RNA polymerase beta'' subunit, partial (chloroplast) [Chenopodium giganteum]
Protein Classification
RNA polymerase beta'' subunit family protein( domain architecture ID 1001353)
RNA polymerase beta'' subunit (rpoC2) family protein is part of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| rpoC2 super family | cl33332 | RNA polymerase beta'' subunit; Reviewed |
1-277 | 0e+00 | |||||
RNA polymerase beta'' subunit; Reviewed The actual alignment was detected with superfamily member CHL00117: Pssm-ID: 214368 [Multi-domain] Cd Length: 1364 Bit Score: 707.09 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||
| rpoC2 | CHL00117 | RNA polymerase beta'' subunit; Reviewed |
1-277 | 0e+00 | |||||
RNA polymerase beta'' subunit; Reviewed Pssm-ID: 214368 [Multi-domain] Cd Length: 1364 Bit Score: 707.09 E-value: 0e+00
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| rpoC2_cyan | TIGR02388 | DNA-directed RNA polymerase, beta'' subunit; The family consists of the product of the rpoC2 ... |
2-277 | 1.15e-116 | |||||
DNA-directed RNA polymerase, beta'' subunit; The family consists of the product of the rpoC2 gene, a subunit of DNA-directed RNA polymerase of cyanobacteria and chloroplasts. RpoC2 corresponds largely to the C-terminal region of the RpoC (the beta' subunit) of other bacteria. Members of this family are designated beta'' in chloroplasts/plastids, and beta' (confusingly) in Cyanobacteria, where RpoC1 is called beta' in chloroplasts/plastids and gamma in Cyanobacteria. We prefer to name this family beta'', after its organellar members, to emphasize that this RpoC1 and RpoC2 together replace RpoC in other bacteria. [Transcription, DNA-dependent RNA polymerase] Pssm-ID: 274104 [Multi-domain] Cd Length: 1227 Bit Score: 362.25 E-value: 1.15e-116
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| RpoC | COG0086 | DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ... |
1-262 | 5.04e-76 | |||||
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase Pssm-ID: 439856 [Multi-domain] Cd Length: 1165 Bit Score: 250.85 E-value: 5.04e-76
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| RNAP_beta'_N | cd01609 | Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; ... |
1-117 | 2.07e-64 | |||||
Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Beta' is the largest subunit of bacterial DNA-dependent RNA polymerase (RNAP). This family also includes the eukaryotic plastid-encoded RNAP beta' subunit. Bacterial RNAP is a large multi-subunit complex responsible for the synthesis of all RNAs in the cell. Structure studies suggest that RNA polymerase complexes from different organisms share a crab-claw-shaped structure with two "pincers" defining a central cleft. Beta' and beta, the largest and the second largest subunits of bacterial RNAP, each makes up one pincer and part of the base of the cleft. Beta' contains part of the active site and binds two zinc ions that have a structural role in the formation of the active polymerase. Pssm-ID: 259845 [Multi-domain] Cd Length: 659 Bit Score: 213.15 E-value: 2.07e-64
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| RNA_pol_Rpb1_5 | pfam04998 | RNA polymerase Rpb1, domain 5; RNA polymerases catalyze the DNA dependent polymerization of ... |
70-241 | 4.25e-45 | |||||
RNA polymerase Rpb1, domain 5; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound. Pssm-ID: 398596 [Multi-domain] Cd Length: 516 Bit Score: 159.06 E-value: 4.25e-45
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| Name | Accession | Description | Interval | E-value | |||||
| rpoC2 | CHL00117 | RNA polymerase beta'' subunit; Reviewed |
1-277 | 0e+00 | |||||
RNA polymerase beta'' subunit; Reviewed Pssm-ID: 214368 [Multi-domain] Cd Length: 1364 Bit Score: 707.09 E-value: 0e+00
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| rpoC2 | PRK02597 | DNA-directed RNA polymerase subunit beta'; Provisional |
2-277 | 8.17e-128 | |||||
DNA-directed RNA polymerase subunit beta'; Provisional Pssm-ID: 235052 [Multi-domain] Cd Length: 1331 Bit Score: 393.59 E-value: 8.17e-128
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| rpoC2_cyan | TIGR02388 | DNA-directed RNA polymerase, beta'' subunit; The family consists of the product of the rpoC2 ... |
2-277 | 1.15e-116 | |||||
DNA-directed RNA polymerase, beta'' subunit; The family consists of the product of the rpoC2 gene, a subunit of DNA-directed RNA polymerase of cyanobacteria and chloroplasts. RpoC2 corresponds largely to the C-terminal region of the RpoC (the beta' subunit) of other bacteria. Members of this family are designated beta'' in chloroplasts/plastids, and beta' (confusingly) in Cyanobacteria, where RpoC1 is called beta' in chloroplasts/plastids and gamma in Cyanobacteria. We prefer to name this family beta'', after its organellar members, to emphasize that this RpoC1 and RpoC2 together replace RpoC in other bacteria. [Transcription, DNA-dependent RNA polymerase] Pssm-ID: 274104 [Multi-domain] Cd Length: 1227 Bit Score: 362.25 E-value: 1.15e-116
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| PRK00566 | PRK00566 | DNA-directed RNA polymerase subunit beta'; Provisional |
1-241 | 1.95e-102 | |||||
DNA-directed RNA polymerase subunit beta'; Provisional Pssm-ID: 234794 [Multi-domain] Cd Length: 1156 Bit Score: 322.79 E-value: 1.95e-102
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| rpoC_TIGR | TIGR02386 | DNA-directed RNA polymerase, beta' subunit, predominant form; Bacteria have a single ... |
1-241 | 8.07e-91 | |||||
DNA-directed RNA polymerase, beta' subunit, predominant form; Bacteria have a single DNA-directed RNA polymerase, with required subunits that include alpha, beta, and beta-prime. This model describes the predominant architecture of the beta-prime subunit in most bacteria. This model excludes from among the bacterial mostly sequences from the cyanobacteria, where RpoC is replaced by two tandem genes homologous to it but also encoding an additional domain. [Transcription, DNA-dependent RNA polymerase] Pssm-ID: 274103 [Multi-domain] Cd Length: 1140 Bit Score: 291.18 E-value: 8.07e-91
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| RpoC | COG0086 | DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ... |
1-262 | 5.04e-76 | |||||
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase Pssm-ID: 439856 [Multi-domain] Cd Length: 1165 Bit Score: 250.85 E-value: 5.04e-76
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| PRK14906 | PRK14906 | DNA-directed RNA polymerase subunit beta'; |
1-241 | 2.12e-74 | |||||
DNA-directed RNA polymerase subunit beta'; Pssm-ID: 184899 [Multi-domain] Cd Length: 1460 Bit Score: 247.09 E-value: 2.12e-74
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| PRK14844 | PRK14844 | DNA-directed RNA polymerase subunit beta/beta'; |
2-261 | 1.03e-64 | |||||
DNA-directed RNA polymerase subunit beta/beta'; Pssm-ID: 173305 [Multi-domain] Cd Length: 2836 Bit Score: 219.11 E-value: 1.03e-64
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| RNAP_beta'_N | cd01609 | Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; ... |
1-117 | 2.07e-64 | |||||
Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Beta' is the largest subunit of bacterial DNA-dependent RNA polymerase (RNAP). This family also includes the eukaryotic plastid-encoded RNAP beta' subunit. Bacterial RNAP is a large multi-subunit complex responsible for the synthesis of all RNAs in the cell. Structure studies suggest that RNA polymerase complexes from different organisms share a crab-claw-shaped structure with two "pincers" defining a central cleft. Beta' and beta, the largest and the second largest subunits of bacterial RNAP, each makes up one pincer and part of the base of the cleft. Beta' contains part of the active site and binds two zinc ions that have a structural role in the formation of the active polymerase. Pssm-ID: 259845 [Multi-domain] Cd Length: 659 Bit Score: 213.15 E-value: 2.07e-64
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| PRK09603 | PRK09603 | DNA-directed RNA polymerase subunit beta/beta'; |
1-260 | 1.38e-60 | |||||
DNA-directed RNA polymerase subunit beta/beta'; Pssm-ID: 181983 [Multi-domain] Cd Length: 2890 Bit Score: 207.47 E-value: 1.38e-60
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| RNA_pol_Rpb1_5 | pfam04998 | RNA polymerase Rpb1, domain 5; RNA polymerases catalyze the DNA dependent polymerization of ... |
70-241 | 4.25e-45 | |||||
RNA polymerase Rpb1, domain 5; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound. Pssm-ID: 398596 [Multi-domain] Cd Length: 516 Bit Score: 159.06 E-value: 4.25e-45
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| RNAP_largest_subunit_N | cd00399 | Largest subunit of RNA polymerase (RNAP), N-terminal domain; This region represents the ... |
1-114 | 5.03e-26 | |||||
Largest subunit of RNA polymerase (RNAP), N-terminal domain; This region represents the N-terminal domain of the largest subunit of RNA polymerase (RNAP). RNAP is a large multi-protein complex responsible for the synthesis of RNA. It is the principle enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei; RNAP I transcribes the ribosomal RNA precursor, RNAP II the mRNA precursor, and RNAP III the 5S and tRNA genes. A single distinct RNAP complex is found in prokaryotes and archaea, respectively, which may be responsible for the synthesis of all RNAs. Structure studies reveal that prokaryotic and eukaryotic RNAPs share a conserved crab-claw-shaped structure. The largest and the second largest subunits each make up one clamp, one jaw, and part of the cleft. All RNAPs are metalloenzymes. At least one Mg2+ ion is bound in the catalytic center. In addition, all cellular RNAPs contain several tightly bound zinc ions to different subunits that vary between RNAPs from prokaryotic to eukaryotic lineages. This domain represents the N-terminal region of the largest subunit of RNAP, and includes part of the active site. In archaea and some of the photosynthetic organisms or cellular organelle, however, this domain exists as a separate subunit. Pssm-ID: 259843 [Multi-domain] Cd Length: 528 Bit Score: 106.75 E-value: 5.03e-26
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| RNAP_beta'_C | cd02655 | Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; ... |
208-243 | 4.22e-21 | |||||
Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Bacterial RNA polymerase (RNAP) is a large multi-subunit complex responsible for the synthesis of all RNAs in the cell. This family also includes the eukaryotic plastid-encoded RNAP beta" subunit. Structure studies suggest that RNAP complexes from different organisms share a crab-claw-shape structure with two pincers defining a central cleft. Beta' and beta, the largest and the second largest subunits of bacterial RNAP, each makes up one pincer and part of the base of the cleft. The C-terminal domain includes a G loop that forms part of the floor of the downstream DNA-binding cavity. The position of the G loop may determine the switch of the bridge helix between flipped-out and normal alpha-helical conformations. Pssm-ID: 132721 [Multi-domain] Cd Length: 204 Bit Score: 88.35 E-value: 4.22e-21
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| PRK14977 | PRK14977 | bifunctional DNA-directed RNA polymerase A'/A'' subunit; Provisional |
21-241 | 1.00e-19 | |||||
bifunctional DNA-directed RNA polymerase A'/A'' subunit; Provisional Pssm-ID: 184940 [Multi-domain] Cd Length: 1321 Bit Score: 88.93 E-value: 1.00e-19
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| RNAP_archeal_A' | cd02582 | A' subunit of archaeal RNA polymerase (RNAP); A' is the largest subunit of the archaeal RNA ... |
21-117 | 4.25e-17 | |||||
A' subunit of archaeal RNA polymerase (RNAP); A' is the largest subunit of the archaeal RNA polymerase (RNAP). Archaeal RNAP is closely related to RNA polymerases in eukaryotes based on the subunit compositions. Archaeal RNAP is a large multi-protein complex, made up of 11 to 13 subunits, depending on the species, that are responsible for the synthesis of RNA. Structure studies suggest that RNAP complexes from different organisms share a crab-claw-shaped structure. The largest eukaryotic RNAP subunit is encoded by two separate archaeal subunits (A' and A'') which correspond to the N- and C-terminal domains of eukaryotic RNAP II Rpb1, respectively. The N-terminal domain of Rpb1 forms part of the active site and includes the head and the core of one clamp as well as the pore and funnel structures of RNAP II. Based on a structural comparison among the archaeal, bacterial and eukaryotic RNAPs the DNA binding channel and the active site are part of A' subunit which is conserved. The strong similarity between subunit A' and the N-terminal domain of Rpb1 suggests a similar functional and structural role for these two proteins. Pssm-ID: 259846 [Multi-domain] Cd Length: 861 Bit Score: 81.14 E-value: 4.25e-17
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| PRK08566 | PRK08566 | DNA-directed RNA polymerase subunit A'; Validated |
21-113 | 6.89e-15 | |||||
DNA-directed RNA polymerase subunit A'; Validated Pssm-ID: 236292 [Multi-domain] Cd Length: 882 Bit Score: 74.51 E-value: 6.89e-15
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| PRK04309 | PRK04309 | DNA-directed RNA polymerase subunit A''; Validated |
209-241 | 1.89e-12 | |||||
DNA-directed RNA polymerase subunit A''; Validated Pssm-ID: 235277 [Multi-domain] Cd Length: 383 Bit Score: 66.41 E-value: 1.89e-12
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| RNAP_A'' | cd06528 | A'' subunit of Archaeal RNA Polymerase (RNAP); Archaeal RNA polymerase (RNAP), like bacterial ... |
209-241 | 5.16e-12 | |||||
A'' subunit of Archaeal RNA Polymerase (RNAP); Archaeal RNA polymerase (RNAP), like bacterial RNAP, is a large multi-subunit complex responsible for the synthesis of all RNAs in the cell. The relative positioning of the RNAP core is highly conserved between archaeal RNAP and the three classes of eukaryotic RNAPs. In archaea, the largest subunit is split into two polypeptides, A' and A'', which are encoded by separate genes in an operon. Sequence alignments reveal that the archaeal A'' subunit corresponds to the C-terminal one-third of the RNAPII largest subunit (Rpb1). In subunit A'', several loops in the jaw domain are shorter. The RNAPII Rpb1 interacts with the second-largest subunit (Rpb2) to form the DNA entry and RNA exit channels in addition to the catalytic center of RNA synthesis. Pssm-ID: 132725 [Multi-domain] Cd Length: 363 Bit Score: 65.35 E-value: 5.16e-12
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| RNA_pol_rpoA2 | TIGR02389 | DNA-directed RNA polymerase, subunit A''; This family consists of the archaeal A'' subunit of ... |
200-241 | 1.33e-11 | |||||
DNA-directed RNA polymerase, subunit A''; This family consists of the archaeal A'' subunit of the DNA-directed RNA polymerase. The example from Methanocaldococcus jannaschii contains an intein. [Transcription, DNA-dependent RNA polymerase] Pssm-ID: 274105 [Multi-domain] Cd Length: 367 Bit Score: 63.92 E-value: 1.33e-11
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| RNA_pol_Rpb1_4 | pfam05000 | RNA polymerase Rpb1, domain 4; RNA polymerases catalyze the DNA dependent polymerization of ... |
1-54 | 1.56e-11 | |||||
RNA polymerase Rpb1, domain 4; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 4, represents the funnel domain. The funnel contain the binding site for some elongation factors. Pssm-ID: 398598 Cd Length: 108 Bit Score: 59.69 E-value: 1.56e-11
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| PRK14897 | PRK14897 | unknown domain/DNA-directed RNA polymerase subunit A'' fusion protein; Provisional |
209-241 | 7.30e-11 | |||||
unknown domain/DNA-directed RNA polymerase subunit A'' fusion protein; Provisional Pssm-ID: 237853 [Multi-domain] Cd Length: 509 Bit Score: 62.13 E-value: 7.30e-11
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| RNAP_I_Rpa1_C | cd02735 | Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain; RNA ... |
209-240 | 1.34e-10 | |||||
Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain; RNA polymerase I (RNAP I) is a multi-subunit protein complex responsible for the synthesis of rRNA precursor. It consists of at least 14 different subunits, and the largest one is homologous to subunit Rpb1 of yeast RNAP II and subunit beta' of bacterial RNAP. Rpa1 is also known as Rpa190 in yeast. Structure studies suggest that different RNAP complexes share a similar crab-claw-shape structure. The C-terminal domain of Rpb1, the largest subunit of RNAP II, makes up part of the foot and jaw structures of RNAP II. The similarity between this domain and the C-terminal domain of Rpb1, its counterpart in RNAP II, suggests a similar functional and structural role. Pssm-ID: 132722 [Multi-domain] Cd Length: 309 Bit Score: 60.67 E-value: 1.34e-10
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| RNAP_III_Rpc1_C | cd02736 | Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain; ... |
209-241 | 1.84e-10 | |||||
Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain; Eukaryotic RNA polymerase III (RNAP III) is a large multi-subunit complex responsible for the synthesis of tRNAs, 5SrRNA, Alu-RNA, U6 snRNA, among others. Rpc1 is also known as C160 in yeast. Structure studies suggest that different RNA polymerase complexes share a similar crab-claw-shape structure. The C-terminal domain of Rpb1, the largest subunit of RNAP II, makes up part of the foot and jaw structures of RNAP II. The similarity between this domain and the C-terminal domain of Rpb1, its counterpart in RNAP II, suggests a similar functional and structural role. Pssm-ID: 132723 [Multi-domain] Cd Length: 300 Bit Score: 60.31 E-value: 1.84e-10
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| RNAP_largest_subunit_C | cd00630 | Largest subunit of RNA polymerase (RNAP), C-terminal domain; RNA polymerase (RNAP) is a large ... |
213-241 | 8.99e-10 | |||||
Largest subunit of RNA polymerase (RNAP), C-terminal domain; RNA polymerase (RNAP) is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is the final target in many regulatory pathways that control gene expression in all living cells. At least three distinct RNAP complexes are found in eukaryotic nuclei, RNAP I, RNAP II, and RNAP III, for the synthesis of ribosomal RNA precursor, mRNA precursor, and 5S and tRNA, respectively. A single distinct RNAP complex is found in prokaryotes and archaea, which may be responsible for the synthesis of all RNAs. Structure studies revealed that prokaryotic and eukaryotic RNAPs share a conserved crab-claw-shape structure. The largest and the second largest subunits each make up one clamp, one jaw, and part of the cleft. The largest RNAP subunit (Rpb1) interacts with the second-largest RNAP subunit (Rpb2) to form the DNA entry and RNA exit channels in addition to the catalytic center of RNA synthesis. The region covered by this domain makes up part of the foot and jaw structures. In archaea, some photosynthetic organisms, and some organelles, this domain exists as a separate subunit, while it forms the C-terminal region of the RNAP largest subunit in eukaryotes and bacteria. Pssm-ID: 132719 [Multi-domain] Cd Length: 158 Bit Score: 56.27 E-value: 8.99e-10
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| RNAP_II_Rpb1_C | cd02584 | Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain; RNA ... |
194-241 | 3.26e-08 | |||||
Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain; RNA polymerase II (RNAP II) is a large multi-subunit complex responsible for the synthesis of mRNA. RNAP II consists of a 10-subunit core enzyme and a peripheral heterodimer of two subunits. The largest core subunit (Rpb1) of yeast RNAP II is the best characterized member of this family. Structure studies suggest that RNAP complexes from different organisms share a crab-claw-shape structure. In yeast, Rpb1 and Rpb2, the largest and the second largest subunits, each makes up one clamp, one jaw, and part of the cleft. Rpb1 interacts with Rpb2 to form the DNA entry and RNA exit channels in addition to the catalytic center of RNA synthesis. The C-terminal domain of Rpb1 makes up part of the foot and jaw structures. Pssm-ID: 132720 [Multi-domain] Cd Length: 410 Bit Score: 53.75 E-value: 3.26e-08
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| RNAP_II_RPB1_N | cd02733 | Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain; The two ... |
21-114 | 3.27e-07 | |||||
Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain; The two largest subunits of RNA polymerase II (RNAP II), Rpb1 and Rpb2, form the active site, DNA entry channel and RNA exit channel. RNAP II is a large multi-subunit complex responsible for the synthesis of mRNA in eukaryotes. RNAP II consists of a 10-subunit core enzyme and a peripheral heterodimer of two subunits. Structure studies suggest that RNAP complexes from different organisms share a crab-claw-shape structure. In yeast, Rpb1 and Rpb2, each makes up one clamp, one jaw, and part of the cleft. Rpb1_N contains part of the active site, forms the head and core of the one clamp, and makes up the pore and funnel regions of RNAP II. Pssm-ID: 259848 [Multi-domain] Cd Length: 751 Bit Score: 51.00 E-value: 3.27e-07
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| RNAP_III_RPC1_N | cd02583 | Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain; Rpc1 ... |
21-105 | 3.83e-07 | |||||
Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain; Rpc1 (C160) subunit forms part of the active site region of RNAP III. RNAP III is one of the three distinct classes of nuclear RNAP in eukaryotes that is responsible for the synthesis of tRNAs, 5SrRNA, Alu-RNA, U6 snRNA genes, and some others. RNAP III is the largest nuclear RNA polymerase with 17 subunits. Structure studies suggest that different RNA polymerase complexes share a similar crab-claw-shaped structure. The N-terminal domain of Rpb1, the largest subunit of RNAP II in yeast, forms part of the active site, making up the head and core of the one clamp, as well as the pore and funnel structures of RNAP II. The strong homology between Rpc1 and Rpb1 suggests a similar functional and structural role. Pssm-ID: 259847 [Multi-domain] Cd Length: 816 Bit Score: 51.01 E-value: 3.83e-07
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| PRK14898 | PRK14898 | DNA-directed RNA polymerase subunit A''; Provisional |
209-233 | 7.80e-04 | |||||
DNA-directed RNA polymerase subunit A''; Provisional Pssm-ID: 237854 [Multi-domain] Cd Length: 858 Bit Score: 40.65 E-value: 7.80e-04
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| RNAP_I_RPA1_N | cd01435 | Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain; RPA1 is the ... |
70-105 | 9.01e-03 | |||||
Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain; RPA1 is the largest subunit of the eukaryotic RNA polymerase I (RNAP I). RNAP I is a multi-subunit protein complex responsible for the synthesis of rRNA precursors. RNAP I consists of at least 14 different subunits, the largest being homologous to subunit Rpb1 of yeast RNAP II and subunit beta' of bacterial RNAP. The yeast member of this family is known as Rpb190. Structure studies suggest that different RNA polymerase complexes share a similar crab-claw-shaped structure. The N-terminal domain of Rpb1, the largest subunit of RNAP II in yeast, forms part of the active site. It makes up the head and core of one clamp, as well as the pore and funnel structures of RNAP II. The strong homology between RPA1 and Rpb1 suggests a similar functional and structural role. Pssm-ID: 259844 [Multi-domain] Cd Length: 779 Bit Score: 37.55 E-value: 9.01e-03
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