NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1372150844|gb|AVR59163|]
View 

putative RuvB-like helicase, partial [Plasmodium floridense]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIP49 super family cl37554
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 33-200 7.85e-100

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


The actual alignment was detected with superfamily member pfam06068:

Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 292.29  E-value: 7.85e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844  33 KIGKMILKTTEMETLYDLGNKMIDALQKENITAGDVICIDKGTGKITKIGKSFSRSKDYDAmdPNTNFVQCPEGELQKRK 112
Cdd:pfam06068 141 KGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844 113 EVVHTVTLHDIDAINSRTQGFLALFSGDTGEIKNEIREHIDMKINEWQEDEKAEIVPGVLFIDEVHMLDIECFSYLNRAL 192
Cdd:pfam06068 219 EVVQTVTLHDIDVANARPQGILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRAL 298


                  ....*...
gi 1372150844 193 ESEQSPIV 200
Cdd:pfam06068 299 ESDLAPIV 306
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 33-200 7.85e-100

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 292.29  E-value: 7.85e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844  33 KIGKMILKTTEMETLYDLGNKMIDALQKENITAGDVICIDKGTGKITKIGKSFSRSKDYDAmdPNTNFVQCPEGELQKRK 112
Cdd:pfam06068 141 KGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844 113 EVVHTVTLHDIDAINSRTQGFLALFSGDTGEIKNEIREHIDMKINEWQEDEKAEIVPGVLFIDEVHMLDIECFSYLNRAL 192
Cdd:pfam06068 219 EVVQTVTLHDIDVANARPQGILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRAL 298


                  ....*...
gi 1372150844 193 ESEQSPIV 200
Cdd:pfam06068 299 ESDLAPIV 306
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
36-200 2.83e-45

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 155.13  E-value: 2.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844  36 KMILKTTEMETLYDLGNKMIDALQKENITAGDVICIDKGTGKITKIGKS-FSRSKDYDAMDpnTNFVQCPEGELQKRKEV 114
Cdd:COG1224   159 TITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKLGRAkGEGAKTYDIET--KRIVEVPSGPVKKEKEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844 115 VHTVTLHDIDAINSRTQG-FLALFS-GDTGEIKNEIREHIDMKINEWQEDEKAEIVPGVLFIDEVHMLDIECFSYLNRAL 192
Cdd:COG1224   237 VRTLTLHDLDLYLAAQRAaFSALFGfFEEREIPSEVRKQVDELVKKWIEEGKAELVPGVLFIDDAHMLDIEAFSFLTRAM 316


                  ....*...
gi 1372150844 193 ESEQSPIV 200
Cdd:COG1224   317 ESELAPII 324
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 33-200 7.85e-100

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 292.29  E-value: 7.85e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844  33 KIGKMILKTTEMETLYDLGNKMIDALQKENITAGDVICIDKGTGKITKIGKSFSRSKDYDAmdPNTNFVQCPEGELQKRK 112
Cdd:pfam06068 141 KGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARATDFDL--EATEFVPCPKGEVHKRK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844 113 EVVHTVTLHDIDAINSRTQGFLALFSGDTGEIKNEIREHIDMKINEWQEDEKAEIVPGVLFIDEVHMLDIECFSYLNRAL 192
Cdd:pfam06068 219 EVVQTVTLHDIDVANARPQGILSLFSPKKGEITSELREEINKKVNKWIEEGKAEIVPGVLFIDEVHMLDIECFSFLNRAL 298


                  ....*...
gi 1372150844 193 ESEQSPIV 200
Cdd:pfam06068 299 ESDLAPIV 306
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
36-200 2.83e-45

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 155.13  E-value: 2.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844  36 KMILKTTEMETLYDLGNKMIDALQKENITAGDVICIDKGTGKITKIGKS-FSRSKDYDAMDpnTNFVQCPEGELQKRKEV 114
Cdd:COG1224   159 TITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKLGRAkGEGAKTYDIET--KRIVEVPSGPVKKEKEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1372150844 115 VHTVTLHDIDAINSRTQG-FLALFS-GDTGEIKNEIREHIDMKINEWQEDEKAEIVPGVLFIDEVHMLDIECFSYLNRAL 192
Cdd:COG1224   237 VRTLTLHDLDLYLAAQRAaFSALFGfFEEREIPSEVRKQVDELVKKWIEEGKAELVPGVLFIDDAHMLDIEAFSFLTRAM 316


                  ....*...
gi 1372150844 193 ESEQSPIV 200
Cdd:COG1224   317 ESELAPII 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH