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Conserved domains on  [gi|1032899482|gb|ANH22438|]
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diverse immunoglobulin domain-containing protein 3.7 transcript variant 5293, partial [Danio rerio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|8176743|23842991|10436082|3289571|9541533

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-91 7.01e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 7.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032899482    7 GENVRLPCNnaLSGCTST--TWNYNrhsetvelvaGGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCRQYVNGQQ 84
Cdd:smart00410   9 GESVTLSCE--ASGSPPPevTWYKQ----------GGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*..
gi 1032899482   85 YGTDANV 91
Cdd:smart00410  77 ASSGTTL 83
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-91 7.01e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 7.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032899482    7 GENVRLPCNnaLSGCTST--TWNYNrhsetvelvaGGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCRQYVNGQQ 84
Cdd:smart00410   9 GESVTLSCE--ASGSPPPevTWYKQ----------GGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*..
gi 1032899482   85 YGTDANV 91
Cdd:smart00410  77 ASSGTTL 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 5-85 2.77e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032899482   5 SSGENVRLPC---NNALSGCTSTTWNYNR--HSETVELVAGGKLKTDIKRRERLSVG-----SDCSLNFKKVTKEDYGSY 74
Cdd:pfam07686   9 ALGGSVTLPCtysSSMSEASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRgdpsnGDGSLTIQNLTLSDSGTY 88

                          90
                  ....*....|.
gi 1032899482  75 SCRQYVNGQQY 85
Cdd:pfam07686  89 TCAVIPSGEGV 99
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-77 2.42e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 33.84  E-value: 2.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1032899482  40 GGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCR 77
Cdd:cd00096    20 NGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-91 7.01e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 7.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032899482    7 GENVRLPCNnaLSGCTST--TWNYNrhsetvelvaGGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCRQYVNGQQ 84
Cdd:smart00410   9 GESVTLSCE--ASGSPPPevTWYKQ----------GGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*..
gi 1032899482   85 YGTDANV 91
Cdd:smart00410  77 ASSGTTL 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 5-85 2.77e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032899482   5 SSGENVRLPC---NNALSGCTSTTWNYNR--HSETVELVAGGKLKTDIKRRERLSVG-----SDCSLNFKKVTKEDYGSY 74
Cdd:pfam07686   9 ALGGSVTLPCtysSSMSEASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRgdpsnGDGSLTIQNLTLSDSGTY 88

                          90
                  ....*....|.
gi 1032899482  75 SCRQYVNGQQY 85
Cdd:pfam07686  89 TCAVIPSGEGV 99
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 7-77 8.01e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 35.23  E-value: 8.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1032899482   7 GENVRLPCNnALSGCTST-TWNYNrhsetvelvagGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCR 77
Cdd:pfam13927  16 GETVTLTCE-ATGSPPPTiTWYKN-----------GEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-77 2.42e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 33.84  E-value: 2.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1032899482  40 GGKLKTDIKRRERLSVGSDCSLNFKKVTKEDYGSYSCR 77
Cdd:cd00096    20 NGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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