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Conserved domains on  [gi|973691176|gb|ALX39136|]
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early growth response 2B, partial [Parabramis sp. cyp81]

Protein Classification

zinc finger and BTB domain-containing protein( domain architecture ID 12112529)

H2C2 zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Homo sapiens zinc finger and BTB domain-containing protein 7C (ZBTB7C/APM-1), which may act as a tumor suppressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 2-75 4.11e-11

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 58.31  E-value: 4.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973691176    2 IVSaGILGMTQPSSASSSPASSVSPSHFSSTLSCTM-AQNQ-ADMEHIYSPPPPY--SGCGEVYQDPSAFLSTSTCPI 75
Cdd:pfam11928  23 LVS-GLVGMANPPSSSSSSSPSSSSSPNSSGPLCTMsCSVQsSEMEHIYSAPPPYpsSGCGDLYQDPSAFLSTPSGPP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 7.26e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 7.26e-06
                          10        20
                  ....*....|....*....|....*.
gi 973691176  233 HLTTHIRTHTGEKPFACDFCGRKFAR 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 174-265 8.25e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 8.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973691176 174 KYPNRPSKTpVHERPYPCPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFA 248
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*..
gi 973691176 249 CDFCGRKFARSDERKRH 265
Cdd:COG5189  401 CEVCDKRYKNLNGLKYH 417
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 2-75 4.11e-11

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 58.31  E-value: 4.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973691176    2 IVSaGILGMTQPSSASSSPASSVSPSHFSSTLSCTM-AQNQ-ADMEHIYSPPPPY--SGCGEVYQDPSAFLSTSTCPI 75
Cdd:pfam11928  23 LVS-GLVGMANPPSSSSSSSPSSSSSPNSSGPLCTMsCSVQsSEMEHIYSAPPPYpsSGCGDLYQDPSAFLSTPSGPP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 7.26e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 7.26e-06
                          10        20
                  ....*....|....*....|....*.
gi 973691176  233 HLTTHIRTHTGEKPFACDFCGRKFAR 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 174-265 8.25e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 8.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973691176 174 KYPNRPSKTpVHERPYPCPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFA 248
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*..
gi 973691176 249 CDFCGRKFARSDERKRH 265
Cdd:COG5189  401 CEVCDKRYKNLNGLKYH 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-260 1.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 1.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 973691176 217 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSD 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR 75
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 2.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 973691176  205 ELTRHIRIHTGHKPFQCRICMRNFSR 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 2-75 4.11e-11

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 58.31  E-value: 4.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973691176    2 IVSaGILGMTQPSSASSSPASSVSPSHFSSTLSCTM-AQNQ-ADMEHIYSPPPPY--SGCGEVYQDPSAFLSTSTCPI 75
Cdd:pfam11928  23 LVS-GLVGMANPPSSSSSSSPSSSSSPNSSGPLCTMsCSVQsSEMEHIYSAPPPYpsSGCGDLYQDPSAFLSTPSGPP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 7.26e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 7.26e-06
                          10        20
                  ....*....|....*....|....*.
gi 973691176  233 HLTTHIRTHTGEKPFACDFCGRKFAR 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 174-265 8.25e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 8.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973691176 174 KYPNRPSKTpVHERPYPCPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFA 248
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*..
gi 973691176 249 CDFCGRKFARSDERKRH 265
Cdd:COG5189  401 CEVCDKRYKNLNGLKYH 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-260 1.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 1.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 973691176 217 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSD 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR 75
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 2.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 973691176  205 ELTRHIRIHTGHKPFQCRICMRNFSR 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-247 3.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 3.21e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 973691176 185 HERPYPCPaeGCDRRFSRSDELTRHIRIHTGHKPFQCRICMR--NFSRSDHLTTHIRTHTGEKPF 247
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 189-213 2.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|....*
gi 973691176  189 YPCPaeGCDRRFSRSDELTRHIRIH 213
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
191-265 3.59e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 38.46  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973691176 191 CPAEGCDRRFSRSDELTRHIRIHtgHKPFQCRICMRN---------FSRSDHLTTHIRTHTGEKPFA----CDFCGRKFA 257
Cdd:COG5236  154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGNkkdfwneirLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231


                 ....*...
gi 973691176 258 RSDERKRH 265
Cdd:COG5236  232 DDDELRRH 239
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 219-241 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|...
gi 973691176  219 FQCRICMRNFSRSDHLTTHIRTH 241
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-254 9.51e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 36.98  E-value: 9.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 973691176 189 YPCPAEGCDRRFSRSDELTRHIR--IHTG--HKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDFCGR 254
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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