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Conserved domains on  [gi|1026358128|gb|ANC96607|]
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RTX toxin, partial [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTX_C super family cl07086
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 56-100 1.37e-04

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


The actual alignment was detected with superfamily member pfam08339:

Pssm-ID: 429930  Cd Length: 131  Bit Score: 38.34  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1026358128  56 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENI 100
Cdd:pfam08339   2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEI 56
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1-33 3.11e-03

RTX calcium-binding nonapeptide repeat (4 copies);


:

Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 32.79  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1026358128   1 YGGNGDDTLIGGKGNDILR*GYGADTYIFSKGH 33
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGN 33
 
Name Accession Description Interval E-value
RTX_C pfam08339
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 56-100 1.37e-04

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


Pssm-ID: 429930  Cd Length: 131  Bit Score: 38.34  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1026358128  56 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENI 100
Cdd:pfam08339   2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEI 56
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1-33 3.11e-03

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 32.79  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1026358128   1 YGGNGDDTLIGGKGNDILR*GYGADTYIFSKGH 33
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGN 33
 
Name Accession Description Interval E-value
RTX_C pfam08339
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 56-100 1.37e-04

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


Pssm-ID: 429930  Cd Length: 131  Bit Score: 38.34  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1026358128  56 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENI 100
Cdd:pfam08339   2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEI 56
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1-33 3.11e-03

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 32.79  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1026358128   1 YGGNGDDTLIGGKGNDILR*GYGADTYIFSKGH 33
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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