLFATLSFqtadadsakdtANQAVYLDEITVTATKVA-HRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   70 DLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRS---SSGAINEIEYENLRSIQISKGASSS 146
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTSQGSRSgtaGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  147 EFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTHRDGKETKAHKDAESRS 226
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTKRRGKETKAHGDANKGV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  227 QNITRVGVETNELDTsnrytatTNNQHTygWFLIKDECPTLDCTPKQMARVTKDTpsfrsypEYTPEEKQAYENQKHITE 306
Cdd:TIGR01776 243 QSIDRLDAFEQKYDL-------RPPQGR--SFIVENECASLDCAPCAQYGYVYDN-------QLSDEEKAQVLASRYRHE 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  307 RLNAQDYTGEYRALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLLRtGRNWYpmnNAK 386
Cdd:TIGR01776 307 QVSAKDYTGENRLLPNPLDYRSDSWLAKLGYHLNNRHYVGGVLEDTKQRYDIRDMTEPAYLGLSDAVK-GRLKN---GGG 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  387 GLYRDNALDGVAIDyfteDGVKSSKGLRWAKARFIDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLREN 466
Cdd:TIGR01776 383 IYLGDNYLEGLNFN----AGPASFKGLRYARGKFFDERHTKRRYGLEYRYKNEDYDRWLDTAKLSLDKQKIELRSRLQEL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  467 NCSEYPTIDKNCRATLDKLWSSTKNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGT 546
Cdd:TIGR01776 459 HCSQYPKVDKNCRPSLDKPYSFYKNDRNHYKEKHNVIQAEFDKSFDLGGGRHHLNLLLGYDKFKSQLSRHDYRRQNAVGT 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  547 WHRIRGNGYKDTPYIYELKDQAIYSKNECDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRS 626
Cdd:TIGR01776 539 YESIRGDEPKQNPYKYRLGKATIVKNSLCRYSETNGYANCCEPRKIKGSNHYISLNDNFTIGKYVDLGLGGRYDKHNFKS 618

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  627 THRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPEKSLNQEVAAT 706
Cdd:TIGR01776 619 TDRLVYSGTYRNLSWNFGIVVKPTPFFSLSYRASTGFRVPSFYELYGERRGKASKKNVQQFLRTPDLKPEKSLNHEIGAR 698

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  707 FKGDFGVVEVSYFKNDYKQLIAPAERM--------HQTQSMINYFNVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAY 778
Cdd:TIGR01776 699 FKGDFGHLEVSYFRNRYKDMIAEAPETrtdneagqTYGYCDHNYHNAQNAVLKGINILGKLDLNGVASKLPDGLYSTLAY 778

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  779 SKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPDELRGNEQVGFAN-YERTATKKR 857
Cdd:TIGR01776 779 NRIKVKEVKNRAGRLDVRSPLLDAIQPARYVVGLGYDHPSQKWGINLTLTYSKAKNPDELAGTEYLGNGNvVKQTATKKL 858

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920783348  858 TRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQHTNVKDYARYAAPGRNYV 924
Cdd:TIGR01776 859 SRSWYTLDVTGYVNLKKNLTLRAGVYNLFNYRYTTWESVRQTASNAVNQHTGVSNYNRYAAPGRNYS 925
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 33-923 6.76e-165

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 498.86  E-value: 6.76e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   33 VTGTK-KKAHKKENEVTGLGKVVKTPDTLSKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQI 111
Cdd:TIGR01786   5 VTATRtADPQRRDLSVTPASVSVISREQLKSQQVRNLRDLLRYEPGVSVVEGGRGGSQGINIRGLDKNRVAVLVDGIRQN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  112 QSYVSQysRSSSGAINEIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLN 191
Cdd:TIGR01786  85 TSYGGQ--GSTFYAINSIDPELIKSIEIVKGASSSLYGSGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYSSANNRFTQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  192 SLAFAGTHNGFDALVIYTHRDGKETKAHKDAESRSQnitrvgvetneldtsnrytattnnqhtygwflikdecptldctp 271
Cdd:TIGR01786 163 SVAAAGRNDDVDALVQATYRRGHELKNGNKANIGNE-------------------------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  272 kqmarvtkdtpsfrsypeytpeekqayenqkhiterlnaqdytgEYRALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEH 351
Cdd:TIGR01786 199 --------------------------------------------SKRSKPNPSDYKSQSFLAKLGWQLNDAHRLGLSLEY 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  352 SKQRYDTRDMTYTAYwqpsdllRTGRNWYPMNNAKGlyrdnaldgvaidyftedgvksskglrwakaRFIDEWHTRDRLG 431
Cdd:TIGR01786 235 TQTDYDEPEMTNTSY-------LTKPLGAPLLSSTV-------------------------------VLGDSKTRDRRTG 276

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  432 ALYRYTNQdgNRLIDRLSLSFDQQKINLSTRLRENNCSEYPTIDKNCRatldklwsstkneqssYEEKHDTIQLSLDKTV 511
Cdd:TIGR01786 277 LDYELNPD--NSWLDTVKLALDKQYIQLYNYLNATSASDYPGVDKNGR----------------YKDKYDYYTLGFDTNN 338

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  512 QTGLGKHQLNMLLGSDRFNSTLKRHeilSEFsvgtwhrirgNGYKDTPYiyelkDQAIYSKNecdysgtiagradcaTSK 591
Cdd:TIGR01786 339 KIEFSVHSLSLTYGLDRFKDKVSTG---DSR----------RNLPTAAY-----NLYGYEGE---------------NRP 385

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  592 IKGHNHYIALRDNFAITKYLDIGLGYRFDKHKF-----RSTHRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVP 666
Cdd:TIGR01786 386 VKGSNFGLFLQDNIKLGDWLSLSAGLRYDHYKTdpkadESKDYGAISKTYSRWSPSLGLTYKPTPWLTLYYSYSQGFRAP 465

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  667 SFQELFGLRYDGAmkGSSDAYQKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYKQLIA------PAERMHQTQSM- 739
Cdd:TIGR01786 466 SFDELYGTGAHPG--GGPYTFLPNPNLKPETSKNWEIGINLHFDQLDFKVSYFRNDYKDFIDlgigvtAKGNMAQVGSNt 543

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  740 -INYFNVQDIKLDGINLIGKLDWNGVFDKiPEGIYTTLAYSKMRVKEVKNyqgymnirSPLLDTIQPARYVVGVGYDQPD 818
Cdd:TIGR01786 544 iTNYVNIDNARIRGIELSGRYDLGSFFSG-PDGWTTTLKYGYTKGKDSDT--------NPWLNAITPLKVVLGLGYDHPD 614

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  819 EKWGVNLTMTHSSGKNPDELRGNEQVgfANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQ 898
Cdd:TIGR01786 615 EKWGVGLTLTFSGAKDAVDAYATYYE--NGEAAKAGPLRTPSYTVVDLYGYYKPNKNLTLRFGVYNLLDRKYTTWESARQ 692

                         890       900
                  ....*....|....*....|....*
gi 920783348  899 SSLNAIhqhtnvkdyaRYAAPGRNY 923
Cdd:TIGR01786 693 AGPLAT----------GYTAPGRNY 707
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 58-924 3.38e-82

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 278.18  E-value: 3.38e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  58 DTLSKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYsrsssGAINEIEYENLRSI 137
Cdd:cd01347    8 EDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSNYGRG-----VDLNTIPPELIERV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 138 QISKGASSSEFGSGSLGGSVQFRTKEVSDiiKPGQSWGLDTKSA--YSSKNQQWLNSLAFAGtHNGFDALVIYTHRDGKE 215
Cdd:cd01347   83 EVLKGPSSALYGSGAIGGVVNIITKRPTD--EFGGSVTAGYGSDnsGSSGGGGFDVSGALAD-DGAFGARLYGAYRDGDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 216 TKAHKdaesrsqnitrvgvetneldtsnrytattnnqhtygwflikdecptldctpkqmarvtkdtpsfrsypeytpeek 295
Cdd:cd01347  160 TIDGD--------------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 296 qayenqkhiterlnaqdytgeyrALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLlrT 375
Cdd:cd01347  165 -----------------------GQADDSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSL--G 219

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 376 GRNWYPMNNAKGLYRDNALDGVAIDYFTEDgvksskglrwakarFIDEWHTRdRLGALYRYTNQDGNRLIDRLSLSFDQQ 455
Cdd:cd01347  220 GGPSSNTNGDRDWDYRDRYRKRASLGLEHD--------------LNDTGWTL-RANLSYSYTDNDGDPLILNGGNNAAGG 284

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 456 KINLSTRlrenncseyptidkncratldklwsstkneQSSYEEKHDTIQLSLDKTVQTGLGKHQLnmLLGSDRFNSTLKr 535
Cdd:cd01347  285 DLGRSGY------------------------------SSERDTTQLGFDAGLNAPFGTGPVAHTL--TLGVEYRREELD- 331

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 536 heilsefsvgtwhrirgngykdtpyiyelkdqaiysknecdysgtiagradcatskIKGHNHYIAlrDNFAITKYLDIGL 615
Cdd:cd01347  332 --------------------------------------------------------EKQTALYAQ--DTIELTDDLTLTL 353

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 616 GYRFDKHKFRSTHRWA----NQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGamkgsSDAYQKTE 691
Cdd:cd01347  354 GLRYDHYDQDSKDTIAggttAKKSYSHWSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHG-----GTAAVGNP 428

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 692 KLSPEKSLNQEVAATFK-GDFGVVEVSYFKNDYKQLIAPAERMHQTQSMINYFNVQDIKLDGINLIGKLDWNGVFdkipe 770
Cdd:cd01347  429 NLKPEKSKQYELGLKYDpGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGKARIRGVELEASYDLTDGL----- 503

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 771 GIYTTLAYSKMRVKEVknyqgYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPDELRGNEQvgfanye 850
Cdd:cd01347  504 GLTGSYTYTDTEVKRT-----DGATTGNRLPGIPKHTANLGLDYELPDEGLTAGGGVRYRGKQYADTANGNNT------- 571

                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 920783348 851 rtatkKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSslnaihqhtnvkDYARYAAPGRNYV 924
Cdd:cd01347  572 -----VKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKDYYTSLSVRGS------------GLYGYYGPGRTYY 628
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 54-923 8.03e-40

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 157.55  E-value: 8.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   54 VKTPDTLSKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQ-IQSYVSQYSRSSsgaineIEYE 132
Cdd:TIGR01785  24 VISGEQIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDNRVLVVVDGARQnYQRGGAHNGSLF------VDPE 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  133 NLRSIQISKGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHN-GFDALVIYTHR 211
Cdd:TIGR01785  98 LLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKLSYGSNNNSFGGSVAVAGRLDdNLDALVAATYR 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  212 DGketkahkdaesrsqnitrvgvetNELDTSNRYTATtnnqhtygwflikdecptldctpkqmarvtkdtpsfrsypeyt 291
Cdd:TIGR01785 178 DG-----------------------GNYRNGNKEEAT------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  292 peekqayenqkhiterlnaqdYTGeyralpdplkYKSDSWLVKLGYTFSPKHYVAGTYehskqrydtrdmtytaywqpsd 371
Cdd:TIGR01785 192 ---------------------NSA----------YVQKNLLAKLGWQLDDAQRLEFSY---------------------- 218

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  372 llRTGRNWYPMNNAKGLYRDNALdgvaidyftedgvksskglrwakarfiDEWHTRDRlgalyrytnqdgnrlidrlsls 451
Cdd:TIGR01785 219 --FTTEGSLDEAQNSGPGTEYVL---------------------------GSSSTLLA---------------------- 247

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  452 fdQQKINLSTRLRENncseYPTIDKNC-RATLDKLWSSTKNEQ---SSYEEKHDTIQLSldktvqtglgkhqlnmLLGSD 527
Cdd:TIGR01785 248 --SSTRDRSATLTYN----WTPEDNPWlDATASLYYNRTENDNdrsARGVGREEGYQYT----------------TYGAT 305

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  528 RFNSTLKRHEILSEFSVGT-WHRirgngYKDTPYIYelkdqaiysknecDYSGTIAGRADCATSKIKGHNHYiaLRDNFA 606
Cdd:TIGR01785 306 LQNTSRFDVASWSTLTYGVdWMK-----DKRRTESF-------------DPNSVTTIVPNPPSAKEYFFGLF--LQDNIP 365

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  607 I-TKYLDIGLGYRFDKHKFRS-THRWANQGDYKNSAWN--IGIVAKPTSFLSLSYRASSGFRVPSFQELFGlRYDGAMKG 682
Cdd:TIGR01785 366 LlDDRLTLSAGLRYDHYKLSPkTTADTEAVDRSYSRWSpsLGLSYKPVDWLTLYASYSQGFRAPSIDELYG-TGDHPGTP 444

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  683 SSDAYQKTEKLSPEKSLNQEVAATFK--------GDFGvVEVSYFKNDYKQLIAPAERMHQ--TQSMIN---YFNVQDIK 749
Cdd:TIGR01785 445 GGYTFAPNPNLKPETSKTWELGANLSfdnllldnDQLQ-FKVAYFYNDVKDFIDLTIGVTDnvTAGMNNitqYVNIDGAR 523

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  750 LDGINLIGKLDWNgvfdkipeGIYTTLAYSKMRVKEVKNYQGymnirsplLDTIQPARYVVGVGYDQPDEKWGVNLTMTH 829
Cdd:TIGR01785 524 IRGIEASASYDAG--------LWATGLSYGYTIGKDQNTNQW--------LSNIPPLKLVVTVGYRFPDRRLDLGAKAAY 587

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  830 SSGKnpDELRGNEQVGFANYERTAtkkrtrSWHTFDLTGYITP--WKHTTVRAGVYNLMNYRYTTWESVrqsslnaihqh 907
Cdd:TIGR01785 588 YERQ--SESPTTEDVAANGLLTTP------GYTVVDLYATYQPnaVKGLTVRFGVNNLTDRKYTPAQSV----------- 648

                         890
                  ....*....|....*.
gi 920783348  908 tnvkdyaRYAAPGRNY 923
Cdd:TIGR01785 649 -------PGAGPGRNF 657
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
28-905 1.75e-32

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 134.57  E-value: 1.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  28 LNDVYVTGTKkkAHKKENEVTGLGKVVkTPDTLSKEQVLGMRDLTRYDPGISVvEQGRGATTGYSIRGVD--RNRVGLAL 105
Cdd:COG1629    1 LEEVVVTATR--TDESLQDVPGSVSVI-SREQLEDQPATDLGDLLRRVPGVSV-TSAGGGAGQISIRGFGggGNRVLVLV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 106 DGLPQiqsyvsQYSRSSSGAINEIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTKevsdiiKPGQSWGLDTKSAYSSK 185
Cdd:COG1629   77 DGVPL------NDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTK------KPKDGKGGEVSASYGSY 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 186 NQQwLNSLAFAGTHNGFDALVIYTHRDGketkahkdaesrsqnitrvgvetneldtsnrytattnnqhtygwflikdecp 265
Cdd:COG1629  145 GTY-RASLSLSGGNGKLAYRLSASYRDS---------------------------------------------------- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 266 tldctpkqmarvtkdtpsfrsypeytpeekqayenqkhiterlnaqdytGEYRalpDPLKYKSDSWLVKLGYTFSPKHYV 345
Cdd:COG1629  172 -------------------------------------------------DGYR---DNSDSDRYNLRAKLGYQLGDDTRL 199

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 346 AGTYEHSKQRYDTRDMTYTAYWQPSDLLRTGRNWYPMNNAKGlyrdnaldgvaidyftedgvksskglrwakarfidewh 425
Cdd:COG1629  200 TLSASYSDSDQDSPGYLTLAALRPRGAMDDGTNPYSNDTDDN-------------------------------------- 241

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 426 TRDRLGALYRYTNQDgnrlidrlslsfDQQKINLSTRLRENncseyptiDKNCRATLDKLWSSTKN-EQSSYEEKHDTIQ 504
Cdd:COG1629  242 TRDRYSLSLEYEHLG------------DGLKLSASAYYRYD--------DTDLDSDFTPTPADGGTlEQTDFDNRTYGLE 301

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 505 LSLDKTVQTGlGKHQLnmLLGSDRFNSTLKRheilSEFSVGTWHRIRGNGYKDTPYIYELKDQAIYsknecdysgtiagr 584
Cdd:COG1629  302 LRLTYDLGFG-GKHTL--LVGLDYQRQDLDG----SGYPLDLGSGSLPTLTSGADDDGTTTSLALY-------------- 360

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 585 adcatskikghnhyiaLRDNFAITKYLDIGLGYRFDKHKFRSTHRWANQG------DYKNSAWNIGIVAKPTSFLSLSYR 658
Cdd:COG1629  361 ----------------AQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDsasgsrSYSAFSPSLGLTYQLSPNLSLYAS 424

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 659 ASSGFRVPSFQELFGLRYDGAMKGSSDayqktekLSPEKSLNQEVAATFKGDFGVV--EVSYFKNDYKQLIAPAERMHQT 736
Cdd:COG1629  425 YSRGFRAPTFGELYANGTDPYSVGNPD-------LKPETSTNYELGLRYRLLDGRLslSLALFYSDVDNEILSVPLPNDS 497

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 737 QSMINYFNVQDIKLDGINLigKLDWNgvfdkIPEGIYTTLAYSKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQ 816
Cdd:COG1629  498 GFSTYYTNAGKARSYGVEL--ELSYQ-----LTPGLSLNASYSYTDAKFDDDTDGSADLDGNRLPGVPPLTANLGLTYEF 570

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 817 PDeKWGVNLTMTHssgknpdelrgneqVGFANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESV 896
Cdd:COG1629  571 PG-GWSLGLGVRY--------------VGDRYLDDANTQGAPGGYTLVDLGAGYRFGDNLTLSLGVDNLFDKKYATSLSV 635


                 ....*....
gi 920783348 897 RQSSLNAIH 905
Cdd:COG1629  636 RASNVRGFL 644
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 414-923 3.45e-32

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 131.43  E-value: 3.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  414 RWAKARFIDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLRENNCSEYPT----IDKNCRATLDKLWSST 489
Cdd:pfam00593   1 GWQLSLDLLGDDTLLTLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRkrlsLGYDYDLGDGLSWLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  490 KNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGTWHRIRGNGYKDTPYIYelkdqai 569
Cdd:pfam00593  81 LRLGLRYSSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLDYRRLDDDA------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  570 ysknecDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRSTHRWANQGDYKNSA----WNIGI 645
Cdd:pfam00593 154 ------YDPYDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNGGGDNFSRSYsafsPRLGL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  646 VAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGamkGSSDAYQKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYKQ 725
Cdd:pfam00593 228 VYKPTDNLSLYASYSRGFRAPSLGELYGSGSGG---GGGAVAGGNPDLKPETSDNYELGLKYDDGRLSLSLALFYIDIKN 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  726 LIAPAERMHQTQSMIN-YFNVQDIKLDGINLIGKLD-WNGVFdkipegIYTTLAYSKMRVKEVKNYQGYmnirspLLDTI 803
Cdd:pfam00593 305 LITSDPDGPGLGGTVYtYTNVGKARIRGVELELSGRlWGLGL------SGGGYTYTDADDDADADDTGN------PLPNV 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  804 QPARYVVGVGYDQPDEKWGVNLTMTHSSgknpdelrgneqVGFANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVY 883
Cdd:pfam00593 373 PRHTANLGLTYDFPLGGWGARLGARYVG------------SGERRYGDAANTFKTPGYTLVDLSAGYRLNKNLTLRLGVN 440

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 920783348  884 NLMNYRYTTWESvrqsslnaihqhTNVKDYARYAAPGRNY 923
Cdd:pfam00593 441 NLFDKYYKRYYS------------SGGGNLGGYPGPGRTF 468
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 5-879 2.02e-25

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 112.26  E-value: 2.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   5 LNLISLALLSLFAVQSYAEQAVQLNDVYVTGTKKKAHKKENEVTglgKVVKTPDTLSKEQVLGMRDLTRYDPGISVVEQ- 83
Cdd:COG4771    4 ASLLLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPAS---VSVITAEEIEKLGATDLADALRLLPGVSVTRSg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  84 GRGATTGYSIRGVDRNRVGLALDGLPqiqsyVSQYSRSSSGAINEIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTKE 163
Cdd:COG4771   81 GRGGSSGISIRGLGGDRVLVLIDGVP-----VNNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 164 VSDIIKPGQSWGldtksAYSSKNQQWLNSLAFAGTHNGFDALVIYTHRDGKETKahkdaesrsqnitrvgvetneldtsn 243
Cdd:COG4771  156 PTDELEGSVSLG-----YGSNGNGTYSGSLSLGGPGDKLSFLLSGSYRDRDGYL-------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 244 rytattnnqhtygwflikdecptldctpkqmarvtkdtpsfrsypeytpeekqayenqkhiterlnaqDYTGEYRAlpDP 323
Cdd:COG4771  205 --------------------------------------------------------------------DYRNGGFV--GN 214

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 324 LKYKSDSWLVKLGYTFSPKHYVAGTYEHSKQRYDTRDMTYTAYWQPSDLLRtgrnwypmnnakglyrdnaldgvaidyft 403
Cdd:COG4771  215 SGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSDNAG----------------------------- 265

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 404 edgvksskglrwakarfiDEWHTRDRLGALYRYTNQDGNRLidRLSLSFDQQKINlstrlrenncseyptidkncraTLD 483
Cdd:COG4771  266 ------------------DRDTTTDRGNYSLRYNGDLGDNL--DLSLYYSRTDRD----------------------STN 303

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 484 KLWSSTKNEQSSYEEKHDTIQLSLDKTVQtglGKHQLnmLLGSDrfnstlkrheilsefsvgtwhrirgngykdtpYIYE 563
Cdd:COG4771  304 GSLGGSTGSFSDSDDTTYGLELDLTYPLG---GNHTL--TLGAE--------------------------------YRYD 346

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 564 LKDQAIYSKNecdysgtiagradcatSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFrsthrwANQGDYKNSAWNI 643
Cdd:COG4771  347 DLDSSSFLGG----------------ADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYST------FGASNYTAFSPRL 404

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 644 GIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDgamkGSSDAYQKTEKLSPEKSLNQEVAATFKGDFG--VVEVSYFKN 721
Cdd:COG4771  405 GLRYDLSDNLTLRASYGRGFRAPSLAELYGSGTG----TPGRYVLGNPDLKPETSDNYELGLEYRLGNGglSLSLTGFYT 480

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 722 DYKQLIAPAERMHQTQSMINYFNVQDIKLDGINLIGKLDWNgvfdkipEGIYTTLAYSKMRVKEVKNYQGYmnirspLLD 801
Cdd:COG4771  481 DIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLG-------KGLTLTASYTYLDSKIDDGDTGE------PLP 547

                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 920783348 802 TIQPARYVVGVGYdQPDEKWGVNLTMTHSSGKNPDelrgneqvgfanYERTATKKRTRSWHTFDLTGYITPWKHTTVR 879
Cdd:COG4771  548 NVPPHKANLGLDY-RLPKWWLLLLLTRYYGGRYVT------------PPSGRLEGYTPGYTLLDLRASYKLTKNLTLS 612
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 54-155 8.58e-19

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 82.32  E-value: 8.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   54 VKTPDTLSKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQiqsyvsQYSRSSSGAINEIEYEN 133
Cdd:pfam07715  11 VVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSNRVLVLVDGVPL------NSGGGGSVDLNSIDPED 84

                          90       100
                  ....*....|....*....|..
gi 920783348  134 LRSIQISKGASSSEFGSGSLGG 155
Cdd:pfam07715  85 IERVEVLKGPASALYGSGAIGG 106
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
8-256 1.65e-15

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 81.13  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   8 ISLALLSLFAVQSYAEQAVQLNDVYVTGTKKkAHKKENEVTGLGKVVkTPDTLSKEQVLGMRDLTRYDPGISVV-EQGRG 86
Cdd:COG4772    3 RALAAALLLAAAAAAEAATTLETVVVTGSRA-AEARLKDVPGSVSVV-DREELENQAATSLREVLRRVPGVNVQeEDGFG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  87 ATTGYSIRGVDRNR---VGLALDGLP-------QIQSYvsqYSRSSsgaineieyENLRSIQISKGASSSEFGSGSLGGS 156
Cdd:COG4772   81 LRPNIGIRGLGPRRsrgITLLEDGIPiapapygDPAAY---YFPDL---------ERMERIEVLRGAAALRYGPQTVGGA 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 157 VQFRTKEVSDiikpgqSWGLDTKSAYSSkNQQWLNSLAFAGTHNGFDALVIYTHRDGKETKAHKDAESRSQNItRVGVET 236
Cdd:COG4772  149 INFVTRTIPT------AFGGELRVTGGS-FGYRRTHASVGGTVGNFGYLVEYSRKRGDGFRDNSGFDINDFNA-KLGYRL 220

                        250       260
                 ....*....|....*....|.
gi 920783348 237 NE-LDTSNRYTATTNNQHTYG 256
Cdd:COG4772  221 SDrQELTLKFQYYDEDANTPG 241
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
31-259 6.59e-15

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 76.06  E-value: 6.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  31 VYVTGTKKKahKKENEVTGLGKVVkTPDTLSKEQVLGMRDLTRYDPGISVVEQGR-GATTGYSIRGVDRNRVGLALDGLP 109
Cdd:COG4206    1 VVVTATRLE--QSKSDLTGSVTVI-DAEELERSGATSLADALRRVPGVQVSSSGGpGSAASISIRGLGSNQTLVLIDGVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 110 QIQSYVSQYSrsssgaINEIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTKevsdiiKPGQSWGLDTKSAYSSKNQQW 189
Cdd:COG4206   78 LNDPSLGGVD------LSLIPPDDIERIEVLKGAASALYGSDAIGGVINITTK------KGKKGFKGSVSASYGSFGTRR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 190 LN-SLAFAGTHNGFDALVIYTHRDG--------------KETKAHKDAESRSQNITRVGVETNELDTSNRYTATTNNQHT 254
Cdd:COG4206  146 LSaSLSGGAGKFSYSLSASYRRSDGyryndpdlrnndgyENTSLNARLGYKLGDNGSLSLSGGYSDSERGYPGAVGSDRN 225


                 ....*
gi 920783348 255 YGWFL 259
Cdd:COG4206  226 LRLSL 230
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
64-162 1.23e-09

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 61.82  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  64 QVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDrNRVGLALDGLPQIqsyvSQYSRSSsgaineieyENLRSIQISKGA 143
Cdd:COG4774   25 GATSLADALRNVPGVTFGAGEGGNGDSFSIRGFS-ASGDIYVDGLRDP----GQYRRDT---------FNLERVEVLKGP 90

                         90
                 ....*....|....*....
gi 920783348 144 SSSEFGSGSLGGSVQFRTK 162
Cdd:COG4774   91 ASVLYGRGSPGGVINLVTK 109
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 17-162 3.05e-08

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 57.60  E-value: 3.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  17 AVQSYAEQAVQLNDVYVTGTKKKAHKKENEVTGLG-----KVVKTP---DTLSKE-----QVLGMRDLTRYDPGISVVEQ 83
Cdd:COG4773   21 AAAAAAAEATTLPEVTVTGTAEGTGGYTAKSSSTAtkldtPLRETPqsvSVVTRQliedqGATTLDDALRNVPGVTVSSY 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 920783348  84 GRGATTGYSIRGVDRNRVglALDGLPQIQSYVSQysrsssgaineIEYENLRSIQISKGASSSEFGSGSLGGSVQFRTK 162
Cdd:COG4773  101 DGGGRDSFSIRGFSIDNY--LRDGLPLGGFGGGQ-----------PDTANLERVEVLKGPAGLLYGAGSPGGLVNLVTK 166
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 54-923 4.97e-07

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 53.57  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348   54 VKTPDTLSKEQVLGMRDLTRYDPGISVVE-QGRGATTGYSIRGVDRN--RVGLALDGLPQiqsyVSQYSRSSsgaineIE 130
Cdd:TIGR01783   8 VITRQELEDQQAGSLSEALQRVPGVVVGGsGGTTQFGNITIRGFGLEvdIDNVYLDGVPL----LSRGNLAI------VD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  131 YENLRSIQISKGASSSEFGSGSLGGSVQFRTKEVSDIIKP--GQSWGLDTKSAYSSKNQQWLnslafaGTHNGFDALVIY 208
Cdd:TIGR01783  78 PAMVERVEVLRGPASLLYGGSAPGGVINIVTKRPQDEPKGsvTFGAGTRSGYRTAFDLGGPL------GADGTFRGRLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  209 THRDGKETKAHKDAESRSQNitrvgvetneldTSNRYTATTNNQHTYGWflikdecptldctpkqmarvtkdtpsfrsyp 288
Cdd:TIGR01783 152 ARQDGDSFYDGAGEETRLGA------------TATDWQLDDRTLLRLGA------------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  289 EYTPEEKQAYenqkhiterlnaqdytgeYRALP-----DPLKYKSDSWlvkLGYtfSPKHYVAgtyehskqRYDTRDMTY 363
Cdd:TIGR01783 189 YYQKERDRGG------------------YGGLPasggtSGRDLSSDRY---LGT--SSNRNYD--------DREYLSYGL 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  364 TAYWQpsdllrTGRNWYPMNNAKGLYRDnaldgvaidyftedgvksskglrwakarfidewHTRDRLGAlYRYTNQDGnr 443
Cdd:TIGR01783 238 SLEYQ------FNDVWTGKQNLRYSYFD---------------------------------TDSNQVQA-SGYSSDGG-- 275

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  444 LIDRLSLSFDqqkinlstrlrenncseyptidkncratldklwsstkneqssYEEKHDTIQLSLDKTVQTGLGKHQLnmL 523
Cdd:TIGR01783 276 LFGRSLTVVN------------------------------------------VKQDRVQIDAGLDGEFETGPIEHDL--L 311

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  524 LGSDRFNSTLKRHEILSEFSVGTwhrirgngykdTPYIYELKDQAIYSKNECDYSGtiagradcaTSKIKGHNHY----I 599
Cdd:TIGR01783 312 LGVSYGQRTTNRFNNTGYPSDNI-----------YSLTATSSARTDIGDSPKDRAL---------SSTTKALNGValqrI 371

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  600 ALRDNFAITkyldigLGYRFDKHKFRSTHRWANQ---GDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRY 676
Cdd:TIGR01783 372 LLADKWTLT------LGGRYDSVDVKSNNGVAGStgkRDDSQFTPSLGVAYKPTDDWSLYASYAESFKPGGYYPKGAGNS 445

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  677 DgamkgssdayqktEKLSPEKSLNQEVAATFK-GDFGVVEVSYFKNDYKQLIapaerMHQTQSMINYFNVQDIKLDGINL 755
Cdd:TIGR01783 446 G-------------DILEPEKGKNYELGVRYDlGDSLLATAALFRITKDNQL-----VQDPVNGTFSVNAGKTRNRGVEL 507

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  756 igkldwnGVFDKIPEG--IYTTLAYSKMRVKEVKN--YQGYMNIRSP-LLDTIQpARYVVGVGYDQPDEKWGVNLTmths 830
Cdd:TIGR01783 508 -------EARGYLTPGlsLSAGYTYTDAEFTEDTNgdTQGNTVPFVPkHTASLW-ASYAPPVGDNGLTLGGGVQYT---- 575

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  831 SGKNPDELRGNEQVGFAnyertatkkrtrswhTFDL-TGY-ITPWKHTTVRAGVYNLMNYRYTTWESVRQSSlnaihqht 908
Cdd:TIGR01783 576 GKAYVDGGNTGKVPSYT---------------VVDLsVRYdLTKKKNLTLALNVNNLFDRDYYTSGYRWGPS-------- 632

                         890
                  ....*....|....*
gi 920783348  909 nvkdYARYAAPGRNY 923
Cdd:TIGR01783 633 ----AYIYPGAPRTV 643
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 578-889 1.64e-05

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 48.60  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 578 SGTIAGRADCATSK-IKGHNHYIAL--RDNFAITKYLDIGLGYRFDKH-KFRSthrwaNQGDYKNSAWNIGivakptSFL 653
Cdd:PRK13528 403 DGDIGGISGSAADRsSKNKSEISALyvEDNIEPVPGTNLIPGLRFDYHsEFGS-----NWSPSLNLSQELG------DYF 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 654 SLSYRASSGFRVPSFQE-----LFGLRYDGAMKG--SSDAY-QKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYK- 724
Cdd:PRK13528 472 KVKAGIARAFKAPNLYQssegyLLYSRGNGCPKDitSGGCYlVGNKNLDPEISVNKEIGLEFTVDDYHASVTYFRNDYQn 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 725 QLIAPAERMHQTQSminyfnvqdikldGINLigkLDWNGVFDKIPEGIYTTLAYSKMrvKEVKNYQ---GYMnIRSPLLD 801
Cdd:PRK13528 552 KIVAGDDVIGRTAS-------------GAYI---LQWQNGGKAVVEGLEGNLLVPLM--KDRLNWNtnaTYM-ITSEQKD 612

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 802 TIQP----ARYVVGVGYD-QPDEKWGVNLTMTHSSGKNP---DELRGNEQVGFANYERTAtkkrtrsWHTFDLTGYITPW 873
Cdd:PRK13528 613 TGNPlsviPKYTINSTLDwQITQALSANVNWTLYGKQKPrthAESRSEETGGLSGKELGA-------YSLVGVNVNYDIN 685

                        330
                 ....*....|....*....
gi 920783348 874 KHTTVRAGVYNLMN---YR 889
Cdd:PRK13528 686 KNLRLNVGVSNLFDkqiYR 704
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 54-174 4.60e-05

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 47.19  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348  54 VKTPDTLSKEQVLGMRDLTRYDPGISVVEQGRGaTTGYSIRGVDRNRVGLALDGlPQIQSYVSQYsRSSSGAINEIEYEN 133
Cdd:PRK10064  53 VITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDN-RKGVSIRGLDSSYTLILIDG-KRVNSRNAVF-RHNDFDLNWIPVDA 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 920783348 134 LRSIQISKGASSSEFGSGSLGGSVQFRTKEVsdiikpGQSW 174
Cdd:PRK10064 130 IERIEVVRGPMSSLYGSDALGGVVNIITKKI------GQKW 164
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
583-724 3.67e-04

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 44.23  E-value: 3.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920783348 583 GRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRSTHrwanqgdyknsaWN--IGIVAKPTSFLSLSYRAS 660
Cdd:PRK13484 371 GKKTTETQSVSIKQKAVFIENEYAATDSLALTGGLRLDNHEIYGSY------------WNprLYAVYNLTDNLTLKGGIA 438

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 920783348 661 SGFRVPSFQEL---FGLRYDGA---MKGSSDayqktekLSPEKSLNQEVAATFKGDFG-VVEVSYFKNDYK 724
Cdd:PRK13484 439 KAFRAPSIREVspgFGTLTQGGasiMYGNRD-------LKPETSVTEEIGIIYSNDSGfSASATLFNTDFK 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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