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Conserved domains on  [gi|1159611614|gb|AQY77231|]
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ZFP57 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
44-104 1.40e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.68  E-value: 1.40e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159611614   44 VTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVArIFLHKPELITKLEQEEEQW 104
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-430 9.31e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 185 SRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGER-PFCCTLCDKTYCDASGLSRHRRVHL----GYRPH 259
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 260 SC--SVCGKSFRDQSELKRHQKIHQNQEPvdgnqectlripgtqaeFQTPIARSQGSIQGLLDvnhapvARSQEPIFRTE 337
Cdd:COG5048   323 SCpySLCGKLFSRNDALKRHILLHTSISP-----------------AKEKLLNSSSKFSPLLN------NEPPQSLQQYK 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 338 GPMAQNQASVLKNQAPVTRTQAPItgtlcqdARSNSHPVKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPnYCFHC 417
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRDSN-------LSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAP-LLCSI 451

                         250
                  ....*....|...
gi 1159611614 418 SKSFSSFSRLVRH 430
Cdd:COG5048   452 LKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
44-104 1.40e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.68  E-value: 1.40e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159611614   44 VTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVArIFLHKPELITKLEQEEEQW 104
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 43-83 6.34e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 6.34e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1159611614  43 PVTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSV 83
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 44-82 1.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.23e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1159611614  44 VTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTS 82
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-430 9.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 185 SRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGER-PFCCTLCDKTYCDASGLSRHRRVHL----GYRPH 259
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 260 SC--SVCGKSFRDQSELKRHQKIHQNQEPvdgnqectlripgtqaeFQTPIARSQGSIQGLLDvnhapvARSQEPIFRTE 337
Cdd:COG5048   323 SCpySLCGKLFSRNDALKRHILLHTSISP-----------------AKEKLLNSSSKFSPLLN------NEPPQSLQQYK 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 338 GPMAQNQASVLKNQAPVTRTQAPItgtlcqdARSNSHPVKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPnYCFHC 417
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRDSN-------LSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAP-LLCSI 451

                         250
                  ....*....|...
gi 1159611614 418 SKSFSSFSRLVRH 430
Cdd:COG5048   452 LKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 259-281 2.80e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|...
gi 1159611614 259 HSCSVCGKSFRDQSELKRHQKIH 281
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 196-277 2.52e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 196 VHNPKLTNSCSQCGKLFRSpKSLSyhrrmhlgerPFCCTLCDKTYCDASGLSRHRRvhlgYRPHS--CSVCGKSFRDQSE 273
Cdd:PHA00733   50 IYNPQLLDESSYLYKLLTS-KAVS----------PYVCPLCLMPFSSSVSLKQHIR----YTEHSkvCPVCGKEFRNTDS 114


                  ....
gi 1159611614 274 LKRH 277
Cdd:PHA00733  115 TLDH 118
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
44-104 1.40e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.68  E-value: 1.40e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159611614   44 VTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSVArIFLHKPELITKLEQEEEQW 104
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 43-83 6.34e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 6.34e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1159611614  43 PVTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTSV 83
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 44-82 1.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.23e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1159611614  44 VTFEDVAVNFTQEEWDCLDASQRVLYQDVMSETFKNLTS 82
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-430 9.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 185 SRRSYLYSHQFVHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGER-PFCCTLCDKTYCDASGLSRHRRVHL----GYRPH 259
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 260 SC--SVCGKSFRDQSELKRHQKIHQNQEPvdgnqectlripgtqaeFQTPIARSQGSIQGLLDvnhapvARSQEPIFRTE 337
Cdd:COG5048   323 SCpySLCGKLFSRNDALKRHILLHTSISP-----------------AKEKLLNSSSKFSPLLN------NEPPQSLQQYK 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 338 GPMAQNQASVLKNQAPVTRTQAPItgtlcqdARSNSHPVKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPnYCFHC 417
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRDSN-------LSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAP-LLCSI 451

                         250
                  ....*....|...
gi 1159611614 418 SKSFSSFSRLVRH 430
Cdd:COG5048   452 LKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-296 1.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 180 CGKCFSRRSYLYSHQFVHNPKLTNSC--SQCGKLFRSPK-----SLSYHRRMHLGERPFCCTL--CDKTYCDASGLSRHR 250
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1159611614 251 RVHLGYRPHSC--SVCGKSFRDQSELKRHQKIHQNQEPVDGNQECTLR 296
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 259-281 2.80e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|...
gi 1159611614 259 HSCSVCGKSFRDQSELKRHQKIH 281
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 202-279 3.71e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 202 TNSCSQCGKLFRSPKSLSYHRRMH--LGERPFCCTL--CDKTYCDASGLSRHRR---------------VHLGY----RP 258
Cdd:COG5189   319 TNSSSNGKLAHGGERNIDTPSRMLkvKDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIFsakdKP 398

                          90       100
                  ....*....|....*....|.
gi 1159611614 259 HSCSVCGKSFRDQSELKRHQK 279
Cdd:COG5189   399 YRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-449 8.52e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 174 PFFCYTCGKCFSRRSYLYSHQFVHNPKLTNSCSQ--CGKLFRSPKSLSYHRRMHLGERPFCC------TLCDKTYCDASG 245
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 246 LSRHRRVHLGYRPHSCSVCGK----SFRDQSELKRHQKIHQNQEPVDGNQECTLRIPGTQAEFQTPIARSQGSIQGLLDV 321
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 322 NHaPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQ-----------------------------DARSN 372
Cdd:COG5048   193 ST-SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqspsslsssdssssasesprsslpTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 373 SHPVKPS-------RLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNY----CFH--CSKSFSSFSRLVRHQQTHWKQKS 439
Cdd:COG5048   272 SSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLkpfsCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330
                  ....*....|
gi 1159611614 440 YLCPICDLSF 449
Cdd:COG5048   352 AKEKLLNSSS 361
PHA00733 PHA00733
hypothetical protein
 196-277 2.52e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159611614 196 VHNPKLTNSCSQCGKLFRSpKSLSyhrrmhlgerPFCCTLCDKTYCDASGLSRHRRvhlgYRPHS--CSVCGKSFRDQSE 273
Cdd:PHA00733   50 IYNPQLLDESSYLYKLLTS-KAVS----------PYVCPLCLMPFSSSVSLKQHIR----YTEHSkvCPVCGKEFRNTDS 114


                  ....
gi 1159611614 274 LKRH 277
Cdd:PHA00733  115 TLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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