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Conserved domains on  [gi|1187837513|gb|ARM55344|]
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olfactory receptor family 2, partial [Vampyrum spectrum]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 1-113 8.63e-58

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15420:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 277  Bit Score: 179.45  E-value: 8.63e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15420    37 FFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15420   117 CTTLAATSWACGFLLALVHVVLLLRLPFCGPNE 149
 
Name Accession Description Interval E-value
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 1-113 8.63e-58

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 179.45  E-value: 8.63e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15420    37 FFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15420   117 CTTLAATSWACGFLLALVHVVLLLRLPFCGPNE 149
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 1-103 1.26e-16

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 72.33  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQ-PISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:pfam00001  21 IFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPR 100

                          90       100
                  ....*....|....*....|....
gi 1187837513  80 VCVTLAVTCWTLGFLLTLVDIVLL 103
Cdd:pfam00001 101 RAKVLILVIWVLALLLSLPPLLFG 124
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
 53-96 8.00e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 34.60  E-value: 8.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLT 96
Cdd:PHA02638  184 FLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIIT 227
 
Name Accession Description Interval E-value
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 1-113 8.63e-58

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 179.45  E-value: 8.63e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15420    37 FFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15420   117 CTTLAATSWACGFLLALVHVVLLLRLPFCGPNE 149
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 1-113 5.65e-49

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 156.85  E-value: 5.65e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15225    37 FFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15225   117 CLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNE 149
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 1-111 9.33e-48

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 153.59  E-value: 9.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15237    37 FFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15237   117 CVRLAATSWASGFLNSLVLTSLTLRLPFCGP 147
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 1-113 1.21e-47

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 153.02  E-value: 1.21e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd13954    37 FFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd13954   117 CILLAAGSWLIGFLNSLIHTVLISQLPFCGSNV 149
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 1-111 1.61e-44

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 145.32  E-value: 1.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15912    37 FFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15912   117 CLQLVLGSWVGGFLLILPPTILVFQLPFCGP 147
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 1-113 3.53e-43

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 141.92  E-value: 3.53e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15421    37 FLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15421   117 CLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSRE 149
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 1-111 1.14e-42

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 140.44  E-value: 1.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15431    37 FFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDiVLLLPLPFCGP 111
Cdd:cd15431   117 CIQLAAGSWVSAFLLTVIP-VLTMPLHFCGP 146
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 1-113 8.02e-41

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 135.81  E-value: 8.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15235    38 FFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKR 117

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15235   118 CLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNE 150
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 1-111 1.24e-40

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 135.33  E-value: 1.24e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15230    37 FFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15230   117 CIQLVAGSYLCGFVNSIVHTSSTFSLSFCGS 147
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 1-111 1.27e-40

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 135.30  E-value: 1.27e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15911    37 FFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15911   117 CLQLAAGSWISGFLASTITVILMSQLTFCGP 147
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 1-113 4.65e-40

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 133.93  E-value: 4.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15231    37 FFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15231   117 CLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQ 149
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 1-111 1.70e-39

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 132.33  E-value: 1.70e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15226    37 FLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRM 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15226   117 CILLVVASWIIGFIHSLSQLAFVVNLPFCGP 147
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-110 6.22e-39

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 130.95  E-value: 6.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15430    37 FFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRL 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15430   117 CVQMAAGSWVTGFLNSLVETVLAMQLPFCG 146
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 1-113 1.13e-38

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 130.05  E-value: 1.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15947    37 FFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15947   117 CVQLAALSWLSGLANSLLQTTLTLQLPLCGHHT 149
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 1-113 1.82e-38

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 130.02  E-value: 1.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15229    37 FFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15229   117 CVQLVGGAWALGFLYALINTLLLLNLHFCGPNE 149
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-111 2.43e-37

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 126.99  E-value: 2.43e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15232    37 FFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15232   117 CVGLATGVWAIGMLNSAVHTGLMLRLSFCGP 147
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 1-113 3.79e-37

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 126.27  E-value: 3.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15915    37 FFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15915   117 CLLLAVACWVTGFFHALMHTVMTSRLPFCGPNK 149
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 1-113 7.79e-37

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 125.90  E-value: 7.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15408    50 FFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRV 129

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15408   130 CVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNV 162
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 1-113 1.00e-36

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 125.14  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15936    37 FLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15936   117 CTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNV 149
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 1-110 1.29e-36

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 125.21  E-value: 1.29e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15429    37 FFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGL 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15429   117 CIQLAAASWTSGFLNSLVQTAFTFRLPFCG 146
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 1-111 2.50e-36

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 124.35  E-value: 2.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15913    37 ILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15913   117 CGKLVAFCWVCGFLWFLIPVVLISQLPFCGP 147
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 1-111 2.71e-36

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 124.43  E-value: 2.71e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15412    37 FFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15412   117 CISLVTFPYIYGFLNGLIQTILTFRLSFCGS 147
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 1-110 2.89e-36

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 123.88  E-value: 2.89e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15918    37 FFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRL 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15918   117 CILLVAASWVITNLHSLLHTLLMARLSFCA 146
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 1-111 4.37e-36

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 123.48  E-value: 4.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15939    37 FFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15939   117 CGLLVGVAWVGGFLHSTIQILLTLQLPFCGP 147
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 1-111 6.64e-36

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 122.95  E-value: 6.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15227    37 FFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGA 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15227   117 CVQMAAASWLSGLLYGALHTANTFSLPFCGS 147
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 1-111 2.35e-35

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 121.77  E-value: 2.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15424    37 FFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWR 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15424   117 QLQLALSCWAIGFLLSVINVGCTLRHPFCGP 147
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 1-113 5.55e-35

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 120.66  E-value: 5.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15946    37 FFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15946   117 CILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNE 149
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 1-111 5.80e-35

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 120.83  E-value: 5.80e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15417    37 FFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15417   117 CVQLVAGAYLGGFLNSLIQTVSMFQLSFCGP 147
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 1-111 1.16e-34

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 120.08  E-value: 1.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15224    37 FFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15224   117 CVQLAAGSWLSGFLISMIKVYFISQLSFCGP 147
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 1-110 1.51e-34

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 119.73  E-value: 1.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15411    37 FFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15411   117 CLKLAAGSYAAGFLNSLIHTTLISRLSFCG 146
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 1-110 4.48e-34

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 118.73  E-value: 4.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15432    37 FFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRL 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15432   117 CQQLAAGAWISGFANSLVQSTLTLKMPRCG 146
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 1-110 4.62e-34

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 118.74  E-value: 4.62e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15428    37 FFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15428   117 CISLATGSWVGGLLVSAVDTAFTLNLSFGG 146
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 1-111 5.86e-34

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 118.53  E-value: 5.86e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15410    50 FFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKL 129

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15410   130 CVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 1-113 3.14e-33

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 116.32  E-value: 3.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15914    37 FFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15914   117 CTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQ 149
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 1-111 6.82e-33

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 115.23  E-value: 6.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15940    37 FFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15940   117 CLWLVAALWLGGTVHSLAQTFLTIRLPYCGP 147
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 1-113 1.37e-32

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 114.78  E-value: 1.37e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15434    37 FFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15434   117 CWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHR 149
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 1-110 3.14e-32

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 114.38  E-value: 3.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15943    51 FFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRV 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15943   131 CIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 1-111 3.37e-32

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 113.66  E-value: 3.37e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15409    37 FFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15409   117 CVQLITASYIGGFLHSMIHVGLTFRLSFCGS 147
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 1-113 8.37e-32

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 112.67  E-value: 8.37e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15234    37 FFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15234   117 CGLLVLLSLLISILDSLLHSLMVLQLSFCTDVE 149
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 1-113 1.55e-31

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 112.07  E-value: 1.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15416    37 FFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15416   117 CVLLVAASYLGGCLNALVFTTCVFSLSFCGPNE 149
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 1-113 8.09e-31

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 109.83  E-value: 8.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15937    37 FFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15937   117 CCVLVGASWAGGFIHSIIQVALIIRLPFCGPNV 149
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 1-111 3.12e-30

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 108.67  E-value: 3.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15228    37 FFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15228   117 CALLAAGTWITSSFHATILTSLTFTLPYCGS 147
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 1-111 5.89e-30

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 107.89  E-value: 5.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15415    37 FFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15415   117 CVQLVAGSYLGGLINSLTHTIGLLKLSFCGP 147
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 1-111 2.67e-29

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 106.30  E-value: 2.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15406    46 YFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRV 125

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15406   126 CSLLVAGVYIMGLIGATVHTSCMLRLSFCGD 156
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 1-113 3.38e-29

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 105.85  E-value: 3.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15419    37 FFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15419   117 CVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNE 149
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 1-111 4.37e-29

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 105.87  E-value: 4.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15413    37 FFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15413   117 CIVLVAIPYLYSFFVALFHTIKTFRLSFCGS 147
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 1-113 1.20e-28

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 104.46  E-value: 1.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15935    38 FFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQL 117

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15935   118 CIKLLAACWAGGFLHSATQAALVLRLPFCGPNE 150
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 1-112 1.50e-28

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 104.10  E-value: 1.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15433    37 YFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRL 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQ 112
Cdd:cd15433   117 CQTLASISWLSGFVNSVAQTGLLAERPLCGHR 148
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 1-113 2.73e-28

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 104.06  E-value: 2.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15945    50 YFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRV 129

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15945   130 CYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNT 162
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 1-111 3.05e-28

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 103.33  E-value: 3.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15233    37 FFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15233   117 QTALVGISCACAFTNALTHTVAMSTLKFCGP 147
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 1-113 3.05e-27

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 100.96  E-value: 3.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15414    37 FFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRV 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15414   117 CVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNV 149
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 1-113 1.14e-26

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 99.18  E-value: 1.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15938    37 FLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRL 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15938   117 CWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQ 149
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 1-110 5.95e-26

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 97.49  E-value: 5.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15407    37 FFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15407   117 CACLTIGCYVCGFLNASIHTGNTFRLSFCK 146
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 1-113 9.09e-26

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 97.13  E-value: 9.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPA-QPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:cd15916    37 IFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGR 116

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1187837513  80 VCVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQK 113
Cdd:cd15916   117 LCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNR 150
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 1-111 5.82e-25

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 94.81  E-value: 5.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15942    37 WFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRA 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15942   117 CLCLSLGTWLGGCLHSTFQTSLTFRLPYGQK 147
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 1-111 9.81e-25

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 94.45  E-value: 9.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15236    37 FFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPEL 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15236   117 CVLLVAGSWVLTCFHALLHTLLLARLSFCAD 147
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 1-110 2.67e-24

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 93.31  E-value: 2.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15944    50 FFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRV 129

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15944   130 CLQLMAGSYLAGLVNLVIHTTATFSLSFCG 159
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 1-110 7.84e-24

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 92.09  E-value: 7.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15405    37 FFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15405   117 CSLLMLGSYVMGFAGAMAHTGCMLRLTFCD 146
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 1-111 1.61e-23

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 91.20  E-value: 1.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15221    37 LFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSV 116

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15221   117 IGKIGVAAVARSFCIVFPFVFLLKRLPYCGH 147
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 1-112 2.36e-23

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 90.52  E-value: 2.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15952    37 YFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKV 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQ 112
Cdd:cd15952   117 ISVIALGIVLRPLLLVLPFVFLILRLPFCGHN 148
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 1-110 3.30e-21

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 85.04  E-value: 3.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15223    37 ILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSF 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15223   117 ILKLVLFALIRSGLLVLPIVVLASQLSYCS 146
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 1-110 2.68e-20

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 82.52  E-value: 2.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15418    38 FFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKL 117

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15418   118 CMGLVAASYLGGFANAIIHTSNTFRLHFCG 147
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 1-111 4.99e-20

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 81.82  E-value: 4.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPA-QPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:cd15941    38 HFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRR 117

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1187837513  80 VCVTLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15941   118 MCAGLAGGTWATGATHAAIHTSLTFRLPYCGP 149
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 1-109 3.61e-19

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 79.61  E-value: 3.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15953    37 LLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSR 116

                          90       100
                  ....*....|....*....|....*....
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFC 109
Cdd:cd15953   117 IAKLGLVGLIRGVLLILPLPLLLSRLPFC 145
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 1-112 7.55e-19

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 78.70  E-value: 7.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15222    37 YFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSR 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCGPQ 112
Cdd:cd15222   117 IAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSN 148
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 1-110 1.10e-17

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 75.40  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15917    37 LFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15917   117 VGKIGLAILLRAVALIIPLPLLVRRLPYCG 146
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 3-111 1.21e-16

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 72.83  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   3 LSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVCV 82
Cdd:cd15950    39 LCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIA 118

                          90       100
                  ....*....|....*....|....*....
gi 1187837513  83 TLAVTCWTLGFLLTLVDIVLLLPLPFCGP 111
Cdd:cd15950   119 QIGLAIVLRALLFMTPLTCLVTSLPYCGS 147
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 1-103 1.26e-16

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 72.33  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQ-PISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:pfam00001  21 IFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPR 100

                          90       100
                  ....*....|....*....|....
gi 1187837513  80 VCVTLAVTCWTLGFLLTLVDIVLL 103
Cdd:pfam00001 101 RAKVLILVIWVLALLLSLPPLLFG 124
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 1-109 4.17e-15

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 68.53  E-value: 4.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15951    37 LFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSV 116

                          90       100
                  ....*....|....*....|....*....
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFC 109
Cdd:cd15951   117 VAKIGLAVVLRGGILVSPHPFLLRRLPYC 145
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 1-110 4.27e-14

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 66.08  E-value: 4.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15948    38 YFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSV 117

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15948   118 ITKIGLAALARAVTLMTPLPFLLRRLPYCR 147
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 1-110 1.36e-13

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 64.44  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:pfam13853  31 LFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTILTNPV 110

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:pfam13853 111 ISRIGLGVSVRSFILVLPLPFLLRRLPFCG 140
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 1-101 1.73e-13

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 64.23  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd00637    35 YFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRR 114

                          90       100
                  ....*....|....*....|.
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIV 101
Cdd:cd00637   115 AKLLIALIWLLSLLLALPPLL 135
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 1-110 3.98e-12

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 60.61  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15954    37 YFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPV 116

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVLLLPLPFCG 110
Cdd:cd15954   117 ITKAGLATFLRGVMLIIPFPLLTKRLPYCR 146
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 1-94 4.97e-12

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 60.56  E-value: 4.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15949    53 FFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTT 132

                          90
                  ....*....|....
gi 1187837513  81 CVTLAVTCWTLGFL 94
Cdd:cd15949   133 VIRIGLAAVIRGVL 146
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 2-107 2.40e-11

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 58.24  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVC 81
Cdd:cd15955    38 FLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVL 117

                          90       100
                  ....*....|....*....|....*.
gi 1187837513  82 VTLAVtcwtlgfLLTLVDIVLLLPLP 107
Cdd:cd15955   118 LGIGV-------LVVVRAVVLIIPCP 136
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 2-107 1.16e-10

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 56.41  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSwRVC 81
Cdd:cd15956    38 FLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYATILT-LEV 116

                          90       100
                  ....*....|....*....|....*.
gi 1187837513  82 VTLAvtcwtlGFLLTLVDIVLLLPLP 107
Cdd:cd15956   117 VAKA------GLLLALRGVAIVIPFP 136
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 1-97 5.61e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 49.13  E-value: 5.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd14969    37 LFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRA 116

                          90
                  ....*....|....*..
gi 1187837513  81 CVTLAVtCWTLGFLLTL 97
Cdd:cd14969   117 LILIAF-IWLYGLFWAL 132
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 1-102 2.94e-07

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 46.79  E-value: 2.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd14967    36 YFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKR 115

                          90       100
                  ....*....|....*....|..
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd14967   116 ALIMIAAVWVYSLLISLPPLVG 137
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 6-98 3.50e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 46.86  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   6 LATVDIAYACNTVPqmLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLA 85
Cdd:cd14968    42 LAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAI 119

                          90
                  ....*....|...
gi 1187837513  86 VTCWTLGFLLTLV 98
Cdd:cd14968   120 AVCWVLSFLVGLT 132
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 55-107 6.87e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 42.93  E-value: 6.87e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837513  55 LVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTLVDIVLLLPLP 107
Cdd:cd15055    91 LVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQP 143
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 1-98 6.63e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 40.35  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVmSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd14972    35 ILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLAI-AVDRYISIVHGLTYVNNVTNKR 113

                          90
                  ....*....|....*...
gi 1187837513  81 CVTLAVTCWTLGFLLTLV 98
Cdd:cd14972   114 VKVLIALVWVWSVLLALL 131
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 1-97 7.08e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 40.31  E-value: 7.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVnlLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15068    37 YFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 114

                          90
                  ....*....|....*..
gi 1187837513  81 CVTLAVTCWTLGFLLTL 97
Cdd:cd15068   115 AKGIIAICWVLSFAIGL 131
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 53-102 8.41e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 40.11  E-value: 8.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd15057    89 LNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQL 138
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 55-104 2.09e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 38.76  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837513  55 LVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTLVDIVLLL 104
Cdd:cd15314    91 LCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLEL 140
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 1-102 2.28e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSnLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15065    37 FIVS-LAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRR 115

                          90       100
                  ....*....|....*....|..
gi 1187837513  81 CVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd15065   116 ALVVIASVWILSALISFLPIHL 137
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 1-98 3.16e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 38.22  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPqmLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15070    37 YFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRR 114

                          90
                  ....*....|....*...
gi 1187837513  81 CVTLAVTCWTLGFLLTLV 98
Cdd:cd15070   115 IWLALGLCWLVSFLVGLT 132
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 1-97 3.95e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 37.99  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVnlLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15069    37 YFLVSLAAADVAVGLFAIPFAIT--ISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKR 114

                          90
                  ....*....|....*..
gi 1187837513  81 CVTLAVTCWTLGFLLTL 97
Cdd:cd15069   115 ARGVIAVLWVLAFGIGL 131
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 1-95 4.53e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 37.72  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15312    37 FLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPV 116

                          90
                  ....*....|....*
gi 1187837513  81 CVTLAVTCWTLGFLL 95
Cdd:cd15312   117 IKVFLVISWSVPCLF 131
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
 1-97 4.62e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 38.03  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15095    37 YYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRV 116

                          90
                  ....*....|....*..
gi 1187837513  81 CVTLAVTCWTLGFLLTL 97
Cdd:cd15095   117 AVVVSACIWIVSFLLSI 133
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 1-113 5.14e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 37.74  E-value: 5.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15104    37 CFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKS 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1187837513  81 CVTLAVTCWTLGFLltlvdiVLLLPLPFCGPQK 113
Cdd:cd15104   117 AGALIAGLWLYSGL------IGFLPLISPQFQQ 143
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 1-98 5.62e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 37.70  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPaQPISF--AGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSW 78
Cdd:cd15134    37 YYLFSLAVSDLLLLILGLPFELYTIWQQ-YPWVFgeVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKL 115

                          90       100
                  ....*....|....*....|
gi 1187837513  79 RVCVTLAVTCWTLGFLLTLV 98
Cdd:cd15134   116 SRAIRIIIAIWIIAFVCALP 135
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 53-102 7.00e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 37.24  E-value: 7.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd15319    89 LNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQL 138
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 55-102 7.02e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 37.40  E-value: 7.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1187837513  55 LVVMSYDRYVAICLPLRYSTimSWRVCVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd15197    91 LVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSIPMLII 136
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
 5-82 9.99e-04

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 36.78  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   5 NLATVDIAYACnTVPQMLVNLLSPAQ-PISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPL-----RYSTIMSW 78
Cdd:cd15379    41 NLATADLLYVC-SLPLLIYNYTQKDYwPFGDFTCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPLaswhkKKGKKLTW 119


                  ....
gi 1187837513  79 RVCV 82
Cdd:cd15379   120 LVCG 123
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
 5-97 1.40e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 36.68  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   5 NLATVDIAYACnTVPQMLVNLLSPAQ-PISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVCVT 83
Cdd:cd15968    41 NLALADLLYAL-SLPLLIYNYAMRDRwLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWL 119

                          90
                  ....*....|....
gi 1187837513  84 LAVTCWTLGFLLTL 97
Cdd:cd15968   120 TCVLVWILVFAQTL 133
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 1-89 1.41e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 36.65  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15012    36 FFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAAR 115


                  ....*....
gi 1187837513  81 CVTLAVTCW 89
Cdd:cd15012   116 LRVTIVTVW 124
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 53-102 1.62e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 36.52  E-value: 1.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTLVDIVL 102
Cdd:cd15320    90 LNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQL 139
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 1-97 1.69e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 36.18  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSP-AQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:cd14979    37 YYLFSLAVSDLLILLVGLPVELYNFWWQyPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKR 116

                          90
                  ....*....|....*...
gi 1187837513  80 VCVTLAVTCWTLGFLLTL 97
Cdd:cd14979   117 RVKRFILAIWLVSILCAI 134
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 5-97 1.95e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 36.12  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   5 NLATVDIAYACnTVPQMLVNLLSPAQPISFAGC-VTQTFLYLTfGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVCVT 83
Cdd:cd14970    41 NLAVADELFLL-GLPFLATSYLLGYWPFGEVMCkIVLSVDAYN-MFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKL 118

                          90
                  ....*....|....
gi 1187837513  84 LAVTCWTLGFLLTL 97
Cdd:cd14970   119 VSLCVWALSLVLGL 132
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 2-101 2.68e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 35.87  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTiMSWRVC 81
Cdd:cd15073    38 LIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRK-MTTNTY 116

                          90       100
                  ....*....|....*....|
gi 1187837513  82 VTLAVTCWTLGFLLTLVDIV 101
Cdd:cd15073   117 TVMILLAWTNAFFWAAMPLV 136
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 53-102 3.68e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 35.39  E-value: 3.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMS-WRVCVTLAVTcWTLGFLLTLVDIVL 102
Cdd:cd15051    89 LNLFAISLDRYLAITAPLRYPSRVTpRRVAIALAAI-WVVSLAVSFLPIHL 138
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 1-95 3.86e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 35.33  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15001    36 VFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGR 115

                          90
                  ....*....|....*
gi 1187837513  81 CVTLAVTCWTLGFLL 95
Cdd:cd15001   116 ARKVALLIWILSAIL 130
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
 5-97 4.00e-03

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 34.99  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   5 NLATVDIAYACnTVPQMLVNLLSPAQ-PISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVCVT 83
Cdd:cd15168    41 NLAVSDLLYLL-SLPFLIYYYANGDHwIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVA 119

                          90
                  ....*....|....
gi 1187837513  84 LAVTCWTLGFLLTL 97
Cdd:cd15168   120 ISVAVWILVLLQLL 133
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
 50-97 5.23e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 34.76  E-value: 5.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1187837513  50 TECLLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLTL 97
Cdd:cd15094    85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVML 132
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
 2-97 5.73e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 34.69  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVC 81
Cdd:cd15002    39 LILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRIT 118

                          90
                  ....*....|....*.
gi 1187837513  82 VTLAVtCWTLGFLLTL 97
Cdd:cd15002   119 AVVAS-IWVPACLLPL 133
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 1-97 6.02e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 34.53  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAG-----CVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTI 75
Cdd:cd14978    36 VYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTW 115

                          90       100
                  ....*....|....*....|..
gi 1187837513  76 MSWRVCVTLAVTCWTLGFLLTL 97
Cdd:cd14978   116 CTPRRARRVILIIIIFSLLLNL 137
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 55-109 6.03e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 34.50  E-value: 6.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1187837513  55 LVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWtlgflltLVDIVLLLPLPFC 109
Cdd:cd14993    91 LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW-------VIAIIIMLPLLVV 138
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 1-98 6.16e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 34.71  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd14964    35 LLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGK 114

                          90
                  ....*....|....*...
gi 1187837513  81 CVTLAVTCWTLGFLLTLV 98
Cdd:cd14964   115 TRVIILGCWGVSLLLSIP 132
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 1-91 6.34e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 34.58  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGC-VTQTFLYLTfGHTECLLLVVMSYDRYVAICLPLRYSTIMSWR 79
Cdd:cd15096    37 ILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCkIVQYLVYVT-AYASVYTLVLMSLDRYLAVVHPITSMSIRTER 115

                          90
                  ....*....|..
gi 1187837513  80 VCVTLAVTCWTL 91
Cdd:cd15096   116 NTLIAIVGIWIV 127
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
 1-98 6.34e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 34.82  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   1 FLLSNLATVDIAYACNTVPqmLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15071    37 CFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRR 114

                          90
                  ....*....|....*...
gi 1187837513  81 CVTLAVTCWTLGFLLTLV 98
Cdd:cd15071   115 AAVAIAGCWILSFLVGLT 132
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 2-97 6.46e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 34.60  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAY-ACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRV 80
Cdd:cd15337    38 FIINLAISDFGFsAVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKR 117

                          90
                  ....*....|....*..
gi 1187837513  81 CVTLAVTCWTLGFLLTL 97
Cdd:cd15337   118 AFIMIIIIWLWSLLWSI 134
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 2-97 6.46e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 34.62  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837513   2 LLSNLATVDIAYACNTVPQMLVNLLSPAQPISFAGCVTQTFLYLTFGHTECLLLVVMSYDRYVAICLPLRYSTIMSWRVC 81
Cdd:cd15083    38 LIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRA 117

                          90
                  ....*....|....*.
gi 1187837513  82 VTLAVTCWTLGFLLTL 97
Cdd:cd15083   118 LIVIAVVWLYSLLWVL 133
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
 53-96 8.00e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 34.60  E-value: 8.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1187837513  53 LLLVVMSYDRYVAICLPLRYSTIMSWRVCVTLAVTCWTLGFLLT 96
Cdd:PHA02638  184 FLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIIT 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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