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Conserved domains on  [gi|1005658406|gb|AMQ18627|]
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cation:proton antiporter [Thermococcus peptonophilus]

Protein Classification

Na(+)/H(+) antiporter subunit C( domain architecture ID 10013067)

Na(+)/H(+) antiporter subunit C (MrpC) is part of a heterooligomeric complex together with MrpA, MrpB, MrpD, MrpE, MrpF and MrpG, which is involved in resistance to Na(+) and excretion of Li(+) and Na(+)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08388 PRK08388
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-119 1.19e-66

putative monovalent cation/H+ antiporter subunit C; Reviewed


:

Pssm-ID: 236257  Cd Length: 119  Bit Score: 196.66  E-value: 1.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELNELPTAPIYTGYETLKSPMVGPLPQAL 80
Cdd:PRK08388    1 MIAFQFITAFLMIALGIYAFLYKRNLIKLILALDLIDSGIHLLLISLGYRMENGLPPTAPIYTGYETLKSPMVGPIPQAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:PRK08388   81 VLTSIVIGVCVLSLAMALTINAYRHYGTLDVTKLRRLRG 119
 
Name Accession Description Interval E-value
PRK08388 PRK08388
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-119 1.19e-66

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236257  Cd Length: 119  Bit Score: 196.66  E-value: 1.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELNELPTAPIYTGYETLKSPMVGPLPQAL 80
Cdd:PRK08388    1 MIAFQFITAFLMIALGIYAFLYKRNLIKLILALDLIDSGIHLLLISLGYRMENGLPPTAPIYTGYETLKSPMVGPIPQAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:PRK08388   81 VLTSIVIGVCVLSLAMALTINAYRHYGTLDVTKLRRLRG 119
MnhC COG1006
Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];
1-119 4.33e-30

Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440630  Cd Length: 113  Bit Score: 104.04  E-value: 4.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLaKRNLLKLVLALNIIDSGIHLLLISLGYRmelnELPTAPIYTGYETLkSPMVGPLPQAL 80
Cdd:COG1006     1 MELLLALVIGVLFAIGVYLLL-RRNLIKVIIGLSLLSNAVNLLLFAMGGL----TGGAPPILGEGPPA-APYADPLPQAL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:COG1006    75 VLTAIVIGFAVTAFLLALAYRIYQLYGTDDVDELREDER 113
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-119 1.95e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.35  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   6 FIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELnelptapiytgyetlkspmvgPLPQALVLTSI 85
Cdd:pfam00420   3 LLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTAD---------------------PLPQALILTAI 61

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1005658406  86 VIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:pfam00420  62 VIAAAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
PRK08388 PRK08388
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-119 1.19e-66

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236257  Cd Length: 119  Bit Score: 196.66  E-value: 1.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELNELPTAPIYTGYETLKSPMVGPLPQAL 80
Cdd:PRK08388    1 MIAFQFITAFLMIALGIYAFLYKRNLIKLILALDLIDSGIHLLLISLGYRMENGLPPTAPIYTGYETLKSPMVGPIPQAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:PRK08388   81 VLTSIVIGVCVLSLAMALTINAYRHYGTLDVTKLRRLRG 119
MnhC COG1006
Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];
1-119 4.33e-30

Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440630  Cd Length: 113  Bit Score: 104.04  E-value: 4.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLaKRNLLKLVLALNIIDSGIHLLLISLGYRmelnELPTAPIYTGYETLkSPMVGPLPQAL 80
Cdd:COG1006     1 MELLLALVIGVLFAIGVYLLL-RRNLIKVIIGLSLLSNAVNLLLFAMGGL----TGGAPPILGEGPPA-APYADPLPQAL 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:COG1006    75 VLTAIVIGFAVTAFLLALAYRIYQLYGTDDVDELREDER 113
PRK08389 PRK08389
putative monovalent cation/H+ antiporter subunit C; Reviewed
 1-119 1.60e-22

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236258  Cd Length: 114  Bit Score: 84.78  E-value: 1.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELnelpTAPIYTGYETlKSPMVGPLPQAL 80
Cdd:PRK08389    1 MIEAYYFGAIALVLIGLYGVLVKKNLLKIIIGLDIMETGVNLLLISIGYVSGR----SAPILSEGIT-PSNYVDPIPQAL 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:PRK08389   76 VLTAIVIGVSTTALALSVAIKLYEKYGTLNVEEIRRLRG 114
PRK07375 PRK07375
Na+/H+ antiporter subunit C;
1-118 2.40e-21

Na+/H+ antiporter subunit C;


Pssm-ID: 236004  Cd Length: 112  Bit Score: 81.47  E-value: 2.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   1 MIQFQFIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELNElptaPIYTGyeTLKSPMVGPLPQAL 80
Cdd:PRK07375    1 MQLMIYALAIALLVIGLYGLIFKRNLLKKIIGLDVFQTGVNLFYIAIGYRSGGGV----PILSP--SGFTTYADPLPQAL 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1005658406  81 VLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLR 118
Cdd:PRK07375   75 VLTAIVIGFATTAVMLALIVKLYKDYGTLSESEIEKED 112
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-119 1.95e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.35  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   6 FIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMELnelptapiytgyetlkspmvgPLPQALVLTSI 85
Cdd:pfam00420   3 LLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTAD---------------------PLPQALILTAI 61

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1005658406  86 VIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:pfam00420  62 VIAAAEAAVGLALLVRIYRTHGTDDVDSLNLLKG 95
PRK12658 PRK12658
Na+/H+ antiporter subunit C;
7-116 2.24e-12

Na+/H+ antiporter subunit C;


Pssm-ID: 183658  Cd Length: 125  Bit Score: 58.92  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   7 IVAFLMIALGIYAFLAkRNLLKLVLALNIIDSGIHLLLISLGyRMELNELPTAPiyTGYETLKSPMVGPLPQALVLTSIV 86
Cdd:PRK12658    7 ILVGVFFAAAIYLMLS-RHIIRILFGLALLGNAVNLLIFTAG-RLTREVPPLIP--AGADVLAEGAANPLPQALILTAIV 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1005658406  87 IGVCVLSLAVALTINAYRHYGTLDVRALRR 116
Cdd:PRK12658   83 IGFGLLAFLLVLAYRAYQDLGTDDTDEMRV 112
PRK12659 PRK12659
Na+/H+ antiporter subunit C;
7-115 3.16e-10

Na+/H+ antiporter subunit C;


Pssm-ID: 183659  Cd Length: 117  Bit Score: 53.13  E-value: 3.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   7 IVAFLMIALGIYAFLaKRNLLKLVLALNIIDSGIHLLLISLGyRMELNELPTAPiyTGYETLKSPMVGPLPQALVLTSIV 86
Cdd:PRK12659    7 IVVGGLYAAGIYMML-RRSIVKLVIGLILLGNAANLLIFTVG-RLTRGAPPLVP--EGATAPAGPVADPLPQALILTAIV 82

                          90       100
                  ....*....|....*....|....*....
gi 1005658406  87 IGVCVLSLAVALTINAYRHYGTLDVRALR 115
Cdd:PRK12659   83 IGFGVQAFAIVLIKRAYQVVGTDDLDEMK 111
PRK08600 PRK08600
putative monovalent cation/H+ antiporter subunit C; Reviewed
 6-115 1.67e-09

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 181497  Cd Length: 113  Bit Score: 51.11  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   6 FIVAFLMIALGIYAFLAKrNLLKLVLALNIIDSGIHLLLISLGyRMELNElptAPIYTGYETlksPMVGPLPQALVLTSI 85
Cdd:PRK08600    6 IIVIGILTAIAVYLILSK-SLLRIIIGTTLLSHGANLLLLTMG-GLKKGA---VPILGEGVT---SYVDPLPQALILTAI 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1005658406  86 VIGVCVLSLAVALTINAYRHYGTLDVRALR 115
Cdd:PRK08600   78 VISFGVTAFFLVLAYRTYKELGTDNVEQMR 107
PRK07946 PRK07946
putative monovalent cation/H+ antiporter subunit C; Reviewed
 6-106 2.11e-09

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236136  Cd Length: 163  Bit Score: 51.97  E-value: 2.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   6 FIVAFLMIALGIYAFLaKRNLLKLVLALNIIDSGIHLLLISLGYRMElnelpTAPIYTGYETLKSPMVGPLPQALVLTSI 85
Cdd:PRK07946    8 LVAIGVLTSAGVYLLL-ERSLTRMLLGLLLIGNGVNLLILTAGGPAG-----NPPILGRTSEYGETMADPLAQAMILTAI 81

                          90       100
                  ....*....|....*....|.
gi 1005658406  86 VIGVCVLSLAVALtinAYRHY 106
Cdd:PRK07946   82 VITMGITAFVLAL---AYRSY 99
PRK12660 PRK12660
putative monovalent cation/H+ antiporter subunit C; Reviewed
 7-115 1.10e-08

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 183660  Cd Length: 114  Bit Score: 49.35  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   7 IVAFLMIALGIYAFLAKrNLLKLVLALNIIDSGIHLLLISLGyrmELNELPTAPIYTGYETLkspMVGPLPQALVLTSIV 86
Cdd:PRK12660    7 LVIGFLVFIGTYMILSI-NLIRIVIGISIYTHAGNLIIMSMG---GYGSSRSEPLITGGNQL---FVDPLLQAIVLTAIV 79

                          90       100
                  ....*....|....*....|....*....
gi 1005658406  87 IGVCVLSLAVALTINAYRHYGTLDVRALR 115
Cdd:PRK12660   80 IGFGMTAFLLVLVYRTYKVTKEDEIEGLR 108
PRK12661 PRK12661
putative monovalent cation/H+ antiporter subunit C; Reviewed
 13-119 2.28e-08

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 237162  Cd Length: 140  Bit Score: 49.00  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406  13 IALGIYAFLA-KRNLLKLVLALNIIDSGIHLLLISLG-----------------------YRMELNELPTAPIYTGyeTL 68
Cdd:PRK12661   12 LLFGIGTFLIlRRDMIKVIIGLSIISHAVNLLIVSSGvfegtkvpiiteqghegsgsgiiYNDNLTSGILAPIVTN--GP 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1005658406  69 KSPMVGPLPQALVLTSIVIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:PRK12661   90 ETEFVDPLVQALVLTAIVIGLATTAFILILAYRIYEEYGTTDIRELRRLRG 140
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 6-119 4.73e-08

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 46.98  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406   6 FIVAFLMIALGIYAFLAKRNLLKLVLALNIIDSGIHLLLISLGYRMElnelptapiytgyetlkspmvGPLPQALVLTSI 85
Cdd:COG0713     7 LILAAILFAIGLYGVLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLG---------------------DLDGQVFALFVI 65

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1005658406  86 VIGVCVLSLAVALTINAYRHYGTLDVRALRRLRG 119
Cdd:COG0713    66 AVAAAEVAVGLAIIVALYRNRGTIDVDDLNELKG 99
PRK09094 PRK09094
putative monovalent cation/H+ antiporter subunit C; Reviewed
 11-103 2.09e-03

putative monovalent cation/H+ antiporter subunit C; Reviewed


Pssm-ID: 236377  Cd Length: 114  Bit Score: 35.24  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005658406  11 LMIALGIYAFLAKRNLlKLVLALNIIDSGIHLLLISLGyRMELNElptAPIYTGYETLKSPMVG-PLPQALVLTSIVIGV 89
Cdd:PRK09094   11 VLTASGVWLLLRPRTF-QVILGLSLLSYAVNLFIFAMG-RLRVGA---PPVLQPGVPVDLANYTdPLPQALVLTAIVIGF 85

                          90
                  ....*....|....
gi 1005658406  90 CVLSLAVALTINAY 103
Cdd:PRK09094   86 AMTALFLVVALASR 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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