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Conserved domains on  [gi|1187837365|gb|ARM55301|]
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olfactory receptor family 10, partial [Vampyrum spectrum]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 1-169 1.22e-76

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15225:

Pssm-ID: 475119  Cd Length: 277  Bit Score: 229.65  E-value: 1.22e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15225   101 AICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15225   181 LVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15225   261 LNPIIYSLR 269
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 1-169 1.22e-76

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 229.65  E-value: 1.22e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15225   101 AICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15225   181 LVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15225   261 LNPIIYSLR 269
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 1-169 6.26e-16

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 72.92  E-value: 6.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:pfam13853  95 AICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:pfam13853 175 STFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTpmiGLSMVH-RFGHNVPPLLQIMMANAYLFF 253

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:pfam13853 254 PPVLNPIVYSVK 265
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 1-169 1.22e-76

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 229.65  E-value: 1.22e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15225   101 AICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15225   181 LVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15225   261 LNPIIYSLR 269
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 1-169 1.14e-64

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 198.86  E-value: 1.14e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd13954   101 AICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd13954   181 FVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVVSVFYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd13954   261 LNPIIYSLR 269
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 1-169 4.88e-60

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 187.31  E-value: 4.88e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15912   101 AICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILAS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15912   181 VVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKVVALLNTVVTPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15912   261 LNPFIYTLR 269
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 1-169 2.52e-58

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 182.68  E-value: 2.52e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15911   101 AICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15911   181 IVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVFSLFYTVLTPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15911   261 VNPLIYSLR 269
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 1-169 4.37e-58

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 182.32  E-value: 4.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15230   101 AICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15230   181 FIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSVFYTVVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15230   261 LNPLIYSLR 269
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 1-169 2.35e-57

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 180.53  E-value: 2.35e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15417   101 AICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15417   181 LFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKVASVFYTVVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15417   261 LNPLIYSLR 269
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 1-169 1.33e-56

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 178.42  E-value: 1.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15227   101 AICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15227   181 CLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPT 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15227   261 LNPIIYSLR 269
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 1-169 5.89e-53

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 169.33  E-value: 5.89e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15235   102 AICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15235   182 VVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDRVATVMYTVVTPM 261


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15235   262 LNPFIYSLR 270
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 1-169 6.12e-53

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 169.00  E-value: 6.12e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15224   101 AICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILAL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15224   181 IILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLVSVLYTVVTPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15224   261 LNPIIYCLR 269
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 1-169 6.15e-53

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 169.41  E-value: 6.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15419   101 AICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15419   181 LIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKVVSVFYTLVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15419   261 LNPLIYSLR 269
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 1-169 1.89e-52

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 168.27  E-value: 1.89e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15411   101 AICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15411   181 LTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVASVFYTVVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15411   261 LNPLIYSLR 269
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 1-169 2.49e-52

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 167.73  E-value: 2.49e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15421   101 AICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15421   181 LFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDKVVSVFYTILTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15421   261 LNPLIYSLR 269
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 1-169 3.02e-52

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 167.44  E-value: 3.02e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15231   101 AICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15231   181 FIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDTLISVLYSIVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15231   261 LNPIIYSLR 269
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 1-169 1.91e-51

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 165.96  E-value: 1.91e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15408   114 AICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15408   194 FNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPM 273


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15408   274 LNPLIYSLR 282
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 1-169 8.71e-51

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 163.55  E-value: 8.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15918   101 AICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15918   181 LVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDSVAAVMYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15918   261 LNPFIYSLR 269
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 1-169 2.25e-50

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 162.77  E-value: 2.25e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15229   101 AICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15229   181 IFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVFSIQYSILTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15229   261 LNPIIYSLK 269
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 1-169 2.51e-50

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 163.30  E-value: 2.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15943   115 AICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15943   195 FLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPM 274


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15943   275 LNPLIYSLR 283
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 1-169 6.65e-50

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 162.06  E-value: 6.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15410   114 AICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGS 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15410   194 LNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPM 273


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15410   274 LNPLIYSLR 282
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 1-169 1.69e-49

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 160.57  E-value: 1.69e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15413   101 AICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15413   181 FNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15413   261 LNPLIYSLR 269
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 1-169 2.06e-48

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 157.39  E-value: 2.06e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLcIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15431   101 AICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTV-IPVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSI 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15431   180 FTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKIISVFYGVVTPM 259


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15431   260 LNPLIYSLR 268
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 1-169 2.55e-48

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 157.47  E-value: 2.55e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15915   101 AICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLNIVTG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMP-SARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTP 159
Cdd:cd15915   181 SIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDRIVALLYTVVTP 260

                         170
                  ....*....|
gi 1187837365 160 LLNPIIYSLR 169
Cdd:cd15915   261 VLNPLIYTLR 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 1-169 5.51e-48

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 156.80  E-value: 5.51e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15409   101 AICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLFIFSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15409   181 SIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMMDSLFYTIVIPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15409   261 LNPFIYSLR 269
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 1-169 5.71e-48

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 156.28  E-value: 5.71e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15237   101 AICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15237   181 LVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDKMISVFYTIVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15237   261 LNPLIYSLR 269
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 1-169 1.83e-46

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 152.53  E-value: 1.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15914   101 AICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDFVIHA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15914   181 VIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAIAVVYAVLTPF 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15914   261 FNPIIYSLR 269
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 1-169 2.49e-45

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 149.88  E-value: 2.49e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15407   101 AVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLAS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15407   181 FNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKMASVFYTMVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15407   261 LNPLVYSLR 269
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 1-169 4.80e-45

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 149.51  E-value: 4.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15945   114 AICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15945   194 FIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPM 273


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15945   274 LNPLIYSLR 282
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-169 6.77e-45

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 148.67  E-value: 6.77e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15430   101 AICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNI 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15430   181 IFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKLITLFYGVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15430   261 LNPIIYSLR 269
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-169 3.18e-44

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 147.02  E-value: 3.18e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLAC-DYTLFQKMILLGLT 79
Cdd:cd15232   101 AICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCsDTSLNEIMAFVADV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  80 SFVlVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTP 159
Cdd:cd15232   181 FFG-VGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVVAVLYSVVTP 259

                         170
                  ....*....|
gi 1187837365 160 LLNPIIYSLR 169
Cdd:cd15232   260 TLNPLIYSLR 269
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 1-169 1.19e-43

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 145.69  E-value: 1.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15418   102 AICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15418   182 FNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVVALFYTVVNPL 261


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15418   262 LNPLIYSLR 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 1-169 1.98e-43

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 145.20  E-value: 1.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15416   101 AICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15416   181 IIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKVVSVFYMVVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15416   261 LNPLIYSLR 269
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 1-169 2.34e-43

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 145.31  E-value: 2.34e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15944   114 AICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15944   194 FVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPM 273


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15944   274 LNPLIYSLR 282
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 1-169 4.94e-43

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 144.08  E-value: 4.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15412   101 AICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15412   181 FNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15412   261 LNPLIYSLR 269
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 1-169 1.76e-42

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 142.95  E-value: 1.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15414   101 AICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWVLFIMAG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15414   181 ALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVVSVFYTAVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15414   261 LNPLIYSLR 269
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 1-169 2.92e-42

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 142.15  E-value: 2.92e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15429   101 AVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15429   181 VVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKMISLFYAVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15429   261 LNPLIYSLR 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 1-169 5.63e-42

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 141.31  E-value: 5.63e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15420   101 AICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15420   181 FILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKILSLFYSLFNPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15420   261 LNPLIYSLR 269
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 1-169 7.69e-42

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 141.01  E-value: 7.69e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15415   101 AICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15415   181 VIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKVSAVFYTLVIPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15415   261 LNPLIYSLR 269
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 1-169 1.03e-41

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 140.45  E-value: 1.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15947   101 AVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15947   181 FFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFISLFYTVVTPT 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15947   261 LNPLIYTLR 269
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 1-169 2.02e-41

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 139.89  E-value: 2.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15916   102 AICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFASIG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEdmLMSVTYTVLTPL 160
Cdd:cd15916   182 VVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALDG--VIAVFYTVVTPL 259


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15916   260 LNPLIYTLR 268
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 1-169 1.03e-40

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 138.09  E-value: 1.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15234   101 AICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15234   181 IFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTAVASVMYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15234   261 LNPFIYSLR 269
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 1-169 3.03e-40

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 137.11  E-value: 3.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15406   110 AICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGG 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15406   190 FNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKVSSVFYTTVIPM 269


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15406   270 LNPLIYSLR 278
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 1-169 8.40e-39

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 133.27  E-value: 8.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15434   101 AVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15434   181 FILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKFLTLFYTIVTPS 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15434   261 LNPLIYTLR 269
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 1-169 4.37e-38

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 130.90  E-value: 4.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15913   101 AICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTLSS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15913   181 LIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQKIVTLFYSVVTPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15913   261 LNPLIYSLR 269
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 1-169 7.46e-38

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 130.41  E-value: 7.46e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15939   101 AICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTvVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPkeNDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15939   181 LICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRP--VTTFPIDKVVAVFYTIITPM 257


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15939   258 LNPLIYTLR 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 1-169 7.48e-38

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 130.25  E-value: 7.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15940   101 AICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMpSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPkeNDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15940   181 LISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRP--STSFSEDKVVSVFYTVVTPL 257


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15940   258 LNPIIYTLR 266
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 1-169 1.00e-37

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 130.24  E-value: 1.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15424   101 AICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15424   181 LILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQIAVFYIVITPL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15424   261 LNPIIYTLR 269
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 1-169 1.27e-37

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 129.63  E-value: 1.27e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15226   101 AICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELMVVANSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMpSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPkeNDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15226   181 LISLVCFLLLLISYIVILVTVRKH-SSGGSSKALSTCSAHITVVVLFFGPCIFIYVWP--FSTFPVDKFLAVFYTVITPL 257


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15226   258 LNPIIYTLR 266
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 1-169 1.77e-37

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 129.89  E-value: 1.77e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15236   101 AICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15236   181 LLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYTVVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15236   261 LNPFIYSLR 269
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 1-169 8.52e-37

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 127.98  E-value: 8.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15428   101 AICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15428   181 FTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKMISVFYIIVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15428   261 LNPLIYSLR 269
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 1-169 2.41e-36

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 126.89  E-value: 2.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15941   103 AICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIG 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSfhEDMLMSVTYTVLTPL 160
Cdd:cd15941   183 IVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQA--GAGAPAVFYTIVTPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15941   261 LNPFIYTLR 269
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 1-169 3.47e-36

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 126.38  E-value: 3.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15405   101 AICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15405   181 INIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVSSVFYTNVVPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15405   261 LNPLIYSLR 269
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 1-169 4.01e-36

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 126.01  E-value: 4.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15942   101 AICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFheDMLMSVTYTVLTPL 160
Cdd:cd15942   181 LVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPL--DGVVAVFYTTVTPL 258


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15942   259 LNPVIYTLR 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 1-169 1.05e-34

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 122.59  E-value: 1.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15233   101 AICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAF 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15233   181 FMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVIGILNTVLSPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15233   261 LNPLIYSLR 269
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 1-169 1.57e-34

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 122.20  E-value: 1.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15432   101 AICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15432   181 LLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMVALFYGIITPM 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15432   261 LNPLIYTLR 269
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 1-169 2.31e-34

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 121.43  E-value: 2.31e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15946   101 AICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15946   181 IVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKKISLFYNVFTAL 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15946   261 LNPVIYSLR 269
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 1-169 3.89e-34

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 120.90  E-value: 3.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15936   101 AIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSNSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIvLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENdsFHEDMLMSVTYTVLTPL 160
Cdd:cd15936   181 LVTLLIFFILLISYTVI-LVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT--FPMDKAVSVLYTVITPM 257


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15936   258 LNPMIYTLR 266
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 1-169 3.15e-33

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 118.69  E-value: 3.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15228   101 AICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENdsfheDMLMSVTY---TVL 157
Cdd:cd15228   181 LVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS-----PVLVTPVQifnNVV 255

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:cd15228   256 TPMLNPLIYTLR 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 1-169 1.54e-29

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 108.81  E-value: 1.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15938   101 AICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIvltVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKEndSFHEDMLMSVTYTVLTPL 160
Cdd:cd15938   181 LISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFS--TFPVDKHVSVLYNVITPM 255


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15938   256 LNPLIYTLR 264
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 1-169 2.09e-29

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 108.92  E-value: 2.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15223   101 AICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAW 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY--GFSGFVHLRPKENDSFHEDMLMSVTYTVLT 158
Cdd:cd15223   181 LIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFGKTIPPDVHVLLSVLYILIP 260

                         170
                  ....*....|.
gi 1187837365 159 PLLNPIIYSLR 169
Cdd:cd15223   261 PALNPIIYGVR 271
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 1-169 5.91e-27

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 102.12  E-value: 5.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15937   101 AICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMFSNSG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIvLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPkeNDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15937   181 LVILLCFLLLLISYAFL-LAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--FRSFPMDKVVAVFHTVIFPL 257


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15937   258 LNPMIYTLR 266
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 1-169 1.32e-25

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 98.71  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15433   101 AVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKENDSFHEDMLMSVTYTVLTPL 160
Cdd:cd15433   181 VILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFVSLFYTVMTPA 260


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15433   261 LNPLIYTLR 269
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 1-169 5.54e-25

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 96.95  E-value: 5.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15953   101 AICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTINRIYGLVVAL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:cd15953   181 LVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTpalFSFLTH-RFGQGIAPHIHIILANLYLLV 259

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:cd15953   260 PPMLNPIIYGVK 271
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 1-169 5.92e-25

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 96.97  E-value: 5.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15917   101 AICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVAL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY--GFSGFVHLRPKENDSFHEDMLMSVTYTVLT 158
Cdd:cd15917   181 LIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYtpALFSFLTHRFGHHVPPHVHILLANLYLLLP 260

                         170
                  ....*....|.
gi 1187837365 159 PLLNPIIYSLR 169
Cdd:cd15917   261 PMLNPIVYGVR 271
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 1-169 8.55e-25

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 96.37  E-value: 8.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15935   102 AICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLMVANSG 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVfIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYGFSGFVHLRPKEndSFHEDMLMSVTYTVLTPL 160
Cdd:cd15935   182 LLSLVCFLVLLVSYG-IILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS--SSSVDKVASVFYTLITPA 258


                  ....*....
gi 1187837365 161 LNPIIYSLR 169
Cdd:cd15935   259 LNPLIYTLR 267
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 1-169 9.57e-24

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 93.89  E-value: 9.57e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLAC-DYTLfqkMILLGLT 79
Cdd:cd15221   101 AICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACaDITV---NIWYGLT 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  80 -SFVLVGT-FILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTY 154
Cdd:cd15221   178 vALLTVGLdVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTpafFSFLTH-RFGRHIPRHVHILLANLY 256

                         170
                  ....*....|....*
gi 1187837365 155 TVLTPLLNPIIYSLR 169
Cdd:cd15221   257 VLVPPMLNPIVYGVK 271
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 1-169 1.02e-23

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 93.60  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15952   101 AICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRINIIYGLFAIS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVgTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:cd15952   181 VLVL-DVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTpalFSFLTH-RFGHNIPRYIHILLANLYVVL 258

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:cd15952   259 PPMLNPVIYGVR 270
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 1-169 7.27e-23

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 91.41  E-value: 7.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15222   101 AICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY----GFSgFVHlRPKENDSFHEDMLMSVTYTV 156
Cdd:cd15222   181 STMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYvpmiGLS-MVH-RFGKHASPLVHVLMANVYLL 258

                         170
                  ....*....|...
gi 1187837365 157 LTPLLNPIIYSLR 169
Cdd:cd15222   259 VPPVLNPIIYSVK 271
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 1-169 9.08e-23

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 91.32  E-value: 9.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15950   101 AICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSITGST 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY--GFSGFVHLRPKENDSFHEDMLMSVTYTVLT 158
Cdd:cd15950   181 LVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIYTQRFGQGVPPHTQVLLADLYLLVP 260

                         170
                  ....*....|.
gi 1187837365 159 PLLNPIIYSLR 169
Cdd:cd15950   261 PMLNPIIYGMR 271
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 1-169 1.44e-21

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 88.00  E-value: 1.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15956   101 AICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALAL 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY--GFSGFVHLRPKENDSFHEDMLMSVTYTVLT 158
Cdd:cd15956   181 FIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYipGLLSVLMHRFGHSVPSAAHVLLSNLYLLLP 260

                         170
                  ....*....|.
gi 1187837365 159 PLLNPIIYSLR 169
Cdd:cd15956   261 PALNPIVYGIR 271
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 1-169 6.11e-21

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 86.25  E-value: 6.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15951   101 AICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAF 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY--GFSGFVHLRPKENDSFHEDMLMSVTYTVLT 158
Cdd:cd15951   181 LVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYipALFSFLTHRFGHNVPPHVHILIANVYLLVP 260

                         170
                  ....*....|.
gi 1187837365 159 PLLNPIIYSLR 169
Cdd:cd15951   261 PMLNPIIYGVR 271
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 1-169 5.09e-20

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 83.80  E-value: 5.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15948   102 AICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVAL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:cd15948   182 FIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTpvvLSSTMH-RFARHVAPHVHILLANFYLLF 260

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:cd15948   261 PPMMNPIVYGVK 272
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 1-169 2.99e-19

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 81.79  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACdyTLFQKMILLGLTS 80
Cdd:cd15954   101 AICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLAC--ANIRVDAIYGLMV 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTF--ILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHLRPKENDSFHEDMLMSVTYT 155
Cdd:cd15954   179 ALLIGGFdiLCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTpafFTFFAHRFGGHHITPHIHIIMANLYL 258

                         170
                  ....*....|....
gi 1187837365 156 VLTPLLNPIIYSLR 169
Cdd:cd15954   259 LLPPMMNPIVYGVK 272
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 1-169 2.16e-16

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 74.43  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:cd15949   117 AICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGF 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHY---GFSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:cd15949   197 LVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYvpiAVSSLIH-RFGQNVPPPTHILLANFYLLI 275

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:cd15949   276 PPMLNPIVYGVR 287
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 1-169 6.26e-16

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 72.92  E-value: 6.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLTS 80
Cdd:pfam13853  95 AICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTVL 157
Cdd:pfam13853 175 STFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTpmiGLSMVH-RFGHNVPPLLQIMMANAYLFF 253

                         170
                  ....*....|..
gi 1187837365 158 TPLLNPIIYSLR 169
Cdd:pfam13853 254 PPVLNPIVYSVK 265
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 1-169 7.35e-15

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 70.18  E-value: 7.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIV-VSLCIVLIVFNLSFCDSSIIQHFFCDITPVASLACDYTLFQKMILLGLT 79
Cdd:cd15955   101 AICHPLRHSSILTPQVLLGIGVLVVVRAVVlIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYGLFVA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  80 SFVLVGTFILIMISYVFIVLTVVKMPSARGRYKAFSTCSSHLTVVCIHYG---FSGFVHlRPKENDSFHEDMLMSVTYTV 156
Cdd:cd15955   181 FSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTlafFSFFAH-RFGHHVAPYVHILLSNLYLL 259

                         170
                  ....*....|...
gi 1187837365 157 LTPLLNPIIYSLR 169
Cdd:cd15955   260 VPPVLNPIVYGVK 272
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 1-166 9.18e-10

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 55.77  E-value: 9.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365   1 AIHNPLHYPILMTHKICLKLMMASSVTGIVVSLCIVLIVFNLSFCDSSiiqHFFCDITPVASLACDYTlfqkmILLGLTS 80
Cdd:pfam00001  86 AIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVS-----YTLLISV 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  81 FVLVGTFILIMISYVFIVLTVVKMPSARGR-------YKAFSTCSSHLTVVCIHYG-FSGFVHLRPKENDSFHED----- 147
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLpYHIVNLLDSLALDCELSRlldka 237

                         170
                  ....*....|....*....
gi 1187837365 148 MLMSVTYTVLTPLLNPIIY 166
Cdd:pfam00001 238 LSVTLWLAYVNSCLNPIIY 256
XPF_nuclease-like cd19940
nuclease domain of XPF/MUS81 family proteins; The XPF/MUS81 family belongs to 3'-flap ...
 48-130 4.87e-03

nuclease domain of XPF/MUS81 family proteins; The XPF/MUS81 family belongs to 3'-flap endonuclease that act upon 3'-flap structures and involved in DNA repair pathways that are necessary for the removal of UV-light-induced DNA lesions and cross-links between DNA strands. Family members exist either as heterodimers or as homodimers in their functionally competent states which consist of a catalytic and a noncatalytic subunit. The catalytic subunits have a DX(n)RKX(3)D motif. This motif is required for metal-dependent endonuclease activity but not for DNA junction binding. The equivalent regions of the noncatalytic subunits (ERCC1, EME1, and FAAP24) have diverged. The noncatalytic subunits have roles such as binding ssDNA or an ability to target the endonuclease to defined DNA structures or sites of DNA damage.


Pssm-ID: 410849 [Multi-domain]  Cd Length: 126  Bit Score: 35.44  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837365  48 SIIQHFFCDITPVASLACDYTLFQKMILLGLTSFVLV-----GTFILIMIS----YVFIVLTVVKMPSARGRYKAFSTCS 118
Cdd:cd19940    15 SELQRLGVQVEFEDLAVGDYVLSNRTCVERKSLSDLVssinkGRLREQLQRltrkFERRVLLVEKDRSKFRSMVSSVQAL 94

                          90
                  ....*....|..
gi 1187837365 119 SHLTVVCIHYGF 130
Cdd:cd19940    95 SALTKLQLLTGI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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