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Conserved domains on  [gi|1137645103|gb|APZ74072|]
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dehydrogenase subunit two, partial (mitochondrion) [Scyliorhinus canicula]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475913)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 2-316 1.90e-149

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 423.45  E-value: 1.90e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00135   24 SHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTGQWDIQQMSHPLPTTMITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLlFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00135  104 LKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLIT-LGLTSTLVGGWGGLNQTQLRKILAYSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00135  183 IAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTPLILLSLGGLPPLTGFMPK 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00135  263 WLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQLTLPLAISTTATLMLLP 337
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 2-316 1.90e-149

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 423.45  E-value: 1.90e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00135   24 SHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTGQWDIQQMSHPLPTTMITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLlFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00135  104 LKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLIT-LGLTSTLVGGWGGLNQTQLRKILAYSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00135  183 IAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTPLILLSLGGLPPLTGFMPK 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00135  263 WLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQLTLPLAISTTATLMLLP 337
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 3-316 4.00e-20

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 90.18  E-value: 4.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPL-MIRQHHPRAVEATTKYFITQATASALLLF-ASVTNAWTsGEWSLIEMLNPTSATLATAAL 80
Cdd:COG1007   123 DLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYgISLLYGAT-GSLNLAGIAAALAAGGANSPL 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  81 AL------------KIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFG-------VTSTI 141
Cdd:COG1007   202 LLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGLAADWQlllavlaVLSMT 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 142 VGGWGGLNQTQLRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFLLF-----KTFNSTKINSISSST 212
Cdd:COG1007   282 VGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFMNLGAFAVIlllsrKGGEAEEIEDLAGLA 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 213 LKSPLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMAST 292
Cdd:COG1007   362 RRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDEPEEEAPISAP 441

                         330       340
                  ....*....|....*....|....
gi 1137645103 293 WRTKShqpTLILLTSASISIFMLP 316
Cdd:COG1007   442 PGLRV---ALVIAALLVLLLGIFP 462
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-254 2.75e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 85.83  E-value: 2.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPLM-IRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:pfam00361   3 DLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSGLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 L-----------KIGLAPLHFWLPEVLQGLDLTTGLILA-TWQKLAPFAI-----LLQLSPLLNSNLLLLFGVTSTIVGG 144
Cdd:pfam00361  83 LlfllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLirrslLYLPSSPFIQQILLILAIISMLLGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 145 WGGLNQTQLRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFLLFKTF-----NSTKINSISSSTLKS 215
Cdd:pfam00361 163 LAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSViyrrvHTRNIRDYGGLAKTM 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1137645103 216 PLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLI 254
Cdd:pfam00361 243 PILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 3-274 2.47e-14

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 73.06  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPLM-IRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:TIGR01770 123 DLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFEDLLLFLSNGMLNISLL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 L------------KIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLF-------GVTSTIV 142
Cdd:TIGR01770 203 LlgivlilvgllfKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYILFGFSEAWqiflaiiAFLSMLI 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 143 GGWGGLNQTQLRKILAYSSIANLGWMITILHYSPSLTLLNLILYMF----MTLTTFLLFKTFNSTKINSISS-STLKS-- 215
Cdd:TIGR01770 283 GNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFiyalMSLGAFGVLSLLRSYKDEWIEYiSDFAGlf 362

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1137645103 216 ---PLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:TIGR01770 363 ktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 2-316 1.90e-149

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 423.45  E-value: 1.90e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00135   24 SHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTGQWDIQQMSHPLPTTMITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLlFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00135  104 LKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLIT-LGLTSTLVGGWGGLNQTQLRKILAYSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00135  183 IAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTPLILLSLGGLPPLTGFMPK 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00135  263 WLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQLTLPLAISTTATLMLLP 337
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 2-316 1.29e-123

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 357.69  E-value: 1.29e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00070   24 NHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTGEWTIMNMQTPLPTIMLTIALM 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00070  104 MKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLLSTLIGGWGGLNQTQLRKIMAYSS 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00070  184 IAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLTLLSLGGLPPTTGFIPK 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKsHQPTLILLTSASISIFMLP 316
Cdd:MTH00070  264 WLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK-NKTNNLLSLTIILSLMLLP 337
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 2-316 7.06e-113

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 330.65  E-value: 7.06e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00105   24 SHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGQWTITKLTNPTASTLMTIALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00105  104 MKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAILSILIGGWGGLNQTQLRKILAYSS 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00105  184 IAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLILLTLLSLGGLPPLTGFMPK 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00105  264 WMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENTKPMTLLPTLIILSTMLLP 338
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 2-316 4.70e-110

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 323.31  E-value: 4.70e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00112   24 NHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQWDITQLTNPTSCTLLTLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00112  104 MKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAILSTLIGGWGGLNQTQLRKIMAFSS 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00112  184 IAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTLMLTLLSLAGLPPLTGFMPK 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTsASISIFMLP 316
Cdd:MTH00112  264 WLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPKKNTLTATL-TTLSTLLLP 337
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-316 5.32e-109

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 320.76  E-value: 5.32e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   1 GSHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAAL 80
Cdd:MTH00200   23 SSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISEMLGPLSETLILLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  81 ALKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYS 160
Cdd:MTH00200  103 ALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLLSVLVGGWGGLNQTQLRKILAYS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 161 SIANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMP 240
Cdd:MTH00200  183 SIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLGLTLLSLGGLPPLTGFFP 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137645103 241 KWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHqPTLILLTSASISIFMLP 316
Cdd:MTH00200  263 KWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN-SNLLVGLLLLLSILGLP 337
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 2-315 1.72e-75

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 235.21  E-value: 1.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00041   24 NHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWSINGPLNTLSSIIITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00041  104 LKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGILSVLVGGWGGLNQTQTRKILAFSS 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00041  184 IAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFLFILSILSLGGLPPLTGFLNK 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFML 315
Cdd:MTH00041  264 FISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGNITVYGVILSILSSISIL 337
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 2-316 2.31e-51

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 172.32  E-value: 2.31e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAwtsgewSLIEMLNPTSATLATAALA 81
Cdd:MTH00160   25 NSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNM------LNLMLFNNISSMLINSSLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLqlsPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00160   99 LKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLS---YLINNNFIIIIIILSAIIGAIGGLNQTSLRKILAYSS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00160  176 INHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLGFLPK 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKapgPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00160  256 WIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLN---YNKNKWNLKKKKNKFSLILNFLSFISLFGLI 327
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-280 2.97e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 153.89  E-value: 2.97e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLnptsatlaTAALA 81
Cdd:MTH00144   24 SHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFSMSLL--------LLGLC 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLS-PLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYS 160
Cdd:MTH00144   96 LKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdLYWLAYLLCVISVLSALVGSIGGLNQTQVRALLAYS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 161 SIANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSStLKSPLMSVIALMTLLSLGGLPPLSGFMP 240
Cdd:MTH00144  176 SISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSIISLLLSLGGLPPFLGFCS 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1137645103 241 KWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTL 280
Cdd:MTH00144  255 KLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFL 294
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 2-316 5.00e-41

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 145.31  E-value: 5.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASvtnawtSGEWSLIEMLNPTSATLATAALA 81
Cdd:MTH00011   26 NNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGM------TMMWSFPSLLKNITALMLLVSLM 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 LKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSS 161
Cdd:MTH00011  100 LKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMNQTQLRPLLAYSS 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 162 IANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGFMPK 241
Cdd:MTH00011  180 IGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSLGGLPPFTGFMPK 259

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137645103 242 WLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTltkaPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:MTH00011  260 LMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFM----YLSPTFSSLKSAPYEPKTKILISMCTLSLGLIP 330
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 2-278 2.59e-34

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 127.48  E-value: 2.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLF---ASVTNAWTSGEWSLIEMLNptsatlata 78
Cdd:MTH00197   18 SNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMggsLSFSNLYLSLLSVVLVILG--------- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  79 aLALKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLqlSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILA 158
Cdd:MTH00197   89 -LLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILA--FNSSSFMGLLICSVLSSLIGGIGGMNQSNIRQLLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 159 YSSIANLGWMITILHYSPSLTLLNLILYMFMTLTTFLLFKTFNSTKINSISSSTLKSPLMSVIALMTLLSLGGLPPLSGF 238
Cdd:MTH00197  166 YSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLGGLPPLSGF 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1137645103 239 MPKWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYAT 278
Cdd:MTH00197  246 FLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 3-316 4.00e-20

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 90.18  E-value: 4.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPL-MIRQHHPRAVEATTKYFITQATASALLLF-ASVTNAWTsGEWSLIEMLNPTSATLATAAL 80
Cdd:COG1007   123 DLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYgISLLYGAT-GSLNLAGIAAALAAGGANSPL 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  81 AL------------KIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLFG-------VTSTI 141
Cdd:COG1007   202 LLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGLAADWQlllavlaVLSMT 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 142 VGGWGGLNQTQLRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFLLF-----KTFNSTKINSISSST 212
Cdd:COG1007   282 VGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFMNLGAFAVIlllsrKGGEAEEIEDLAGLA 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 213 LKSPLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGPINMAST 292
Cdd:COG1007   362 RRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDEPEEEAPISAP 441

                         330       340
                  ....*....|....*....|....
gi 1137645103 293 WRTKShqpTLILLTSASISIFMLP 316
Cdd:COG1007   442 PGLRV---ALVIAALLVLLLGIFP 462
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 4-274 9.19e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 89.31  E-value: 9.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   4 WLLVWMGLEINTLAI-IPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIE----MLNPTSATLATA 78
Cdd:MTH00199  119 WLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSIQGinsiLTGDVGKILITI 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  79 ALALKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLlfGVTSTIVGGWGGLNQTQLRKILA 158
Cdd:MTH00199  199 SLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLIC--AVLSIIYGAIGALNQTKIKRLLA 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 159 YSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFLLFKTFNSTK--INSISSSTLKSPLMSVIALMTLLSLGGL 232
Cdd:MTH00199  277 YSGIGHMGFILFGVaigsFESIQASLIYMIIYVIMSICSFSIILSLKLTKglIVEVSGLSRKNPVIALTLALTFLSIAGI 356

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1137645103 233 PPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:MTH00199  357 PPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 2-274 1.37e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 87.78  E-value: 1.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHP-RAVEATTKYFITQATASALLLFASVTNAWTSG--EWSLIEMLN--------- 69
Cdd:MTH00196   13 SNWLSVYLAIELQTLSLFILIAQNRGSgYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGglHLSYINLVLnsgqsfssv 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  70 --PTSATLATAALALKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLlfGVTSTIVGGWGG 147
Cdd:MTH00196   93 svPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIG--GLFSLFVGAIGA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 148 LNQTQLRKILAYSSIANLG---WMITILHY-SPSLTLLNLILYMFMTLTTFLLFKTFNSTK--INSISSSTLKSPLMSVI 221
Cdd:MTH00196  171 LNQTKIKRLLAYSGIGHMGfvlWGIEIGSFeSIQASLVYLFIYIIMSICVFSIILALNVYKnlIIEFSGLSRRLPILAIT 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1137645103 222 ALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:MTH00196  251 LALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-254 2.75e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 85.83  E-value: 2.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPLM-IRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:pfam00361   3 DLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSGLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 L-----------KIGLAPLHFWLPEVLQGLDLTTGLILA-TWQKLAPFAI-----LLQLSPLLNSNLLLLFGVTSTIVGG 144
Cdd:pfam00361  83 LlfllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLirrslLYLPSSPFIQQILLILAIISMLLGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 145 WGGLNQTQLRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFLLFKTF-----NSTKINSISSSTLKS 215
Cdd:pfam00361 163 LAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSViyrrvHTRNIRDYGGLAKTM 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1137645103 216 PLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLI 254
Cdd:pfam00361 243 PILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWI 281
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
3-274 4.34e-17

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 81.41  E-value: 4.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPL-MIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:PRK05777  124 DLLTLFLGLELLSLPLYALaALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGSLSFAGIAKALADGSGNSLLL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 L------------KIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLF-------GVTSTIV 142
Cdd:PRK05777  204 LfglvfllvglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLLVVAFGGLSEDWqqvlaiiAIASMLV 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 143 GGWGGLNQTQLRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTF-----LLFKTFNSTKINSISSSTL 213
Cdd:PRK05777  284 GNLAALSQTNIKRLLAYSSIAHAGYLLVGLaagtAEGYSAVLFYLLAYLFMTLGAFgvislLRRKGGEAESISDFAGLSK 363

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1137645103 214 KSPLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:PRK05777  364 RSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRV 424
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 3-274 2.47e-14

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 73.06  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   3 HWLLVWMGLEINTLAIIPLM-IRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA 81
Cdd:TIGR01770 123 DLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFEDLLLFLSNGMLNISLL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 L------------KIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPLLNSNLLLLF-------GVTSTIV 142
Cdd:TIGR01770 203 LlgivlilvgllfKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYILFGFSEAWqiflaiiAFLSMLI 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 143 GGWGGLNQTQLRKILAYSSIANLGWMITILHYSPSLTLLNLILYMF----MTLTTFLLFKTFNSTKINSISS-STLKS-- 215
Cdd:TIGR01770 283 GNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFiyalMSLGAFGVLSLLRSYKDEWIEYiSDFAGlf 362

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1137645103 216 ---PLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:TIGR01770 363 ktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 8-274 6.12e-12

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 65.94  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   8 WMGLEINTLAIIPLMIRQHHPRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALA------ 81
Cdd:COG0651   133 FVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLAARLAELDPGLLLAafalll 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  82 ----LKIGLAPLHFWLPE-----------VLQGLDLTTGL--ILATWqklapFAILLQLSPLLNSNLLLLFGVTSTIVGG 144
Cdd:COG0651   213 vgfgIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVL-----TLLFGADPALFLGTLLLVLGLLTMLVGA 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 145 WGGLNQTQLRKILAYSSIANLGWMITILHYSPSLTLLNLILYMFM-TLTTFLLF-------KTFNSTKINSISSSTLKSP 216
Cdd:COG0651   288 LGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNhALAKALLFlaagaieRATGTRDLDKLGGLGKRMP 367

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1137645103 217 LMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:COG0651   368 LTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 2-195 1.58e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 55.64  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   2 SHWLLVWMGLEINTLAIIPLMIRQHHPRAV---------EATTKYFITQATASALLLFA-SVTNAWTSGEWSLIEMLNPT 71
Cdd:MTH00198  208 ANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGcALYFGFTGNEGMLGTILSAT 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  72 SATL-------------ATAALALKIGLAPLHFWLPEVLQGLDLTTGLILATWQKLAPFAILlqLSPLLNSNLLLLFGVT 138
Cdd:MTH00198  288 LETTnielrqgslgylfITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL--TSLVITSKLLLSVAII 365

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1137645103 139 STIVGGWGGLNQTQLRKILAYSSIANLGWMITILHYSPSLTLLNLILYMFMTLTTFL 195
Cdd:MTH00198  366 SLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQASWTYAVTYLVSAL 422
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 269-316 6.38e-08

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 48.41  E-value: 6.38e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1137645103 269 FFYLRLCYATTLTKAPGPINMASTWRTKSHQPTLILLTSASISIFMLP 316
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLP 48
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 83-276 9.27e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 46.89  E-value: 9.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  83 KIGLAPLHFWLPEV-----------LQGLDLTTG---------LILATWQKLAPFAILLQLSPLLNsnllllfGVTSTIV 142
Cdd:PRK12667  236 KAAIFPNHFWLPDAhpaapspvsamLSGLVVNVGayaiirflyTIFGISPSLIDFRAALSPILIIL-------GAVSAII 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 143 GGWGGLNQTQLRKILAYSSIANLGWMITILHYSPSLTLLNLILYM--------FMTLTTFLLFKTFNSTKINSISSSTLK 214
Cdd:PRK12667  309 GALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIinhaiaksLLFLASGVFIHAAGTRDIDELAGLGRK 388

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1137645103 215 SPLMSVIALMTLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRLCY 276
Cdd:PRK12667  389 MPIASFAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWY 450
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 83-286 1.37e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 43.33  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  83 KIGLAPLHFWLPEVLQGL-DLTTGLILATWQKLAPFAILL---------QLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQ 152
Cdd:PRK08375  215 KAAVFPLHTWLPRAYPAApPVVTALLSGLVTKVAVYALIRiyftvfggdFRFALGLGWLLAVLALLSMLVGSLAALGQDD 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 153 LRKILAYSSIANLGWMITIL----HYSPSLTLLNLILYMFMTLTTFL----LFKTFNSTKINSISSSTLKSPLMSVIALM 224
Cdd:PRK08375  295 VKRVLAYSTVSQMGYILLGLalltPLALAAGLLHLLHHALMKGALFLaagaIEVTYGTRRLSELSGLGRRMPLTAAAFAV 374

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1137645103 225 TLLSLGGLPPLSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRLCYATTLTKAPGP 286
Cdd:PRK08375  375 ASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYRAFFGPPPPG 436
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 27-166 8.12e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 40.83  E-value: 8.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  27 HPRAVEATTKYFITQATASALLLFASVTNAWTSGEWS--LIEMLNPTSATLATAALAL--------KIGLAPLHFWLPE- 95
Cdd:COG1008   156 GERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTfdIAELAAAPLPLTAQLLLFLaffiafavKVPMFPFHTWLPDa 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  96 ----------VLQGLDLTTG----------LILATWQKLAPFAILLqlspllnsnllllfGVTSTIVGGWGGLNQTQLRK 155
Cdd:COG1008   236 hveaptagsvLLAGVLLKMGgygllrfalpLFPEASAYFAPLLAAL--------------GVIGIIYGALVALAQTDLKR 301

                         170
                  ....*....|.
gi 1137645103 156 ILAYSSIANLG 166
Cdd:COG1008   302 LIAYSSVSHMG 312
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 28-197 1.11e-03

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 40.31  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  28 PRAVEATTKYFITQATASALLLFASVTNAWTSGEWSLIEMLNPTSATLATAALAL---------KIGLAPLHFWLPEV-L 97
Cdd:TIGR01972 152 PNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGGTFDLLELLNLPLPFGVQTWLFlaffiafavKVPLFPLHTWLPDAhV 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  98 QGLDLTTGLILATWQKLAPFAI------LLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSSIANLGWMITI 171
Cdd:TIGR01972 232 EAPTAGSVILAGVLLKMGTYGFlrfnlpLFPDASLYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLG 311

                         170       180
                  ....*....|....*....|....*..
gi 1137645103 172 LHYSPSLTLLNLILYMFM-TLTTFLLF 197
Cdd:TIGR01972 312 IFSFNELGISGAVFQMIShGLITAALF 338
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 6-168 1.49e-03

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 39.91  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103   6 LVWMGLEINTLAIIPLMIRQHHPRAVEATTKYFI------TQATASALLLFASVTNAWTSGE----WSLI----EMLNPT 71
Cdd:PRK06458  132 LMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVMGDGEmailWTELlkhaSLLDPT 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  72 SATLATAALAL----KIGLAPLHFWLPE-----------VLQGLDLTTGL---------ILATWQKLAPFAILLqlspll 127
Cdd:PRK06458  212 LMKLAFVFLLIgfgtKVGLFPMHAWLPDahseapspvsaLLSGVLLNVALyavlryyilIDAAIGSDFPGRLLL------ 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1137645103 128 nsnlllLFGVTSTIVGGWGGLNQTQLRKILAYSSIANLGWM 168
Cdd:PRK06458  286 ------IFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLI 320
ndhB CHL00049
NADH dehydrogenase subunit 2
 29-274 8.07e-03

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 37.68  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  29 RAVEATTKYFITQATASALLLFA-SVTNAWTSGEWSLIEMLNPTSATLATAALAL-------------KIGLAPLHFWLP 94
Cdd:CHL00049  159 RSNEATMKYLLMGGASSSILVYGfSWLYGLSGGEIELQEIVNGLINTQMYNSPGIsialifitvgigfKLSLAPFHQWTP 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  95 EVLQG--------LDLTT---GLILATwqklAPFAILLQLSPLLNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSSIA 163
Cdd:CHL00049  239 DVYEGsptpvvafLSVTSkvaASALAT----RIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIG 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103 164 NLGW-MITILHYSPSLTLLNLILYM----FMTLTTF---LLFKTFNST-KINSISSSTLKSPLMSVIALMTLLSLGGLPP 234
Cdd:CHL00049  315 QIGYvIIGIIVGDSNDGYASMITYMlfyiFMNLGTFaciVLFGLRTGTdNIRDYAGLYTKDPFLALSLALCLLSLGGIPP 394

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1137645103 235 LSGFMPKWLILQELTKQSLIIPATIMALMALLSLFFYLRL 274
Cdd:CHL00049  395 LAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISIYYYLKI 434
ND5 MTH00032
NADH dehydrogenase subunit 5; Provisional
 89-195 8.13e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 214407 [Multi-domain]  Cd Length: 669  Bit Score: 38.02  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137645103  89 LHFWLPEVLQGLDLTTGLILATWQKLAPFAILLQLSPL-----LNSNLLLLFGVTSTIVGGWGGLNQTQLRKILAYSSIA 163
Cdd:MTH00032  244 LHTWLPDAMEGPTPVSALIHAATMVTAGVFLMIRSFPLfekapLTLLIITIFGALTAFFAATVGLVQNDLKKVIAYSTCS 323

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1137645103 164 NLGWMITI--LHYSPSLTLLNLILYMFMTLTTFL 195
Cdd:MTH00032  324 QLGYMVLIigIEGSHNVGLFHLVNHAFFKALLFL 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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