seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15222    39 LSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIA 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15222   119 KIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNS 172

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15222    39 LSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIA 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15222   119 KIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNS 172

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15222    39 LSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIA 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15222   119 KIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNS 172

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15917    39 LAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVG 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15917   119 KIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNS 172

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15952    39 LAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVIS 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15952   119 VIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRIN 171

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:pfam13853  33 LAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTILTNPVIS 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:pfam13853 113 RIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNN 166

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15223    39 LGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFIL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15223   119 KLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINS 172

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15949    55 LSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVI 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15949   135 RIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINN 188

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15955    39 LAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLK-RLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15955   119 GIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAADDVRVN 172

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd13954    39 LSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCI 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd13954   119 LLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLN 171

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15912    39 LRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITI 132
Cdd:cd15912   119 QLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRL 170

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15230    39 LSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCI 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15230   119 QLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINE 172

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYaTVLTDARVa 80
Cdd:cd15420    39 LSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRY-TVIMNWRV- 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1187837454  81 RMGMSVIIRSFCTVFPMP--VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15420   117 CTTLAATSWACGFLLALVhvVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWIN 171

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTdarvA 80
Cdd:cd15225    39 LRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMN----R 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837454  81 RMGMSVIIRSFCTVFPMP----VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15225   115 RVCLQLVAGSWLSGILVSlgqtTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLN 171

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15914    39 ISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCT 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15914   119 QLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLN 171

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15226    39 LANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCI 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGD 129
Cdd:cd15226   119 LLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTD 167

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDarva 80
Cdd:cd15409    39 LGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSN---- 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837454  81 RMGMSVIIRSFCTVFPMP----VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15409   115 RLCVQLITASYIGGFLHSmihvGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSIN 171

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   4 LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVARMG 83
Cdd:cd15232    42 LSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLA 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1187837454  84 MSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15232   122 TGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNE 172

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15234    39 LSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCG 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN 134
Cdd:cd15234   119 LLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINN 172

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15911    39 LGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITI 132
Cdd:cd15911   119 QLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSL 170

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15413    39 LRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCI 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGD 129
Cdd:cd15413   119 VLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSD 167

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15417    39 LSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15417   119 QLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFIS 171

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454   1 LSLLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVA 80
Cdd:cd15411    39 LSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCL 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837454  81 RMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN 133
Cdd:cd15411   119 KLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVN 171

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837454  15 TLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLAMSFDRYVAICNPLRYATVLTDARVARMGMSVIIRSFCTV 94
Cdd:cd15224    53 TVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLIS 132

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1187837454  95 FPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITI 132
Cdd:cd15224   133 MIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170