NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|944375220|gb|ALL72078|]
View 

DNA gyrase subunit A, partial [Aeromonas sp. PDCDC-47]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-235 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 557.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:PRK05560  21 YAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:PRK05560 101 DGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEvdEKTSRET 235
Cdd:PRK05560 181 PHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIE--EIKGREA 253
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-235 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 557.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:PRK05560  21 YAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:PRK05560 101 DGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEvdEKTSRET 235
Cdd:PRK05560 181 PHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIE--EIKGREA 253
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-226 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 548.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:COG0188   26 YAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLV 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:COG0188  106 DGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIP 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:COG0188  186 PHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIE 251
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-235 4.04e-168

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 483.35  E-value: 4.04e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:TIGR01063  17 YAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:TIGR01063  97 DGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIP 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220  161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEVDEKtSRET 235
Cdd:TIGR01063 177 PHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSK-GREA 250
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 7-233 3.15e-153

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 433.15  E-value: 3.15e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   7 VGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLVDGQGNF 86
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  87 GSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIPPHNLTE 166
Cdd:cd00187   81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 944375220 167 IVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEVDEKTSR 233
Cdd:cd00187  161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDEGRNT 227
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-230 5.10e-141

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 401.94  E-value: 5.10e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220     1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:smart00434  14 YSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    81 DGQGNFGSV-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNI 159
Cdd:smart00434  94 DGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNI 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 944375220   160 PPHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVqayrtgrgsvyVRAKAEVEVDEK 230
Cdd:smart00434 174 PPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPGKYV-----------VRGKIEIEDDNT 233
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
9-226 8.00e-136

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 388.45  E-value: 8.00e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    9 RALPDVRDGLKPVHRRVLYAMNELGNDwNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLVDGQGNFGS 88
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   89 V-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIPPHNLTEI 167
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 944375220  168 VNGCLALIENGDLTIdeLMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIE 216
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-235 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 557.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:PRK05560  21 YAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:PRK05560 101 DGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEvdEKTSRET 235
Cdd:PRK05560 181 PHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIE--EIKGREA 253
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-226 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 548.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:COG0188   26 YAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLV 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:COG0188  106 DGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIP 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:COG0188  186 PHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIE 251
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-235 4.04e-168

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 483.35  E-value: 4.04e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:TIGR01063  17 YAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:TIGR01063  97 DGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIP 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220  161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEVDEKtSRET 235
Cdd:TIGR01063 177 PHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSK-GREA 250
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-226 5.00e-164

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 470.74  E-value: 5.00e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:PRK05561  26 YAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLV 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:PRK05561 106 DGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIP 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGG-IINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:PRK05561 186 PHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGeIITGRDGIRKAYETGRGSIRVRARWEIE 252
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 7-233 3.15e-153

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 433.15  E-value: 3.15e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   7 VGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLVDGQGNF 86
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  87 GSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIPPHNLTE 166
Cdd:cd00187   81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 944375220 167 IVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEVDEKTSR 233
Cdd:cd00187  161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDEGRNT 227
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-230 5.10e-141

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 401.94  E-value: 5.10e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220     1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:smart00434  14 YSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    81 DGQGNFGSV-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNI 159
Cdd:smart00434  94 DGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNI 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 944375220   160 PPHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVqayrtgrgsvyVRAKAEVEVDEK 230
Cdd:smart00434 174 PPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPGKYV-----------VRGKIEIEDDNT 233
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
9-226 8.00e-136

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 388.45  E-value: 8.00e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    9 RALPDVRDGLKPVHRRVLYAMNELGNDwNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLVDGQGNFGS 88
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   89 V-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIPPHNLTEI 167
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 944375220  168 VNGCLALIENGDLTIdeLMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIE 216
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-226 6.19e-115

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 350.56  E-value: 6.19e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:PRK13979  29 YAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:PRK13979 109 DGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIP 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 944375220 161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:PRK13979 189 PHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIE 254
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-226 8.05e-113

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 339.58  E-value: 8.05e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:TIGR01062  17 YSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   81 DGQGNFGSVDG-DNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNI 159
Cdd:TIGR01062  97 DGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDI 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 944375220  160 PPHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGG-IINGRSGIVQAYRTGRGSVYVRAKAEVE 226
Cdd:TIGR01062 177 PPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAeIIDKAEEIRKIYETGRGSFRMRARWKKE 244
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-227 2.59e-106

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 322.52  E-value: 2.59e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYDTIVRMAQDFSMRYMLV 80
Cdd:TIGR01061  17 YAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   81 DGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNIP 160
Cdd:TIGR01061  97 EMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIP 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 944375220  161 PHNLTEIVNGCLALIENGDLTIDELMTHVTGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEV 227
Cdd:TIGR01061 177 PHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEV 243
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-231 2.06e-60

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 200.32  E-value: 2.06e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELgNDWNkpYKKSARVVGDVIgKYHPHGDIAVYDTIVRMA-QDFsmrymL 79
Cdd:PRK09631  15 YASYVIKDRAIPDVIDGLKPVQRRILHSLFEM-HDGK--FHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----F 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  80 VDGQGNFGSV-DGDNAAAMRYTEVRMARISHELLadLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATN 158
Cdd:PRK09631  86 IDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATK 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944375220 159 IPPHNLTEIVNGCLALIENGDLTIdelmthvtGPDFPTGGIINgrsgiVQAYRTGRGSVYVRAKAEvEVDEKT 231
Cdd:PRK09631 164 ILPHNFNEILQAVKSELLGESFAL--------YPDFPTGGIVD-----VSEYADGNGKVLVRAKIE-TKDEKT 222
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-231 6.09e-56

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 190.99  E-value: 6.09e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDwnkPYKKSARVVGDVIgKYHPHGDIAVYDTIVRMAQdfsmRYMLV 80
Cdd:PRK12758  34 YASYVILERAVPHIEDGLKPVQRRILHSMKEMDDG---RYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  81 DGQGNFGSV-DGDNAAAMRYTEVRMARISHELLadLDKETVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMATNI 159
Cdd:PRK12758 106 DTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKI 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 944375220 160 PPHNLTEIVNGCLALIENGDLTIdelmthvtGPDFPTGGIINgrsgiVQAYRTGR--GSVYVRAKAEvEVDEKT 231
Cdd:PRK12758 184 LPHNFNELIDASIAYLKGKEFKL--------YPDFPTGGIID-----VSNYNDGErgGRVRVRAKIE-KLDKKT 243
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 1-231 2.44e-42

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 149.27  E-value: 2.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELgnDWNKPYKksarvVGDVIGK---YHPHGDIAVYDTIVRMAQdfsmRY 77
Cdd:PRK09630  15 YASYVILERAIPHILDGLKPVQRRLLWTLFRM--DDGKMHK-----VANIAGRtmaLHPHGDAPIVEALVVLAN----KG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  78 MLVDGQGNFGS-VDGDNAAAMRYTEVRMARISHELLADLDkeTVDWVPNYDGTEMIPAVMPTKVPTLLVNGSSGIAVGMA 156
Cdd:PRK09630  84 YLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVLFNTD--LMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMT 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944375220 157 TNIPPHNLTEIVNGCLALIENGDLTIdelmthvtGPDFPTGGIINGRSgivqaYRTGRGSVYVRAKAEVeVDEKT 231
Cdd:PRK09630 162 TKIFPHNFCELLEAQIAILNDQPFTL--------LPDFPSGGTMDASE-----YQDGLGSITLRASIDI-INDKT 222
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 1-224 4.86e-38

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 137.11  E-value: 4.86e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   1 YAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDV--IGkYHpHGDIAVYDTIVRMAQDFSMRYM 78
Cdd:PHA02592  19 YAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220  79 LVDGQGNFGSVDGDNAAAMRYTEVRMarisHELLADLDKETvDWVPNYDGTEMIPAV--MPTkVPTLLVNGSSGIAVGMA 156
Cdd:PHA02592  97 LLDGQGNFGSRLVQKAAAARYIFARV----HDNFRKIYKDE-DLAPVHEDPEHIPPAfyLPI-IPMVLLNGVSGIATGYA 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 944375220 157 TNIPPHNLTEIVNGCLALIENGDltIDELMthvtgPDFPtggiinGRSGIVQayRTGRGSVYVRAKAE 224
Cdd:PHA02592 171 TNILPHSPKSVIKAVLAALNGKD--ITEPK-----VQFP------EFKGEVV--EIEPGSYEIRGTYE 223
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 9-181 2.66e-24

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 100.89  E-value: 2.66e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    9 RALPDVRDGLKPVHRRVLYAM------NELgndwnkpykKSARVVGDVIGK--YHpHGDIAVYDTIVRMAQDF----SMR 76
Cdd:PTZ00108  680 RSIPSLVDGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNIN 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   77 YMLVDGQgnFGS--VDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLVNGSSGIAV 153
Cdd:PTZ00108  750 LLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYL-EDDGQSVEPFyYVPI-IPMVLVNGAEGIGT 825

                         170       180
                  ....*....|....*....|....*...
gi 944375220  154 GMATNIPPHNLTEIVNGCLALIENGDLT 181
Cdd:PTZ00108  826 GFSTSIPNYNPLDIIDNLRRRLNGEEVR 853
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 9-181 1.76e-22

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 95.55  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    9 RALPDVRDGLKPVHRRVLYAMneLGNDWnKPYKKSARVVGDVI--GKYHpHGDIAVYDTIVRMAQDF--SMRYMLVDGQG 84
Cdd:PLN03128  673 RSIPSMVDGLKPSQRKVLFAC--FKRNL-KSEIKVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgSNNINLLTPSG 748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   85 NFGS--VDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLVNGSSGIAVGMATNIPP 161
Cdd:PLN03128  749 QFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEwYCPI-IPMVLVNGSEGIGTGWSTFIPN 826

                         170       180
                  ....*....|....*....|
gi 944375220  162 HNLTEIVNGCLALIENGDLT 181
Cdd:PLN03128  827 YNPRDIIANIRRLLRGEELE 846
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 9-168 1.61e-19

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 86.84  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220    9 RALPDVRDGLKPVHRRVLYAmnelgnDWNKPYKKSARV---VGDV--IGKYHpHGDIAVYDTIVRMAQDF--SMRYMLVD 81
Cdd:PLN03237  698 RSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVaqlSGYVseHSAYH-HGEQSLASTIIGMAQDFvgSNNINLLL 770

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944375220   82 GQGNFG--SVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLVNGSSGIAVGMATN 158
Cdd:PLN03237  771 PNGQFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTF 848

                         170
                  ....*....|
gi 944375220  159 IPPHNLTEIV 168
Cdd:PLN03237  849 IPNYNPRDIV 858
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH