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Conserved domains on  [gi|1052247111|gb|AOC60633|]
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Toll-like receptor 8, partial [Nyctalus noctula]

Protein Classification

toll-like receptor( domain architecture ID 12156291)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-758 1.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  495 LNLSSNGNGQALNGSEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNAHyfqiagvthrlgfIKNLTKLQVL 574
Cdd:COG4886     52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------------LSNLTNLESL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  575 NVSRNNIFTLTEYNLSSGSLKELVFSGNRLDILWKAadkrymciFRNLVALEQLDISFNNLERIPqQAFVNLPrNLTRLY 654
Cdd:COG4886    119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--------LGNLTNLKSLDLSNNQLTDLP-EELGNLT-NLKELD 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  655 LNDNRLKFFNWTLLQyFPRLQLLDLSRNRLYYLTYSLSKIThSLQTLLLSENKIVQLPpgFVSQNSSLVTLDLSANQLKM 734
Cdd:COG4886    189 LSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264

                          250       260
                   ....*....|....*....|....
gi 1052247111  735 INRSTfqtnENSNLALLRLDGNPF 758
Cdd:COG4886    265 LPPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-491 3.82e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  117 ELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNcyfgnvcnktfiddGAFEEMTNLKVLTL 196
Cdd:COG4886     55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------EELSNLTNLESLDL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  197 SFNNLSRVPLNLPR--SLRKLFLSNTNIHTIHKAdFEGLGNLTVLDLSGNcprcfnapfpctpcpgdaSISIHGSAFESL 274
Cdd:COG4886    121 SGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN------------------QLTDLPEELGNL 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  275 TNLKYLNLSSTSLRKVnSSWFDKMPHLKELHLEFNYLvHEIasGEFLTKLPSLEILDLSFNyrktqYLDYIilsPNFSKL 354
Cdd:COG4886    182 TNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-TDL--PEPLANLTNLETLDLSNN-----QLTDL---PELGNL 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  355 TLLRSLHLRgyvfqNLRSEDFQPLMNLPNLMTINLGVNFINKIDFGIFKNFPNLNVIYLSVNRISPLVSDTRKSLSTLHS 434
Cdd:COG4886    250 TNLEELDLS-----NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  435 HVLKPRSADSEFDPHSNFYHSTKPLIKPECAKYGKAIDLSRNNIFFIGQKQFEAFPN 491
Cdd:COG4886    325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
TIR smart00255
Toll - interleukin 1 - resistance;
864-1006 1.29e-15

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 74.67  E-value: 1.29e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   864 YDAYVSYdtkdaSVTDWVINELRFHLEESEEKNVLlCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARSWSFKTA 943
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111   944 FYLALQRLMDENMDVVVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEvlFWQNLKNVV 1006
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 726-809 4.57e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 51.24  E-value: 4.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  726 DLSANQLKMINRSTFqtNENSNLALLRLDGNPFDCTCDMGDFLRWMDENpNVTIPRLTYVMCGSPGDQIGKSIVTLELTT 805
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....
gi 1052247111  806 CVSD 809
Cdd:TIGR00864   78 SGCD 81
LRR_8 pfam13855
Leucine rich repeat;
51-125 7.57e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247111   51 PGVTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAMLppycenyrrtkkgmNITDGAFLNLQKLMELLLENNQL 125
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--------------TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-758 1.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  495 LNLSSNGNGQALNGSEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNAHyfqiagvthrlgfIKNLTKLQVL 574
Cdd:COG4886     52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------------LSNLTNLESL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  575 NVSRNNIFTLTEYNLSSGSLKELVFSGNRLDILWKAadkrymciFRNLVALEQLDISFNNLERIPqQAFVNLPrNLTRLY 654
Cdd:COG4886    119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--------LGNLTNLKSLDLSNNQLTDLP-EELGNLT-NLKELD 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  655 LNDNRLKFFNWTLLQyFPRLQLLDLSRNRLYYLTYSLSKIThSLQTLLLSENKIVQLPpgFVSQNSSLVTLDLSANQLKM 734
Cdd:COG4886    189 LSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264

                          250       260
                   ....*....|....*....|....
gi 1052247111  735 INRSTfqtnENSNLALLRLDGNPF 758
Cdd:COG4886    265 LPPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-491 3.82e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  117 ELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNcyfgnvcnktfiddGAFEEMTNLKVLTL 196
Cdd:COG4886     55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------EELSNLTNLESLDL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  197 SFNNLSRVPLNLPR--SLRKLFLSNTNIHTIHKAdFEGLGNLTVLDLSGNcprcfnapfpctpcpgdaSISIHGSAFESL 274
Cdd:COG4886    121 SGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN------------------QLTDLPEELGNL 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  275 TNLKYLNLSSTSLRKVnSSWFDKMPHLKELHLEFNYLvHEIasGEFLTKLPSLEILDLSFNyrktqYLDYIilsPNFSKL 354
Cdd:COG4886    182 TNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-TDL--PEPLANLTNLETLDLSNN-----QLTDL---PELGNL 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  355 TLLRSLHLRgyvfqNLRSEDFQPLMNLPNLMTINLGVNFINKIDFGIFKNFPNLNVIYLSVNRISPLVSDTRKSLSTLHS 434
Cdd:COG4886    250 TNLEELDLS-----NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  435 HVLKPRSADSEFDPHSNFYHSTKPLIKPECAKYGKAIDLSRNNIFFIGQKQFEAFPN 491
Cdd:COG4886    325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
TIR smart00255
Toll - interleukin 1 - resistance;
864-1006 1.29e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 74.67  E-value: 1.29e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   864 YDAYVSYdtkdaSVTDWVINELRFHLEESEEKNVLlCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARSWSFKTA 943
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111   944 FYLALQRLMDENMDVVVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEvlFWQNLKNVV 1006
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-579 1.47e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   53 VTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAMLPPycenyrrtkkgmnITDGAFLNLQKLMELLLENNQLD-KIPSD 131
Cdd:PLN00113    71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP-------------IPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  132 LPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNCYFGNVcnktfidDGAFEEMTNLKVLTLSFNNLS-RVPLNLP- 209
Cdd:PLN00113   138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKI-------PNSLTNLTSLEFLTLASNQLVgQIPRELGq 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  210 -RSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGNcprcfNAPFPCTPCPGDA-------------SISIHGSAFeSLT 275
Cdd:PLN00113   211 mKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLknlqylflyqnklSGPIPPSIF-SLQ 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  276 NLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHEIASGefLTKLPSLEILDL---------SFNYRKTQYLDYII 346
Cdd:PLN00113   285 KLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLwsnkfsgeiPKNLGKHNNLTVLD 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  347 LSPNFSKLTLLRSLHLRGYVFQ------NLRSEDFQPLMNLPNLMTINLGVN-FINKIDFGiFKNFPNLNVIYLSVNRIS 419
Cdd:PLN00113   363 LSTNNLTGEIPEGLCSSGNLFKlilfsnSLEGEIPKSLGACRSLRRVRLQDNsFSGELPSE-FTKLPLVYFLDISNNNLQ 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  420 PLVSDTRKSLSTLHSHVLkprSADSEFDPHSNFYHSTKPlikpecakygKAIDLSRNNIFFIGQKQFEAFPNISCLNLSS 499
Cdd:PLN00113   442 GRINSRKWDMPSLQMLSL---ARNKFFGGLPDSFGSKRL----------ENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  500 NgngqALNG---SEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNahyfQIAG-VTHRLGFIKNLtkLQVlN 575
Cdd:PLN00113   509 N----KLSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSGeIPKNLGNVESL--VQV-N 577


                   ....
gi 1052247111  576 VSRN 579
Cdd:PLN00113   578 ISHN 581
LRR_8 pfam13855
Leucine rich repeat;
625-684 2.97e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.97e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  625 LEQLDISFNNLERIPQQAFVNLPrNLTRLYLNDNRLKFFNWTLLQYFPRLQLLDLSRNRL 684
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
571-758 1.78e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 1.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  571 LQVLNVSRNNIFTLTEYnLSSgSLKELVFSGNRLDILWKAADK--RYMCIFRNLV---------ALEQLDISFNNLERIP 639
Cdd:PRK15370   243 IQEMELSINRITELPER-LPS-ALQSLDLFHNKISCLPENLPEelRYLSVYDNSIrtlpahlpsGITHLNVQSNSLTALP 320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  640 QqafvNLPRNLTRLYLNDNRLKFFNWTLLqyfPRLQLLDLSRNRLYYLTYSLSKithSLQTLLLSENKIVQLPPGFvsqN 719
Cdd:PRK15370   321 E----TLPPGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLPENL---P 387

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1052247111  720 SSLVTLDLSANQLKMINRS--TFQTnENSNLALLRLDGNPF 758
Cdd:PRK15370   388 AALQIMQASRNNLVRLPESlpHFRG-EGPQPTRIIVEYNPF 427
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 864-1009 2.90e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 54.29  E-value: 2.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  864 YDAYVSYDTKDasVTDWVINELRFHLEEseeKNVLLCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARS-WS--- 939
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  940 FKTAFYLALQRLMdenmdVVVFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEVLF 998
Cdd:pfam01582   76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150

                          170
                   ....*....|.
gi 1052247111  999 WQNLKNVVLTA 1009
Cdd:pfam01582  151 WKKIAYDISNK 161
LRR_8 pfam13855
Leucine rich repeat;
189-244 3.36e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.36e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  189 TNLKVLTLSFNNLSRVP----LNLPrSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGN 244
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDdgafKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-348 8.42e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  112 LQKLMELLLENNQLDKIPS-DLPGSLRVLSLIQNNIISVSknNTSALKNLESLNLGWNCyfgnvcnktfIddgafEEMTN 190
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQ----------I-----EKIEN 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  191 LKVLtlsfnnlsrvplnlpRSLRKLFLSNTNIHTIhkADFEGLGNLTVLDLSGNcprcfNAPFPCTPCPGDASISihgsa 270
Cdd:cd21340     64 LENL---------------VNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ-----RLPPGEKLTFDPRSLA----- 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  271 feSLTN-LKYLNLSSTSLRkvNSSWFDKMPHLKELHLEFNYL--VHEIAsgEFLTKLPSLEILDLSFN--YRKTQYLDYI 345
Cdd:cd21340    117 --ALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQIsdLEELL--DLLSSWPSLRELDLTGNpvCKKPKYRDKI 190


                   ...
gi 1052247111  346 ILS 348
Cdd:cd21340    191 ILA 193
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 726-809 4.57e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 51.24  E-value: 4.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  726 DLSANQLKMINRSTFqtNENSNLALLRLDGNPFDCTCDMGDFLRWMDENpNVTIPRLTYVMCGSPGDQIGKSIVTLELTT 805
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....
gi 1052247111  806 CVSD 809
Cdd:TIGR00864   78 SGCD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 621-758 1.06e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  621 NLVALEQLDISFNNLERIpqQAFVNLpRNLTRLYLNDNRLKffnwTL--LQYFPRLQLLDLSRNRL------YYLTYSLS 692
Cdd:cd21340     44 FLTNLTHLYLQNNQIEKI--ENLENL-VNLKKLYLGGNRIS----VVegLENLTNLEELHIENQRLppgeklTFDPRSLA 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052247111  693 KITHSLQTLLLSENKIVQLPPgfVSQNSSLVTLDLSANQLKMINRSTFQTNENSNLALLRLDGNPF 758
Cdd:cd21340    117 ALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
51-125 7.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247111   51 PGVTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAMLppycenyrrtkkgmNITDGAFLNLQKLMELLLENNQL 125
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--------------TLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
756-796 3.30e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 3.30e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1052247111   756 NPFDCTCDMGDFLRWMDENPNVTIPRLTYvmCGSPGDQIGK 796
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDPVDLR--CASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-758 1.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  495 LNLSSNGNGQALNGSEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNAHyfqiagvthrlgfIKNLTKLQVL 574
Cdd:COG4886     52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------------LSNLTNLESL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  575 NVSRNNIFTLTEYNLSSGSLKELVFSGNRLDILWKAadkrymciFRNLVALEQLDISFNNLERIPqQAFVNLPrNLTRLY 654
Cdd:COG4886    119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--------LGNLTNLKSLDLSNNQLTDLP-EELGNLT-NLKELD 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  655 LNDNRLKFFNWTLLQyFPRLQLLDLSRNRLYYLTYSLSKIThSLQTLLLSENKIVQLPpgFVSQNSSLVTLDLSANQLKM 734
Cdd:COG4886    189 LSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264

                          250       260
                   ....*....|....*....|....
gi 1052247111  735 INRSTfqtnENSNLALLRLDGNPF 758
Cdd:COG4886    265 LPPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-756 4.81e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 4.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  495 LNLSSNGNGQALNGSEFSALTQLKYLDFTHNKldfdansAFNELPELKVLDLSDNAhyfqiagVTHRLGFIKNLTKLQVL 574
Cdd:COG4886     76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKEL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  575 NVSRNNIFTLTEYNLSSGSLKELVFSGNRLDILWKAadkrymciFRNLVALEQLDISFNNLERIPqQAFVNLPrNLTRLY 654
Cdd:COG4886    142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--------LGNLTNLKELDLSNNQITDLP-EPLGNLT-NLEELD 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  655 LNDNRLKFFNWTLLQyFPRLQLLDLSRNRLYYLTySLSKIThSLQTLLLSENKIVQLPPGfvSQNSSLVTLDLSANQLKM 734
Cdd:COG4886    212 LSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP-ELGNLT-NLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTD 286

                          250       260
                   ....*....|....*....|..
gi 1052247111  735 INRSTFQTNENSNLALLRLDGN 756
Cdd:COG4886    287 LKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-491 3.82e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  117 ELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNcyfgnvcnktfiddGAFEEMTNLKVLTL 196
Cdd:COG4886     55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------EELSNLTNLESLDL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  197 SFNNLSRVPLNLPR--SLRKLFLSNTNIHTIHKAdFEGLGNLTVLDLSGNcprcfnapfpctpcpgdaSISIHGSAFESL 274
Cdd:COG4886    121 SGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN------------------QLTDLPEELGNL 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  275 TNLKYLNLSSTSLRKVnSSWFDKMPHLKELHLEFNYLvHEIasGEFLTKLPSLEILDLSFNyrktqYLDYIilsPNFSKL 354
Cdd:COG4886    182 TNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-TDL--PEPLANLTNLETLDLSNN-----QLTDL---PELGNL 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  355 TLLRSLHLRgyvfqNLRSEDFQPLMNLPNLMTINLGVNFINKIDFGIFKNFPNLNVIYLSVNRISPLVSDTRKSLSTLHS 434
Cdd:COG4886    250 TNLEELDLS-----NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  435 HVLKPRSADSEFDPHSNFYHSTKPLIKPECAKYGKAIDLSRNNIFFIGQKQFEAFPN 491
Cdd:COG4886    325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-522 4.76e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 4.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  103 NITDGAFLNLQKLMELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNCYFGNVCNKTFIDD 182
Cdd:COG4886     10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  183 GAFEEMTNLKVLTLSFNNlsrvPLNLPRSLRKLFLSNTNIHTIhKADFEGLGNLTVLDLSGNcprcfnapfpctpcpgda 262
Cdd:COG4886     90 TDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN------------------ 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  263 SISIHGSAFESLTNLKYLNLSSTSLRKVnSSWFDKMPHLKELHLEFNYLvHEIasGEFLTKLPSLEILDLSFNYRKTqyl 342
Cdd:COG4886    147 QLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELDLSGNQLTD--- 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  343 dyiiLSPNFSKLTLLRSLHLRGyvfqNlRSEDFQPLMNLPNLMTINLGVNFINKIDFgiFKNFPNLNVIYLSVNRISPLV 422
Cdd:COG4886    220 ----LPEPLANLTNLETLDLSN----N-QLTDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLK 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  423 SDTRKSLSTLHSHVLKPRSADSEFDPHSNFYHSTKPLIKPECAKYGKAIDLSRNNIFFIGQKQFEAFPNISCLNLSSNGN 502
Cdd:COG4886    289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                          410       420
                   ....*....|....*....|
gi 1052247111  503 GQALNGSEFSALTQLKYLDF 522
Cdd:COG4886    369 LGLLGLLEATLLTLALLLLT 388
TIR smart00255
Toll - interleukin 1 - resistance;
864-1006 1.29e-15

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 74.67  E-value: 1.29e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   864 YDAYVSYdtkdaSVTDWVINELRFHLEESEEKNVLlCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARSWSFKTA 943
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111   944 FYLALQRLMDENMDVVVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEvlFWQNLKNVV 1006
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
469-770 2.93e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  469 KAIDLSRNNIFFIGqKQFEAFPNISCLNLSSNgNGQALnGSEFSALTQLKYLDFTHNKLDfDANSAFNELPELKVLDLSD 548
Cdd:COG4886    116 ESLDLSGNQLTDLP-EELANLTNLKELDLSNN-QLTDL-PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSN 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  549 NahyfQIAGVTHRLGfikNLTKLQVLNVSRNNIFTLTEYNLSSGSLKELVFSGNRLDILwkaadkrymCIFRNLVALEQL 628
Cdd:COG4886    192 N----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL---------PELGNLTNLEEL 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  629 DISFNNLERIPQQAfvNLPrNLTRLYLNDNRLKFFN---WTLLQYFPRLQLLDLSRNRLYYLTYSLSKITHSLQTLLLSE 705
Cdd:COG4886    256 DLSNNQLTDLPPLA--NLT-NLKTLDLSNNQLTDLKlkeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247111  706 NKIVQLPPGFVSQNSSLVTLDLSANQLKMINRSTFQTNENSNLALLRLDGNPFDCTCDMGDFLRW 770
Cdd:COG4886    333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-443 4.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 4.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   52 GVTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAmlppycenyrrtkkgmnitdgAFLNLQKLMELLLENNQLDKIPSD 131
Cdd:COG4886     73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------------------ELSNLTNLESLDLSGNQLTDLPEE 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  132 LpgslrvlsliqnniisvsknntSALKNLESLNLGWNcyfgnvcNKTFIDDgAFEEMTNLKVLTLSFNNLSRVPLNLPR- 210
Cdd:COG4886    132 L----------------------ANLTNLKELDLSNN-------QLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNl 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  211 -SLRKLFLSNTNIHTIHKAdFEGLGNLTVLDLSGNcprcfnapfpctpcpgdaSISIHGSAFESLTNLKYLNLSSTSLRK 289
Cdd:COG4886    182 tNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN------------------QLTDLPEPLANLTNLETLDLSNNQLTD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  290 VnsSWFDKMPHLKELHLEFNylvhEIASGEFLTKLPSLEILDLSFNYRKTQYLDYIILSPNFSKLTLLRSLHLRGYVFQN 369
Cdd:COG4886    243 L--PELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1052247111  370 LRSEDFQPLMNLPNLMTINLGVNFINKIDFGIFKNFPNLNVIYLSVNRISPLVSDTRKSLSTLHSHVLKPRSAD 443
Cdd:COG4886    317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-579 1.47e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   53 VTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAMLPPycenyrrtkkgmnITDGAFLNLQKLMELLLENNQLD-KIPSD 131
Cdd:PLN00113    71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP-------------IPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  132 LPGSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNCYFGNVcnktfidDGAFEEMTNLKVLTLSFNNLS-RVPLNLP- 209
Cdd:PLN00113   138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKI-------PNSLTNLTSLEFLTLASNQLVgQIPRELGq 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  210 -RSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGNcprcfNAPFPCTPCPGDA-------------SISIHGSAFeSLT 275
Cdd:PLN00113   211 mKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLknlqylflyqnklSGPIPPSIF-SLQ 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  276 NLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHEIASGefLTKLPSLEILDL---------SFNYRKTQYLDYII 346
Cdd:PLN00113   285 KLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLwsnkfsgeiPKNLGKHNNLTVLD 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  347 LSPNFSKLTLLRSLHLRGYVFQ------NLRSEDFQPLMNLPNLMTINLGVN-FINKIDFGiFKNFPNLNVIYLSVNRIS 419
Cdd:PLN00113   363 LSTNNLTGEIPEGLCSSGNLFKlilfsnSLEGEIPKSLGACRSLRRVRLQDNsFSGELPSE-FTKLPLVYFLDISNNNLQ 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  420 PLVSDTRKSLSTLHSHVLkprSADSEFDPHSNFYHSTKPlikpecakygKAIDLSRNNIFFIGQKQFEAFPNISCLNLSS 499
Cdd:PLN00113   442 GRINSRKWDMPSLQMLSL---ARNKFFGGLPDSFGSKRL----------ENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  500 NgngqALNG---SEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNahyfQIAG-VTHRLGFIKNLtkLQVlN 575
Cdd:PLN00113   509 N----KLSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSGeIPKNLGNVESL--VQV-N 577


                   ....
gi 1052247111  576 VSRN 579
Cdd:PLN00113   578 ISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 160-684 2.93e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 2.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  160 LESLNLGWNCYFGNvcnktfIDDGAFEEMTNLKVLTLSFNNLS-RVPLNLPRSLRKLFLSNTNIHTIHKADFEGLGNLTV 238
Cdd:PLN00113    95 IQTINLSNNQLSGP------IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKV 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  239 LDLSGNCprcfnapfpctpCPGDASISIhgsafESLTNLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHEIASG 318
Cdd:PLN00113   169 LDLGGNV------------LVGKIPNSL-----TNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  319 efLTKLPSLEILDLSFNYRKTQyldyiiLSPNFSKLTLLRSLHLrgyvFQNLRSEDFQP-LMNLPNLMTINLGVNFINKI 397
Cdd:PLN00113   232 --IGGLTSLNHLDLVYNNLTGP------IPSSLGNLKNLQYLFL----YQNKLSGPIPPsIFSLQKLISLDLSDNSLSGE 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  398 DFGIFKNFPNLNVIYLSVNRISPLVSDTRKSLSTLHSHVLKPRSADSE----FDPHSNFyhstkplikpecakygKAIDL 473
Cdd:PLN00113   300 IPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEipknLGKHNNL----------------TVLDL 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  474 SRNNIFFIGQKQFEAFPNISCLNLSSNgngqALNGS---EFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDNa 550
Cdd:PLN00113   364 STNNLTGEIPEGLCSSGNLFKLILFSN----SLEGEipkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN- 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  551 hyfqiaGVTHRLGFIK-NLTKLQVLNVSRNNIFTLTEYNLSSGSLKELVFSGNRLDilwKAADKRymciFRNLVALEQLD 629
Cdd:PLN00113   439 ------NLQGRINSRKwDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFS---GAVPRK----LGSLSELMQLK 505

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1052247111  630 ISFNNLE-RIPQQafVNLPRNLTRLYLNDNRLKFFNWTLLQYFPRLQLLDLSRNRL 684
Cdd:PLN00113   506 LSENKLSgEIPDE--LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-244 4.44e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 4.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   36 DCNNRRLQEVPQTVD--PGVTVLDLSDNVITQIRNgSFESLRNLTSINLNRNamlppycenyrrtkkgmNITD--GAFLN 111
Cdd:COG4886    119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-----------------QLTDlpEELGN 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  112 LQKLMELLLENNQLDKIPSDLPG--SLRVLSLIQNNIISVSKnNTSALKNLESLNLGWNcyfgnvcnkTFIDDGAFEEMT 189
Cdd:COG4886    181 LTNLKELDLSNNQITDLPEPLGNltNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN---------QLTDLPELGNLT 250

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  190 NLKVLTLSFNNLSRVP--LNLPrSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGN 244
Cdd:COG4886    251 NLEELDLSNNQLTDLPplANLT-NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
625-684 2.97e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.97e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  625 LEQLDISFNNLERIPQQAFVNLPrNLTRLYLNDNRLKFFNWTLLQYFPRLQLLDLSRNRL 684
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
571-758 1.78e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 1.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  571 LQVLNVSRNNIFTLTEYnLSSgSLKELVFSGNRLDILWKAADK--RYMCIFRNLV---------ALEQLDISFNNLERIP 639
Cdd:PRK15370   243 IQEMELSINRITELPER-LPS-ALQSLDLFHNKISCLPENLPEelRYLSVYDNSIrtlpahlpsGITHLNVQSNSLTALP 320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  640 QqafvNLPRNLTRLYLNDNRLKFFNWTLLqyfPRLQLLDLSRNRLYYLTYSLSKithSLQTLLLSENKIVQLPPGFvsqN 719
Cdd:PRK15370   321 E----TLPPGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLPENL---P 387

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1052247111  720 SSLVTLDLSANQLKMINRS--TFQTnENSNLALLRLDGNPF 758
Cdd:PRK15370   388 AALQIMQASRNNLVRLPESlpHFRG-EGPQPTRIIVEYNPF 427
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 864-1009 2.90e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 54.29  E-value: 2.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  864 YDAYVSYDTKDasVTDWVINELRFHLEEseeKNVLLCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARS-WS--- 939
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  940 FKTAFYLALQRLMdenmdVVVFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEVLF 998
Cdd:pfam01582   76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150

                          170
                   ....*....|.
gi 1052247111  999 WQNLKNVVLTA 1009
Cdd:pfam01582  151 WKKIAYDISNK 161
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-706 1.05e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  262 ASISIHGSAFESLTNLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHEIASGEFLTKLPSLEILDLSFNyrktqy 341
Cdd:COG4886     33 LLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  342 ldyiilsPNFSKLTLLRSLHLRGYVFQNLrsedFQPLMNLPNLMTINLGVNFINKIDFGIfKNFPNLNVIYLSVNRISPL 421
Cdd:COG4886    107 -------EELSNLTNLESLDLSGNQLTDL----PEELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDL 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  422 vSDTRKSLSTLHShvlkprsadsefdphsnfyhstkplikpecakygkaIDLSRNNIFFIGqKQFEAFPNISCLNLSSNG 501
Cdd:COG4886    175 -PEELGNLTNLKE------------------------------------LDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  502 NGQAlnGSEFSALTQLKYLDFTHNKLDfdANSAFNELPELKVLDLSDNahyfQIAGvthrLGFIKNLTKLQVLNVSRNNI 581
Cdd:COG4886    217 LTDL--PEPLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNN----QLTD----LPPLANLTNLKTLDLSNNQL 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  582 -----FTLTEYNLSSGSLKELVFSGNRLDILWKAADKRYMCIFRNLVALEQLDISFNNLERIPQQAFVNLPRNLTRLYLN 656
Cdd:COG4886    285 tdlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1052247111  657 DNRLKFFNWTLLQYFPRLQLLDLSRNRLYYLTYSLSKITHSLQTLLLSEN 706
Cdd:COG4886    365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 867-978 1.62e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 50.78  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  867 YVSYDTKDASVTDWVINELrfhleesEEKNVLLCLEERDWDPGLANIDNLMQSINQSKKTIFVLTKKYARSWSFKTAFYL 946
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1052247111  947 ALQRLMDENmdVVVFILLE-----PVLQHSQYLRLRQ 978
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
LRR_8 pfam13855
Leucine rich repeat;
189-244 3.36e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.36e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  189 TNLKVLTLSFNNLSRVP----LNLPrSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGN 244
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDdgafKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
265-311 7.81e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 7.81e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1052247111  265 SIHGSAFESLTNLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYL 311
Cdd:pfam13855   15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-348 8.42e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  112 LQKLMELLLENNQLDKIPS-DLPGSLRVLSLIQNNIISVSknNTSALKNLESLNLGWNCyfgnvcnktfIddgafEEMTN 190
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQ----------I-----EKIEN 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  191 LKVLtlsfnnlsrvplnlpRSLRKLFLSNTNIHTIhkADFEGLGNLTVLDLSGNcprcfNAPFPCTPCPGDASISihgsa 270
Cdd:cd21340     64 LENL---------------VNLKKLYLGGNRISVV--EGLENLTNLEELHIENQ-----RLPPGEKLTFDPRSLA----- 116

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  271 feSLTN-LKYLNLSSTSLRkvNSSWFDKMPHLKELHLEFNYL--VHEIAsgEFLTKLPSLEILDLSFN--YRKTQYLDYI 345
Cdd:cd21340    117 --ALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQIsdLEELL--DLLSSWPSLRELDLTGNpvCKKPKYRDKI 190


                   ...
gi 1052247111  346 ILS 348
Cdd:cd21340    191 ILA 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
111-254 8.90e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 8.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  111 NLQ-KLMELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLESLnlgwncyfgnvCNK-TFIDDGAFEEM 188
Cdd:PRK15370   217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF-----------HNKiSCLPENLPEEL 285

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  189 TNLKVLTlsfNNLSRVPLNLPRSLRKLFLSNTNIHTIHkadfEGLG-NLTVLDLSGNCPRCFNAPFP 254
Cdd:PRK15370   286 RYLSVYD---NSIRTLPAHLPSGITHLNVQSNSLTALP----ETLPpGLKTLEAGENALTSLPASLP 345
LRR_8 pfam13855
Leucine rich repeat;
275-335 1.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.19e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052247111  275 TNLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHeIASGEFlTKLPSLEILDLSFN 335
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAF-SGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
210-287 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.43e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247111  210 RSLRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGNCPRcfnapfpctpcpgdasiSIHGSAFESLTNLKYLNLSSTSL 287
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------------TLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 469-732 2.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 2.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  469 KAIDLSRNNIFFIGQKQFEAFPNISCLNLSSNGNGQALNGSEFSALTQLKYLDFTHNK---------------LDFDANS 533
Cdd:PLN00113    72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNftgsiprgsipnletLDLSNNM 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  534 AFNELPE-------LKVLDLSDNAHyfqiagVTHRLGFIKNLTKLQVLNVSRNNI----------------FTLTEYNLS 590
Cdd:PLN00113   152 LSGEIPNdigsfssLKVLDLGGNVL------VGKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmkslkwIYLGYNNLS 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  591 SGSLKEL--VFSGNRLDILWKAADKRYMCIFRNLVALEQLDISFNNLE-RIPQQAFvNLpRNLTRLYLNDNRLKFFNWTL 667
Cdd:PLN00113   226 GEIPYEIggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SL-QKLISLDLSDNSLSGEIPEL 303

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052247111  668 LQYFPRLQLLDLSRNRLY-YLTYSLSKITHsLQTLLLSENKIVQLPPGFVSQNSSLVTLDLSANQL 732
Cdd:PLN00113   304 VIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 726-809 4.57e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 51.24  E-value: 4.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  726 DLSANQLKMINRSTFqtNENSNLALLRLDGNPFDCTCDMGDFLRWMDENpNVTIPRLTYVMCGSPGDQIGKSIVTLELTT 805
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....
gi 1052247111  806 CVSD 809
Cdd:TIGR00864   78 SGCD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-364 9.68e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 9.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  176 NKTFIDDgaFEEMTNLKVLTLSFNNLSRVP-LNLPRSLRKLFLSNTNIHTIhkADFEGLGNLTVLDLSGNCprcfnapfp 254
Cdd:cd21340     13 NITKIDN--LSLCKNLKVLYLYDNKITKIEnLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR--------- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  255 ctpcpgdasIS-IHGsaFESLTNLKYLNLSSTSLRKVNSSWFDKM------PHLKELHLEFNylvhEIASGEFLTKLPSL 327
Cdd:cd21340     80 ---------ISvVEG--LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGN----NIDSLEPLAPLRNL 144

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1052247111  328 EILDLSFNyrKTQYLDYIILSpnFSKLTLLRSLHLRG 364
Cdd:cd21340    145 EQLDASNN--QISDLEELLDL--LSSWPSLRELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 621-758 1.06e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  621 NLVALEQLDISFNNLERIpqQAFVNLpRNLTRLYLNDNRLKffnwTL--LQYFPRLQLLDLSRNRL------YYLTYSLS 692
Cdd:cd21340     44 FLTNLTHLYLQNNQIEKI--ENLENL-VNLKKLYLGGNRIS----VVegLENLTNLEELHIENQRLppgeklTFDPRSLA 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1052247111  693 KITHSLQTLLLSENKIVQLPPgfVSQNSSLVTLDLSANQLKMINRSTFQTNENSNLALLRLDGNPF 758
Cdd:cd21340    117 ALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
20-222 1.70e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   20 RSFPCDEKIQNESVVA---DC--NNR--------RLQEVPQTVDPGVTVLDLSDNVITQIRNGSFESLRNLtSINLNRNA 86
Cdd:PRK15370   155 KEAPAKEAANREEAVQrmrDClkNNKtelrlkilGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTL-YANSNQLT 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   87 MLPpycENYRRTKKGMNITDGAFLNLQK-----LMELLLENNQLDKIPSDLPGSLRVLSLIQNNIISVSKNNTSALKNLe 161
Cdd:PRK15370   234 SIP---ATLPDTIQEMELSINRITELPErlpsaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHL- 309

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052247111  162 slnlgwncyfgNVCNKTFIDDGAFEEMtNLKVLTLSFNNLSRVPLNLPRSLRKLFLSNTNI 222
Cdd:PRK15370   310 -----------NVQSNSLTALPETLPP-GLKTLEAGENALTSLPASLPPELQVLDVSKNQI 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 51-244 2.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   51 PGVTVLDLSDNVITQIRNgsFESLRNLTSinlnrnamlppycenyrrtkkgmnitdgaflnlqklmeLLLENNQLDKIP- 129
Cdd:cd21340     24 KNLKVLYLYDNKITKIEN--LEFLTNLTH--------------------------------------LYLQNNQIEKIEn 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  130 -SDLPgSLRVLSLIQNNIISVSknNTSALKNLESLNLGwncyfgnvCNKTFIDDG-AFEEMT------NLKVLTLSFNNL 201
Cdd:cd21340     64 lENLV-NLKKLYLGGNRISVVE--GLENLTNLEELHIE--------NQRLPPGEKlTFDPRSlaalsnSLRVLNISGNNI 132

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1052247111  202 SRV-PLNLPRSLRKLFLSNTNIHTIH--KADFEGLGNLTVLDLSGN 244
Cdd:cd21340    133 DSLePLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
633-735 2.55e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  633 NNLERIPQqafvNLPRNLTRLYLNDNRLKFFNWTLLQyfpRLQLLDLSRNRLYYLTYSLSKithSLQTLLLSENKIVQLP 712
Cdd:PRK15370   209 NELKSLPE----NLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPERLPS---ALQSLDLFHNKISCLP 278

                           90       100
                   ....*....|....*....|...
gi 1052247111  713 PGFVSQnssLVTLDLSANQLKMI 735
Cdd:PRK15370   279 ENLPEE---LRYLSVYDNSIRTL 298
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 378-549 5.32e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  378 LMNLPNLMTINLGVNFINKIDFgiFKNFPNLNVIYLSVNRISPLVS-DTRKSLSTLhsHVLKPRSADSE---FDPHSNFY 453
Cdd:cd21340     42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEGlENLTNLEEL--HIENQRLPPGEkltFDPRSLAA 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  454 HStkplikpECAKYgkaIDLSRNNIffigqkqfeafPNISCLnlssngngqalngsefSALTQLKYLDFTHNKL-DFDA- 531
Cdd:cd21340    118 LS-------NSLRV---LNISGNNI-----------DSLEPL----------------APLRNLEQLDASNNQIsDLEEl 160

                          170
                   ....*....|....*...
gi 1052247111  532 NSAFNELPELKVLDLSDN 549
Cdd:cd21340    161 LDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
593-660 5.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 5.75e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247111  593 SLKELVFSGNRLDILWKAAdkrymciFRNLVALEQLDISFNNLERIPQQAFVNLPrNLTRLYLNDNRL 660
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGA-------FKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-125 7.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247111   51 PGVTVLDLSDNVITQIRNGSFESLRNLTSINLNRNAMLppycenyrrtkkgmNITDGAFLNLQKLMELLLENNQL 125
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--------------TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
471-527 9.87e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 9.87e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  471 IDLSRNNIFFIGQKQFEAFPNISCLNLSSNgNGQALNGSEFSALTQLKYLDFTHNKL 527
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
135-201 2.91e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.91e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  135 SLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNcyfgnvcNKTFIDDGAFEEMTNLKVLTLSFNNL 201
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
490-549 6.15e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 6.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  490 PNISCLNLSSNgNGQALNGSEFSALTQLKYLDFTHNKLDFDANSAFNELPELKVLDLSDN 549
Cdd:pfam13855    1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
697-758 9.29e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 9.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052247111  697 SLQTLLLSENKIVQLPPGFVSQNSSLVTLDLSANQLKMINRSTFQtnENSNLALLRLDGNPF 758
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
299-364 9.38e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 9.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247111  299 PHLKELHLEFNYLVHeiASGEFLTKLPSLEILDLSFNYRKTqyldyiiLSPN-FSKLTLLRSLHLRG 364
Cdd:pfam13855    1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTT-------LSPGaFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
648-708 1.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052247111  648 RNLTRLYLNDNRLKFFNWTLLQYFPRLQLLDLSRNRLYYLTY-SLSKItHSLQTLLLSENKI 708
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 51-245 1.64e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111   51 PGVTVLDLSDNVITQIRNGSFESLRNLTSI---NLNRNAM--------------LPP-----YCENYRRTKKGMNITDGA 108
Cdd:cd00116     81 CGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLgdrglrllakglkdLPPaleklVLGRNRLEGASCEALAKA 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  109 FLNLQKLMELLLENNQLdkipsdLPGSLRVLSLIqnniisvsknnTSALKNLESLNLgWNCyfgnvcnkTFIDDGA---- 184
Cdd:cd00116    161 LRANRDLKELNLANNGI------GDAGIRALAEG-----------LKANCNLEVLDL-NNN--------GLTDEGAsala 214

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247111  185 --FEEMTNLKVLTLSFNNLSRVP--------LNLPRSLRKLFLSNTNIHTIHKADF-EGLGN---LTVLDLSGNC 245
Cdd:cd00116    215 etLASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDITDDGAKDLaEVLAEkesLLELDLRGNK 289
LRRCT smart00082
Leucine rich repeat C-terminal domain;
756-796 3.30e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 3.30e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1052247111   756 NPFDCTCDMGDFLRWMDENPNVTIPRLTYvmCGSPGDQIGK 796
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDPVDLR--CASPSSLRGP 39
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 538-733 3.67e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 3.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  538 LPELKVLDLSDNAHYFQIAGVTHRLGFIKNlTKLQVLNVSRNNI-----FTLTEYNLSSGSLKELVFSGNRLDilwKAAD 612
Cdd:COG5238    150 PLGGNAVHLLGLAARLGLLAAISMAKALQN-NSVETVYLGCNQIgdegiEELAEALTQNTTVTTLWLKRNPIG---DEGA 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  613 KRYMCIFRNLVALEQLDISFNNlerIPQQAFVNL------PRNLTRLYLNDNRL-----KFFNwTLLQYFPRLQLLDLSR 681
Cdd:COG5238    226 EILAEALKGNKSLTTLDLSNNQ---IGDEGVIALaealknNTTVETLYLSGNQIgaegaIALA-KALQGNTTLTSLDLSV 301

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247111  682 NRL-----YYLTYSLSKiTHSLQTLLLSENKIVqlPPGFVS------QNSSLVTLDLSANQLK 733
Cdd:COG5238    302 NRIgdegaIALAEGLQG-NKTLHTLNLAYNGIG--AQGAIAlakalqENTTLHSLDLSDNQIG 361
LRR_8 pfam13855
Leucine rich repeat;
113-168 4.15e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 4.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  113 QKLMELLLENNQLDKIP----SDLPgSLRVLSLIQNNIISVSKNNTSALKNLESLNLGWN 168
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDdgafKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 526-602 5.26e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  526 KLDFDANSAFNELPELKVLDLSDNahyfQIAGvthrLGFIKNLTKLQVLNVSRNNIFTLTEYN--LSS-GSLKELVFSGN 602
Cdd:cd21340    107 KLTFDPRSLAALSNSLRVLNISGN----NIDS----LEPLAPLRNLEQLDASNNQISDLEELLdlLSSwPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-336 7.61e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 7.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  115 LMELLLENNQLD-KIPSDLPG--SLRVLSLIQNNIISVSKNNTSALKNLESLNLGWNCYFGNVCNKTFiddgafeEMTNL 191
Cdd:PLN00113   382 LFKLILFSNSLEgEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKW-------DMPSL 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247111  192 KVLTLSFNNLSRvplNLPRS-----LRKLFLSNTNIHTIHKADFEGLGNLTVLDLSGNcprcfnapfpctpcpgdasiSI 266
Cdd:PLN00113   455 QMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN--------------------KL 511

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247111  267 HG---SAFESLTNLKYLNLSSTSLRKVNSSWFDKMPHLKELHLEFNYLVHEIASGefLTKLPSLEILDLSFNY 336
Cdd:PLN00113   512 SGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKN--LGNVESLVQVNISHNH 582
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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