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Conserved domains on  [gi|1112922283|gb|API84853|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Gadus morhua]

Protein Classification

NADH-ubiquinone oxidoreductase subunit 4L( domain architecture ID 10009576)

NADH-ubiquinone oxidoreductase subunit 4L (ND4L) is core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.35e-49

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177185  Cd Length: 98  Bit Score: 150.89  E-value: 3.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.35e-49

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 150.89  E-value: 3.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 5.63e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 64.12  E-value: 5.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  5 HFTISSAFLLGMMGLAFHRtHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATART 84
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 1112922283 85 HGTDHMQALNLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 3.08e-06

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 41.59  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSA--FLLGMMGLAFHRtHLLSALLCLEAMMLALFIAL-SLWSLQLDATGCSTApMLMLAFSACEASAGLAL 77
Cdd:COG0713    1 IPLEHYLILAAilFAIGLYGVLTRR-NLIVVLMSIELMLNAVNLNLvAFSRYLGDLDGQVFA-LFVIAVAAAEVAVGLAI 78

                         90
                 ....*....|....*....
gi 1112922283 78 LVATARTHGTDHMQALNLL 96
Cdd:COG0713   79 IVALYRNRGTIDVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.35e-49

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 150.89  E-value: 3.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.13e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 123.17  E-value: 3.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.61e-34

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 112.63  E-value: 4.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.15e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 86.14  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 2.14e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 80.37  E-value: 2.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  4 THFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATAR 83
Cdd:MTH00181   1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                         90
                 ....*....|...
gi 1112922283 84 THGTDHMQALNLL 96
Cdd:MTH00181  81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.02e-19

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 76.11  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1112922283 81 TARTHGTDHMQALNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 5.63e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 64.12  E-value: 5.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  5 HFTISSAFLLGMMGLAFHRtHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATART 84
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 1112922283 85 HGTDHMQALNLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 12-98 1.82e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 52.54  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283 12 FLLGMMGLAFHRTHLLSALLCLEAMMLALFIalSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATARTHGTDHMQ 91
Cdd:MTH00149  13 FLMGVFALLFQYKHLLSILLSLEALMLSLLV--MMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGNDYVS 90


                 ....*..
gi 1112922283 92 ALNLLQC 98
Cdd:MTH00149  91 SLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 6-98 3.82e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 51.90  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  6 FTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTapMLMLAFSACEASAGLALLVATARTH 85
Cdd:MTH00188   7 LVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIRSH 84

                         90
                 ....*....|...
gi 1112922283 86 GTDHMQALNLLQC 98
Cdd:MTH00188  85 GSDYVSSLNLIKC 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.83e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 47.72  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283 12 FLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATARTHGTDHMQ 91
Cdd:MTH00180  13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                 ....*.
gi 1112922283 92 ALNLLQ 97
Cdd:MTH00180  93 SLNLLR 98
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-91 4.11e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 46.30  E-value: 4.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283 12 FLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCStaPMLMLAFSACEASAGLALLVATARTHGTDHMQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYF--LLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
1-96 5.73e-07

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 43.63  E-value: 5.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283   1 MTPTHFTISSA--FLLGMMGLaFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALL 78
Cdd:PRK05715    2 IPLQHYLILAAilFCIGLVGL-LLRRNAIVVLMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAIL 80

                          90
                  ....*....|....*...
gi 1112922283  79 VATARTHGTDHMQALNLL 96
Cdd:PRK05715   81 LQLYRNRGTIDVDDLNEL 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.09e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 42.82  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSAFLLGMMGLAFHRTHLLSALLCLEAMMLALFIaLSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVA 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLAL-FIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1112922283 81 TARTHGTDHMQALNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.64e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 42.36  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283 12 FLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATARTHGTDHMQ 91
Cdd:MTH00001  13 FLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISLK 92


                 ....*.
gi 1112922283 92 ALNLLQ 97
Cdd:MTH00001  93 SLNSLR 98
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 3.08e-06

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 41.59  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283  1 MTPTHFTISSA--FLLGMMGLAFHRtHLLSALLCLEAMMLALFIAL-SLWSLQLDATGCSTApMLMLAFSACEASAGLAL 77
Cdd:COG0713    1 IPLEHYLILAAilFAIGLYGVLTRR-NLIVVLMSIELMLNAVNLNLvAFSRYLGDLDGQVFA-LFVIAVAAAEVAVGLAI 78

                         90
                 ....*....|....*....
gi 1112922283 78 LVATARTHGTDHMQALNLL 96
Cdd:COG0713   79 IVALYRNRGTIDVDDLNEL 97
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 31-98 6.21e-05

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 39.94  E-value: 6.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1112922283  31 LCLEAMMLALFIALSLWSLQLDATGcstapmlmlafSACEASAGLALLVATARTHGTDHMQALNLLQC 98
Cdd:MTH00127  376 LMGELMIITSLFNWSPWTLALTGLG-----------TLITAGYSLYMFLMTQRGPLPDHIIALNPSHT 432
ND4L MTH00192
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.60e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177240  Cd Length: 99  Bit Score: 34.90  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112922283 12 FLLGMMGLAFHRTHLLSALLCLEAMMLALFIALSLWSLQLDATGCSTAPMLMLAFSACEASAGLALLVATARTHGTDHMQ 91
Cdd:MTH00192  13 FTTGVSGIIINKNNIILILMSIELILLAISYLLIVYSVTLDNLLGIIFSLMVLTVAAAESAIGLAILVAYFRLTGTITIK 92


                 ....*.
gi 1112922283 92 ALNLLQ 97
Cdd:MTH00192  93 ALNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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