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Conserved domains on  [gi|1375379927|gb|AVV65339|]
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long-wavelength sensitive opsin [Phyllops falcatus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
42-333 0e+00

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15081:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 292  Bit Score: 549.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  42 GPNYHIAPRWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVL 121
Cdd:cd15081     1 GPNYHIAPRWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 122 GHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKT 201
Cdd:cd15081    81 GHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 202 SCGPDVFSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCW 281
Cdd:cd15081   161 SCGPDVFSGSSDPGVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKEVSRMVVVMIFAYCFCW 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 282 GPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15081   241 GPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCI 292
 
Name Accession Description Interval E-value
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
42-333 0e+00

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 549.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  42 GPNYHIAPRWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVL 121
Cdd:cd15081     1 GPNYHIAPRWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 122 GHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKT 201
Cdd:cd15081    81 GHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 202 SCGPDVFSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCW 281
Cdd:cd15081   161 SCGPDVFSGSSDPGVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKEVSRMVVVMIFAYCFCW 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 282 GPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15081   241 GPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCI 292
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
71-322 2.15e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 145.52  E-value: 2.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY-GYFVLGHPLCIVEGYTVSLCGITGLWSLAIISW 149
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 150 ERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPP-IFGWSRYWPHGLKTSCGPDVFSGSSYPgvQSYMIVLMTTC 227
Cdd:pfam00001  82 DRYLAIVHPLRYKRRrTPRRAKVLILVIWVLALLLSLPPlLFGWTLTVPEGNVTVCFIDFPEDLSKP--VSYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 228 CIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKeVTRMVVVMILAYCFCWGPYAFFACFAAAHPG---YAFHPLVA 304
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRK-ALKTLAVVVVVFILCWLPYHIVNLLDSLALDcelSRLLDKAL 238
                         250
                  ....*....|....*...
gi 1375379927 305 ALPAYFAKSATIYNPIIY 322
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
61-339 6.88e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 38.07  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNglVLVATMRF-KKLRHPLNWILVNLAVADLAETIIASTIsvvnqIYGYF---VLGHPLCIVEGYTVSLC 136
Cdd:PHA02638  106 IIIFILGLFGN--AAIIMILFcKKIKTITDIYIFNLAISDLIFVIDFPFI-----IYNEFdqwIFGDFMCKVISASYYIG 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDA-KLAIAGITFSWVWSAVWTAPP--IFGWSRYWPHGLKTSCGPDVFSGSSY 213
Cdd:PHA02638  179 FFSNMFLITLMSIDRYFAILYPISFQKYRTfNIGIILCIISWILSLIITSPAyfIFEASNIIFSAQDSNETISNYQCTLI 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCC---------IVPLSVIVLCYLQVWLAIravaKQQKESESTQKaekevTRMVVVMILAYCFCWGPY 284
Cdd:PHA02638  259 EDNEKNNISFLGRILqfeinilgmFIPIIIFAFCYIKIILKL----KQLKKSKKTKS-----IIIVSIIIICSLICWIPL 329
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375379927 285 AFFACFAAAHPGYAFHPLVAALPAYFAK-------------SATIYNPIIYVFMNRQFRNCILQLFGR 339
Cdd:PHA02638  330 NIVILFATMYSFKGFNSIISEHICGFIKlgyammlaeaislTHCCINPLIYTLIGENFRMHLLMIFRN 397
 
Name Accession Description Interval E-value
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
42-333 0e+00

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 549.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  42 GPNYHIAPRWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVL 121
Cdd:cd15081     1 GPNYHIAPRWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 122 GHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKT 201
Cdd:cd15081    81 GHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 202 SCGPDVFSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCW 281
Cdd:cd15081   161 SCGPDVFSGSSDPGVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKEVSRMVVVMIFAYCFCW 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 282 GPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15081   241 GPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCI 292
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
46-336 1.41e-115

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 337.60  E-value: 1.41e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  46 HIAPRWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPL 125
Cdd:cd15084     3 HLAPRSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 126 CIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGP 205
Cdd:cd15084    83 CEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCGP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 206 DVFSGSSypGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYA 285
Cdd:cd15084   163 NWYTGGT--NNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYA 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 286 FFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQL 336
Cdd:cd15084   241 TFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLEL 291
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
54-333 9.38e-105

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 309.52  E-value: 9.38e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSsy 213
Cdd:cd14969    81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYSKD-- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKE------SESTQKAEKEVTRMVVVMILAYCFCWGPYAFF 287
Cdd:cd14969   159 PNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARrknsaiTKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1375379927 288 ACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd14969   239 SLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
40-333 4.44e-96

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 287.46  E-value: 4.44e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  40 FEGPNYHIAPrWVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYF 119
Cdd:cd15082     1 FSGPLKSIAP-WNFTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 120 VLGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGL 199
Cdd:cd15082    80 FLGVWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 200 KTSCGPDVFSGSSYPgvQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCF 279
Cdd:cd15082   160 GTTCEPNWYSGNMHD--HTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPERQVTRMVVVMIVAFMV 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 280 CWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15082   238 CWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
57-333 7.84e-92

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 276.32  E-value: 7.84e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15077     4 SAFMLFLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGV 216
Cdd:cd15077    84 GMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKWNN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPG 296
Cdd:cd15077   164 ESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNRG 243
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15077   244 EPFDLRLASIPSVFSKASTVYNPVIYVFMNKQFRSCM 280
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
60-332 2.11e-85

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 260.09  E-value: 2.11e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15075     7 MAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFGIA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFsgSSYPGVQSY 219
Cdd:cd15075    87 ALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWY--SRDPVNVSY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQ-KESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd15075   165 ILCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLGvAEGGSTAKAEVQVARMVVVMVMAFLLCWLPYAAFALTVVSKPDVY 244
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 299 FHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15075   245 INPLIATVPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
54-333 1.14e-84

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 258.21  E-value: 1.14e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15076     1 YLQAAFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSY 213
Cdd:cd15076    81 SLAGLVTGWSLAFLAFERYIVICKPFGNFRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLQCSCGPDWYTVGTK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15076   161 YRSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESASTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVN 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 294 HPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15076   241 NRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACI 280
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
57-333 1.70e-84

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 257.84  E-value: 1.70e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15080     4 AAYMFLLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGV 216
Cdd:cd15080    84 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPG 296
Cdd:cd15080   164 ESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQG 243
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15080   244 SDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
60-332 7.35e-65

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 207.40  E-value: 7.35e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15085     7 MFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSC--GPDVFSGSSYpgvq 217
Cdd:cd15085    87 SLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCsiGWEERSWSNY---- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAK--QQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP 295
Cdd:cd15085   163 SYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKkiEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVVNP 242
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 296 GYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15085   243 ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
55-332 9.31e-57

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 186.10  E-value: 9.31e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15086     2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSsyP 214
Cdd:cd15086    82 LFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRS--A 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESesTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAH 294
Cdd:cd15086   160 NSISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKST--ARKREQHVLLMVVTMVICYLLCWLPYGVMALLATFG 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 295 PGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15086   238 KPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYRC 275
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
58-333 5.75e-53

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 176.75  E-value: 5.75e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  58 AWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15083     5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSsyPGV 216
Cdd:cd15083    85 IMSINTLAAIAVDRYLVITRPMkASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFDYLSRD--DAN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKE------------SESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15083   163 RSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEmakrfskselssPKARRQAEVKTAKIALLLVLLFCLAWTPY 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 285 AFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15083   243 AVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
58-333 3.18e-51

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 172.51  E-value: 3.18e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  58 AWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIAS----TISVVNQiygYFVLGHPLCIVEGYTV 133
Cdd:cd15337     5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfplkTISSFNK---KWIWGKVACELYGFAG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSs 212
Cdd:cd15337    82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKkMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDYLSRD- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 yPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ---------QKESESTQ---KAEKEVTRMVVVMILAYCFC 280
Cdd:cd15337   161 -LNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEmtqtaksgmGKDTEKNDarkKAEIRIAKVAIILISLFLLS 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 281 WGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15337   240 WTPYAVVALLGQFGPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
65-333 8.80e-51

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 170.92  E-value: 8.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSL 144
Cdd:cd15074    12 ILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 145 AIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLM 224
Cdd:cd15074    92 TAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGASASVGGMSYIISIF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 225 TTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ----KAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFH 300
Cdd:cd15074   172 IFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSkrqhKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVP 251
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1375379927 301 PLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15074   252 ILASILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
57-326 1.06e-47

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 162.84  E-value: 1.06e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd00637     2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWsRYWPHGLKTSCGPDVFSGSSYpg 215
Cdd:cd00637    82 LLASILTLTAISVDRYLAIVHPLrYRRRFTRRRAKLLIALIWLLSLLLALPPLLGW-GVYDYGGYCCCCLCWPDLTLS-- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 vQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ------KAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd00637   159 -KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSsrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLL 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 290 FAAAHPGYAFHPLVAALPAYF-AKSATIYNPIIYVFMN 326
Cdd:cd00637   238 LDVFGPDPSPLPRILYFLALLlAYLNSAINPIIYAFFN 275
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
60-322 7.23e-47

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 161.20  E-value: 7.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIAST--ISVVNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15079     7 YIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDF---LMMIKmpIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWT-APPIFGWSRYWPHGLKTSCGPDVFSGSSYPgv 216
Cdd:cd15079    84 IGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWAlLPLLFGWGRYVPEGFLTSCSFDYLTRDWNT-- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKE------------SESTQK--AEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15079   162 RSFVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALREqakkmnvvslrsNADANKqsAEIRIAKVALTNVFLWFIAWT 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 283 PYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIY 322
Cdd:cd15079   242 PYAVVALIGAFGNQSLLTPLVSMIPALFAKTAACYNPIVY 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
57-333 2.13e-44

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 154.12  E-value: 2.13e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15073     4 AAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPD-VFSGSSYpg 215
Cdd:cd15073    84 GMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINwRKNDSSF-- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 vQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ--KAEKEVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15073   162 -VSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIdwTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASF 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 294 HPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15073   241 GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRAI 280
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
56-333 4.96e-44

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 153.72  E-value: 4.96e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  56 TSAWMIFVV-IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15336     2 TVGSVILIIgITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFsgSSY 213
Cdd:cd15336    82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKkRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDYM--TFT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--------QKES---ESTQKAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15336   160 PSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREvqklgsqdRKEKakqYQRMKNEWKMAKIAFVVILLFVLSWS 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 283 PYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15336   240 PYACVALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYREAI 290
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
71-322 2.15e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 145.52  E-value: 2.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY-GYFVLGHPLCIVEGYTVSLCGITGLWSLAIISW 149
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 150 ERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPP-IFGWSRYWPHGLKTSCGPDVFSGSSYPgvQSYMIVLMTTC 227
Cdd:pfam00001  82 DRYLAIVHPLRYKRRrTPRRAKVLILVIWVLALLLSLPPlLFGWTLTVPEGNVTVCFIDFPEDLSKP--VSYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 228 CIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKeVTRMVVVMILAYCFCWGPYAFFACFAAAHPG---YAFHPLVA 304
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRK-ALKTLAVVVVVFILCWLPYHIVNLLDSLALDcelSRLLDKAL 238
                         250
                  ....*....|....*...
gi 1375379927 305 ALPAYFAKSATIYNPIIY 322
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
68-333 1.77e-37

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 136.11  E-value: 1.77e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  68 VFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAII 147
Cdd:cd15078    15 VCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTLTVL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 148 SWERWLVVCKPfgnMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDvfSGSSYPGVQSYMIVLMTTC 227
Cdd:cd15078    95 AYERYIRVVHA---KVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFD--WKSKDPNDTSFVLLFFLGC 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 228 CIVPLSVIVLCYLQVWLAIRAVAK----QQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFHPLV 303
Cdd:cd15078   170 LVVPLGIMAYCYGHILYEIRMLRSvedlQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTPTI 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1375379927 304 AALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15078   250 AIIPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
60-331 2.27e-35

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 129.99  E-value: 2.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14967     6 LSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWsRYWPHGLKTSCGPDVFSGssypgvQS 218
Cdd:cd14967    86 SILNLCAISLDRYLAITRPLRyRQLMTKKRALIMIAAVWVYSLLISLPPLVGW-RDETQPSVVDCECEFTPN------KI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKesestqkaekeVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd14967   159 YVLVSSVISFFIPLLIMIVLYARI---FRVARRELK-----------AAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDC 224
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1375379927 299 FHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd14967   225 VPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
60-333 1.15e-29

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 115.39  E-value: 1.15e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14993     9 VVFLL--ALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRF----DAKLAIAGItfsWVWSAVWTAPPIFG---WSRYWPHG---LKTSCgPDVFS 209
Cdd:cd14993    87 SVLTLVAISIDRYLAICYPLKARRVstkrRARIIIVAI---WVIAIIIMLPLLVVyelEEIISSEPgtiTIYIC-TEDWP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPgvQSYMIVLMTTCCIVPLSVIVLCYLQVW--LAIRAVAKQQKESESTQ-----KAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd14993   163 SPELR--KAYNVALFVVLYVLPLLIISVAYSLIGrrLWRRKPPGDRGSANSTSsrrilRSKKKVARMLIVVVVLFALSWL 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 283 PYAFFACFAAAHPGYAFHP-----LVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd14993   241 PYYVLSILLDFGPLSSEESdenflLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
61-331 3.09e-28

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 111.54  E-value: 3.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYT--VSLCGI 138
Cdd:cd15203     8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLqgVSIFVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TglWSLAIISWERWLVVCKPFGNmRFDAKLAIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCGpdVFSGSSYPGVQ 217
Cdd:cd15203    88 T--LTLTAIAIDRYQLIVYPTRP-RMSKRHALLIIALIWILSLLLSLPlAIFQELSDVPIEILPYCG--YFCTESWPSSS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 S---YMIVLMTTCCIVPLSVIVLCYLQVWLAI--RAVAKQQKESESTQKAEKEV------TRMVVVMILAYCFCWGPYAF 286
Cdd:cd15203   163 SrliYTISVLVLQFVIPLLIISFCYFRISLKLrkRVKKKRGKRTLSSRRRRSELrrkrrtNRLLIAMVVVFAVCWLPLNL 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 287 FACFAAAHPGYAFHP----LVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15203   243 FNLLRDFEPLPQIDGrhfyLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
68-330 7.63e-24

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 98.97  E-value: 7.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  68 VFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETI---IASTISVVnqiyGYFVLGHPLCIVEGYTVSLCGITGLWSL 144
Cdd:cd15072    15 FSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLnalVAASSSLL----RRWPYGSEGCQAHGFQGFFTALASICSS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 145 AIISWERWLVVCKPfgnMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSypGVQSYMIVLM 224
Cdd:cd15072    91 AAIAWDRYHHYCTR---SKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDR--NYVSYLFTMA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 225 TTCCIVPLSVIVLCYLQVWlairavakqqkeseSTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFHPLVA 304
Cdd:cd15072   166 FFNFILPLFILLTSYSSIE--------------QKLKKEGHLRFNTGLPLLTLLICWGPYAILALYAAITDVTSISPKLR 231
                         250       260
                  ....*....|....*....|....*.
gi 1375379927 305 ALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15072   232 MVPALLAKTSPTINAILYALGNENYR 257
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
61-331 3.87e-23

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 96.96  E-value: 3.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVegYTVS--LCGI 138
Cdd:cd15329     8 LIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV--WISFdvLLCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrywphglKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15329    86 ASILNLCAISVDRYLVITRPLTyAVKRTPKRMALMIAIVWLLSALISIPPLFGWK-------NKVNDPGVCQVSQDFGYQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLmttCCIVPLSVIVLCYLQVWLAiravakqqkesestQKAEKEVTRMVVVMILAYCFCWGPY---AFFACFAAAH 294
Cdd:cd15329   159 IYATFG---AFYIPLIVMLVLYYKIYRA--------------AKSERKAIKTLGIIMGAFTLCWLPFfilALLRPFLKPI 221
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 295 PGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15329   222 KCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
55-331 1.02e-22

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 95.86  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15064     2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIFGWSRywphglKTSCGPDVFSGSSY 213
Cdd:cd15064    82 TCCTASILHLCVIALDRYWAITDAVEYAHKrTPKRAAVMIALVWTLSICISLPPLFGWRT------PDSEDPSECLISQD 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYmivlmTTCC--IVPLSVIVLCYlqvWLAIRAVAKQQKesestqkaekeVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15064   156 IGYTIF-----STFGafYIPLLLMLILY---WKIYRAAARERK-----------AAKTLGIILGAFIVCWLPFFLVALIV 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 292 AAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15064   217 PLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
62-333 2.26e-21

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 92.36  E-value: 2.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNqIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd14970     9 VVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSY-LLGYWPFGEVMCKIVLSVDAYNMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDvfsgssYPGVQ 217
Cdd:cd14970    88 FCLTVMSVDRYLAVVHPVKSLRFRtprkAKLVSLCV---WALSLVLGLPVIIFARTLQEEGGTISCNLQ------WPDPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCC-----IVPLSVIVLCYLQVWLAIRAVAKQQK-ESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd14970   159 DYWGRVFTIYTfvlgfAVPLLVITVCYSLIIRRLRSSRNLSTsGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVR 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 292 AAhpgYAFHPLVAALPAYFAKSATIY-----NPIIYVFMNRQFRNCI 333
Cdd:cd14970   239 LL---IDPPETLTVVGVFLFCIALSYansclNPILYAFLDENFRKSF 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
60-332 9.28e-21

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 90.53  E-value: 9.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15206     9 VIFLL--AVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCgPDVFSGSSYPgvQ 217
Cdd:cd15206    87 STFTLVAISLERYFAICHPLKSRVWQTLShAYKVIAGIWLLSFLIMSPiLVFSNLIPMSRPGGHKC-REVWPNEIAE--Q 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqqkesestqKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15206   164 AWYVFLDLMLLVIPGLVMSVAYGLISWTLL-------------EAKKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPS 230
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 298 AFH---PLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15206   231 AARyvsSTTISLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
63-331 5.31e-20

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 88.89  E-value: 5.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISVVNQIYGY---FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15390    10 MVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADL---LISAFNTVFNFTYLLyndWPFGLFYCKFSNFVAITTVAA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWS----RYWPHGLKTSCGPDVFSGSSYPG 215
Cdd:cd15390    87 SVFTLMAISIDRYIAIVHPL-RPRLSRRTTKIAIAVIWLASFLLALPQLLYSTtetyYYYTGSERTVCFIAWPDGPNSLQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAvAKQQKESESTQ----KAEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15390   166 DFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWG-SKTIGENTPRQlesvRAKRKVVKMMIVVVVIFAICWLPYHLYFILT 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 292 AAHPGYAFHPLV--AALPAYF-AKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15390   245 YLYPDINSWKYIqqIYLAIYWlAMSNSMYNPIIYCWMNKRFRY 287
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
62-330 9.70e-20

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 87.92  E-value: 9.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15094     9 LICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADEC-FLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTApPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYM 220
Cdd:cd15094    88 FTLTVMSADRYLAVCHPIRSMRYrTPFIAKVVCATTWSISFLVML-PIILYASTVPDSGRYSCTIVWPDSSAVNGQKAFT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESEStQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFH 300
Cdd:cd15094   167 LYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEK-RRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDM 245
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 301 P----LVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15094   246 PkweiLMFLLLTVLSYANSMVNPLLYAFLSENFR 279
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
57-331 2.03e-19

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 86.89  E-value: 2.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15401     4 AGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWphglktscGPDVFSGSSYPG 215
Cdd:cd15401    84 VIGSVFNITAIAINRYCYICHSLRYDKlYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQY--------DPRIYSCTFAQT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQ-SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTR----MVVVMILaYCFCWGPYAFFACF 290
Cdd:cd15401   156 VSsSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQV-KHRVRQDSKQKLKANDIRnfltMFVVFVL-FAVCWGPLNFIGLA 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 291 AAAHPgYAFHPLVA----ALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15401   234 VAINP-LKVAPKIPewlfVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
60-332 2.66e-18

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 83.18  E-value: 2.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIV-EGYTVSLCGI 138
Cdd:cd15061     6 LILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFwISLDVLLCTA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLwSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKtSCgpdvfsgsSYPGVQ 217
Cdd:cd15061    86 SIL-NLCCISLDRYFAITYPLKYRTKRSRrLAITMILAVWVISLLITSPPLVGPSWHGRRGLG-SC--------YYTYDK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLAIravakqqkesestqKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPgY 297
Cdd:cd15061   156 GYRIYSSMGSFFLPLLLMLFVYLRIFRVI--------------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCD-C 220
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1375379927 298 AFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15061   221 QFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRA 255
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
61-331 3.94e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 83.56  E-value: 3.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIA-STISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15392     8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCvPFSFIALLILQYWPFGEFMCPVVNYLQAVSVFV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVwTAPPIFGWSRYWPHgLKTSCGPDvFSGSSYPGVQS- 218
Cdd:cd15392    88 SAFTLVAISIDRYVAIMWPL-RPRMTKRQALLLIAVIWIFALA-TALPIAITSRLFED-SNASCGQY-ICTESWPSDTNr 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 --YMIVLMTTCCIVPLSVIVLCY----LQVWlaIRAVAKQQKESESTQKAE--KEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15392   164 yiYSLVLMILQYFVPLAVLVFTYtrigIVVW--AKRTPGEAENNRDQRMAEskRKLVKMMITVVAIFALCWLPLNILNLV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 291 AAAHPG---YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15392   242 GDHDESiysWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
61-333 9.53e-18

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 82.33  E-value: 9.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVI--ASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGY----TVS 134
Cdd:cd15095     6 IFAIIflVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYmmqvTVQ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITglwsLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAP--PIFGWSRYWPHGLKTSCGPDVFSGS 211
Cdd:cd15095    86 ATCLT----LTALSVDRYYAIVHPIRSLRFrTPRVAVVVSACIWIVSFLLSIPvaIYYRLEEGYWYGPQTYCREVWPSKA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGvqsYMIVLMTTCCIVPLSVIVLCY----LQVW-LAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15095   162 FQKA---YMIYTVLLTYVIPLAIIAVCYglilRRLWrRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHV 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 287 FACFAAAHPGYAFHPLV-----AALPAYFAKSATiyNPIIYVFMNRQFRNCI 333
Cdd:cd15095   239 LNLWQRFDPNFPETYATyalkiAALCLSYANSAV--NPFVYAFMGENFRKYF 288
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
55-330 1.14e-17

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 81.62  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15059     2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWP-HGLKTSCGPDVFSGss 212
Cdd:cd15059    82 LFCTASIVNLCAISLDRYWSVTQAVEyNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPwHGAEPQCELSDDPG-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 ypgvqsYMIVLMTTCCIVPLSVIVLCYLQVWLAiravakqqkesesTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAA 292
Cdd:cd15059   160 ------YVLFSSIGSFYIPLLIMIIVYARIYRA-------------AKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVV 220
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 293 AHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15059   221 VCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFR 258
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
63-330 3.25e-17

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 80.40  E-value: 3.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTIsvvnQIYGYFV----LGHPLCIVEGYTVSLCGI 138
Cdd:cd15001     9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPL----KTAEYFSptwsLGAFLCKAVAYLQLLSFI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRF----DAKLAIAGItfsWVWSAVWTAPPIFGWSRY---WPHGLKTSCGPDVFSGS 211
Cdd:cd15001    85 CSVLTLTAISIERYYVILHPMKAKSFctigRARKVALLI---WILSAILASPVLFGQGLVryeSENGVTVYHCQKAWPST 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGV-QSYMIVLMTtccIVPLSVIVLCYlqvwlairavakqqkesesTQKAEKEVTRMVVVMILAYCFCWGP-----YA 285
Cdd:cd15001   162 LYSRLyVVYLAIVIF---FIPLIVMTFAY-------------------ARDTRKQVIKMLISVVVLFAVCWGPllidnLL 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 286 FFACFAAAHPGYAFHPLVAALPAYFAKSATIyNPIIYVFMNRQFR 330
Cdd:cd15001   220 VSFDVISTLHTQALKYMRIAFHLLSYANSCI-NPIIYAFMSKNFR 263
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
55-330 3.46e-17

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 80.63  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15202     2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGN--MRFDAKLAIAGItfsWVWsAVWTAPPIFGWSR-----YWPHGLKTSCGPDv 207
Cdd:cd15202    82 CSVHVSAYTLTAIAVDRYQAIMHPLKPriSKTKAKFIIAVI---WTL-ALAFALPHAICSKletfkYSEDIVRSLCLED- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 fsGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQK-ESESTQ-----KAEKEVTRMVVVMILAYCFCW 281
Cdd:cd15202   157 --WPERADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPgDATTERyfalrRKKKKVIKMLMVVVVLFALCW 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 282 GPYAFFACFAAAHPGYAFHPLVAALPA--YFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15202   235 LPFNIYVLLLSSKPDYLIKTINAVYFAfhWLAMSSTCYNPFIYCWLNERFR 285
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
55-330 4.16e-17

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 80.59  E-value: 4.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd14971     2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNM-RFDAKLAIAGITFSWVWSAVWTAPPIF--GWSRYWPHGLkTSCGPDVfsgS 211
Cdd:cd14971    82 VSMHASIFTLVAMSLDRFLAVVYPLRSLhIRTPRNALAASGCIWVVSLAVAAPVLAlhRLRNYTPGNR-TVCSEAW---P 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd14971   158 SRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 292 AAHP------GYAFHpLVAALPAYfAKSATiyNPIIYVFMNRQFR 330
Cdd:cd14971   238 ALGPfpltyaTYALR-IWAHCLAY-SNSAV--NPVLYAFLSEHFR 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
54-330 5.00e-17

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 80.55  E-value: 5.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd14992     2 ILGVALVVIILV-SVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSCGPDVFSGSS 212
Cdd:cd14992    81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYtTTVIIIITIWVVSLLLAIPQLY-YATTEVLFSVKNQEKIFCCQIP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGVQSYM----IVLMTTCCIVPLSVIVLCYLQV----WlAIRAVAKQQKESESTQ-KAEKEVTRMVVVMILAYCFCWGP 283
Cdd:cd14992   160 PVDNKTYEkvyfLLIFVVIFVLPLIVMTLAYARIsrelW-FRKVPGFSIKEVERKRlKCKRRVIKMLVCVVVLFVICWLP 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 284 YAFFACFAAAHPgyAFHPLVAALPAYF-----AKSATIYNPIIYVFMNRQFR 330
Cdd:cd14992   239 FHLFFLLRDFFP--LIMKEKHTLQVYYflhwiAMSNSMYNPIIYVTLNNNFR 288
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
61-330 1.39e-16

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 79.36  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15208     8 ILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKP--FGNMRFDAKLAIAGItfsWVWSAVWTAP--------PIFGWSRYWPhgLKTSCGPDvFSG 210
Cdd:cd15208    88 VLTLSCIALDRWYAICHPlmFKSTAKRARVSILII---WIVSLLIMIPqaivmecsRVVPLANKTI--LLTVCDER-WSD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTccIVPLSVIVLCYLQVWL----------AIRAVAKQQKESESTQKAE-------KEVTRMVVVM 273
Cdd:cd15208   162 SIYQKVYHICFFLVTY--LLPLCLMILAYFQIFRklwcrqipgtSSVVQRKWNKPRKSAVAAEekqlrsrRKTAKMLIVV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375379927 274 ILAYCFCWGP--------YAFFACFAAAHPGYAFHpLVAALPAYFAKSAtiyNPIIYVFMNRQFR 330
Cdd:cd15208   240 VIMFAICYLPvhllnilrYVFGLFTVDRETIYAWF-LFSHWLVYANSAI---NPIIYNFMSGKFR 300
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
60-331 1.86e-16

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 78.46  E-value: 1.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14982     7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFG-----NMRFDAKLAIAgitfswVWSAVWTA--PPIFGWSRYWPHGLKTSCgpdvFSGSS 212
Cdd:cd14982    87 SILFLTCISVDRYLAVVHPLKsrrlrRKRYAVGVCAG------VWILVLVAsvPLLLLRSTIAKENNSTTC----FEFLS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPG--VQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAekevTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd14982   157 EWLasAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKA----LRMILIVLAVFLVCFLPYHVTRIL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 291 AAAHPGYAFHPLVAALPAYFAKSATI--------YNPIIYVFMNRQFRN 331
Cdd:cd14982   233 YLLVRLSFIADCSARNSLYKAYRITLclaslnscLDPLIYYFLSKTFRK 281
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
62-331 1.91e-16

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 78.93  E-value: 1.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15065     8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIF-GWSRYWPHGLKTSCGPDVFSGSSYPGVQ-S 218
Cdd:cd15065    88 LNLCAISLDRYIHIKKPLKYERWmTTRRALVVIASVWILSALISFLPIHlGWHRLSQDEIKGLNHASNPKPSCALDLNpT 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKesesTQKAEKEVTRMVVVMILAY--------------------- 277
Cdd:cd15065   168 YAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIK----SQKLPSESGSKFQVPSLSSkhnnqgvsdhkaavtlgiimg 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 278 --CFCWGPYAFFACFAAAHPgYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15065   244 vfLICWLPFFIINIIAAFCK-TCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
58-330 5.87e-16

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 76.54  E-value: 5.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  58 AWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15210     5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIFG-WSRYwphGLKtscgPDVFSGSSYP 214
Cdd:cd15210    85 AVSLLTLVLITLNRYILIAHPslYPRIYTRRGLALM-IAGTWIFSFGSFLPLWLGiWGRF---GLD----PKVCSCSILR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQ--SYMIVLMTTCCIVPLSVIVLCYlqvwlairavakqqkesesTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAA 292
Cdd:cd15210   157 DKKgrSPKTFLFVFGFVLPCLVIIICY-------------------ARREDRRLTRMMLVIFLCFLVCYLPITLVNVFDD 217
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 293 AHPGYAFHpLVAALPAYFakSATIyNPIIYVFMNRQFR 330
Cdd:cd15210   218 EVAPPVLH-IIAYVLIWL--SSCI-NPIIYVAMNRQYR 251
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
61-331 6.73e-16

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 77.40  E-value: 6.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14979     8 VAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEACTYA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgNMR--FDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd14979    88 TVLTIVALSVERYVAICHPL-KAKtlVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCTLVVDRS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCI---VPLSVIVLCYLQVWLAIRAVAKQQK----------ESESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd14979   167 TFKYVFQVSTFIffvLPMFVISILYFRIGVKLRSMRNIKKgtraqgtrnvELSLSQQARRQVVKMLGAVVIAFFVCWLPF 246
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 285 AFFACFAAAHPGY---------AFHPLVAALpayFAKSATIyNPIIYVFMNRQFRN 331
Cdd:cd14979   247 HAQRLMFSYASKEdtflfdfyqYLYPISGIL---FYLSSAI-NPILYNLMSSRFRV 298
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
62-330 1.05e-15

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 76.57  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15096     9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFDAK----LAIAGItfsWVWSAVWTAPPIF--GWSRYWPHGLKTS-CgpdVFSGSSYP 214
Cdd:cd15096    89 YTLVLMSLDRYLAVVHPITSMSIRTErntlIAIVGI---WIVILVANIPVLFlhGVVSYGFSSEAYSyC---TFLTEVGT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIR-AVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPY--AFFACFA 291
Cdd:cd15096   163 AAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRrQKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIhiILLLKYY 242
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1375379927 292 AAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15096   243 GVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFR 281
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
54-331 1.67e-15

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 76.01  E-value: 1.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVvIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGY-- 131
Cdd:cd15391     2 HLINLYQSTI-FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYvq 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGitGLWSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPPIF---GWSRYWPHGLKTSCGpDVF 208
Cdd:cd15391    81 LVSVTA--SVLTNTAIGIDRFFAVIFPL-RSRHTKSRTKCIIASIWAISFSLSSVQLFagrTQRYGQYSEGRVLCG-ESW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGVqSYMIVLMTTCCIVPLSVIVLCYLQVWLAI---RAVAKQQKESESTQ-KAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15391   157 PGPDTSRS-AYTVFVMLLTYIIPLLILTSTYGYVGFRLwnrTAPGNADKGRDDMQiKSKRKVIKMLVFVVLMFGICWLPL 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 285 AFFACFAAAHPGYAFHP-----LVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15391   236 HLFNLVQDFSTVFRNMPqhttrLIYGACHWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
59-331 1.77e-15

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 75.88  E-value: 1.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVviASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC--IVEGYTVSLC 136
Cdd:cd14986     8 GVLFV--FTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCriVKYLQVVGLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLwsLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPP--IFGWSRywpHGLKTSCGPDVFSGSSYP 214
Cdd:cd14986    86 ASTYI--LVSMSLDRYQAIVKPM-SSLKPRKRARLMIVVAWVLSFLFSIPQlvIFVERE---LGDGVHQCWSSFYTPWQR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 gvQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESEST-------------------QKAEKEVTRMVVVMIL 275
Cdd:cd14986   160 --KVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAptamscrsvscvssrvsliSRAKIKTIKMTLVIIL 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 276 AYCFCWGPYaFFACFAAAHPGYAFHPLVA-ALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd14986   238 AFILCWTPY-FIVQLLDVYAGMQQLENDAyVVSETLASLNSALNPLIYGFFSSHLSF 293
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
60-330 2.03e-15

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 75.62  E-value: 2.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15979     9 VIFLL--SVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15979    87 STFSLVAIAIERYSAICNPLQSRVWQTRShAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGDRPRGHQCRHAWPSAQVRQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVwlairavakqQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15979   167 AWYVLLLLILFFIPGVVMIVAYGLI----------SRELYRGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWRAFDPLS 236
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 298 AFHPLVAAlPAYF----AKSATIYNPIIYVFMNRQFR 330
Cdd:cd15979   237 AHRALSGA-PISFihllSYTSACVNPLVYCFMNRRFR 272
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
57-331 2.36e-15

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 75.27  E-value: 2.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15400     4 SSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWphglktscGPDVFSGSSYPG 215
Cdd:cd15400    84 VIGSIFNITGIAINRYCYICHSFAYDKlYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEY--------DPRIYSCTFVQT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQS-YMIVLMTTCCIVPLSVIVLCYLQVW---LAIRAVAKQQKESESTQKAEKEVTRMVVVMILaYCFCWGPYAFFACFA 291
Cdd:cd15400   156 ASSsYTIAVVVIHFIVPITVVSFCYLRIWvlvIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVI-FAICWAPLNLIGLAV 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 292 AAHPGyAFHP-------LVAALPAYFaksATIYNPIIYVFMNRQFRN 331
Cdd:cd15400   235 AINPQ-EMAPkvpewlfVVSYFMAYF---NSCLNAIIYGLLNQNFRK 277
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
60-330 5.18e-15

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 74.56  E-value: 5.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15402     7 LIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWphglktscGPDVFSGSSYPGVQS 218
Cdd:cd15402    87 SIFNITGIAINRYCYICHSLKyDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQY--------DPRIYSCTFAQSVSS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 -YMIVLMTTCCIVPLSVIVLCYLQVW---LAIRAVAKQQKESESTQKAEKEVTRMVVVMILaYCFCWGPYAFFACFAAAH 294
Cdd:cd15402   159 aYTIAVVFFHFILPIIIVTFCYLRIWilvIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVL-FAVCWAPLNFIGLAVAVD 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 295 PgyafHPLVAALPA-------YFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15402   238 P----ETIVPRIPEwlfvasyYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
55-331 7.27e-15

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 73.62  E-value: 7.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15060     2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRyWPHGL--KTSCGPDVFSGs 211
Cdd:cd15060    82 LCCTASILNLCAIALDRYWAIHDPINyAQKRTLKRVLLMIVVVWALSALISVPPLIGWND-WPENFteTTPCTLTEEKG- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 sypgvqsYMIVLMTTCCIVPLSVIVLCYLQVWLAiravakqqkesesTQKaEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15060   160 -------YVIYSSSGSFFIPLLIMTIVYVKIFIA-------------TSK-ERRAARTLGIIMGVFVVCWLPFFLMYVIL 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 292 AAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15060   219 PFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
61-332 8.12e-15

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 73.83  E-value: 8.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVV------NQIYGYFVLGHPLCIvegytvs 134
Cdd:cd14968     8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILislglpTNFHGCLFMACLVLV------- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITgLWSLAIISWERWLVVCKPF---GNMRfdAKLAIAGITFSWVWSAVWTAPPIFGWSRywphglktscGPDVFSGS 211
Cdd:cd14968    81 LTQSS-IFSLLAIAIDRYLAIKIPLrykSLVT--GRRAWGAIAVCWVLSFLVGLTPMFGWNN----------GAPLESGC 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQ---------SYMI-VLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ------QKESESTQKAEKEVTRMVVVMIL 275
Cdd:cd14968   148 GEGGIQclfeevipmDYMVyFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQiesllrSRRSRSTLQKEVKAAKSLAIILF 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 276 AYCFCWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd14968   228 LFALCWLPLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
62-333 8.14e-15

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 73.81  E-value: 8.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILV-NLAVADLAETIIASTISVVNQIYGYFV-------LGHPLCIVEGYTV 133
Cdd:cd14980     9 IIGILALIGNILVIIWHISSKKKKKKVPKLLIiNLAIADFLMGIYLLIIAIADQYYRGRYaqyseewLRSPPCLLACFLV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWP----HGLKTSCGPdvfS 209
Cdd:cd14980    89 SLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQPGdnrlYGYSSICMP---S 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMI--VLMTTCCIVplsVIVLCYLQVWLAIRAVAKQQKESEStqKAEKEVTRMVVVMILAYCFCWGP-YAF 286
Cdd:cd14980   166 NVSNPYYRGWLIayLLLTFIAWI---IICILYILIFISVRKSRKSARRSSS--KRDKRIAIRLALILITDLICWLPyYIV 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 287 FACFAAAHPGYAFHPL----VAALPAyfaKSATiyNPIIYVFMNRQFRNCI 333
Cdd:cd14980   241 IFSGLLTSTEIDIHVLqfiaILALPL---NSAI--NPYLYTLTTPTFKRDF 286
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-326 9.74e-15

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 73.85  E-value: 9.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASV--FTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTIS----VVNQiyGYFVLGHPLCIVEGY-- 131
Cdd:cd15204     5 VVYVLIMLVcgVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEmdyyVVRQ--RSWTHGDVLCAVVNYlr 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGlwSLAIISWERWLVVCKPfGNMRFDAKLAIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCGpDVFSG 210
Cdd:cd15204    83 TVSLYVSTN--ALLVIAIDRYLVIVHP-LKPRMKRRTACVVIALVWVVSLLLAIPsAVYSKTTPYANQGKIFCG-QIWPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAI--RAVAKQQKES-ESTQKAEKEVTRMVVVMILAYCFCWGPYAff 287
Cdd:cd15204   159 DQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVwfRRVPGQQTEQiRRRLRRRRRKVRLLVVILTAFVLCWAPYY-- 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 288 acfaaahpGYA----FHPLVAALPAY----------FAKSATIYNPIIYVFMN 326
Cdd:cd15204   237 --------GYAivrdFFPTLLSKEKLnttifyiveaLAMSNSMINTVVYVAFN 281
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
59-333 1.52e-14

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 73.20  E-value: 1.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15195     8 WVLFVI--SAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAgITFSWVWSAVWTAPP--IFGWSRYWPHGLKTSCGPDVFSGSSYPGV 216
Cdd:cd15195    86 LSSFMLVVIALDRVFAILSPLSANQARKRVKIM-LTVAWVLSALCSIPQsfIFSVLRKMPEQPGFHQCVDFGSAPTKKQE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESE----------STQKAEKEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15195   165 RLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPisnrrrsrtnSLERARMRTLRMTALIVLTFIVCWGPYYV 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1375379927 287 FACfaaahpGYAFHP-LVAALPAY-------FAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15195   245 LGL------WYWFDKeSIKNLPPAlshimflLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
55-332 1.54e-14

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 72.91  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTV 133
Cdd:cd15063     2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCqIWLAVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCgITGLWSLAIISWERWLVVCKPFGN----MRFDAKLAIAGItfsWVWSAVWTAPPIFGWSRYwPHGLKTSCGPDVFS 209
Cdd:cd15063    82 WMC-TASILNLCAISLDRYLAITRPIRYpslmSTKRAKCLIAGV---WVLSFVICFPPLVGWNDG-KDGIMDYSGSSSLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYP-GVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqqkesestqkAEKEVTRMVVVMILAYCFCWGPYAFFA 288
Cdd:cd15063   157 CTCELtNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAAR--------------METKAAKTVAIIVGCFIFCWLPFFTVY 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 289 CFAAAhPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15063   223 LVRAF-CEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
55-330 1.93e-14

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 72.91  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIV-EGYTV 133
Cdd:cd15056     2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVrTSLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITgLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIF-GWSRYWPHGLKTSCGPdvfSGSS 212
Cdd:cd15056    82 LLTTAS-IMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMqGWNHIGIEDLIAFNCA---SGST 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGV---QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--------------QKESESTQKAEKEVTRMVVVMIL 275
Cdd:cd15056   158 SCVFmvnKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQirslqragssnheaDQHRNSRMRTETKAAKTLGIIMG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 276 AYCFCWGPYAFFACF-AAAHPGYAFHPLVAALPAYFAKSatIYNPIIYVFMNRQFR 330
Cdd:cd15056   238 CFCVCWAPFFVTNIVdPFIGYRVPYLLWTAFLWLGYINS--GLNPFLYAFFNKSFR 291
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
60-331 2.27e-14

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 72.41  E-value: 2.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15066     6 MTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIF-GWSRYWPHGLKTSCGPDVfsgSSYPGVQ 217
Cdd:cd15066    86 SILHLCCISVDRYYAIVQPLEyPSKMTKRRVAIMLANVWISPALISFLPIFlGWYTTEEHLQYRKTHPDQ---CEFVVNK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLairavakqqkesesTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15066   163 IYALISSSVSFWIPCIVMIFTYYRIYL--------------EAKREHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDA 228
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 298 AFHP--LVAAL--PAYFAKSatiYNPIIYVFMNRQFRN 331
Cdd:cd15066   229 CPYPpiLVSILfwIGYFNST---LNPLIYAYFNRDFRE 263
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
60-330 2.31e-14

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 72.72  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC---IVEGYTVSLC 136
Cdd:cd15048     7 ISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCkawLVVDYTLCTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GItglWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITF-SWVWSAVWTAPPIFGWSrYWPHGLKtscgpdVFSGSSYPG 215
Cdd:cd15048    87 SA---LTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMAlVWILAFLLYGPAIIGWD-LWTGYSI------VPTGDCEVE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCI---VPLSVIVLCYLQVWLAIRA-------------VAKQQKESESTQKAEKEVTR----MVVVMIL 275
Cdd:cd15048   157 FFDHFYFTFITSVLeffIPFISVSFFNLLIYLNIRKrsrrrplrsvpilPASQNPSRARSQREQVKLRRdrkaAKSLAIL 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 276 AYCF--CWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15048   237 VLVFliCWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFR 293
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
59-330 2.95e-14

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 72.37  E-value: 2.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVVI--ASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTVSL 135
Cdd:cd15051     4 GVVLAVIilLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCnIYISLDVML 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 136 CGITgLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPI-FGWS----RYWPHGLKTSCGpdvFS 209
Cdd:cd15051    84 CTAS-ILNLFAISLDRYLAITAPLRyPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNtpdgRVQNGDTPNQCR---FE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYpgvqsYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ---------QKESESTQ-KAEKEVTRMVVVMILAYCF 279
Cdd:cd15051   160 LNPP-----YVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRinaltpastANSSKSAAtAREHKATVTLAAVLGAFII 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 280 CWGPYAF---FACFAAAHPGYAFHPLVAALPayFAKSAtiYNPIIYVFMNRQFR 330
Cdd:cd15051   235 CWFPYFTyftYRGLCGDNINETALSVVLWLG--YANSA--LNPILYAFLNRDFR 284
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
65-330 5.70e-14

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 71.29  E-value: 5.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSL 144
Cdd:cd15393    12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 145 AIISWERWLVVCKPF--GNMRFDAKLAIAGItfsWVWSAVWTAP-PIFGWSRYWP----HGLKTSCGPdvfSGSSYPGVQ 217
Cdd:cd15393    92 TVIAVDRYRAVIHPLkaRCSKKSAKIIILII---WILALLVALPvALALRVEELTdktnNGVKPFCLP---VGPSDDWWK 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRaVAKQQKESESTQ-----KAEKEVTRMVVVMILAYCFCWGPYAFFACFAA 292
Cdd:cd15393   166 IYNLYLVCVQYFVPLVIICYAYTRIAVKIW-GTKAPGNAQDVRddeilKNKKKVIKMLIIVVALFALCWLPLQTYNLLNE 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 293 AHP---GYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15393   245 IKPeinKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFK 285
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
60-333 5.70e-14

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 71.43  E-value: 5.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15055     7 LSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgnmRFDAKLAI----AGITFSWVWSAVWTAPPIFGwSRYWPHGLKT-SC-GPDVFSGSsy 213
Cdd:cd15055    87 SIFNLVLIAIDRYVAVCDPL---LYPTKITIrrvkICICLCWFVSALYSSVLLYD-NLNQPGLIRYnSCyGECVVVVN-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 pgvQSYMIVLMTTCCIVPLSVIVLCYLQVWL-------AIRAVAKQQ----KESESTQKAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15055   161 ---FIWGVVDLVLTFILPCTVMIVLYMRIFVvarsqarAIRSHTAQVslegSSKKVSKKSERKAAKTLGIVVGVFLLCWL 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 283 PYaffACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15055   238 PY---YIVSLVDPYISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
71-330 6.90e-14

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 70.94  E-value: 6.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWE 150
Cdd:cd15088    18 NGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQFTSTYILTAMSVD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 151 RWLVVCKPFGNM----RFDAKLAIAGItfsWVWSAVWTAPP-IFGWSRYWPHGlKTSCGPDVFSGSsypGVQSYMIVLMT 225
Cdd:cd15088    98 RYLAVVHPIRSTkyrtRFVAKLVNVGL---WAASFLSILPVwVYSSLIYFPDG-TTFCYVSLPSPD---DLYWFTIYHFI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 226 TCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAeKEVTRMVVVMILAYCFCWGPYAFF--ACFAAAHPGYAFhplv 303
Cdd:cd15088   171 LGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRT-KRVTKMVILIVVVFIVCWLPFHVVqlVNLAMNRPTLAF---- 245
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1375379927 304 aaLPAYFAKSATIY-----NPIIYVFMNRQFR 330
Cdd:cd15088   246 --EVAYFLSICLGYansclNPFVYILVSENFR 275
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
55-331 7.73e-14

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 70.92  E-value: 7.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15000     1 IKSSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPfGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWS---RYWPHGLKTSCGPDVFSgs 211
Cdd:cd15000    81 SLLLASVLALCAVSYDRLTAIVLP-SEARLTKRGAKIVIVITWIVGLLLALPLAIYRSyreRQWKNFLETYCAENTQV-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 sypgVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--QKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15000   158 ----LPIYWHVIITVLVWLPLGIMLICYSAIFWKLDKYERRvlRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIF 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375379927 290 FAAAHPGYAFHPLVAA---LPAYFAKSATIY-----NPIIYVFMNRQFRN 331
Cdd:cd15000   234 YRYKLVPNDNTQNSVSgsfHILWFASKYLMFlnaavNPLIYGFTNENFRK 283
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
63-326 1.07e-13

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 70.57  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYG-YFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15212    10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRpGWLFGDRLCLANGFFNACFGIVST 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPfGNMRFDAKLAIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYM 220
Cdd:cd15212    90 LTMTLISFDRYYAIVRQ-PQGKIGRRRALQLLAAAWLTALGFSLPwYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKA-----EKEVTRMVVVMILAYCFCWGPYAFFACFAAAHp 295
Cdd:cd15212   169 SVLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLlrfysEMRTATTVLIMIVFIICCWGPYCLLGLVAAAG- 247
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1375379927 296 GYAFHPLVAALPAYFAKSATIYNPIIYVFMN 326
Cdd:cd15212   248 GYQFPPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
60-330 1.20e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 70.08  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYG-YFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15067     6 LSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGgYWLFGRDWCDVWHSFDVLAST 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHG-LKTSCgpdVFSGSSypgv 216
Cdd:cd15067    86 ASILNLCVISLDRYWAITDPISyPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPsPPNQC---LFTDDS---- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 qSYMIVLMTTCCIVPLSVIVLCYLQVWlaiRAVAKQqkesestQKAEKEVTRMVVVMILaycfCWGPYAFFACFAAAHPG 296
Cdd:cd15067   159 -GYLIFSSCVSFYIPLVVMLFTYYRIY---RAAAKE-------QKAAKTLGIVMGVFIL----CWLPFFVTNILIGFCPS 223
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1375379927 297 YAFH--PLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15067   224 NCVSnpDILFPLVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
57-330 2.74e-13

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 69.42  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15209     4 ACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIF-GWSRYWPHglKTSCgpdVFSGSSYP 214
Cdd:cd15209    84 VIGSIFNITAIAINRYCYICHSLQYDRlYSLRNTCCYLCLTWLLTVLAVLPNFFiGSLQYDPR--IYSC---TFAQTVST 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 gvqSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTR----MVVVMILaYCFCWGPYAFFACF 290
Cdd:cd15209   159 ---VYTITVVVIHFLLPLLIVSFCYLRIWVLVLQV-RQRVKPDQRPKLKPADVRnfltMFVVFVL-FAVCWAPLNFIGLA 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 291 AAAHPGYAFH--PLVAALPAYF-AKSATIYNPIIYVFMNRQFR 330
Cdd:cd15209   234 VAINPKEMAPkiPEWLFVASYFmAYFNSCLNAIIYGLLNQNFR 276
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
55-331 3.45e-13

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 68.85  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15330     2 ITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIFGWsrywpHGLKTSCGPDVFSGSS 212
Cdd:cd15330    82 LCCTSSILHLCAIALDRYWAITDPidYVNKRTPRRAAVL-ISLTWLIGFSISIPPMLGW-----RTPEDRSDPDACTISK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGvqsYMIVLMTTCCIVPLSVIVLCYLQVWlaiRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAA 292
Cdd:cd15330   156 DPG---YTIYSTFGAFYIPLILMLVLYGRIF---KAAAR-----------ERKTVKTLGIIMGTFILCWLPFFIVALVLP 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 293 AHPGYAFHP-LVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15330   219 FCESTCHMPeLLGAIINWLGYSNSLLNPIIYAYFNKDFQS 258
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
60-330 3.92e-13

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 68.98  E-value: 3.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKL--RHPLNWILVNLAVADLAETIIA----STISVVNQiygyFVLGHPLCIVEGYTV 133
Cdd:cd15098     9 LIFCL--GVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCvpfqATIYSLPE----WVFGAFMCKFVHYFF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVwTAPPI---FGWSRYWPHGLKTSCGPDVFS 209
Cdd:cd15098    83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLrTRRNALLGVLVIWVLSLA-MASPVavhQDLVHHWTASNQTFCWENWPE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGvqsYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQkeSESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15098   162 KQQKPV---YVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNM--SKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 290 FAAahpgYAFHPLVAA------LPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15098   237 WVE----FGDFPLTQAsfvlriTAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
55-331 5.15e-13

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 68.15  E-value: 5.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15331     2 LTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWER-WLVVCKPFGNMRfDAKLAIAGITFSWVWSAVWTAPPIFGWSR--YWPHGLKTscGPDVFSgs 211
Cdd:cd15331    82 LCCTASILHLVAIALDRyWAVTNIDYIRRR-TAKRILIMIAVVWFVSLIISIAPLFGWKDedDLDRVLKT--GVCLIS-- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 sypgvQSYMIVLMTTCC--IVPLSVIVLCYLQVWLAiravakqqkesestQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15331   157 -----QDYGYTIFSTVGafYVPLLLMIIIYWKIYQA--------------AKRERKAARTLAIITGAFVVCWLPFFLVAL 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1375379927 290 FAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15331   218 VMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRG 259
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
60-330 5.56e-13

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 68.36  E-value: 5.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15978     9 LIFLL--SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15978    87 STFNLVAISLERYSAICKPLKSRVWQTKShALKVIAATWCLSFTIMLPyPIYSNLVPFTRINNSTGNMCRLLWPNDVTQQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCY----LQVWLAIRAVAkqqkesestqkAEKEVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15978   167 SWYIFLLLILFLIPGIVMMTAYglisLELYRGIKFLM-----------AKKRVIRMLIVIVILFFLCWTPIFSANAWRAF 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 294 HPGYAFHPLVAALPAY---FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15978   236 DTRSADRLLSGAPISFihlLSYTSACVNPIIYCFMNKRFR 275
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
60-330 7.47e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 67.72  E-value: 7.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYG-YFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15052     7 LLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTLDVLFCT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAP-PIFGWsrywphgLKTScgpDVFS-GSSYPG 215
Cdd:cd15052    87 ASIMHLCTISLDRYMAIRYPLRTRRNKSRtTVFLKIAIVWLISIGISSPiPVLGI-------IDTT---NVLNnGTCVLF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCIVPLSVIVLCYLqvwLAIRAVAKQQKESEstqkaekevtrmvVVMILAYCF--CWGPYAFFACFAAA 293
Cdd:cd15052   157 NPNFVIYGSIVAFFIPLLIMVVTYA---LTIRLLSNEQKASK-------------VLGIVFAVFviCWCPFFITNILTGL 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1375379927 294 --HPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15052   221 ceECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
60-330 1.06e-12

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 67.65  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYT-VSLCgI 138
Cdd:cd15314     7 LGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFdITLC-T 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFG----WSRYWPHglKTSCGPDVFSGSSY 213
Cdd:cd15314    86 ASILNLCFISIDRYYAVCQPLLyRSKITVRVVLVMILISWSVSALVGFGIIFLelniKGIYYNH--VACEGGCLVFFSKV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMttcciVPLSVIVLCYLQVWLairaVAKQQ---------KESESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15314   164 SSVVGSVFSFY-----IPAVIMLCIYLKIFL----VAQRQarsiqsartKSGASSSKMERKATKTLAIVMGVFLLCWTPF 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 285 AFFACFAaahP--GYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15314   235 FLCNIID---PfiNYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFR 279
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
63-332 1.45e-12

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 67.13  E-value: 1.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15333    14 ITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASIL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWER-WLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSC--GPDVFSGSSYPGVQSY 219
Cdd:cd15333    94 HLCVIALDRyWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQAKAEEEVSECvvNTDHILYTVYSTVGAF 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIvlmttccivPLSVIVLCYLQVWLAIRAvakqqkesestqkAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP-GYA 298
Cdd:cd15333   173 YI---------PTLLLIALYGRIYVEARA-------------RERKATKTLGIILGAFIVCWLPFFIISLVLPICKdACW 230
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 299 FHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15333   231 FHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQA 264
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
64-330 1.87e-12

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 66.45  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  64 VIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWS 143
Cdd:cd15325    11 ILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 144 LAIISWERWLVVCKPfgnMRFDA----KLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGlKTSCgpdvfSGSSYPGvqsY 219
Cdd:cd15325    91 LCIISIDRYIGVSYP---LRYPSimteRRGLLALLCVWVLSLVISIGPLFGWKEPAPED-ETIC-----QITEEPG---Y 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAF 299
Cdd:cd15325   159 ALFSALGSFYLPLAIILVMYCRVYVVALKFSR-----------EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKP 227
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1375379927 300 HPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15325   228 SDTVFKITFWLGYFNSCINPIIYPCSSQEFK 258
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
61-337 2.00e-12

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 66.90  E-value: 2.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15307     8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIFGWSRYwPHGLktscgpdVFSGSSYPGVQS 218
Cdd:cd15307    88 IMHLCTISVDRYLSLRYPmrFGRNKTRRRVTLK-IVFVWLLSIAMSLPLSLMYSKD-HASV-------LVNGTCQIPDPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCCIVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd15307   159 YKLVGSIVCFYIPLGVMLLTYC---LTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECE 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 299 FH--PLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLF 337
Cdd:cd15307   236 ERisHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
61-330 2.62e-12

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 66.78  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15396     8 SVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGnMRFDAKLAIAGITFSWVWSAVWTAPpIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYM 220
Cdd:cd15396    88 IFSLVLIAIERYQLIVNPRG-WKPSASHAYWGIVLIWLFSLMISIP-FLIFHQLTDEPFRNLSSHSDFYKDKVVCIEAWP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IV----LMTTCCIV-----PLSVIVLCYLQVWLAIR---AVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFA 288
Cdd:cd15396   166 SEterlIFTTSLLVfqyfvPLGFIFICYLKIFVCLKkrnSKIDRMRENESRLSENKRINTMLISIVVTFAACWLPLNIFN 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 289 CFAAAHPGYAF---HPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15396   246 VVFDWNHEVLMschHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
62-330 2.72e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 66.59  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15389     9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWS----RYWPHGLKTSCGPDvfsgssYPGVQ 217
Cdd:cd15389    89 LTLTAIALDRHRVILHPL-KPRITPCQGVVVIAIIWIMASCLSLPHAIYQKlvefEYSNERTRSRCLPS------FPEPS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 ---SYMIVLMTTCC--IVPLSVIVLCYLQV----WL--AIRAVAKQQKESEstQKAEKEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15389   162 dlfWKYLDLATFILqyVLPLLIIGVAYTRVakklWLrnAIGDVTTEQYVAQ--RRKKKKTIKMLMLVVLLFAICWLPLNC 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 287 FACFAAAHPG-------YAFHplvaalpaYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15389   240 YHVLLSSHPIrsnsalfFAFH--------WLAMSSTCYNPFIYCWLNDSFR 282
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
57-330 3.87e-12

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 65.85  E-value: 3.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15213     4 AILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKpfgnmRFD------AKLAIAGitfSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpdVFSG 210
Cdd:cd15213    84 VLEGVAILLIISVDRYLIIVQ-----RQDklnphrAKILIAV---SWVLSFCVSFPPLVGWGKYEFPPRAPQC---VLGY 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKESESTqkaekevtrmVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15213   153 TESPADRIYVVLLLVAVFFIPFLIMLYSYFCI---LNTVRSFKTRAFTT----------ILILFIGFSVCWLPYTVYSLL 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 291 A----AAHPGYAFHPLVAALpAYFaKSAtiYNPIIYVFMNRQFR 330
Cdd:cd15213   220 SvfsrYSSSFYVISTCLLWL-SYL-KSA--FNPVIYCWRIKKFR 259
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
62-330 3.87e-12

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 66.11  E-value: 3.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd16003     9 FVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPP-IFGWSRYWPHglKTSCGPdVFSGSSYPGVQSYM 220
Cdd:cd16003    89 YSMTAIAVDRYMAIIDPL-KPRLSATATKVVIGSIWILAFLLAFPQcLYSKTKVMPG--RTLCFV-AWPGGPDQHFTYHI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCCIvPLSVIVLCYLQVWLAIRAVAKQQKESESTQ---KAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP-- 295
Cdd:cd16003   165 IVIVLVYCL-PLLVMGITYTIVGITLWGGEIPGDTSDKYHeqlRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQql 243
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 296 ---GYAFHPLVAALpaYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd16003   244 nrwKYIQQVYLASF--WLAMSSTMYNPIIYCCLNKRFR 279
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
62-330 3.93e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 65.68  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIAsVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15326    10 FILFA-IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGN----MRFDAKLAIAGItfsWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15326    89 LSLCAISIDRYIGVRHSLQYptivTRKRAILALLGV---WVLSTVISIGPLLGWKEPAPPDDKVCEITEEPFYALFSSLG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIvlmttccivPLSVIVLCYLQVWLAIRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPYAFF----ACFAAA 293
Cdd:cd15326   166 SFYI---------PLIVILVMYCRVYIVALKFSR-----------EKKAAKTLGIVVGMFILCWLPFFIAlplgSLFSHL 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 294 HPGYAFHPLVAALpAYFaksATIYNPIIYVFMNRQFR 330
Cdd:cd15326   226 KPPETLFKIIFWL-GYF---NSCLNPIIYPCSSKEFK 258
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
62-333 4.94e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 65.54  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15012     8 LVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFGWSRY-WPHGLKTSCGPDVFSGSSYPGVQSY 219
Cdd:cd15012    88 GILVVISVERYIAILHPLRCKQlLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVeILVTQDGQEEEICVLDREMFNSKLY 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIravakqqkESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA- 298
Cdd:cd15012   168 DTINFIVWYLIPLLIMTVLYSKISIVL--------WKSSSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYRc 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 299 ---FHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15012   240 dsnWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-330 5.78e-12

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 65.66  E-value: 5.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd16002    10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWsAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIV 222
Cdd:cd16002    90 SMTAIALDRYMAIIHPL-QPRLSATATKVVICVIWVL-AFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKYETVYHVC 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 223 LMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQK---AEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAF 299
Cdd:cd16002   168 VTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEqvsAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYE 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 300 HPLVAAL---PAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd16002   248 QKFIQQVylaIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
55-331 6.74e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 65.53  E-value: 6.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPL-NWILVNLAVADLAETIIASTISVVNQIYGYFVLGHpLCIVEGYTV 133
Cdd:cd15057     2 ITGCILYLLVLLTLLGNALVIAAVLRFRHLRSKVtNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPI-FGWSR----YWPHGLKTSCGPDV 207
Cdd:cd15057    81 IMCSTASILNLCVISVDRYWAISSPFRyERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRaddtSEALALYADPCQCD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 FSGSsypgvQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--------------QKESESTQKAEKEVTRMVVVM 273
Cdd:cd15057   161 SSLN-----RTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRiaaleraaqestnpDSSLRSSLRRETKALKTLSII 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 274 ILAYCFCWGPYAFFACFAAAHPGYAFHPLVAALPAY-----FAKSATIYNPIIYVFmNRQFRN 331
Cdd:cd15057   236 MGVFVCCWLPFFILNCVLPFCDLRTAQFPCVPDTTFivfvwLGWANSSLNPIIYAF-NADFRK 297
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
63-330 8.58e-12

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 64.61  E-value: 8.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC--IVEGYTVSLCgITG 140
Cdd:cd15310    10 LILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICcdVFVTLDVMMC-TAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKP----FGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrywphglkTSCGPDVFSGSSypgv 216
Cdd:cd15310    89 ILNLCAISIDRYTAVVMPvhyqHGTGQSSCRRVSLMITAVWVLAFAVSCPLLFGFN--------TTGDPTVCSISN---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIravakqqkesestqKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPG 296
Cdd:cd15310   157 PDFVIYSSVVSFYLPFGVTLLVYVRIYVVL--------------LREKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQA 222
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15310   223 CHVPPELYSATTWLGYVNSALNPVIYTTFNIEFR 256
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
55-331 9.07e-12

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 65.00  E-value: 9.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTV 133
Cdd:cd14997     2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpWLLGEFMCKLVPFVE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAP----PIFGWSRYWPHGLKTSCGPDVF 208
Cdd:cd14997    82 LTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALiWLLALLTSSPvlfiTEFKEEDFNDGTPVAVCRTPAD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSypgvQSYMIVLMTTCCIVPLSVIVLCYLQ-----VWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGP 283
Cdd:cd14997   162 TFWK----VAYILSTIVVFFVVPLAILSGLYSVicrrlVGHPALESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLP 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 284 YAFFACFAAahpgYAFHPLVAALPA-------YFAK------SATiyNPIIYVFMNRQFRN 331
Cdd:cd14997   238 FRVVTLWII----FAPDEDLQALGLegylnllVFCRvmvylnSAL--NPILYNLMSTKFRS 292
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
61-330 1.06e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 64.62  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd14972     6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLAS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPF---GNM-RFDAKLAIAgitFSWVWSAVWTAPPIFGWSRYWPhgLKTSCGPdVFSGSSYpgv 216
Cdd:cd14972    85 AYSLLAIAVDRYISIVHGLtyvNNVtNKRVKVLIA---LVWVWSVLLALLPVLGWNCVLC--DQESCSP-LGPGLPK--- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 qSYmIVLMTTCCIVPLSVIVLCYLQV-WLAIRAVAKQQKESESTQKAEKEVTR--MVVVMILAYCF--CWGPYAFFACFA 291
Cdd:cd14972   156 -SY-LVLILVFFFIALVIIVFLYVRIfWCLWRHANAIAARQEAAVPAQPSTSRklAKTVVIVLGVFlvCWLPLLILLVLD 233
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1375379927 292 AAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd14972   234 VLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMR 272
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
63-330 1.10e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 64.84  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYtVSLCGIT-GL 141
Cdd:cd15395    10 VIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSM-VQCISITvSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGnMRFDAKLAIAGITFSWVWsAVWTAPPIFGWSRYWPHGLKT-SCGPDVFSG-----SSYPG 215
Cdd:cd15395    89 FSLVLIAIERHQLIINPRG-WRPNNRHAYVGIAVIWVL-AVLTSLPFLIFQVLTDEPFKNvNVSLDAYKGkyvclDQFPS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQ---SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRA---VAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15395   167 DTirlSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRrnnMMDKMRDNKYRSSETKRINIMLISIVVAFAVCWLPLNIFNA 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 290 FA-AAHPGYA--FHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15395   247 VFdWNHEAIAtcNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
61-331 1.12e-11

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 64.56  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC----IVEGYTVSlc 136
Cdd:cd15207    10 IFLL--CVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCklspLVQGVSVA-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 giTGLWSLAIISWERWLVVCKPFGNmRFDAKLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTScGPDVFSGSSYPGV 216
Cdd:cd15207    86 --ASVFTLVAIAVDRYRAVVHPTEP-KLTNRQAFVIIVAIWVLALAIMIPQAL-VLEVKEYQFFRG-QTVHICVEFWPSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 ---QSYMIVLMTTCCIVPLSVIVLCYLQVWLAI------RAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFF 287
Cdd:cd15207   161 eyrKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLwfkpvpGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTV 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 288 A--------CFAAAHPGYAFHPLVAALPAYFAKSAtiyNPIIYVFMNRQFRN 331
Cdd:cd15207   241 TmlddfgnlSPNQREVLYVYIYPIAHWLAYFNSCV---NPIVYGYFNRNFRK 289
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
61-331 1.65e-11

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 64.27  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVviASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIA--STISVVNQIYGYfVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15134    10 IFV--TGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGlpFELYTIWQQYPW-VFGEVFCKLRAFLSEMSSY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVwTAPPIFGWSR--YWPHGL-KTSCGPDV-FSGSSY 213
Cdd:cd15134    87 ASVLTITAFSVERYLAICHPLrSHTMSKLSRAIRIIIAIWIIAFV-CALPFAIQTRivYLEYPPtSGEALEESaFCAMLN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCC--IVPLSVIVLCYLQVWLAIRAVAKQQKESEST------QKAEKEVTRMVVVMILAYCFCWGPYA 285
Cdd:cd15134   166 EIPPITPVFQLSTFLffIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVsggrrsSQSRRTVLRMLVAVVVAFFICWAPFH 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 286 FFACFAAAHPGYAFHPLVAALPAYFAK------SATIyNPIIYVFMNRQFRN 331
Cdd:cd15134   246 AQRLLTVYAKNMTPPYLFINRILFYISgvlyyvSSTV-NPILYNVMSAKYRQ 296
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
61-331 1.82e-11

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 64.19  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVnqIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15068     8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWP----HGLKTSCGPDVFSGSSYPG 215
Cdd:cd15068    86 IFSLLAIAIDRYIAIRIPLRyNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQpkegKNHSQGCGEGQVACLFEDV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 V-QSYMIVL-MTTCCIVPLSVIVLCYLQVWLAIRAVAKQQK-------ESESTQKAEKEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15068   166 VpMNYMVYFnFFACVLVPLLLMLGVYLRIFLAARRQLKQMEsqplpgeRARSTLQKEVHAAKSLAIIVGLFALCWLPLHI 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1375379927 287 FACFAAAHPGYAFHPL-VAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15068   246 INCFTFFCPDCSHAPLwLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
60-331 2.11e-11

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 63.52  E-value: 2.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY-GYFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15053     7 LLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIFG--WSRYWPHGLKTSCGPDVFSGSSypg 215
Cdd:cd15053    87 ASIFNLCAISIDRYIAVTQPIKYARQkNSKRVLLTIAIVWVVSAAIACPLLFGlnNVPYRDPEECRFYNPDFIIYSS--- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIvlmttccivPLSVIVLCYLQVWLAIRavakqqkesestqkAEKEVTRMVVVMILAYCFCWGPYA---------F 286
Cdd:cd15053   164 ISSFYI---------PCIVMLLLYYRIFRALR--------------REKKATKTLAIVLGVFLFCWLPFFtlnilnaicP 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 287 FACFAAAHPGyaFHPLVAALPAYFAKSATiyNPIIYVFMNRQFRN 331
Cdd:cd15053   221 KLQNQSCHVG--PALFSLTTWLGYVNSFL--NPIIYTIFNIEFRK 261
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
58-332 2.20e-11

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 63.86  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  58 AWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVvNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15090     5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGNILCKIVISIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITF-SWVWSAVWTAPPIFGWSRYWPHGLkTSCGPdVFSGSSYPGV 216
Cdd:cd15090    84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVcNWILSSAIGLPVMFMATTKYRQGS-IDCTL-TFSHPSWYWE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTRMVVVMILAYCFCWGP--YAFFACFAAAH 294
Cdd:cd15090   162 NLLKICVFIFAFIMPVLIITVCYGLMILRLKSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPihIYVIIKALVTI 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 295 PGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15090   241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 278
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
60-330 2.54e-11

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 63.71  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVV-IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVAD----LAETIIASTISVVnqiygYFVLGHPLCIVEGYTVS 134
Cdd:cd15971     6 IYFVVcIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADelfmLGLPFLAIQVALV-----HWPFGKAICRVVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITfswvwSAVWTAP-----PIFGWSRYWPHGLKTSCGPdVFS 209
Cdd:cd15971    81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMIN-----MAVWGVSllvilPIMIYAGVQTKHGRSSCTI-IWP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESEStQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15971   155 GESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKR-KKSEKKVTRMVSIVVAVFVFCWLPFYIFNV 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 290 FAAAHpGYAFHPLVAALPAY---FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15971   234 SSVSV-SISPTPGLKGMFDFvvvLSYANSCANPILYAFLSDNFK 276
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
55-331 3.48e-11

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 63.05  E-value: 3.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTV 133
Cdd:cd15328     2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWT-APPIFGWSRYWPHGLKTScgpdvfSGS 211
Cdd:cd15328    82 VLCCTASIWNVTAIALDRYWSITRHLEyTLRTRRRISNVMIALTWALSAVISlAPLLFGWGETYSEDSEEC------QVS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPgvqSYMIVLMTTCCIVPLSVIVLCYLQVWLAiravakqqkesesTQKaEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15328   156 QEP---SYTVFSTFGAFYLPLCVVLFVYWKIYKA-------------AQK-EKRAALMVGILIGVFVLCWIPFFLTELIS 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 292 AAhPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15328   219 PL-CSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNN 257
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
61-330 4.75e-11

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 62.86  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVAD----LAETIIASTISVVNQIYGYFvlghpLCIVegyTVSLC 136
Cdd:cd15093     8 AVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADelfmLGLPFLAASNALRHWPFGSV-----LCRL---VLSVD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GI---TGLWSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAPpIFGWSRYWPHGLKTSCGPDVFS 209
Cdd:cd15093    80 GInmfTSIFCLTVMSVDRYLAVVHPIKSARWRrprvAKVVNLAV---WVASLLVILP-VVVFAGTRENQDGSSACNMQWP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKeSESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15093   156 EPAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAG-WQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQL 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 290 FAAAHPG------YAFHPLVAALPayFAKSATiyNPIIYVFMNRQFR 330
Cdd:cd15093   235 VNVFVQLpetpalVGVYHFVVILS--YANSCA--NPILYGFLSDNFK 277
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
59-332 5.09e-11

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 62.83  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVVIasVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15197     8 WVLFVFI--VVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPfgnMRF--DAKLAIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLkTSCGPDVFSGSSYpg 215
Cdd:cd15197    86 ASTYVLVALSIDRYDAICHP---MNFsqSGRQARVLICVAWILSALFSIPmLIIFEKTGLSNGE-VQCWILWPEPWYW-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 vQSYMIVLMTTCCIVPLSVIVLCYL----QVWLA-------IRAVAKQQKESESTQ-----KAEKEVTRMVVVMILAYCF 279
Cdd:cd15197   160 -KVYMTIVAFLVFFIPATIISICYIiivrTIWKKskiqvtiNKAGLHDGSSRRSSSrgiipRAKIKTIKMTFVIVTVFII 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 280 CWGPYAFFACFAA------AHPGYAFHPLVAALPAYfaKSATiyNPIIY-VFMNRQFRNC 332
Cdd:cd15197   239 CWSPYFVFDLLDVfgllprSKTKIAAATFIQSLAPL--NSAI--NPLIYcLFSTHLCRPL 294
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
60-332 5.42e-11

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 62.66  E-value: 5.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADlaeTIIASTISVVNQIY--GYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15091     9 VVFVV--GLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD---ALVTTTMPFQSTVYlmNSWPFGDVLCKIVISIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFswvwsAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGS-SYPG- 215
Cdd:cd15091    84 FTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI-----CIWLLSSSVGISAIVLGGTKVREDVDSTECSlQFPDd 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCC-----IVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15091   159 DYSWWDTFMKICVfifafVIPVLIIIVCYTLMILRLKSV-RLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 291 AAAhpGYAFHPlVAALPAYFAKSATIY-----NPIIYVFMNRQFRNC 332
Cdd:cd15091   238 EAL--GSVSHS-TAAVSSYYFCIALGYtnsslNPILYAFLDENFKRC 281
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
60-284 6.79e-11

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 62.46  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIY-GYFVLGHPLCIVEGYT--VSL- 135
Cdd:cd15158     9 VITVF--GLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLL-CVCTLPLRVVYYVHkGQWLFGDFLCRISSYAlyVNLy 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 136 CGItglWSLAIISWERWLVVCKPFGNMRF----DAKLAIAGItfsWVWSAVwTAPPIFGWSRYWPHGLKTSCgpdvFSGS 211
Cdd:cd15158    86 CSI---YFMTAMSFTRFLAIVFPVQNLNLvtvkKARIVCVGI---WIFVTL-TSSPFLMSGSHDTETNKTKC----FEPP 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375379927 212 SYPGVQSYMIVL----MTTCCIVPLSVIVLCY-LQVWLAIRAVAKQQKESESTQKAekevTRMVVVMILAYCFCWGPY 284
Cdd:cd15158   155 QSNQQLTKLLVLnyisLVVGFIIPFLVILICYaMIIRTLLKNTMKARKQQSSRKKA----IRMIIIVLLAFLVSFMPY 228
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
61-330 7.49e-11

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 62.01  E-value: 7.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14985    10 IFLV--GLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLV-FVLTLPLWATYTANQYdWPFGAFLCKVSSYVISVNMFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAPPIFGWS-RYWPHGLKTSCGPDvFSGSSYP 214
Cdd:cd14985    87 SIFLLTCMSVDRYLAIVHPVASRRLRrrrqARVTCALI---WVVACLLSLPTFLLRSlQAIENLNKTACIML-YPHEAWH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTccIVPLSVIVLCYLQVWLAIRAVAKQQKESestQKAEKEVTRMVVVMILAYCFCWGPYAFFAC----- 289
Cdd:cd14985   163 FGLSLELNILGF--VLPLLIILTCYFHIARSLRKRYERTGKN---GRKRRKSLKIIFALVVAFLVCWLPFHFFKFldfla 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 290 ---FAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd14985   238 qlgAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
61-332 8.42e-11

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 61.57  E-value: 8.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFT---NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC---IVEGYTVS 134
Cdd:cd15049     5 IATGSLSLVTvggNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCdlwLALDYVAS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGlwsLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWsrywphglktscgPDVFSGSSY 213
Cdd:cd15049    85 NASVMN---LLLISFDRYFSVTRPLTyRAKRTPKRAILMIALAWVISFVLWAPAILGW-------------QYFVGERTV 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVL----MTTCCIV-----PLSVIVLCYLQVWLAIRavakqqkesestqkAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15049   149 PDGQCYIQFLddpaITFGTAIaafylPVLVMTILYWRIYRETA--------------RERKAARTLSAILLAFIITWTPY 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375379927 285 AFFACFAAAHPGYAfhPLVAALPAYFAK--SATIyNPIIYVFMNRQFRNC 332
Cdd:cd15049   215 NILVLVSTFCAKCI--PDTLWSFGYWLCyiNSTI-NPFCYALCNKTFRKT 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
61-330 1.15e-10

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 61.87  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIyGYFVLGHPlCIVEGYTVSLCGITG 140
Cdd:cd15069     8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL-GFCTDFHS-CLFLACFVLVLTQSS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRY----------WPHGLKTSCgpdVFS 209
Cdd:cd15069    86 IFSLLAVAVDRYLAIKVPLRyKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAmsatnnstnpADHGTNHSC---CLI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGV--QSYMIVL-MTTCCIVPLSVIVLCYLQVWL-AIRAVAKQQKESESTQKAEKEV--TRMVVVMILAYCFCWGP 283
Cdd:cd15069   163 SCLFENVvpMSYMVYFnFFGCVLPPLLIMLVIYIKIFLvACRQLQRTELMDHSRTTLQREIhaAKSLAIIVGIFALCWLP 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 284 YAFFACFAAAHPGYA-FHPLVAALPAYFAKSA-TIYNPIIYVFMNRQFR 330
Cdd:cd15069   243 VHILNCITLFQPEFSkSKPKWAMNVAILLSHAnSVVNPIVYAYRNRDFR 291
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
61-330 1.39e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 61.36  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIyGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15974     8 LLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAI-SYWPFGSFLCRLVMTVDGVNQFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAPPIFgWSRYWPHGlkTSCGpdvfsgSSYP-- 214
Cdd:cd15974    87 IFCLTVMSIDRYLAVVHPIKSTKWRrprvAKLINATV---WTLSFLVVLPVII-FSDVQPDL--NTCN------ISWPep 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 -GVQSYMIVLMTTCC--IVPLSVIVLCYLQVWLAIRAvAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15974   155 vSVWSTAFIIYTAVLgfFGPLLVICLCYLLIVIKVKS-SGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVN 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 292 aahpgyafhpLVAALP-------AYFAKSATIY-----NPIIYVFMNRQFR 330
Cdd:cd15974   234 ----------LIVILPeepafvgVYFFVVVLSYanscaNPILYGFLSDNFK 274
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
61-330 1.47e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 61.10  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15304     8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAP-PIFgwsrywphGLKTSCgpDVF-SGSSYPGV 216
Cdd:cd15304    88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTkAFLKIIAVWTISVGISMPiPVF--------GLQDDS--KVFkEGSCLLAD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYlqvWLAIRAVakqQKESESTQKAEKevtrMVVVMILAYCFCWGPYAFFACFAAAHPG 296
Cdd:cd15304   158 ENFVLIGSFVAFFIPLTIMVITY---FLTIKSL---QQSISNEQKASK----VLGIVFFLFVVMWCPFFITNVMAVICKE 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 297 YAFHPLVAALPAYF---AKSATIYNPIIYVFMNRQFR 330
Cdd:cd15304   228 SCNEVVIGGLLNVFvwiGYLSSAVNPLVYTLFNKTYR 264
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
57-330 1.68e-10

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 61.09  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15321    10 AAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIF--GWSRYWPHGLKTSCGPDvfsgss 212
Cdd:cd15321    90 CTSSIVHLCAISLDRYWSVSRAieYNSKRTPRRIKCI-ILIVWLIAAVISLPPLIykGKQKDEQGGLPQCKLNE------ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 ypgvQSYMIVLMTTCC-IVPLSVIVLCYLQVWLairaVAKQQkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15321   163 ----EAWYILSSSIGSfFAPCLIMILVYLRIYL----IAKNR---------EKRFTFVLAVVIGVFVLCWFPFFFSYSLG 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 292 AAHPGYAFHP-LVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15321   226 AICPELCKVPhSLFQFFFWIGYCNSSLNPVIYTIFNQDFR 265
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
60-331 1.74e-10

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 61.11  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRfKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHP-----LCIVEGYTVS 134
Cdd:cd14978     7 LPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSyfyayFLPYIYPLAN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRF----DAKLAIAGITFSwvwSAVWTAPPIFGW----SRYWPHGLKTSCGPD 206
Cdd:cd14978    86 TFQTASVWLTVALTVERYIAVCHPLKARTWctprRARRVILIIIIF---SLLLNLPRFFEYevveCENCNNNSYYYVIPT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 207 VFSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAK-------QQKESESTQKAEKEVTRMVVVMILAYCF 279
Cdd:cd14978   163 LLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKrrrllrrRRRLLSRSQRRERRTTIMLIAVVIVFLI 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 280 CWGPYAFFACFAAAHPGYAFHPLVAALPA-----YFAKSATiyNPIIYVFMNRQFRN 331
Cdd:cd14978   243 CNLPAGILNILEAIFGESFLSPIYQLLGDisnllVVLNSAV--NFIIYCLFSSKFRR 297
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
63-332 2.44e-10

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 60.73  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETiiaSTISVVNQIY--GYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15089    10 VCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALAT---STLPFQSAKYlmETWPFGELLCKAVLSIDYYNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRF--DAKLAIAGITFsWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS 218
Cdd:cd15089    87 IFTLTMMSVDRYIAVCHPVKALDFrtPAKAKLINICI-WVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWYWDTVT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCcIVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd15089   166 KICVFIFAF-VVPILVITVCYGLMILRLRSV-RLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDR 243
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 299 FHPLVAA---LPAYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15089   244 RNPLVVAalhLCIALGYANSSLNPVLYAFLDENFKRC 280
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
61-330 2.55e-10

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 60.31  E-value: 2.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIAsVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15327     9 IFILMA-IVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVV--CKPFGNMRFDAKlAIAGITFSWVWSAVWTAPPIFGWSRYWPhglktscgPD--VFSGSSYPGv 216
Cdd:cd15327    88 ILSLCVISVDRYVGVkhSLKYPTIMTERK-AGVILVLLWVSSMVISIGPLLGWKEPPP--------PDesICSITEEPG- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 qsYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQqkesestQKAEKEVTRMVVVMILaycfCWGPYAFFACFAAAHPG 296
Cdd:cd15327   158 --YALFSSLFSFYLPLMVILVMYFRVYVVALKFSRE-------KKAAKTLAIVVGVFIL----CWFPFFFVLPLGSFFPA 224
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15327   225 LKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFK 258
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
61-330 2.81e-10

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 60.59  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYgYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15972     8 LVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALS-YWPFGSFMCRLVMTVDAINQFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIFGwsrywphglktscgPDVFSGSSYPGVQ-- 217
Cdd:cd15972    87 IFCLTVMSVDRYLAVVHPIRSSKWrKPPVAKTVNATVWALSFLVVLPVVIF--------------SGVPGGMGTCHIAwp 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 --------SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ-QKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFA 288
Cdd:cd15972   153 epaqvwraGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRvRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALN 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 289 CFAAAHPG------YAFHPLVAALPayFAKSATiyNPIIYVFMNRQFR 330
Cdd:cd15972   233 IVNLVCPLpeepslFGLYFFVVVLS--YANSCA--NPIIYGFLSDNFK 276
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
63-331 2.89e-10

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 60.60  E-value: 2.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15399    10 IILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFGNmRFDAKLAIAGITFSWVWSAVWTAP-PIFGWSRY--WPHGLKTSCGPDVFSGSSYPGVQSY 219
Cdd:cd15399    90 TLTVIALDRHRCIVYHLES-KISKKISFLIIGLTWAASALLASPlAIFREYSVieISPDFKIQACSEKWPNGTLNDGTIY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP---G 296
Cdd:cd15399   169 SVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLASDIDSkvlD 248
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15399   249 LKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRT 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
54-284 4.79e-10

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 59.64  E-value: 4.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLA-----ETIIASTISVVNQIYGYFvlghpLCIV 128
Cdd:cd15168     1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLyllslPFLIYYYANGDHWIFGDF-----MCKL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 129 EGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFD-AKLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSCGpDV 207
Cdd:cd15168    76 VRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLkKRHAVAISVAVWILVLLQLLPILF-FATTGRKNNRTTCY-DT 153
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 208 FSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAekevTRMVVVMILAYCFCWGPY 284
Cdd:cd15168   154 TSPEELNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKS----IRLVIIVLALFAVCFLPF 226
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
60-330 5.36e-10

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 59.53  E-value: 5.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15305     7 ILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYaWPLPRYLCPIWISLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSCgpdVFSGSSYPGV 216
Cdd:cd15305    87 ASIMHLCAISLDRYVAIRNPIEHSRFNSRTkAMMKIAAVWTISIGISMPiPVIGLQDDEKVFVNGTC---VLNDENFVLI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLmttcciVPLSVIVLCYLqvwLAIRAVAKQQkesesTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPG 296
Cdd:cd15305   164 GSFVAFF------IPLIIMVITYC---LTIQVLQRQQ-----AINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKE 229
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 297 YAFHPLVAALPAYFAKSATI---YNPIIYVFMNRQFR 330
Cdd:cd15305   230 ACDQKLMEELLNVFVWVGYVssgINPLVYTLFNKTYR 266
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
60-330 5.64e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 59.45  E-value: 5.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFT------NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15301     1 VLIVIVAAVLSlvtvggNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWsrywphglktscgPDVFSGSS 212
Cdd:cd15301    81 YLASNASVLNLLIISFDRYFSVTRPLTyRARRTTKKAAVMIASAWIISLLLWPPWIYSW-------------PYIEGKRT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGVQSYMIVLMTTCCI----------VPLSVIVLCYLQVWlaiRAVAKQQKesestqKAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15301   148 VPAGTCYIQFLETNPYVtfgtalaafyVPVTIMCILYWRIW---RETKKRQK------KQESKAAKTLSAILLAFIVTWT 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 283 PYAFFACFAaahpgyAFHPLVAALPAYFAK--------SATIyNPIIYVFMNRQFR 330
Cdd:cd15301   219 PYNVLVLIK------AFFPCSDTIPTELWDfsyylcyiNSTI-NPLCYALCNAAFR 267
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
61-330 7.76e-10

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 59.11  E-value: 7.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15357    10 IFVV--GVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYpFLFGPVGCYFKTALFETVCFA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVWTAPpifgwsRYWPHGLKTSCGPDvfsGSSYPGVQS 218
Cdd:cd15357    88 SILSVTTVSVERYVAILHPFrAKLNSTRERALKIIVVLWVLSVLFSIP------NTSIHGIKLQYFPN---GTLIPDSAT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 ---------YMIVLMTTCC---IVPLSVIVLCYLQVWLAIRAVAKQQKESEST---QKAEKEVTRMVVVMILAYCFCWGP 283
Cdd:cd15357   159 ctvvkplwiYNLIIQITSLlfyVLPMGVISVLYYLMGLKLRGDKSLEADEMNVniqRPSRKSVTKMLFVLVLVFAICWAP 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 284 YAF-----FACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15357   239 FHVdrlffSFVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
52-333 9.62e-10

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 58.72  E-value: 9.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  52 VYHLTSAWMIFVVIASVFtnglVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGY 131
Cdd:cd15318     3 IYLACAIGMLIIVLGNLF----VVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTC 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVWTAppIFGWSRYWPHGLKTSCGPDVFSG 210
Cdd:cd15318    79 LDTLFCLTSIFHLCFISIDRHCAICDPLlYPSKFTIRVACIFIAAGWLVPTVYTS--VFLYTKAVEEGLAELLTSVPCVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAI----RAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15318   157 SCQLLYNKLWGWLNFPVFFIPCLIMIGLYVKIFIVAkrqaRAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTI 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 287 FACFAAAHpGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15318   237 DTMVDSLL-NFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
62-330 1.58e-09

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 58.32  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd16004     9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMI 221
Cdd:cd16004    89 YSMTAIAADRYMAIIHPF-KPRLSAGSTKVVIAGIWLVALALAFPQCF-YSTVTMDQGRTKCIVAWPGDSGGKHQLTYHL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 222 VLMTTCCIVPLSVIVLCYLQVWLAI--RAVAKQQKESE--STQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPG- 296
Cdd:cd16004   167 AVIVLIYLLPLAVMFVTYSIIGITLwrSAVPGHQAHGAyhRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDi 246
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1375379927 297 YAFHPLVAALPAYF--AKSATIYNPIIYVFMNRQFR 330
Cdd:cd16004   247 YCQKYIQQVYLAIFwlAMSSTMYNPIIYCCLNQRFR 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
63-331 1.68e-09

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 58.21  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15397    10 VMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFG--NMRFDAKLAIAGItfsWVWSAVWTAP----------PIFGWSRYW-PHGLKTSCgPDVFS 209
Cdd:cd15397    90 SLVLIALERHQLIINPTGwkPSVSQAYLAVVVI---WMLACFISLPflafhiltdePYKNLSHFFaPLADKAVC-TESWP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCivPLSVIVLCYLQVWLAIRAVAK--QQKESESTQKAE-KEVTRMVVVMILAYCFCWGPYAF 286
Cdd:cd15397   166 SEHHKLAYTTWLLLFQYCL--PLLFILVCYLRIYLRLRRRKDmlERRGEYNRRAGHsKRINVMLVSLVAAFALCWLPLNV 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 287 FACFAAAHPG---YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15397   244 FNAIADWNHEaipHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
57-337 1.71e-09

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 57.91  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15295     4 LFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrYWPHGlKTSCGPDVFSGSSYP 214
Cdd:cd15295    84 CTASVYNIVLISYDRYQSVSNAvsYRNQQTATLRIVTQMVAVWVLAFLVHGPAILVSD-SWKTE-DGECEPEFFSNWYIL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTCCIVPLSVIVlcYLQVWLAIRAvakqqkesestqkaeKEVTRMVVVMILAYCFCWGPYAFFA---CFA 291
Cdd:cd15295   162 AITSVLEFLVPVILVAYFNTQI--YWSLWKRLRD---------------RKLAKSLAIILGTFAICWAPYSLFTiirAAC 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1375379927 292 AAHPGYAFHPLVAALPAYfaksATIYNPIIYVFMNRQFRNCILQLF 337
Cdd:cd15295   225 EKHRGSPWYNFAFWLQWF----NSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
59-331 1.92e-09

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 57.99  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL--AETIIASTISVVNQiygyFVLGHPLC-IVEG-YTVS 134
Cdd:cd14984     8 SLVFLL--GLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLlfVLTLPFWAVYAADG----WVFGSFLCkLVSAlYTIN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LcgITGLWSLAIISWERWLVVCKPFGNMRfDAKLAIAGITFSWVWS-AVWTAPPIFGWSRYWPHGLKTSCGPDvFSGSSY 213
Cdd:cd14984    82 F--YSGILFLACISIDRYLAIVHAVSALR-ARTLLHGKLTCLGVWAlALLLSLPEFIFSQVSEENGSSICSYD-YPEDTA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCC-IVPLSVIVLCYLQVwlaIRAVAKQQkeSESTQKAekevTRMVVVMILAYCFCWGPYAFFACFAA 292
Cdd:cd14984   158 TTWKTLLRLLQNILGfLLPLLVMLFCYSRI---IRTLLRAR--NHKKHRA----LRVIFAVVVVFFLCWLPYNIVLLLDT 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375379927 293 AHPGYAFHPLVAA---LPayFAKSAT--------IYNPIIYVFMNRQFRN 331
Cdd:cd14984   229 LQLLGIISRSCELsksLD--YALQVTeslafshcCLNPVLYAFVGVKFRK 276
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
63-330 1.96e-09

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 57.50  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15062    10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKtSCGPDVFSGssypgvqsymI 221
Cdd:cd15062    90 SLCVISVDRYIGVRYPLNYPTIvTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQ-ACGVNEEPG----------Y 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 222 VLMTTCC--IVPLSVIVLCYLQVWLAIRAVAKQQKESEStqkaekevtrmVVVMILAYCFCWGPYAFFACFAAAHPGYAF 299
Cdd:cd15062   159 VLFSSLGsfYLPLAIILVMYCRVYVVAFKFSREKKAAKT-----------LGIVVGAFVLCWFPFFVVLPLGSLFSTLKP 227
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1375379927 300 HPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15062   228 PEPVFKVVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
62-330 2.22e-09

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 57.64  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTVSLCgITG 140
Cdd:cd15323     9 FLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCnIYLALDVLFC-TSS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWER-WLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRywphglktscGPDvfsGSSYP--GVQ 217
Cdd:cd15323    88 IVHLCAISLDRyWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYR----------DPE---GDVYPqcKLN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCC---IVPLSVIVLCYLQVWlairAVAKQQkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFaaah 294
Cdd:cd15323   155 DETWYILSSCIgsfFAPCLIMILVYIRIY----RVAKAR---------EKRFTFVLAVVMGVFVVCWFPFFFSYSL---- 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 295 pgYAFHPLVAALPAYFAK-------SATIYNPIIYVFMNRQFR 330
Cdd:cd15323   218 --YGICREACEVPEPLFKfffwigyCNSSLNPVIYTIFNQDFR 258
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-332 2.81e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 57.54  E-value: 2.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15133     9 LIFVV--GVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYpFLLGSGGCYFKTFLFETVCL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPfgnmrFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSY---PG 215
Cdd:cd15133    87 ASILNVTALSVERYIAVVHP-----LAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQCTvrkPQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCIV--PLSVI-VLCYLQ-VWLAIR----AVAKQQKESESTQKA------EKEVTRMVVVMILAYCFCW 281
Cdd:cd15133   162 AIYNMIPQHTGHLFFvlPMAVIsVLYLLMaLRLARErgldATGAGSKIGTRTGQLlqhprtRAQVTKMLFILVVVFAICW 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 282 GPY--------AFFACFAAAHPGYAFHPLVAALPAYFAKSAtiyNPIIYVFMNRQFRNC 332
Cdd:cd15133   242 APFhidrlmwsFISDWTDNLHEVFQYVHIISGVFFYLSSAV---NPILYNLMSTRFREM 297
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
56-330 2.90e-09

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 57.26  E-value: 2.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  56 TSAWMIFVVIASVFTNGLVLVATMRFKK-LRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15214     1 TESIAIIIIAILICLGNLVIVVTLYKKSyLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPF-GNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpdvfsGSSY 213
Cdd:cd15214    81 LISSASMLTLGAIAIDRYYAVLYPMvYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMC------VAAW 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAvakqqkesestQKAEKEVTrmVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15214   155 HKEAGYTAFWQVWCALLPFVVMLVCYGFIFRVARA-----------NQCKAFIT--ILVVLGAFVTTWGPYMVVISTEAL 221
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 294 HPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15214   222 WGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVR 258
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
62-330 3.15e-09

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 56.88  E-value: 3.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTVSLCgITG 140
Cdd:cd15322     9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCeIYLALDVLFC-TSS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFgwsrywphGLKTSCGPDVFSGSSYPGVQSY 219
Cdd:cd15322    88 IVHLCAISLDRYWSITQAIEyNLKRTPRRIKCIIFIVWVISAVISFPPLI--------TIEKKSGQPEGPICKINDEKWY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWlairAVAKQQkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAF 299
Cdd:cd15322   160 IISSCIGSFFAPCLIMVLVYIRIY----QIAKNR---------EKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCSVP 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1375379927 300 HPLVAALpAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15322   227 ETLFKFF-FWFGYCNSSLNPVIYTIFNHDFR 256
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
71-284 3.28e-09

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 57.43  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTVSLCGITGLwSLAIISW 149
Cdd:cd14977    18 NLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCkLVPFIQVTSLGVTVF-SLCALSI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 150 ERWLVVCKPF----GNMRFDAKLAIAGItfsWVWSAVWTAPPIFGWS----RYWPHGLKTSCGPDVFSG--SSYPGVQSY 219
Cdd:cd14977    97 DRYRAAVNSMpmqtIGACLSTCVKLAVI---WVGSVLLAVPEAVLSTvareSSLDNSSLTVCIMKPSTPfaETYPKARSW 173
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 220 MIVLMTTCciVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ-KAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd14977   174 WLFGCYFC--LPLAFTAVCYLLMARTLIRAAKEYTRGTKKHmKQRRQLAKTVLCLVLVFAFCWLPE 237
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
71-332 3.32e-09

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 56.93  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATmRFKKLRHPLNWILVNLAVADLAET--IIASTISVVNQIYGYFvlGHPLCIVEGYTVSLCGITGLWSLAIIS 148
Cdd:cd14974    18 NGLVIWVA-GFKMKRTVNTVWFLNLALADFLFClfLPFLIVYIAMGHHWPF--GSVLCKLNSFVISLNMFASVFLLTAIS 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 149 WERWLVVCKP-FGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVfsgSSYPGVQS--YMIVLMT 225
Cdd:cd14974    95 LDRCLLVLHPvWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCV---EDYDLRRSrhKALTVIR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 226 TCC--IVPLSVIVLCYLQVWLAIRA--VAKQQKESestqkaekevtRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFHP 301
Cdd:cd14974   172 FLCgfLLPLLIIAICYSVIAVKLRRkrLAKSSKPL-----------RVLLAVVVAFFLCWLPYHVFALLELVAAAGLPEV 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1375379927 302 LVAALPA----YFAKSatIYNPIIYVFMNRQFRNC 332
Cdd:cd14974   241 VLLGLPLatglAYFNS--CLNPILYVFMGQDFRKR 273
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
55-330 4.38e-09

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 56.74  E-value: 4.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRH--PLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYT 132
Cdd:cd14976     2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 133 VSLCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGS 211
Cdd:cd14976    82 TKLNMYSSIFFLTALSVTRYIAVARALKHGWiRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRFPKNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQSYMIVLMTTCCI----VPLSVIVLCYLqvwLAIRAVakqQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFF 287
Cdd:cd14976   162 SVTRWYNWLGMYQLQKVVlgffLPLGIITLSYL---LLLRFL---QRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQAL 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 288 A---------CFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd14976   236 SlwsalikfdDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFR 287
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
55-284 5.98e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 56.39  E-value: 5.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15215     1 IRSVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpDVFSGSSY 213
Cdd:cd15215    81 LFAFAGVNTIVVVSVDRYLAIIHPLSyPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALC--SVIWGSSY 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 214 pgvqSYMIVLMTTCCIVPLSVIVLCYlqvWLAIRAVAKQQkesestqkaEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15215   159 ----SYTILSVVSSFVLPVIIMLACY---SMVFRAARRCY---------HCKAAKVIFIIIFSYVLSMGPY 213
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
63-330 7.35e-09

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 56.02  E-value: 7.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVAD----LAETIIASTISVVNQIYGYfVLGHPLCIVEGYTVslcgI 138
Cdd:cd15973    10 VCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADelfmLSVPFLAASAALQHWPFGS-AMCRTVLSVDGINM----F 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAP-PIFGwsrywphGLKTSCGPDVFSGSSY 213
Cdd:cd15973    85 TSVFCLTVLSVDRYIAVVHPLRAARYRrptvAKMINICV---WILSLLVISPiIIFA-------DTATRKGQAVACNLIW 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PG-VQSYMIVLMTTCC--IVPLSVIVLCYLQVWLAIRAVAkQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15973   155 PHpAWSAAFVIYTFLLgfLLPVLAIGLCYILIIGKMRAVA-LKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLL 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 291 AAAHPGYAFHPLVAALPAYFAKSATiyNPIIYVFMNRQFR 330
Cdd:cd15973   234 NLFLPRLDATVNHASLILSYANSCA--NPILYGFLSDNFR 271
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
60-330 8.85e-09

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 55.65  E-value: 8.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15324     7 VVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTScgpdvfsgssypgvQS 218
Cdd:cd15324    87 SIVHLCAISLDRYWSVTKAVSyNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWECLLND--------------ET 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVlmtTCCIVPLSVIVLCYLQVWLAIRAVAKQQkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd15324   153 WYIL---SSCTVSFFAPGLIMILVYCKIYRVAKMR---------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRC 220
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1375379927 299 FHP-LVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15324   221 GIPdALFNLFFWIGYCNSSVNPIIYTIFNRDFR 253
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
55-330 1.07e-08

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 56.12  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPL-NWILVNLAVADLAETIIASTISVVNQIYGYFVLGhPLCIVEGYTV 133
Cdd:cd15319     2 VTGCLLSLLILWTLLGNILVCAAVVRFRHLRSKVtNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPI-FGWSRYWPH---GLKTSCGPDVF 208
Cdd:cd15319    81 IMCSTASILNLCVISVDRYWAISSPFRYERkMTQRVALVMISVAWTLSVLISFIPVqLNWHKDSGDdwvGLHNSSISRQV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGV-QSYMIVLMTTCCIVPLSVIVLCYLQVW----LAIRAVAKQQKESESTQ-------------------KAEK 264
Cdd:cd15319   161 EENCDSSLnRTYAISSSLISFYIPVAIMIVTYTRIYriaqIQIRRISSLERAAEHAQscrsnridchhhtslrtsiKKET 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 265 EVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFHPlVAALP----------AYFAKSATIYNPIIYVFmNRQFR 330
Cdd:cd15319   241 KVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPADP-DAGLPcvsettfdvfVWFGWANSSLNPIIYAF-NADFR 314
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
62-330 1.15e-08

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 55.46  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFT------NGLVLVATMRFKKLRH-PLNWILVNLAVADL-----AETIIASTISVVNQIYGYFVLGHPLCIVe 129
Cdd:cd15104     2 AGVILAVLSpliitgNLLVIVALLKLIRKKDtKSNCFLLNLAIADFlvglaIPGLATDELLSDGENTQKVLCLLRMCFV- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 130 gytVSLCGITGLwSLAIISWERWLVVCKPFGNMRFDAKLAIAG-ITFSWVWSAVWTAPPIfGWSRYWPHGLKTSCGpdvF 208
Cdd:cd15104    81 ---ITSCAASVL-SLAAIAFDRYLALKQPLRYKQIMTGKSAGAlIAGLWLYSGLIGFLPL-ISPQFQQTSYKGKCS---F 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPgvqSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVT---------RMVVVMILAYCF 279
Cdd:cd15104   153 FAAFHP---RVLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRrtlsdfkaaRTVAVLIGCFLL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 280 CWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15104   230 SWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVR 280
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
60-330 1.36e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 55.13  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISVVNQIY---GYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15050     7 LSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADL---IVGAVVMPLNIVYlleSKWILGRPVCLFWLSMDYVA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTApPIFGWSRYWPHGLKTScgPDVFSGSSYPG 215
Cdd:cd15050    84 STASIFSLFILCIDRYRSVQQPLKYLKYRTKTrASLMISGAWLLSFLWVI-PILGWHHFARGGERVV--LEDKCETDFHD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqqkesestqkAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP 295
Cdd:cd15050   161 VTWFKVLTAILNFYIPSLLMLWFYAKIFKAVN--------------RERKAAKQLGFIMAAFILCWIPYFILFMVIAFCK 226
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1375379927 296 GYAFHPLVAALPAYFAKSATIyNPIIYVFMNRQFR 330
Cdd:cd15050   227 NCCNENLHMFTIWLGYINSTL-NPFIYPLCNENFK 260
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
63-330 1.47e-08

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 55.30  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADlaETIIAST-ISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15970    10 VCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAD--ELLMLSVpFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVwTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15970    88 YCLTVLSIDRYIAVVHPIKAARYRrptvAKMVNLGV---WVFSIL-VILPIIIFSNTAPNSDGSVACNMQMPEPSQRWLA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESEStQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15970   164 VFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQR-KRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQH 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1375379927 298 afHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15970   243 --DATVSQLSVILGYANSCANPILYGFLSDNFK 273
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
65-284 1.72e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 54.97  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC---IVEGYTVSLCGITgl 141
Cdd:cd15297    12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCdlwLALDYVVSNASVM-- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 wSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGW-----SRYWPHGlktSCGPDVFSGSSypg 215
Cdd:cd15297    90 -NLLIISFDRYFCVTKPLTyPVKRTTKMAGMMIAAAWVLSFILWAPAILFWqfivgGRTVPEG---ECYIQFFSNAA--- 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 216 vqsymIVLMTTCCIVPLSVIVLCYLqVWLAIRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15297   163 -----VTFGTAIAAFYLPVIIMTVL-YWQISRASSR-----------EKKVTRTILAILLAFIITWTPY 214
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
61-331 1.76e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 54.84  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY-GYFVLGHPLC-IVEGYTVSLCgI 138
Cdd:cd15308     8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQgGVWTLSPVLCdALMTMDVMLC-T 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYwPHGLKTSCGPDVFSGSSYPGVQ 217
Cdd:cd15308    87 ASIFNLCAISVDRFIAVSVPLNyNRRQGSVRQLLLISATWILSFAVASPVIFGLNNV-PNRDPAVCKLEDNNYVVYSSVC 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIvlmttccivPLSVIVLCYlqvWLAIRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15308   166 SFFI---------PCPVMLVLY---CAMFRGLGR-----------ERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESC 222
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 298 AFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15308   223 SIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRN 256
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
62-330 1.87e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 54.91  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLV--ATMRFKKLRHplNWILVNLAVADLAETIIASTISVV-----NQIYGYFV---LGhPLCIVEGY 131
Cdd:cd15136     9 FVFLLALVGNIIVLLvlLTSRTKLTVP--RFLMCNLAFADFCMGIYLGLLAIVdaktlGEYYNYAIdwqTG-AGCKTAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYwphgLKTS-CGPdvfS 209
Cdd:cd15136    86 LAVFSSELSVFTLTVITLERWYAITHAMHlNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSY----SKTSiCLP---F 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCIVPLsVIVLCYLQVWLAIRAVAKQQKESESTqkaekeVTRMVVVMILAYCFCWGPYaffac 289
Cdd:cd15136   159 ETETPVSKAYVIFLLLFNGLAFL-IICGCYIKIYLSVRGSGRAANSNDTR------IAKRMALLVFTDFLCWAPI----- 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 290 faaahpgyAFHPLVAALPAYF-----AKSATIY--------NPIIYVFMNRQFR 330
Cdd:cd15136   227 --------AFFGLTAAFGLPLisvsnAKILLVFfyplnscaNPFLYAIFTKQFR 272
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
61-322 2.68e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 54.37  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL--------AETIIASTISvvnqiygyFVLGHPLCIVEGYT 132
Cdd:cd15384    10 MFVI--SFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLlvtffcipSEAIWAYTVA--------WLAGNTMCKLVKYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 133 VSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAgITFSWVWSAVWTAPP--IFGWSRYWPHGLKTSCGPDVFSG 210
Cdd:cd15384    80 QVFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRM-VTVAWILSPIFSIPQavIFHVERGPFVEDFHQCVTYGFYT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGvQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESEST------------QKAEKEVTRMVVVMILAYC 278
Cdd:cd15384   159 AEWQE-QLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYtrnrgpnrqrlfHKAKVKSLRMSAVIVTAFI 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 279 FCWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIY 322
Cdd:cd15384   238 LCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
55-330 2.99e-08

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 54.62  E-value: 2.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPL-NWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15320     3 LTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVtNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 sLCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPI-FGWSRYWPHG---LKTSCGPDVF 208
Cdd:cd15320    83 -MCSTASILNLCVISVDRYWAISSPFRYERkMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPTSfldLNASLRDLTM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWL----AIRAVAKQQKESESTQ------------------------ 260
Cdd:cd15320   162 DNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRiaqkQIRRISALERAAVHAKncqnstgnrgsgdcqqpessfkms 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 261 -KAEKEVTRMVVVMILAYCFCWGPYAFFACFA-AAHPGYAFHPLVAALP----AYFAKSATIYNPIIYVFmNRQFR 330
Cdd:cd15320   242 fKRETKVLKTLSVIMGVFVCCWLPFFILNCMVpFCKPTSTEPFCISSTTfdvfVWFGWANSSLNPIIYAF-NADFR 316
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
71-330 3.34e-08

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 54.06  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRH-PLNWILVNLAVADLAetIIASTISVVNQIYGY--FVLGHPLCIVEGYTVSLCGITGLWSLAII 147
Cdd:cd15097    18 NSLVLAVLLRSGQSGHnTTNLFILNLSVADLC--FILFCVPFQATIYSLegWVFGSFLCKAVHFFIYLTMYASSFTLAAV 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 148 SWERWLVVCKPFGNMRFDA-KLAIAGITFSWVWSAVWTAPPI--FGWSRYwphGLKTSCgpdvfsgssYPGVQSYMIVLM 224
Cdd:cd15097    96 SVDRYLAIRYPLRSRELRTpRNAVAAIALIWGLSLLFAGPYLsyYDLIDY---ANSTVC---------MPGWEEARRKAM 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 225 TTCC-----IVPLSVIVLCYLQ----VWLAIRAVAkqqkESESTQKAEKEVTRMVVVMILAYCFCWGPYaFFACFAAAHP 295
Cdd:cd15097   164 DTCTfafgyLIPVLVVSLSYTRtikyLWTAVDPLE----AMSESKRAKRKVTKMIIIVTALFCLCWLPH-HVVILCYLYG 238
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 296 GYAFHPLVAA---LPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15097   239 DFPFNQATYAfrlLSHCMAYANSCLNPIVYALVSKHFR 276
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
55-330 4.88e-08

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 53.74  E-value: 4.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15980     4 IASYLLIFLL--CMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPPIF--------GWSRYWPHGLKTScgPD 206
Cdd:cd15980    82 ISVSASVFTLVAIAVDRFRCIVYPF-KQKLTISTAVVIIVIIWVLAIAIMCPSAVmlhvqeekNYRVVLGSQNKTS--PV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 207 VFSGSSYPGVQS---YMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVA------KQQKESESTQKAEKEVTRMVVVMILAY 277
Cdd:cd15980   159 YWCREDWPNQEMrkiYTTVLFANIYLAPLSLIVIMYARIGITLFKTAmphtgkHNQEQRHVVSRKKQKVIKMLLIVALLF 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 278 CFCWGP---------YAFFACFAAAHPGYAFHPLVAALpAYFAKSAtiyNPIIYVFMNRQFR 330
Cdd:cd15980   239 ILSWLPlwtlmmlsdYANLSPNQLQIINIYIYPFAHWL-AFFNSSV---NPIIYGFFNENFR 296
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
62-333 5.67e-08

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 53.71  E-value: 5.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEG-YTVSLCgITG 140
Cdd:cd15316     9 FGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTcCDVSFC-YAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRywPHGLKTSCGPDVFSGSSYPGVQSY 219
Cdd:cd15316    88 LFHLCFISVDRYIAVTDPLVyPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVN--DDGLEELVNALNCVGGCQIILNQN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--------QKESESTQ----KAEKEVTRMVVVMILAYCFCWGPYAFF 287
Cdd:cd15316   166 WVLVDFLLFFIPTFAMIILYGKIFLVAKQQARKiemtsskaESSSESYKdrvaRRERKAAKTLGITVIAFLVSWLPYLID 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1375379927 288 ACFAAAHpGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15316   246 VLIDAFM-NFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKAI 290
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
55-331 7.79e-08

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 53.17  E-value: 7.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15161     2 LFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMRF----DAKLAIAgitFSWVWSAVWTAPPIFGwsrywpHGLKTSCGPDVFSG 210
Cdd:cd15161    82 LNMYASLYFLACISVDRFLAIVHPVKSMKIrkplYAHVVCG---FLWVIVTVAMAPLLVS------PQTVEVNNTTVCLQ 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKesestqKAEKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15161   153 LYREKASRGALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEK------PLKDKAIKMIILVLTIFLICFVPYHISRYI 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 291 AAAHpgyafHPL---------VAALPAYFAKSATIYN----PIIYVFMNRQFRN 331
Cdd:cd15161   227 YILS-----HNGagascssrrGLALANRITSCLTCLNgaldPVMYFFVAEKFRE 275
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
60-330 8.22e-08

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 53.25  E-value: 8.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVviASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15205     9 LIFV--LALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgNMR--FDAKLAIAGITFSWVWSAVWTAPPIFGWS---RYWP-HGLKTSCGPDVFSGSSY 213
Cdd:cd15205    87 SILTMTCIAVERHQGIVHPL-KMKwqYTNRRAFTMLGLVWIVSVIVGSPMLFVQQlevKYDFlYEKRHVCCLERWYSPTQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PgvQSYMIVLMTTCCIVPLSVIVLCYLQV----WLAIRA------VAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGP 283
Cdd:cd15205   166 Q--KIYTTFILVILFLLPLTTMLFLYSRIgyelWIKKRVgdasvlQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVCWAP 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 284 YAFFAC------FAAAHPGYAFHPLVAALPAyFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15205   244 FHVVHMmieysnLENKYDGVTIKLIFAIVQL-IGFSNSFNNPIVYAFMNENFK 295
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
60-284 8.35e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 52.91  E-value: 8.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY-GYFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15306     7 ILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFeAMWPLPLVLCPIWLFLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAP-PIFGWSRYWPHGLKTSC--GPDVFsgssyp 214
Cdd:cd15306    87 ASIMHLCAISLDRYIAIKKPIQASQYNSRaTAFIKITVVWLISIGIAIPvPIKGIETDVDNPNNITCvlTKERF------ 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 gvQSYMIVLMTTCCIVPLSVIVLCYlqvWLAIRAVAKQqkesesTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15306   161 --GDFILFGSLAAFFTPLAIMIVTY---FLTIHALRKQ------TITNEQRASKVLGIVFFLFLLMWCPF 219
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
55-251 1.39e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 52.11  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTV 133
Cdd:cd15054     2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCpIWYAFDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLwSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPI-FGWSR--YWPHGLKTSCGPDVFS 209
Cdd:cd15054    82 MCCSASIL-NLCVISLDRYLLIISPLRyKLRMTPPRALALILAAWTLAALASFLPIeLGWHElgHERTLPNLTSGTVEGQ 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1375379927 210 GSSYPGVqSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAK 251
Cdd:cd15054   161 CRLLVSL-PYALVASCLTFFLPSGAICFTYCRILLAARKALK 201
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
61-330 1.48e-07

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 52.19  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15131     8 VLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYST 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFDAKLAI-AGITFSWVWSAVwTAPPIFGWSrywphGLKTSCGPDVFSGS----SYPG 215
Cdd:cd15131    88 ILNITALSVERYFAICFPLRAKVVVTKRRVkLVILVLWAVSFL-SAGPIFVLV-----GVEHENGTNPIDTNeckaTEYA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTCCIVPLSVIVLCYLQVWLAI-RAVAKQQKESEST-----QKAEKEVTRMVVVMILAYCFCWGPYaFFAC 289
Cdd:cd15131   162 VRSGLLTIMVWVSSVFFFLPVFCLTVLYSLIgRKLWRRRRENIGPnashrDKNNRQTVKMLAVVVFAFVLCWLPF-HVGR 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 290 FAAAHPGYAFHPLVAALPAY--------FAKSATIyNPIIYVFMNRQFR 330
Cdd:cd15131   241 YLFSKSFEAGSLEIALISQYcnlvsfvlFYLSAAI-NPILYNIMSKKYR 288
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
68-330 1.53e-07

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 52.09  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  68 VFTNGLVLVATMRFKKLRHPLNWI-----LVNLAVADLAeTIIASTISVVNQIYG-YFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15968    10 VFLLGLPLNSVVLTRCCRHTKAWTrtaiyMVNLALADLL-YALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNLYGSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFDAKLAiAGITFSWVWSAVWT-APPIFGWSRYWPHGLKTSCGpDVFSGSSYPGVQSYM 220
Cdd:cd15968    89 LFLTCISVHRYLGICHPMRPWHKETRRA-AWLTCVLVWILVFAqTLPILIFARTGIIRNRTVCY-DLAPPALFPHYVPYG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKESEST-QKAEKEVTRMVVVMILAYCFCWGPY---AFFACFAAAHPG 296
Cdd:cd15968   167 MALTVSGFLLPFSIILWCYCLV---VRTLCRTLGPAEPPaQARRRKSIRTIVTVTLLFALCFLPFhitRTIYLAVRVTPG 243
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1375379927 297 YAFHPLVAALPAY-----FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15968   244 VPCHVLEAVAACYkitrpLASANSVLNPLLYFLTKKKFG 282
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
54-331 1.55e-07

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 52.10  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAEtIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15153     1 SLYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAH-VLSLPLRIHYYIQHTWPFGRFLCLLCFYLK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPFG----NMRFDAKLAIAgitfswVWSAVWTAPPIFGWSRYWPHGL-KTSCGPDVF 208
Cdd:cd15153    80 YLNMYASICFLTCISIQRCFFLLHPFKardwKRRYDVGISAA------VWIVVGLACLPFPLLRSKSLSNnNRSCFADLG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGVQSYMI-VLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAekevTRMVVVMILAYCFCWGPY--- 284
Cdd:cd15153   154 MKKLNFGAAIAMMtVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTSEKQKA----LRMVRMCAAVFFICFAPYhin 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 285 ----AFFACFAAAHPGYA-----FHPLVAALpayfAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15153   230 flfyLMVSESIITNCEVSqvilqFHPISLCL----ASLNCCLDPILYYFMTSEFQD 281
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
57-331 1.81e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 51.76  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15404     4 SAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAgitFSWVWSAVWTAPPIFGwsryWPHGLKTSCGPD-VFSGSSYP 214
Cdd:cd15404    84 VMEGVAILLIISIDRFLIIVQKQDKLNpYRAKVLIA---VSWAVSFCVAFPLAVG----SPDLQIPSRAPQcVFGYTTNP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESestqkaekevtrmVVVMILAYCFCWGPYAFFACFAAAH 294
Cdd:cd15404   157 GYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRAFTT-------------ILILFIVFTVCWAPFTTYSLVATFN 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1375379927 295 PGYAFHPLVAALPAY-----FAKSAtiYNPIIYVFMNRQFRN 331
Cdd:cd15404   224 SHFYHKHNFFEISTWllwlcYLKSA--LNPLIYYWRIKKFRD 263
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
69-330 3.09e-07

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 51.29  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  69 FTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIIS 148
Cdd:cd15193    16 LGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTGMS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 149 WERWLVVCK-----PFGNMRfdakLAIAGITFSWVWSAVWTAPPIFgwsrYWPHGLKTSCGPDvfsgSSYPGVQSYMIVL 223
Cdd:cd15193    96 VDRYLAVVKlldsrPLRTRR----CALITCCIIWAVSLVLGIPSLV----YRNLINESVCVED----SSSRFFQGISLAT 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 224 MTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKEsesTQKAEKEVTRMVVVMILAYCFCWGPY----------AFFACFAAA 293
Cdd:cd15193   164 LFLTFVLPLIVILFCYCSILVRLRRHFHGAKR---TGRRRRNSLRIVFAIVTAFVLSWLPFntlkavrlllELGGGVLPC 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 294 HPGYAFHPLVAALPAY-FAKSATiyNPIIYVFMNRQFR 330
Cdd:cd15193   241 HTTVAIRQGLTITACLaFVNSCV--NPLIYSLLDRHFR 276
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
60-330 3.33e-07

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 51.26  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLR----HPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSL 135
Cdd:cd15002     4 ILLGVICLLGFAGNLMVIGILLNNARkgkpSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 136 CGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPP-IFGWSRYWPHGLKTSCgpdVFSGSSYP 214
Cdd:cd15002    84 CMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLPLPQwLFRTVKQSEGVYLCIL---CIPPLAHE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSYMIVLMTTCCIVPLSVIVLCYlqvWLAIRAVAKQQKESES--TQKAEKEVTRMVVVMILAYCFCWGP--YAFFACF 290
Cdd:cd15002   161 FMSAFVKLYPLFVFCLPLTFALFYF---WRAYGQCQRRGTKTQNlrNQIRSRKLTHMLLSVVLAFTILWLPewVAWLWLI 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 291 AAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15002   238 HIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
61-284 3.40e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 51.11  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaeTIIASTISVVNQIYGY--FVLGHPLCIVEGY--TVSLc 136
Cdd:cd15927    10 IFLV--GVLGNGTLILIFLRNKSMRNVPNIFILSLALGDL--LLLLTCVPFTSTIYTLdsWPFGEFLCKLSEFlkDTSI- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITgLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGI-TFSWVWSAVWTAPPIFGWSRYWPHGLK----TSCGPDVFS-G 210
Cdd:cd15927    85 GVS-VFTLTALSADRYFAIVNPMRKHRSQATRRTLVTaASIWIVSILLAIPEAIFSHVVTFTLTDnqtiQICYPYPQElG 163
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 211 SSYPGVQSYMIVLMTTCciVPLSVIVLCYL----QVWLAIRAVAKQQKESESTQ-KAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15927   164 PNYPKIMVLLRFLVYYL--IPLLIIGVFYVlmarHLIRSTRNIGSGQNQAAQRQiEARKKVAKTVLAFVVLFAVCWLPR 240
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
63-332 4.42e-07

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 50.64  E-value: 4.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADlAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15092    10 VCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALAD-TLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFG--NMRFDAKLAIAGITFsWVWSAVWTAPPIFgwsrywpHGLKTSCGPDVFSGSSYPGVQSYM 220
Cdd:cd15092    89 TLTAMSVDRYVAICHPIKalDVRTPHKAKVVNVCI-WALASVVGVPVMV-------MGSAQVEDEEIECLVEIPTPQDYW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCC-----IVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAE--KEVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15092   161 DPVFGICVflfsfIIPVLIISVCYS---LMIRRLRGVRLLSGSKEKDRnlRRITRLVLVVVAVFVGCWTPIQIFVLAQGL 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 294 HPGYAFHPLVAALPAYFA--KSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15092   238 GVQPSSETAVAILRFCTAlgYVNSSLNPVLYAFLDENFKAC 278
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
63-330 6.59e-07

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 50.15  E-value: 6.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVL-VATMRFKKLRHPLnWILvNLAVADLAETIIAStISVVNQIYGY-FVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15116    10 VFVLGVLGNGLVIfITGFKMKKTVNTV-WFL-NLAVADFLFTFFLP-FSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPF--GNMRfDAKLAIAGITFSWVWSAVWTAPP-IFGWSRYWPHGLKTSC--GPDVFSGSSYPG 215
Cdd:cd15116    87 VFLLTVISIDRCISVVFPVwsQNHR-SVRLASLVSLAVWVVAFFLSSPSfIFRDTAPSQNNNKIICfnNFSLSGDNSSPE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 V--------QSYMIVLMTTCCIVPLSVIVLCYLqvwlAIRAVAKQQKESEStqkaeKEVTRMVVVMILAYCFCWGPYAFF 287
Cdd:cd15116   166 VnqlrnmrhQVMTITRFLLGFLIPFTIIICCYA----AIVLKLKRNRLAKS-----SKPFKIIAAVIVTFFLCWAPYHIL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 288 ACFAAAH---PGYAF---HPLVAALpayfAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15116   237 NLLEMEAtrsPASVFkigLPITSSL----AFINSCLNPILYVFMGQDFK 281
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
55-330 7.31e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 49.95  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15334     2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIFgWsRYWPHGLKTSC--GPDVFSG 210
Cdd:cd15334    82 TCCTCSILHLSAIALDRYRAITDAveYARKRTPKHAGIM-IAVVWIISIFISMPPLF-W-RHQTTSREDECiiKHDHIVF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIvlmttccivPLSVIVLCYLQVWlaiRAVAKQQKESEStqkaekevtrmVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15334   159 TIYSTFGAFYI---------PLALILILYYKIY---RAATRERKAATT-----------LGLILGAFVICWLPFFVKEVI 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 291 AAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15334   216 VNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFK 255
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
60-330 7.47e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 49.93  E-value: 7.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetiIASTISVVNQ----IYGYFVLGHPLCIVEGY--TV 133
Cdd:cd15196     9 TILVL--ALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL----LVALFNVLPQliwdITYRFYGGDLLCRLVKYlqVV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLwsLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrywphglKTSCGPDVF--SGS 211
Cdd:cd15196    83 GMYASSYV--LVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFS-------YQEVGSGVYdcWAT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYP--GVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqqkesestqKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15196   154 FEPpwGLRAYITWFTVAVFVVPLIILAFCYGRICYVVW-------------RAKIKTVKLTLVVVACYIVCWTPFFVVQM 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 290 FAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15196   221 WAAWDPTAPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLR 261
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
56-326 7.58e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 50.12  E-value: 7.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  56 TSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETI---IASTISVVNQIYGYFVLghpLCIVEGYT 132
Cdd:cd14964     1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLvvlVLFFLLGLTEASSRPQA---LCYLIYLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 133 VSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGIT-FSWVWSAVWTAPPIFGWsryWPHGLKTSCGPDVFSGS 211
Cdd:cd14964    78 WYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIIlGCWGVSLLLSIPPLVGK---GAIPRYNTLTGSCYLIC 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SypgvQSYMIVLM-TTCCIVPLSVIVLCYL-QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd14964   155 T----TIYLTWGFlLVSFLLPLVAFLVIFSrIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFI 230
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 290 FAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMN 326
Cdd:cd14964   231 LHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
65-331 8.36e-07

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 49.97  E-value: 8.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC---IVEGYTVSLCGITgl 141
Cdd:cd17790    12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACdlwLALDYVASNASVM-- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 wSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWphGLKTscgpdVFSGSSYPGVQSYM 220
Cdd:cd17790    90 -NLLIISFDRYFSITRPLTyRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLV--GERT-----VLAGQCYIQFLSQP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMTTCC---IVPLSVIVLCYlqvWLAIRAVAKqqkesestqkaEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd17790   162 IITFGTAIaafYLPVTIMIILY---WRIYRETIK-----------EKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC 227
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 298 AFHPLvAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd17790   228 VPKTL-WELGYWLCYVNSTVNPMCYALCNKSFRD 260
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
63-284 9.22e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 49.80  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15386    10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWS-RYWPHGlktSCGPDVFSGSSYP-GVQSYm 220
Cdd:cd15386    90 MLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSlREVDQG---SGVLDCWADFGFPwGAKAY- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 iVLMTTCCI--VPLSVIVLCYLQVWLAI-----------RAVAKQQKES---------ESTQKAEKEVTRMVVVMILAYC 278
Cdd:cd15386   166 -ITWTTLSIfvLPVAILIVCYSLICYEIcknlkgktqtsRSEGGGWRTQgmpsrvssvRTISRAKIRTVKMTFVIVLAYI 244

                  ....*.
gi 1375379927 279 FCWGPY 284
Cdd:cd15386   245 ACWAPF 250
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
71-284 1.20e-06

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 49.40  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWE 150
Cdd:cd14975    18 NSFVIWSILIKVKQRSVTMLLVLNLALADLA-VLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLE 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 151 RWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSsypgvQSYMIVLMTTCC-- 228
Cdd:cd14975    97 RFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHYSDG-----QLVFHLLLETVVgf 171
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 229 IVPLSVIVLCYLQVWLAIRAVakqqkesesTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd14975   172 AVPFTAVVLCYSCLLRRLRRR---------RFRRRRRTGRLIASVVVAFAACWLPY 218
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
63-330 1.23e-06

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 49.62  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMR-FKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15382    10 LFLIAAVGNLTVLLILLRnRRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFDAKLAIAgITFSWVWSAVWTAP----------PIFGWSrywphglkTSCgpdVFSGS 211
Cdd:cd15382    90 FVLVCISLDRYFAILKPLRLSDARRRGRIM-LAVAWVISFLCSIPqsfifhveshPCVTWF--------SQC---VTFNF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 --SYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ---------------KAEKEVTRMVVVMI 274
Cdd:cd15382   158 fpSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKsssvrlrrssvglleRARSRTLKMTIVIV 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375379927 275 LAYCFCWGPYAFFACFAAAHPGYA--FHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15382   238 LVFIICWTPYFIMSLWYWFDRESAskVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLR 295
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
61-284 1.23e-06

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 49.39  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVfTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15388     9 IIFACALL-SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrywphglKTSCGPDVF---SGSSYP-GV 216
Cdd:cd15388    88 SYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILSLPQVFIFS-------KVEVAPGVYecwACFIEPwGL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIR-------------AVAKQQKESESTQKAE-----KEVTRMVVVMILAYC 278
Cdd:cd15388   161 KAYVTWITLVVFVLPTLIITVCQVLIFKEIHiniylksqiivavVKKKQLLSSRASSVAEvskamIKTVKMTLVIVLVYV 240

                  ....*.
gi 1375379927 279 FCWGPY 284
Cdd:cd15388   241 LCWAPF 246
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
60-330 1.30e-06

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 49.37  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASvfTNGLVLVATMRFK-KLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15190    19 LVFVLGLS--GNGLVLWTVFRSKrKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNMY 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAKL-AIAGITFSWVWSAVWTAPPIF-----GWSRYWphglKTSCGPDvFSGSS 212
Cdd:cd15190    97 ASVFCLTGLSFDRYLAIVRSLASAKLRSRTsGIVALGVIWLLAALLALPALIlrttsDLEGTN----KVICDMD-YSGVV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGVQSYMIV---LMTTCC--IVPLSVIVLCYLqvWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPY--- 284
Cdd:cd15190   172 SNESEWAWIAglgLSSTVLgfLLPFLIMLTCYF--FIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFhlv 249
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 285 ---AFFACFAAAHPGYAFHPLVAALPAY---FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15190   250 ktlYALMYLGILPFSCGFDLFLMNAHPYatcLAYVNSCLNPFLYAFFDPRFR 301
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
95-283 2.11e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 48.78  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  95 LAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKP-FGNMRFDAKLAIAG 172
Cdd:cd14981    44 LAITDLLGILLTSPVVLAVYASNFeWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPfFYNSHVKKRRARLM 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 173 ITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYM-IVLMttccIVPLSVIVLCYLQVWLAIRAVAK 251
Cdd:cd14981   124 LGAVWAFALLIASLPLLGLGSYVLQYPGTWCFLDFYSKNTGDAAYAYLySILG----LLILLVTLLCNLLVIITLLRMRR 199
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1375379927 252 QQKESESTQKAEKEVTR----MVV---VMILAYCFCWGP 283
Cdd:cd14981   200 RKKRHRRSRRSARRQKRneiqMVVlllAITVVFSVCWLP 238
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
60-332 2.15e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 48.89  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGYTVSLCgI 138
Cdd:cd15312     7 MAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCkIHSSLDMMLS-T 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPfgnMRFDAKLAIAGITFSWVWSavWTAPPIFGWsrywphGLktscgpdVFSGSSYPGVQS 218
Cdd:cd15312    86 TSIFHLCFIAVDRYYAVCDP---LHYRTKITTPVIKVFLVIS--WSVPCLFAF------GV-------VFSEVNLEGIED 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMI------------------VLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKE----------SESTQKAEKEVTRMV 270
Cdd:cd15312   148 YVAlvsctgscvlifnklwgvIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNrpsvtkgdskNKLSKKKERKAAKTL 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 271 VVMILAYCFCWGPYAFFACF----AAAHPGYAFHPLVaalpaYFAKSATIYNPIIYVFMNRQFRNC 332
Cdd:cd15312   228 SIVMGVFLLCWLPFFVATLIdpflNFSTPVDLFDALV-----WLGYFNSTCNPLIYGFFYPWFQKA 288
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
62-330 2.36e-06

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 48.54  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY--FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd14995     9 LICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPdsWIYGYAGCLLITYLQYLGINA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFgNMRF-----DAKLAIAGItfsWVWSAVWTAPPIFgwsryWPHGLKTSCGPDVFSGSSYP 214
Cdd:cd14995    89 SSLSITAFTIERYIAICHPM-KAQFictvsRAKKIICFV---WIFTSLYCSPWLF-----LLDLSIKHYGDDIVVRCGYK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 -GVQSYMIVLMTTCCI---VPLSVIVLCYlqvWLAIRAVAkqqkesestqKAEKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd14995   160 vSRHYYLPIYLADFVLfyvIPLLLAIVLY---GLIGRILF----------SSRKQVTKMLAVVVVLFALLWMPYRTLVVY 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 291 AAahpgYAFHPLVAALPAYFAKsATIY-----NPIIYVFMNRQFR 330
Cdd:cd14995   227 NS----FASPPYLDLWFLLFCR-TCIYlnsaiNPILYNLMSQKFR 266
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
65-284 2.46e-06

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 48.48  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC---IVEGYTVSLCGITgl 141
Cdd:cd15298    12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCdlwLALDYVVSNASVM-- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 wSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSryWPHGLKTscgpdVFSGSSYPGVQSYM 220
Cdd:cd15298    90 -NLLIISFDRYFCVTKPLTyPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQ--FVVGKRT-----VPDNQCFIQFLSNP 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 221 IVLMTTCC---IVPLSVIVLCYLQVWLAiravakqqkesestQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15298   162 AVTFGTAIaafYLPVVIMTVLYIHISLA--------------SARERKVTRTIFAILLAFILTWTPY 214
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
95-252 2.61e-06

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 48.65  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  95 LAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKP-FGNMRFDAKLAIAGI 173
Cdd:cd15142    44 LAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLSIICAMSIERYLAINHAyFYNHYVDKRLAGLTL 123
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 174 TFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMTTCCIVplsVIVLCYLQVWLAIRAVAKQ 252
Cdd:cd15142   124 FAIYASNILFCALPSMGLGKSKLQYPKTWCFIDWRTNVSVHAAYSYMYAGFSSLLIL---VTVLCNVLVCGALIRMHRQ 199
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
54-331 2.75e-06

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 48.13  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  54 HLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISV--VNQIYGYfVLGHPLCIVEGY 131
Cdd:cd15182     1 AFLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL---LFTFTLPFwaSYHSSGW-IFGEILCKAVTS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAPPIFGWSRYWPHGLKTSC---GPDV 207
Cdd:cd15182    77 IFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAvWVISILASLPELILSTVMKSDEDGSLCeysSIKW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 FSGSSYPGVQSYMIvlmttccivPLSVIVLCYLQVWLAIRAVAKQQKesestqkaeKEVTRMVVVMILAYCFCWGPY--- 284
Cdd:cd15182   157 KLGYYYQQNLFFLI---------PLGIIVYCYVRILQTLMRTRTMRK---------HRTVKLIFVIVLVFFLSWAPYniv 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 285 ---------AFFACFAAAHPGYAFHplvaaLPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15182   219 iflrslkdlTIPICECSKQLDYAFY-----ICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
60-333 2.81e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 48.21  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15317     7 LVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPfgnMRFDAKLAiagITFSWVWSAV-WTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS 218
Cdd:cd15317    87 SIFHLCFIAIDRYYAVCDP---LRYPSKIT---VQVAWRFIAIgWLVPGIYTFGLIYTGANDEGLEEYSSEISCVGGCQL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YM--IVLMTTCCI--VPLSVIVLCYLQVWLAIRAVAKQ------------QKESESTQKAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15317   161 LFnkIWVLLDFLTffIPCLIMIGLYAKIFLVARRQARKiqnmedkfrsseENSSKASASRERKAAKTLAIVMGIFLFCWL 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 283 PYaFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15317   241 PY-FIDTIVDEYSNFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
55-330 3.02e-06

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 48.00  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15335     2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSCGPDvfsgssy 213
Cdd:cd15335    82 TCCTCSILHLCVIALDRYWAITDAIEYARkRTAKRAGLMILTVWTISIFISIPPLF-WRNHHDANIPSQCIIQ------- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 pgvQSYMIVLMTTCC---IVPLSVIVLCYLQVWLAiravakqqkesestQKAEKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15335   154 ---HDHVIYTIYSTFgafYIPLTLILILYYRIYHA--------------ASRERKAARILGLILGAFILSWLPFFIKELI 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1375379927 291 AAAHPgYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15335   217 VGLSV-MTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFK 255
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
55-253 3.18e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.22  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15058     2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFgnmRFDAKL----AIAGITFSWVWSAVWTAPPIF-GWSRY-WPHGLKTSCGPDVf 208
Cdd:cd15058    82 LCVTASIETLCVIAVDRYIAITRPL---RYQVLLtkrrARVIVCVVWIVSALVSFVPIMnQWWRAnDPEANDCYQDPTC- 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 209 sgSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLairaVAKQQ 253
Cdd:cd15058   158 --CDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFL----IATRQ 196
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
55-330 3.19e-06

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 48.31  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15403     2 LLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYW 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFGNMR-FDAKLAIAGitfSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpdVFSGSSY 213
Cdd:cd15403    82 FFVLEGVAILLIISVDRFLIIVQRQDKLNpHRAKVMIAI---SWVLSFCISFPSVVGWTLVEVPARAPQC---VLGYTES 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVA-KQQKESEST-------------QKAEKEVTRM---------V 270
Cdd:cd15403   156 PADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAvRIHNHADSLclsqvsklglmglQRPHQMNVDMsfktrafttI 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 271 VVMILAYCFCWGPYAFFACFAAAHPGYAFHPLVAALPAY---FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15403   236 LILFVGFSLCWLPHTVFSLLSVFSRRFYYSSSFYPISTCvlwLSYLKSVFNPVIYCWRIKKFR 298
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
55-330 3.71e-06

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 47.95  E-value: 3.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYT-V 133
Cdd:cd15346     2 LTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMfV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGitGLWSLAIISWERWLVVCK---PFGNMRFDAKLAIAGItfsWVWSAVWTAPPIFGWsrywphglktSCGPDVFSG 210
Cdd:cd15346    82 ALSA--SVFSLLAIAIERYITMLKmklHNGSNSFRSFLLISAC---WVISLILGGLPIMGW----------NCISALSSC 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SS-YPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAK----QQKESESTQKAEKEVTRMVVVMILAYCF--CWGP 283
Cdd:cd15346   147 STvLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRrltfRKNIRKASRSSEKSMALLKTVIIVLSVFiaCWAP 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375379927 284 YAFFACFAAAHPGYAFHPLVAAlpAYFAKSATI---YNPIIYVFMNRQFR 330
Cdd:cd15346   227 LFILLLLDVGCKVKTCSILFKA--EYFLVLAVLnsaTNPIIYTLTNKEMR 274
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
92-330 3.90e-06

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 47.85  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  92 LVNLAVADLaetIIAS-----TISVVNQIYGYFvlGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDA 166
Cdd:cd15189    39 LGNLAAADL---VFVSglpfwAMNILNQFNWPF--GELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 167 KLAIAGITFS-WVWSAVWTAPP-IFGWSRYWPHGLKTSCgpdVFSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWL 244
Cdd:cd15189   114 RRYAKLICVLiWVVGLLLSIPTfLLRKIKAIPDLNITAC---VLLYPHEAWHFAHIVLLNIVGFLLPLLVITFCNYNILQ 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 245 AIRavaKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP--------GYAFHPLVAALPAYFAKSATI 316
Cdd:cd15189   191 ALR---TREESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDvgvldecfWEHFIDIGLQLAVFLAFSNSC 267
                         250
                  ....*....|....
gi 1375379927 317 YNPIIYVFMNRQFR 330
Cdd:cd15189   268 LNPVLYVFVGRYFR 281
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
60-331 3.98e-06

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 47.84  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVL-VATMrfkKLRHPLNWI-LVNLAVADLAeTIIASTISVVNQI------YGYFvlghpLCIVEGY 131
Cdd:cd15115     7 LSLTFLLGVPGNGLVIwVAGL---KMKRTVNTIwFLNLAVADLL-CCLSLPFSIAHLLlnghwpYGRF-----LCKLLPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGLWSLAIISWERWLVVCKPF--GNMRfDAKLAIAGITFSWVWSAVWTAPpIFGWSRYWPHGLKTSCGpdvfs 209
Cdd:cd15115    78 IIVLNMFASVFTLTAISLDRFLLVIKPVwaQNHR-SVLLACLLCGCIWILALLLCLP-VFIYRTTVTDGNHTRCG----- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 gssYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqqkeSESTQKAEKEVTRMVVVMILAYCFCWGPY----- 284
Cdd:cd15115   151 ---YDFLVAITITRAVFGFLLPLLIIAACYSFIAFRMQ--------RGRFAKSQSKTFRVIIAVVVAFFVCWAPYhiigi 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 285 -AFFACFAAAHPGYAFHPLVAALpayfAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15115   220 lSLYGDPPLSKVLMSWDHLSIAL----AYANSCLNPVLYVFMGKDFKK 263
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
143-330 4.16e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 47.82  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFGNMRFDAKL--AIAGITfsWVWSAVWTAPPIFGW---SRYWPHGLKTSCGPDVFSGSSYpgvQ 217
Cdd:cd14999    88 TLTVMSTERYLAVVKPLDTVKRSKSYrkLLAGVI--WLLSLLLTLPMAIMIrlvTVEDKSGGSKRICLPTWSEESY---K 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 218 SYMIVLMTTCCIVPLSVIVLCYLQV----WLAIRAVAKQQKESESTQKaekeVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd14999   163 VYLTLLFSTSIVIPGLVIGYLYIRLarkyWLSQAAASNSSRKRLPKQK----VLKMIFTIVLVFWACFLPFWIWQLLYLY 238
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 294 HPGYAFHPLVAALPAYFAKSATIYN----PIIYVFMNRQFR 330
Cdd:cd14999   239 SPSLSLSPRTTTYVNYLLTCLTYSNscinPFLYTLLTKNYK 279
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
61-330 4.95e-06

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 47.43  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15192    10 IFVV--GIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFD----AKLAIAGItfsWVWSAVWTAPP-IFGWSRYWPHGLKTSCGpdvfsgSSYPG 215
Cdd:cd15192    88 VFLLTCLSIDRYLAIVHPMKSRLRRtlvvARVTCIVI---WLLAGVASLPAiIHRDVFFIENTNITVCA------FHYPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 216 VQSYMIVLMTTC-----CIVPLSVIVLCYLQVWLAIRAVAKQQKesesTQKAEKEVTRMVVVMILAYCFCWGPYA----- 285
Cdd:cd15192   159 QNSTLLVGLGLMknllgFLIPFLIILTCYTLIGKALKKAYEIQR----NKPRNDEIFKMIMAVVLFFFFCWIPHQiftfl 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 286 -FFACFAAAHPGYAFHPLVAALP-----AYFAksaTIYNPIIYVFMNRQFR 330
Cdd:cd15192   235 dVLIQLKVIQDCHIADIVDTAMPfticiAYFN---SCLNPILYGFVGKNFR 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
71-330 4.96e-06

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 47.50  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILvNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWE 150
Cdd:cd15339    18 NILVLFTIIRSRKKTVPDIYVC-NLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTAMSLD 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 151 RWLVVCKPFGNMRFDAKLAIAGIT-FSWVWSAVWTAPP-IFGWSRYWPHGLKtSCGPDVFSGSSypgVQSYMIVLMTTCC 228
Cdd:cd15339    97 RYIALVHPFRLTSLRTRSKTIRINlLVWAASFILVLPVwVYAKVIKFRDGLE-SCAFNLTSPDD---VLWYTLYQTITTF 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 229 IVPLSVIVLCYL----QVWLAIRAVAKQQKESESTQKAE-KEVTRMVVVMILAYCFCWGPYAFFACF--AAAHPGYAFHp 301
Cdd:cd15339   173 FFPLPLILICYIlilcYTWEMYRKNKKAGRYNTSIPRQRvMRLTKMVLVLVGVFLVSAAPYHVIQLVnlSVSQPTLAFY- 251
                         250       260
                  ....*....|....*....|....*....
gi 1375379927 302 LVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15339   252 VSYYLSICLSYASSSINPFLYILLSGNFR 280
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
60-330 5.24e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 47.46  E-value: 5.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIAsvFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15358     9 LIFVVGA--VGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYpFLLGAGGCYFKTLLFETVCF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPfgnmrFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGP--DVFSGSSY--- 213
Cdd:cd15358    87 ASILNVTALSVERYIAVVHP-----LKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPcrGPVPDSATcml 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 --PGVQSYMIVLMTTCC--IVPLSVIVLCYLQVWLAIRAV-------AKQQKESESTQ--------KAEKEVTRMVVVMI 274
Cdd:cd15358   162 vkPRWMYNLIIQITTLLffFLPMGTISVLYLLIGLQLKREkmllvleAKGSKAGDSYQhrriqqekRRRRQVTKMLFVLV 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 275 LAYCFCWGPY--------AFFACFAAAHPGYAFHPLVAALPAYFAKSAtiyNPIIYVFMNRQFR 330
Cdd:cd15358   242 VVFGICWAPFhtdrlmwsFISQWTGELHLAFQYVHIISGVFFYLSSAA---NPVLYNLMSTRFR 302
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
90-324 5.40e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 47.49  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  90 WILvNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPF-----GNMRF 164
Cdd:cd15118    37 WIL-NLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVwaqnhRNVAA 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 165 DAKLAIAGitfsWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGV---------QSYMIVLMTTCCIVPLSVI 235
Cdd:cd15118   116 AKKICGVI----WAMALINTIPYFVFRDVIERKDGRKLCYYNFALFSPSPDNnhpickqrqEGLAISKLLLAFLIPLVII 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 236 VLCYLQVWLAIRavakqqkesESTQKAEKEVTRMVVVMILAYCFCWGPY-AFFACFAAAHPGYAFHPLV-AALPayFAKS 313
Cdd:cd15118   192 AVSYAVVSLIIR---------HRCRRRPGRFVRLVVSVVVSFALCWAPYhIFSIIEVMAHNQHSLRPLViQGLP--FATT 260
                         250
                  ....*....|....*
gi 1375379927 314 A----TIYNPIIYVF 324
Cdd:cd15118   261 LaflnSVLNPVLYVF 275
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
59-330 5.74e-06

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 47.45  E-value: 5.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL--AETIIASTISVVNQIYGYFvlGHPLCIVEGYTVSLC 136
Cdd:cd15381     8 WIIFVL--GTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLllVCCLPFWAINISNGFNWPF--GEFLCKSVNAVIYMN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCK--PFGNMRFD--AKLAIAGItfsWVWSAVWTAPPI-FGWSRYWPHGLKTSCGPDVFSGS 211
Cdd:cd15381    84 LYSSIYFLMMVSIDRYLALVKtmSSGRMRRPacAKLNCLII---WMFGLLMSTPMIvFRTVMYFPEYNITACVLDYPSEG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQsymIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTqkaEKEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15381   161 WHVALN---ILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKEIQT---ERKATVLVLAVLLMFFICWLPFHIFTFLD 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 292 AAHPG--------YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15381   235 TLHKLglisgcrwEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
60-331 6.39e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 47.19  E-value: 6.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVV-IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIY--GYFVlgHPLCIVEGYTVSLC 136
Cdd:cd15137     6 FIWVVgIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYYrgVYIK--HDEEWRSSWLCTFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWS-------LAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWsRYWPHGLKTS--CGPDV 207
Cdd:cd15137    84 GFLATLSsevsvliLTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIGLLLAVLPLLPW-DYFGNFYGRSgvCLPLH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 FSGSSYPGVQ---SYMIVLMTTCCIvplsVIVLCYLQVWLAIRAVAKQQKESEStqKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15137   163 ITDERPAGWEysvFVFLGLNFLAFV----FILLSYIAMFISIRRTRKAAASRKS--KRDMAVAKRFFLIVLTDFLCWIPI 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375379927 285 AFFACFAAAhpGYAFHPLVAALPAYFA---KSATiyNPIIYVFMNRQFRN 331
Cdd:cd15137   237 IVIGILALS--GVPIPGEVYAWVAVFVlpiNSAL--NPILYTLSTPKFRK 282
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
68-284 6.54e-06

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 47.06  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  68 VFTNGLVLVATMRFKKLRHPLNWI-----LVNLAVADLAeTIIASTISVVNQIY-GYFVLGHPLCivegYTVSLCGITGL 141
Cdd:cd16001    10 VFVLGLPLNGTVLWLSWCRTKRWTcstiyLVNLAVADLL-YVCSLPLLIVNYAMrDRWPFGDFLC----KLVRFLFYTNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WS----LAIISWERWLVVCKPFGNMRFDA-KLAIAGITFSWVWSAVWTAPPIFgWSRYWPHGLKTSC----GPDVFsGSS 212
Cdd:cd16001    85 YGsilfLTCISVHRFLGVCYPIRSLAYRTrRLAVIGSAATWILVVLQLLPTLV-YARTGSINNRTVCydltSPDNF-GNY 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 213 YPgvqsYMIVLMTTCCIVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd16001   163 FP----YGMVLTVTGFLIPFLIILLCYC---LMIKSLIRSEEAAGVGKAARAKSIRTILLVCGLFALCFVPF 227
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
65-330 6.88e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 47.14  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  65 IASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSL 144
Cdd:cd15008    11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 145 AIISWERWLVVCKP--FGNMRFDAKLAIAGitfSWVWSAVWTAPPIFGWSRYWPHGLktscgpDVFSGSSYPGVqSYMIV 222
Cdd:cd15008    91 LSICVDRFYTIVYPlsFKVSREKAKKMIAA---SWLFDAAFVSPALFFYGSNWGPHC------NFFLPDSWDGA-AYAII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 223 LMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQ----KAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYA 298
Cdd:cd15008   161 HLLVGFLVPSILIILFYQKVIKYIWRIGTDGRTVRRTMnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHPRESDYR 240
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1375379927 299 FHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15008   241 QSSLVFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
55-331 6.95e-06

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 47.13  E-value: 6.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYFVLGhPLCIVEGYTVS 134
Cdd:cd14989     2 LSCLYTIFLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLI-LVADSLIEVFNLNEKYYDIA-VLCTFMSLFLQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVV-----CKPFGNMRFdAKLAIAGItfsWVWSAVWTAPPiFGWSRYWPHGLKTSCGPDVFS 209
Cdd:cd14989    80 INMYSSIFFLTWMSFDRYIALakvmkSSPLRTMQH-ARLSCGLI---WMASISATLLP-FTAVQAQHTGEVHFCFADVRE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 gssypgVQSYMIvlmTTCCIVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAEKEVtRMVVVMILAYCFCWGPY----- 284
Cdd:cd14989   155 ------IQWLEV---TLGFIIPFSIIGLCYS---LIVRVLVRAQKHRRLRPRRQKAL-RMILVVVLVFFICWLPEnvfis 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 285 ------AFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd14989   222 iqllqgTQEPSESYDESFRHNHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRD 274
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
68-284 7.03e-06

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 47.05  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  68 VFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISvvnQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAII 147
Cdd:cd15905    13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFIP---GMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 148 SWERWLVVCKPFGNMRFDAKLAIA-GITFSWVWSAVWTAPPIFGWSRYWPHGLKTScgPDVFSgSSYPGVQSYMIVLMTT 226
Cdd:cd15905    90 HYERYLCIVYPLQYHNFWVHRWVPlALLLTWALPLLFACLPALGWNNWTPGSNCSY--KQVFP-AAYIYLEVYGLVLPSI 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375379927 227 CCIVPLSVIVLCYLQVWLA-----IRAVAKQQKeSESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15905   167 LAIAFMSVRVLAVARRQLQdicklLRAVQRDGP-SELEQQLNLRYAKCIAGVSLTFLVCWVPY 228
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
61-284 8.88e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 46.73  E-value: 8.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISVVNQIY---GYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15921     8 ILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDL---LLVCTLPLRLTYYvlnSHWPFGDIACRIILYVLYVNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFGNMRFDAKlAIAGITFSWVWSAV-WTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYpgV 216
Cdd:cd15921    85 YSSIYFLTALSVFRYLALVWPYLYLRVQTH-SVAGIICGLIWILMgLASSPLLFAKSKQHDEGSTRCLELAHDAVDK--L 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15921   162 LLINYVTLPVGFVVPFMTVIFCYI---FIIKNLLKPSPALGRTRPSRRKACALIIISLGIFLVCFLPY 226
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
53-330 1.12e-05

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 46.18  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  53 YHLTSAWMIFVViasVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLC-IVEGY 131
Cdd:cd15309     3 YAMLLTLLIFVI---VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCdIFVTL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCgITGLWSLAIISWERWLVVCKP-FGNMRFDAKLAIA-GITFSWVWSAVWTAPPIFGWSrywpHGLKTSCGPDVFS 209
Cdd:cd15309    80 DVMMC-TASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTvMISVVWVLSFAISCPLLFGLN----NTDQNECIIANPA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMivlmttcciVPLSVIVLCYLQVWLAIravakqqkesestqKAEKEVTRMVVVMILAYCFCWGPYaFFAC 289
Cdd:cd15309   155 FVVYSSIVSFY---------VPFIVTLLVYVQIYIVL--------------QKEKKATQMLAIVLGVFIICWLPF-FITH 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 290 FAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15309   211 ILNMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFR 251
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
61-330 1.29e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 46.33  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaeTIIASTISVVNQIYGY--FVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15132     8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL--LILLCLPFDLYRLWKSrpWIFGEFLCRLYHYISEGCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKPFGNMRFDAKLAI-AGITFSWVWSAVWTAPPIFGWSRYWPHGLKTS-----CGPDVFSGSS 212
Cdd:cd15132    86 ATILHITALSIERYLAICFPLRAKVLVTRRRVkCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDdfsreCKHTPYAVSS 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 ypGVQSYMIVLMTTCCIVPLSVIVLCY----LQVWLAIRAVakQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFA 288
Cdd:cd15132   166 --GLLGIMIWVTTTYFFLPMLCLSFLYgfigRKLWKSKNDL--RGPNAAARERSHRQTVRILAVVVLAFIICWLPFHIGR 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 289 CFAAAHPGYA------FHPLVAALPAYFakSATIyNPIIYVFMNRQFR 330
Cdd:cd15132   242 ILFANTEDYRtmmfsqYFNIVAMQLFYL--SASI-NPILYNLISRKYR 286
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
59-330 1.59e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 45.86  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVVIASVFTNGL---VLVATMRFKKLRHPLN--WILvNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15114     1 VVALVLYAVVFLVGVpgnALVAWVTGFEAKRSVNavWFL-NLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPF--GNMRfDAKLAIAGITFSWVWSAVWTAPPiFGWSRYWPHGL--KTSCGPDVfs 209
Cdd:cd15114    80 LLNMYASVLLLTAISADRCLLVLRPVwcQNHR-RARLAWIACGAAWLLALLLTVPS-FIYRRIHQEHFpeKTVCVVDY-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCIVPLSVIVLCYlqvWLAIRAVakqqkESESTQKAEKeVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15114   156 GGSTGVEWAVAIIRFLLGFLGPLVVIASCH---GVLLVRT-----WSRRRQKSRR-TLKVVTAVVVGFFLCWTPYHVVGL 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 290 FAAAH-PGYAFHPLVAALPAYFAKSATIY---NPIIYVFMNRQFR 330
Cdd:cd15114   227 IIAASaPNSRLLANALKADPLTVSLAYINsclNPIIYVVAGRGFR 271
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
91-324 2.27e-05

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 45.58  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  91 ILVNLAVADLAeTIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLAI 170
Cdd:cd15121    38 LVLNLALADAA-VLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSV 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 171 AGITFS-WVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSgssyPGVQSYMIVLMT-TCCIVPLSVIVLCYLQVWLAIRA 248
Cdd:cd15121   117 RALLLAiWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPS----VGHEAFQYLFETiTGFLLPFTAIVTCYSTIGRRLRS 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 249 VAKQQKESEStqkaekevtRMVVVMILAYCFCWGPY-------------AFFACFAAAHPGYAFHPLVAALpAYFAKSAt 315
Cdd:cd15121   193 ARFRRKRRTN---------RLVVLIIATFALFWLPYhvvnliqvagalqNQAGNASVLKAAKLARPNVTAL-AFLSSSV- 261

                  ....*....
gi 1375379927 316 iyNPIIYVF 324
Cdd:cd15121   262 --NPVLYAF 268
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
59-284 2.51e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 45.46  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVV--IASVFTNGLVL-VATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGY--TV 133
Cdd:cd15376     4 WPILGVefLVAVLGNGLALwLFVTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFlfTC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGitGLWSLAIISWERWLVVCKPF---GNMR-FDAKLAIAGItfsWVWSAVWTAPPIFGWSRYWPHGLKTSC-GPDVf 208
Cdd:cd15376    84 NLYG--SIFFITCISLNRYLGIVHPFftrSHVRpKHAKLVSLAV---WLLVAALSAPVLSFSHLEVERHNKTEClGTAV- 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 209 sGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKqqkeSESTQKAEK-EVTRMVVVMILAYCFCWGPY 284
Cdd:cd15376   158 -DSRLPTYLPYSLFLAVVGCGLPFLLTLASYLAI---VWAVLR----SPGITTLEKrKVAALVAVVVALYAVSFVPY 226
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
61-330 2.76e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 45.24  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKK-----LRHPLNWILVNLAVADLAETIIASTISVVNQIYGYF--VLGHPLCIVEGYTV 133
Cdd:cd15356     6 VYALIWALGAAGNALTIHLVLKKrslrgLQGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYpwVFGDLVCRGYYFVR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPfgnMRfdAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpDVFSGSSY 213
Cdd:cd15356    86 DICSYATVLNIASLSAERYLAICQP---LR--AKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKYEL--ETADGEPE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAA 293
Cdd:cd15356   159 PSSRVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQHSVQVLRAIVIAYVICWLPYHARRLMFCY 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 294 HPGYAF-HPLVAALPAYFAKSATIY------NPIIYVFMNRQFR 330
Cdd:cd15356   239 VPDDAWtDSLYNFYHYFYMLTNTLFyvssavNPLLYNVVSSSFR 282
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
51-331 3.20e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 44.94  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  51 WVYHLTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEG 130
Cdd:cd15299     1 WQVVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 131 YTVSLCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYwpHGLKTscgpdVFS 209
Cdd:cd15299    81 SIDYVASNASVMNLLVISFDRYFSITRPLTyRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYF--VGKRT-----VPP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSYPGVQSYMIVLMTTCCI---VPLSVIVLCYLQVWlairavakqqKESESTQKAEKEVTrmvvVMILAYCFCWGPYAF 286
Cdd:cd15299   154 DECFIQFLSEPIITFGTAIAafyLPVTIMTILYWRIY----------KETIKEKKAAQTLS----AILLAFIITWTPYNI 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 287 FACFAAAHPGyAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15299   220 MVLVNTFCDS-CIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRT 263
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
55-284 3.92e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 44.78  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15296     2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSrywpHGLKTSCGPDvfsGSS 212
Cdd:cd15296    82 LLCTASVFNIVLISYDRFLSVTRAvsYRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWE----YIAGGSIIPE---GEC 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375379927 213 YPGVQSYMIVLMTTCCI---VPLSVIVLCYLQVWLAIRAVAKQQKEsestqkaEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15296   155 YAEFFYNWYFLMTASTLeffTPFISVTYFNLSIYLNIQKRRFRLSR-------DKKVAKSLAIIVCVFGLCWAPY 222
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
63-330 4.03e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 44.73  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLA--ETIIASTISVVNQIYGYfVLGHPLCivegYTVSLCGITG 140
Cdd:cd15394    10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLmcATCVPLTLAYAFEPRGW-VFGRFMC----YFVFLMQPVT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LW----SLAIISWERWLVVCKPF---GNMRFDAKLaIAGItfsWVWSAVWTAPPIFG--WSRYWPHGLkTSCgpDVFSGS 211
Cdd:cd15394    85 VYvsvfTLTAIAVDRYYVTVYPLrrrISRRTCAYI-VAAI---WLLSCGLALPAAAHtyYVEFKGLDF-SIC--EEFWFG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIR------AVAKQQKESESTQKaeKEVTRMVVVMILAYCFCWGPYA 285
Cdd:cd15394   158 QEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRnrvvpgSMTQSQAEWDRARR--RKTFRLLVVVVVAFAICWLPLH 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 286 FFACFAAAHPGYA---FHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15394   236 IFNVIRDIDIDLIdkqYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
63-239 4.36e-05

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 44.77  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYfVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15177    10 VFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLL-LLLTLPFAAAETLQGW-IFGNAMCKLIQGLYAINFYSGFL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVV------CKPFGNMRFDAKLAIAgitFSWVWSAVWtAPPIFGWSRYWPHGLKTSCG---PDVFSGSSY 213
Cdd:cd15177    88 FLTCISVDRYVVIvratsaHRLRPKTLFYSVLTSL---IVWLLSILF-ALPQLIYSRVENRSELSSCRmifPEVVSRTVK 163
                         170       180
                  ....*....|....*....|....*.
gi 1375379927 214 PGVQSYMIVLMTtccIVPLSVIVLCY 239
Cdd:cd15177   164 GATALTQVVLGF---AIPLIVMAVCY 186
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
229-330 6.38e-05

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 44.12  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 229 IVPLSVIVLCYLqvwLAIRAVAKQQKESESTQKAEKeVTRMVVVMILAYCFCWGP------YAFFACFAAAHPGYA-FHP 301
Cdd:cd15926   179 LIPLGIISLCYL---LLVRFITDKNITGSSTKRRSK-VTKSVTIVVLSFFLCWLPnqalttWGILIKLNVVHFSYEyFTT 254
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1375379927 302 LVAALPAY--FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15926   255 QVYIFPITvcLAHSNSCLNPILYCLMRREFR 285
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
61-284 6.56e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 44.19  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL--AETIIASTISVVNQiygyFVLGHPLCIVEGYTVSLCGI 138
Cdd:cd15178     8 VLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLlfALTLPFWAVSVVKG----WIFGTFMCKLVSLLQEANFY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKP---FGNMRFDAKLAIAGItfsWVWSAVWTAPPIFGWSRYWPHGL-KTSCGPDVFSGSSYp 214
Cdd:cd15178    84 SGILLLACISVDRYLAIVHAtraLTQKRHLVKFVCAGV---WLLSLLLSLPALLNRDAFKPPNSgRTVCYENLGNESAD- 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 215 gvqSYMIVLMTTCCIV----PLSVIVLCYlqvwlAIRAVAKQQKESESTQKAekevTRMVVVMILAYCFCWGPY 284
Cdd:cd15178   160 ---KWRVVLRILRHTLgfllPLVVMLFCY-----GFTIKTLLQTRSFQKHRA----MRVIFAVVLAFLLCWLPY 221
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
55-331 6.76e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.99  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWI-LVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTV 133
Cdd:cd15219     1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPGIfLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPF---GNMRF-DAKLAIAgitFSWVWSAVW-TAPPIFGWSRYwpHGLKTSCGPDVF 208
Cdd:cd15219    81 TFLTSNAMLSMAALSIDRWIAVVFPLsytSKMRYrDAALMVG---YSWLHSLTFsLVALFLSWLGY--SSLYASCTLHLP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWlairAVAKQQKesestqkaekeVTRMVVVMILAYCFCWGPYAFFA 288
Cdd:cd15219   156 REEERRRFAVFTAFFHAFTFLLSLLVLCVTYLKVL----KVRRRQR-----------ATKKISIFIGTFVLCFAPYVITR 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 289 CFAAAhPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRN 331
Cdd:cd15219   221 LVELL-PFVTINRYWGIVSKCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
61-330 7.81e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 44.07  E-value: 7.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETI----IASTISVVNQIYGYfvlghpLCIVEGYTVSLC 136
Cdd:cd15071     8 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAlvipLAIIINIGPQTEFY------SCLMVACPVLIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYwpHGLK-----TSCGPDVFSG 210
Cdd:cd15071    82 TQSSILALLAIAVDRYLRVKIPTRyKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNL--NAVErawaaNSSMGELVIK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQS--YMIVL-MTTCCIVPLSVIVLCYLQVWLAIRA-----VAKQQKESESTQKAEKEVTRMVVVMILAYCFCWG 282
Cdd:cd15071   160 CQFETVISmeYMVYFnFFVWVLPPLLLMLLIYLEVFYLIRKqlnkkVSSSSSDPQKYYGKELKIAKSLALILFLFALSWL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 283 PYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15071   240 PLHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFR 287
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
60-246 7.99e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 43.75  E-value: 7.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADlaetIIASTISV----VNQIYGYFVLGHPLCIVEGYTVSL 135
Cdd:cd15431     7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLD----ICYTTSSVpqmlVNCLSDRPTISYSRCLAQMYISLF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 136 CGITGLWSLAIISWERWLVVCKPFGNM-RFDAKLAIAGITFSWVWSAVWTAPPIFGwsrYWPHglktSCGPDV---FSGS 211
Cdd:cd15431    83 LGITECLLLAVMAYDRFVAICNPLRYTlIMSWRVCIQLAAGSWVSAFLLTVIPVLT---MPLH----FCGPNVinhFFCE 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 212 -------SYPGVQSYMIVLMTTCCI---VPLSVIVLCYLQVWLAI 246
Cdd:cd15431   156 vqallklACSDTSLNEILMFATSIFtllLPFSFILVSYIRIGVAV 200
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
71-330 8.03e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 44.02  E-value: 8.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWE 150
Cdd:cd15928    18 NLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALSVE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 151 RWLVVCKPFGN----MRFDAKLAIAGItfsWVWSAVWTAPP--IFGWSRYWPHGLKTSCGPDVFSGSSypGVQSYMIVLM 224
Cdd:cd15928    98 RYLAICHPLRAkvlvTRGRVKLLIAVI---WAVAIVSAGPAlvLVGVEHIQGQQTPRGFECTVVNVSS--GLLSVMLWVS 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 225 TTCCIVPLSVIVLCY--LQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAF--FACFAAAHPGYAFH 300
Cdd:cd15928   173 TSFFFVPMVCLSLLYglIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVgrVIFNHSRASTKHLH 252
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 301 PLVAALP----AYFAKSATIyNPIIYVFMNRQFR 330
Cdd:cd15928   253 YVSQYFNlvsfVLFYLSAAI-NPILYNLMSKRYR 285
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
55-333 8.91e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 43.71  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVnqiygyfVLGHPLCIVEGYTVS 134
Cdd:cd15006     1 FTTTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIV-------LSASPHCCWWIYTLL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGI----------TGLWSLAIISWERWLVVCKPFGNMRFDAKlAIAGITFSWVwSAVWTAPPIFGWSRYWPHGLKTSCG 204
Cdd:cd15006    74 FCKVikflhkvfcsVTVLSFAAIALDRYYSVLYPLERKISDAK-SRDLVIYIWA-HAVVASVPVFAVTNVTDIYAMSTCT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 205 PdvfSGSSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQ------KESEST------QKAEKEVTRMVVV 272
Cdd:cd15006   152 E---SWGYSLGHLVYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKviiaalRTPQNTisipyvSQREAELHAMLLS 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375379927 273 MILAYCFCWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15006   229 MVLVFILCSVPYATLVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRKCL 289
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
55-330 1.03e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15102     2 ATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLL-AGAAYLANILLSGARTLRLSPAQWFLREGSMF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPF---GNMRFDAKLAIAGitfSWVWSAVWTAPPIFGWSrywphglktsCGPDVFSGS 211
Cdd:cd15102    81 VALSASVFSLLAIAIERHLTMAKMKpygASKTSRVLLLIGA---CWLISLLLGGLPILGWN----------CLGALDACS 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 S-YPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAeKEVTRMVVVMILAYCFCWGPYAFFACF 290
Cdd:cd15102   148 TvLPLYSKHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRS-LALLKTVLIVLLVFIACWGPLFILLLL 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1375379927 291 AAAHPGYAFHPLVAAlpAYFAKSATI---YNPIIYVFMNRQFR 330
Cdd:cd15102   227 DVACPVKTCPILYKA--DWFLALAVLnsaLNPIIYTLRSRELR 267
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
71-284 1.47e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 43.20  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISVVNQIYGY---FVLGHPLCIVEGYTVSLCGITGLWSLAII 147
Cdd:cd15191    18 NSLVVCVFCHQSGPKTVASIYIFNLAVADL---LFLATLPLWATYYSYgynWLFGSVMCKICGSLLTLNLFASIFFITCM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 148 SWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYpGVQSYMIVLM--T 225
Cdd:cd15191    95 SVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNEKY-AQWSAGLALMknT 173
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 226 TCCIVPLSVIVLCYLQVWlaiRAVAKQQKESESTQKAEKeVTRMVVVMILAYCFCWGPY 284
Cdd:cd15191   174 LGFLIPLIVIATCYFGIG---RHLLKTKGFGKNKQRRDK-VLKMVAAVVLAFLICWFPF 228
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
55-322 1.48e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 42.97  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15959     2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFgwSRYWPHGLK---TSCGPDVfSG 210
Cdd:cd15959    82 LCVTASIETLCAIAVDRYLAITNPLRyEALVTKRRARTAVCLVWAISAAISFLPIM--NQWWRDGADeeaQRCYDNP-RC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 211 SSYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVW-LAIRAVAKQQKE-----------SESTQKAEKEVTRMVV------- 271
Cdd:cd15959   159 CDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFvVATRQVRLIRKDkvrfppeesppAESRPACGRRPSRLLAikehkal 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1375379927 272 ----VMILAYCFCWGPYAFFACFAAAHPGYAFHPLVAALpAYFAKSATIYNPIIY 322
Cdd:cd15959   239 ktlgIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFL-NWLGYANSAFNPIIY 292
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
92-330 1.74e-04

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 42.86  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  92 LVNLAVADLAETIIASTISVVNQIYGYFV--LGHPLCIVEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNMRFDAKLA 169
Cdd:cd15135    42 MVSLACSDLLVLLLGMPVELYSAIWDPFAtpSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRV 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 170 IAGITFSWVWSAVWTAP-----------PIFGWSRYWPHGL------KTSCGP-----DVFSGSSYPGVQSYMIVLmttc 227
Cdd:cd15135   122 RLLICFVWLTSALVALPllfamgtedplEAFPSYRGTRHHCqdqksnLTICTSlsskwTVFQASIFSAFVLYLLVL---- 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 228 civpLSVIVLCylqvWLAIRAVAKQQK------------------ESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFAC 289
Cdd:cd15135   198 ----ASVAFMC----RRMMRALMGSKKgavavkgpggsvqllrkhESAEGKTARKQTILFLGLIVGTLAVCWMPNQIRRI 269
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 290 FAAAHP-----GYAFHPLVAALP---AYFAKSATIyNPIIYVFMNRQFR 330
Cdd:cd15135   270 MAAAKPkddwtRSYFRAYIILLPiadTFFYLSSVL-NPLLYNLSSQQFR 317
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
62-330 1.80e-04

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 42.94  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTIS--VVNQIYGYFVLGHPLC-IVEGYTVslcgi 138
Cdd:cd15183     9 LVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL---VFLFTLPfwIDYKLKDDWIFGDAMCkFLSGFYY----- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWS----LAIISWERWLVVCKPFGNMRfdAKLAIAGITFS---WVWSAVWTAPPIFGWSRYWPHGLKTsCGPDVFSGS 211
Cdd:cd15183    81 LGLYSeiffIILLTIDRYLAIVHAVFALR--ARTVTFGIITSiitWALAILASMPCLYFFKSQWEFTHHT-CSAHFPRKS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKESEStqkaekEVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15183   158 LIRWKRFQALKLNLLGLILPLLVMIICYTGI---INILLRRPNEKKA------KAVRLIFVITLLFFLLWTPYNLAAFVS 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 292 AAHpGYAFHP---------LVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15183   229 AFQ-DVLFTPsceqsqqldLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
63-326 2.20e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 42.49  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYG-YFVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15198    10 ILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGdRWMAGDVACRLLKLLQASARGASA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRFDAKLAIAGitfsWVWSAVWTAPPIFGWSRYWPHGLKTS-----CGPDVFSGSSYPGV 216
Cdd:cd15198    90 NLVVLLALDRHQAIRAPLGQPLRAWKLAALG----WLLALLLALPQAYVFRVDFPDDPASAwpghtLCRGIFAPLPRWHL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ--------QKESEST---------QKAEKEVTRMVVVMILAYCF 279
Cdd:cd15198   166 QVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQapgakkpwKKPSKSHlratapsalPRAKVKTLKMTLVIALLFVG 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 280 CWGPYAFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMN 326
Cdd:cd15198   246 CSLPYFIAELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVFLFFN 292
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
60-330 2.24e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 42.42  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL---AETIIASTISVVNQiyGYFVLGHPLC---IVEGYTV 133
Cdd:cd15302     7 TAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLligLESMPFYTVYVLNG--DYWPLGWVLCdlwLSVDYTV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLcgiTGLWSLAIISWERWLVVCKP--FGNMRFDAKLAIAgITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGS 211
Cdd:cd15302    85 CL---VSIYTVLLITIDRYCSVKIPakYRNWRTPRKVLLI-IAITWIIPALLFFISIFGWQYFTGQGRSLPEGECYVQFM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 212 SYPGVQSYMIVlmttcCIVPLSVIVLCYLqvWLAIRAVAKQQKESestqkaekevTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15302   161 TDPYFNMGMYI-----GYYWTTLIVMLIL--YAGIYRAANRARKA----------LRTITFILGAFVICWTPYHILATIY 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 292 AA--HPGYAFhPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15302   224 GFceAPPCVN-ETLYTISYYLCYMNSPINPFCYALANQQFK 263
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
57-261 2.33e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 42.58  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  57 SAWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLC 136
Cdd:cd15958     4 SLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAPPIF--GWSRYWPHGLKTSCGPDVfsgSSY 213
Cdd:cd15958    84 VTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTvWAISALVSFLPIMmhWWRDEDDQALKCYEDPGC---CDF 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 214 PGVQSYMIVLMTTCCIVPLSVIVLCYLQVWlaiRAVAKQQKESESTQK 261
Cdd:cd15958   161 VTNRAYAIASSIISFYIPLLIMIFVYLRVY---REAKKQIKKIDKCEG 205
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
63-284 3.17e-04

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 42.04  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAeTIIASTISVVNQIYGYfVLGHPLCIVEGYTVSLCGITGLW 142
Cdd:cd15181    10 VFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLL-LLLTFPFSVVESIAGW-VFGTFLCKLVGAIHKLNFYCSSL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 143 SLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAPP-IFGWSRYWPHGLKTSCgpdVFSGSSYPGVQSYM 220
Cdd:cd15181    88 LLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSiWLVCFLLSLPNlVFLEVETSTNANRTSC---SFHQYGIHESNWWL 164
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 221 I---VLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKESEStQKAekevTRMVVVMILAYCFCWGPY 284
Cdd:cd15181   165 TsrfLYHVVGFFLPLLIMGYCYATI---VVTLCQSSRRLQK-QKA----IRVAILVTLVFCLCWLPY 223
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
71-330 5.54e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 41.26  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIAStISVVNQIYGYFVLGHPLCIVEgYTVSLCGI-TGLWSLAIISW 149
Cdd:cd15087    18 NTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLP-INIAEHLLQQWPFGELLCKLI-LSIDHYNIfSSIYFLTVMSV 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 150 ERWLVVCKPFGNMRFDAKLAIAGITFS---WVWSAVWTAPPIFGWSRYWPHGLKTSCGPdVFSGSSYPGVQSYMIVLMTT 226
Cdd:cd15087    96 DRYLVVLATVRSRRMPYRTYRAAKIVSlcvWLLVTIIVLPFTVFAGVYSNELGRKSCVL-SFPSPESLWFKASRIYTLVL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 227 CCIVPLSVIVLCYLQVWLAIRAVaKQQKESESTQKAEKEVTRMVVVmILAYC-FCWGPYAFFACFAAAH--PGYafhPLV 303
Cdd:cd15087   175 GFAIPVSTICILYTMMLYKLRNM-RLNSNAKALDKAKKKVTLMVLV-VLAVClFCWTPFHLSTVVALTTdlPQT---PLV 249
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1375379927 304 AALpAYFAKS----ATIYNPIIYVFMNRQFR 330
Cdd:cd15087   250 IGI-SYFITSlsyaNSCLNPFLYAFLDDSFR 279
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
60-330 6.62e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 40.90  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLnwILVNLAVADL--AETIIASTISVVNQIYGYFVLGHPLC----IVEGYTV 133
Cdd:cd15220     6 MVLLDLTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLlaALLLMPLGILSSSPFFLGVVFGEAECrvyiFLSVCLV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCgitgLWSLAIISWERWLVVCKPfgnMRFDAK----LAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFS 209
Cdd:cd15220    84 SAS----ILTISAISVERYYYIVHP---MRYEVKmtigLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 210 GSSyPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIravakqqkeseSTQKAekevtrmVVVMILA---YCFCWGPYAF 286
Cdd:cd15220   157 SHS-GHRGVFVVLFALVCFLLPLLLILVVYCGVFKVF-----------GGGKA-------ALTLAAIvgqFLCCWLPYFA 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 287 FACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15220   218 FHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
62-284 8.01e-04

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 40.91  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFvlGHPLCIVEG--YTVSLcgIT 139
Cdd:cd15179     9 IIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYF--GNFLCKAVHviYTVNL--YS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKLAiAGITFSWVW-SAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS 218
Cdd:cd15179    85 SVLILAFISLDRYLAIVHATNSQRPRKLLA-EKVVYVGVWlPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELWVVA 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375379927 219 YMIVLMTTCCIVPLSVIVLCYLQVwlaIRavakqqKESESTQKAEKEVTRMVVVMILAYCFCWGPY 284
Cdd:cd15179   164 FRFQHILVGLVLPGLVILTCYCII---IS------KLSHSKGHQKRKALKTTVILILAFFACWLPY 220
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
61-330 8.34e-04

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 40.81  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15383     9 VLFVLSACSNLAVLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITfSWVWSAVWTAPPIFGWsrywpHGLKTSCGPD----VFSGSSYPGV 216
Cdd:cd15383    89 AFVTVVISLDRHAAILNPLAIGSARRRNRIMLCA-AWGLSALLALPQLFLF-----HTVTATPPVNftqcATHGSFPAHW 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCC--IVPLSVIVLCYLQVWLAIravAKQQKESESTQKAEKEVTR--------------MVVVMILAYCFC 280
Cdd:cd15383   163 QETLYNMFTFFClfLLPLLIMIFCYTRILLEI---SRRMKEKKDSAKNEVALRSssdnipkarmrtlkMTIVIVSSFIVC 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375379927 281 WGPYAFFACFaaahpgYAFHP--LVAALPAY-------FAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15383   240 WTPYYLLGLW------YWFSPemLEQTVPESlshilflFGLLNACLDPLIYGLFTISFR 292
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
61-330 1.02e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 40.45  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTISVVNQIYGY---FVLGHPLCIVEGYTVSLCG 137
Cdd:cd15160     8 SFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDL---LYILTLPLWIDYTANhhnWTFGPLSCKVVGFFFYTNI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFG-----NMRFDAKLAIAgitfSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSS 212
Cdd:cd15160    85 YASIGFLCCIAVDRYLAVVHPLRfrglrTRRFALKVSAS----IWVLELGTHSVFLGHDELFRDEPNHTLCYEKYPMEGW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YpgvQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAvakqqkeSESTQKAEK-EVTRMVVVMILAYCFCWGPYAFFACFA 291
Cdd:cd15160   161 Q---ASYNYARFLVGFLIPLSLILFFYRRVLRAVRQ-------SPSLEREEKrKIIGLLLSIVVIFLLCFLPYHVVLLVR 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 292 AAhpGYAFHPLVAAL-----PAY-FAKSATIYN----PIIYVFMNRQFR 330
Cdd:cd15160   231 SV--IELVQNGLCGFekrvfTAYqISLCLTSLNcvadPILYIFVTEDVR 277
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
61-159 1.15e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 40.24  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15938     8 LLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAE 87
                          90
                  ....*....|....*....
gi 1375379927 141 LWSLAIISWERWLVVCKPF 159
Cdd:cd15938    88 MFLLTVMAYDRYVAICKPL 106
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
71-330 1.40e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 40.18  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHPLN---WILVNLAVADLaeTIIASTISVVNQIYG--YFVLGHPLCIVEGYTVSLCGITGLWSLA 145
Cdd:cd15338    18 NSIVIYTIVKKSKFRCQQTvpdIFIFNLSIVDL--LFLLGMPFLIHQLLGngVWHFGETMCTLITALDTNSQITSTYILT 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 146 IISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVwTAPPIFGWSRYWP-HGLKTSCG---PDVFSGSSYPGVQSYM 220
Cdd:cd15338    96 VMTLDRYLATVHPIRSTKIrTPRVAVAVICLVWILSLL-SITPVWMYAGLMPlPDGSVGCAlllPNPETDTYWFTLYQFF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 221 IVLMttcciVPLSVIVLCYLQVWLAIrAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACF--AAAHPGYA 298
Cdd:cd15338   175 LAFA-----LPLVVICVVYFKILQNM-ASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAhlSIDRPSLA 248
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1375379927 299 FHPLV-AALPAYFAKSATiyNPIIYVFMNRQFR 330
Cdd:cd15338   249 FLYAYnVAISMGYANSCI--NPFLYIMLSETFK 279
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
63-333 1.40e-03

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 39.84  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNG----LVLVATMRFKK-LRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15194     5 ILYCLVFLVGavgnAILMGALVFKRgVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAPPIFGWSRYWPHGlKTSCGPDvfsgSSYPGV 216
Cdd:cd15194    85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCvWMLSCLLGLPTLLSRELKKYEE-KEYCNED----AGTPSK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 217 QSYMIVLMTTCCIVPLSVIVLCYLQVwlaIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAA--- 293
Cdd:cd15194   160 VIFSLVSLIVAFFLPLLSILTCYCTI---IWKLCHHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIAsgl 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1375379927 294 ---HPG--YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCI 333
Cdd:cd15194   237 qveVTClpYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
63-330 2.04e-03

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 39.37  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaetIIASTI--SVVNQIYGY-FVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15368    10 VALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDL---MLACFLpfQIVYHIQRNhWIFGKPLCNVVTVLFYANMYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS 218
Cdd:cd15368    87 SILTMTCISIERYLGVVYPMRSMRWRKKrYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCFDVLKWTMLPNIAA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCCI---VPLSVIVLCYLQVWLAIravakQQKESESTQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHP 295
Cdd:cd15368   167 WAAFLFTLFILlflIPFIITVYCYVLIILKL-----VQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSR 241
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1375379927 296 GYAFHPLVAA--LPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15368   242 LFYGKSLYHAykLTLSLSCLNSCLDPFIYYFASKEFR 278
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
61-284 2.26e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 39.42  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVViaSVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15385    10 IFAV--AVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSryWPHGLKTSCGPDVFSGSSYP-GVQSY 219
Cdd:cd15385    88 TYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFILSTPQYFIFS--LSEIENGSGVYDCWANFIVPwGIKAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 220 MIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVT-------------------RMVVVMILAYCFC 280
Cdd:cd15385   166 ITWITISIFVVPVIILLTCYGFICYNIWRNIKCKTRRGLSDNALKNILlavcvssvktisrakirtvKMTFVIVLAYIVC 245

                  ....
gi 1375379927 281 WGPY 284
Cdd:cd15385   246 WAPF 249
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-330 2.74e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 39.16  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVLVATMRFKKLRHP---LNWILVNLAVADLAETIIASTISVVNQIYGYF--VLGHPLCIVEGYTVSLCGITGLWSLA 145
Cdd:cd15130    18 NSVTLFTLARKKSLQSLqstVRYHLGSLALSDLLILLLAMPVELYNFIWVHHpwAFGDAGCRGYYFLRDACTYATALNVA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 146 IISWERWLVVCKPfgnmrFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTScgpdvFSGSSYPGVQSYMIVLMT 225
Cdd:cd15130    98 SLSVERYLAICHP-----FKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNE-----SDDGTHPGGLVCTPIVDT 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 226 TCCIVPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEK--EVTRMVVVMilaYCFCWGPYAFFACF-------AAAHPG 296
Cdd:cd15130   168 ATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQALRRgvLVLRAVVIA---FVVCWLPYHVRRLMfcyisdeQWTTFL 244
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375379927 297 YAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15130   245 FDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
61-330 2.95e-03

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 39.04  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15981     8 LFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFgNMRFDAKLAIAGITFSWVWSAVWTAPP--------------IFGWSRYWPhglKTSCgpd 206
Cdd:cd15981    88 VFTLVAIAVERFRCIVHPF-RQKLTLRKAIVTIVIIWVLALIIMCPSavtltvtreehhfmVDDYNNSYP---LYSC--- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 207 vFSGSSYPGVQS-YMIVLMTTCCIVPLSVIVLCYLQVWLA-------IRAVAKQQKESESTQKAEKEVTRMVVVMILAYC 278
Cdd:cd15981   161 -WEAWPDTEMRKiYTTVLFSHIYLAPLTLIVIMYARIAFKlfkssapIRGSQGEEEEGRRVSKRKIKVINMLIIVALFFT 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375379927 279 FCWGPYAFFACFAAAH----------PGYAFhPLVAALpAYFAKSAtiyNPIIYVFMNRQFR 330
Cdd:cd15981   240 LSWLPLWTLMLLTDYGhlsedqlnlvTVYVF-PFAHWL-AFFNSSV---NPIIYGYFNENFR 296
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
62-330 3.40e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 38.75  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASV--FTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15123     7 YAVIISVgiLGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPFGNMRFDAKLAIAGITFS-WVWSAVWTAPP-----IFGWSRYWPHGLKTSCGPDVFSGSSY 213
Cdd:cd15123    87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCvWIVSMLFAIPEavfsdLYSFRDPEKNTTFEACAPYPVSEKIL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTccIVPLSVIVLCYLQVWL-----AIRAVAKQQKESESTQKAEKEVTRMVVVMILAYCFCWGP----- 283
Cdd:cd15123   167 QEIHSLLCFLVFY--IIPLSIISVYYFLIARtlyksTFNMPAEEHSHARKQIESRKRVAKTVLVLVALFAFCWLPnhily 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1375379927 284 -YAFFACFAAAHPGyAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15123   245 lYRSFTYHTSVDSS-AFHLIATIFSRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
55-284 3.46e-03

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 38.61  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  55 LTSAWMIFVVIASVFTNGLVLvATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVS 134
Cdd:cd15120     2 LIAVALFVTFLVGLVVNGLYL-WVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKPF-----GNMRFdAKLAIAGItfsWVWSAVWTAPPIFGWSRYWPHGLKTSCGPD--V 207
Cdd:cd15120    81 VGMFTSVFLLTAISLDRYLLTLHPVwsrqhRTNRW-ASAIVLGV---WISAILLSIPYLAFRETRLDEKGKTICQNNyaL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 FSGSSYPGVQSYMIVLMTTCCIV--------PLSVIVLCYLQVWLAIravaKQQKESESTQKaekevTRMVVVMILAYCF 279
Cdd:cd15120   157 STNWESAEVQASRQWIHVAMFVFrfllgfllPFLIITFCYVRMALKM----KERGLARSSKP-----FKVMFTAVVSFFV 227

                  ....*
gi 1375379927 280 CWGPY 284
Cdd:cd15120   228 CWLPY 232
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
71-254 3.52e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 38.58  E-value: 3.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  71 NGLVL-VATMRFKKLrhPLNWILVNLAVADLAeTIIASTISVVNQIYG-YFVLGHPLCIVegYTVSLCG--ITGLWSLAI 146
Cdd:cd15372    18 NGLALwVLATQVKRL--PSTIFLINLAVADLL-LILVLPFKISYHFLGnNWPFGEGLCRV--VTAFFYGnmYCSVLLLMC 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 147 ISWERWLVVCKPFGNMRFDAK-LAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPG-VQSYMIVLM 224
Cdd:cd15372    93 ISLDRYLAVVHPFFARTLRSRrFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDEQDTyLFYYFACLA 172
                         170       180       190
                  ....*....|....*....|....*....|
gi 1375379927 225 TTCCIVPLSVIVLCYLQVwlaIRAVAKQQK 254
Cdd:cd15372   173 VLGFLLPLVVILFCYGSV---LHTLLRSGQ 199
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
63-158 3.92e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 38.57  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADlaetiIASTISVVNQIYGYFVLGHPL-----CIVEGYTVSLCG 137
Cdd:cd15942    10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILD-----MAVSTVVVPKVIAGFLSGGRIisfggCVTQLFFFHFLG 84
                          90       100
                  ....*....|....*....|.
gi 1375379927 138 ITGLWSLAIISWERWLVVCKP 158
Cdd:cd15942    85 CAECFLYTVMAYDRFLAICKP 105
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
59-247 4.28e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 38.30  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  59 WMIFVVIASVFTNGLVLVATMRFKkLRHPlNWILVNLAVADLAETI----IAST-ISVVNQIYGYFVLGH--PLCIVEGY 131
Cdd:cd15360     8 WFINILAITGNIVVLAILLTSQYK-LTVP-RFLMCNLAFADLCMGIylllIASVdIRTKSQYYNYAIDWQtgAGCAAAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 132 TVSLCGITGLWSLAIISWERWLVVCKPfgnMRFDAKL----AIAGITFSWVWSAVWTAPPIFGWSRYwphgLKTS-CGP- 205
Cdd:cd15360    86 FTVFASELSVYTLTVITLERWHTITYA---MQLDRKVrlrhAAVIMVGGWIFAFTVALLPIFGISSY----MKVSiCLPm 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1375379927 206 DVFSgssyPGVQSYMIVLMTTcCIVPLSVIVLCYLQVWLAIR 247
Cdd:cd15360   159 DIES----PLSQAYIIFILVL-NVLAFLIICACYIKIYLTVR 195
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
61-284 4.34e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 38.62  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLaeTIIASTISVVNQIYGYFVLGH--PLCIVEGYTVSLCGI 138
Cdd:cd15366     8 IIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDL--LYIATLPLWIDYFLHRDNWIHgpESCKLFGFIFYTNIY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 139 TGLWSLAIISWERWLVVCKP--FGNMRfDAKLAIAGITFSWVWSAVWTAPPIFGwsrywpHGLKTSCGPDVFSGSSYPgv 216
Cdd:cd15366    86 ISIAFLCCISVDRYLAVAHPlrFAKVR-RVKTAVAVSAVVWAIEIGANSAPLFH------DELFRDRYNHTFCFEKYP-- 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375379927 217 QSYMIVLMTTCCI-----VPLSVIVLCYLQVWLAIRAvakqqkeSESTQKAEK-EVTRMVVVMILAYCFCWGPY 284
Cdd:cd15366   157 MEDWVAWMNLYRVfvgflFPWVLMLFSYRGILRAVRG-------NVSTEQQEKaKIKRLALSLIAIVLLCFAPY 223
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
62-330 4.74e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 38.35  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVL-VATMRFKKLRHPlNWILVNLAVADLAETIIASTISVVN-----QIYGYFVLGH--PLCIVEGYTV 133
Cdd:cd15964     9 FVNLLAILGNVFVLlILLTSHYKLTVP-RFLMCNLAFADFCMGIYLLLIASVDlhtrsEYYNHAIDWQtgPGCNTAGFFT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPfgnMRFDAKL----AIAGITFSWVWSAVWTAPPIFGWSRYwphgLKTS-CGPdvf 208
Cdd:cd15964    88 VFASELSVYTLTVITLERWYAITFA---MRLDRKIrlrhASAIMLGGWVFCFLLALLPLVGVSSY----AKVSiCLP--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 209 SGSSYPGVQSYmIVLMTTCCIVPLSVIVLCYLQVWLAIRavakqQKESESTQKAEKEVTRMvVVMILAYCFCWGPYAFFA 288
Cdd:cd15964   158 MDTETPLAQAY-IVFVLMLNIIAFVIICACYIKIYITVR-----NPQYKSGDKDTKIAKRM-AVLIFTDFICMAPISFYA 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1375379927 289 CFAAAHpgyafHPLVAA-----LPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15964   231 LSAILN-----KPLITVsnskiLLVLFYPLNSCANPFLYAIFTKAFR 272
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
62-330 5.01e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 38.31  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFK-KLRHPlNWILVNLAVADLAETIIASTISVVN-----QIYGYFVLGH--PLCIVEGYTV 133
Cdd:cd15359     9 FINILAIAGNLIVLFVLLTSRyKLTVP-RFLMCNLSFADFCMGLYLLLIASVDsqtksQYYNHAIDWQtgSGCSTAGFFT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKPfgnMRFDAKL----AIAGITFSWVWSAVWTAPPIFGWSRYwphgLKTS-CGP-DV 207
Cdd:cd15359    88 VFASELSVYTLTVITLERWHTITYA---MQLDRKLrlrhAILIMLGGWVFSLLIAVLPLVGVSNY----MKVSiCLPmDI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 208 FSGSSypgvQSYmIVLMTTCCIVPLSVIVLCYLQVWLAIravakQQKESESTQKAEKEVTRMVVVMILAYCfCWGPYAFF 287
Cdd:cd15359   161 ETLLS----QAY-ILLILVLNVIAFLVICACYIKIYLAV-----QNPELVAKNKDTKIAKRMAILIFTDFT-CMAPISFF 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1375379927 288 ACFAaahpgyAFH-PLVAA-----LPAYFAKSATIYNPIIYVFMNRQFR 330
Cdd:cd15359   230 AISA------AFKvPLITVtnskiLLVLFYPINSCANPFLYAIFTKAFR 272
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
58-326 5.34e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 38.23  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  58 AWMIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCG 137
Cdd:cd15946     5 AVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 138 ITGLWSLAIISWERWLVVCKPFG-NMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYwPHglktsCGPDVFSG--SSYP 214
Cdd:cd15946    85 ITECTLFSVMAYDRYVAICHPLRyKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRL-PY-----CGPNEINHyfCEVP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 215 GVQSY---------MIVLMTT--CCIVPLSVIVLCYLQVWLAIRAVakqqKESESTQKAEKEVTRMVVVMILAYCFCWGP 283
Cdd:cd15946   159 AVLKLacadtslneMVDFVLGviVLVVPLSLILASYVNIFKAILKI----RSTQGRCKAFSTCASHITVVTMFYGPAMFM 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1375379927 284 YaffacfaaAHPGYAFHPLVAALPAYFAKSAT-IYNPIIYVFMN 326
Cdd:cd15946   235 Y--------MRPGSNYSPERDKKISLFYNVFTaLLNPVIYSLRN 270
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
62-252 6.08e-03

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 37.91  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  62 FVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLA--------ETIIASTISVVNQIYGYFVLGhplCIVEGYTV 133
Cdd:cd15211     8 FLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLvcafwmpqEAVLGSTGTLLVLGYRLFREG---LLFLGLTV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCgitglwSLAIISWERWLVVCK-PFGNMRFDAKLAIAG-ITFSWVWSAVWTAPPIFGWSrywPHGLKTSCGPDVFSGS 211
Cdd:cd15211    85 SLL------SHSLIALNRYVLITKlPAVYQALYQKRNTEWmIALSWALALGLLLPWLTSFR---YPTKSCHDSADGSFAV 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1375379927 212 SYPGVQSYMIVLMTTCCIVPLSVIVLCYLQVWLAIRAVAKQ 252
Cdd:cd15211   156 VSVLSSRYPALLLAFTVLGQTALVLHCYFGIFRRVQISVKR 196
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
60-332 6.14e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 38.21  E-value: 6.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAET------IIASTISVVNQIYGYFVlghplCIVEGYTV 133
Cdd:cd15005     7 LGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSlacfpfVMASVRHGSGWIYGALS-----CKVIAFLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 134 SLCGITGLWSLAIISWERWLVVCKP-FGNMRFDAKLAIAGITFSWVWSAVWTAPPIFGWSRYWPHGLKTSCgpdVFSGSS 212
Cdd:cd15005    82 VLFCFHSAFTLFCIAVTRYMAIAHHrFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQC---TFEHRS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 213 YPGVQSYMIVLMTTCCIVPLSVI---VLCYL----------------QVW----------------------------LA 245
Cdd:cd15005   159 YKANDTLGFMLVLAVVIAATHLVylkLLIFLrhhrkmkpaqlvpaisQNWtfhgpgatgqaaanwtagfgrgptpptlLG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 246 IRAVAKQQKESE---STQKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGYAFHP--LVAALPAYFAKSATiyNPI 320
Cdd:cd15005   239 IRQAFHSGARRLlvlDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVPQgfLTAAVWMTFAQAGV--NPI 316
                         330
                  ....*....|..
gi 1375379927 321 IYVFMNRQFRNC 332
Cdd:cd15005   317 VCFFFNRELRKC 328
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-324 6.59e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 37.87  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  73 LVLVATMRFKKLRhpLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGITGLWSLAIISWERW 152
Cdd:cd15387    22 LLAIHTTRHKHSR--MYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSIDRC 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 153 LVVCKPFGNMRFDAKLAIagITFSWVWSAVWTAPPIFGWSRywphglkTSCGPDVF---SGSSYP-GVQSYMIVLMTTCC 228
Cdd:cd15387   100 LAICQPLRSLHRRSDRVY--VLFSWLLSLVFSIPQVHIFSL-------REVGNGVYdcwADFIQPwGPKAYITWITLSVY 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 229 IVPLSVIVLCY----LQVWLAIRAVAKQQKESESTQKAEKEVT------------------RMVVVMILAYCFCWGPYAF 286
Cdd:cd15387   171 IIPVLILSVCYglisFKIWQNVKLKTRRETKTPLSSAASGGAAlarvssvkliskakirtvKMTFVIVLAYIVCWTPFFF 250
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1375379927 287 FACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVF 324
Cdd:cd15387   251 VQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMF 288
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
61-339 6.88e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 38.07  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  61 IFVVIASVFTNglVLVATMRF-KKLRHPLNWILVNLAVADLAETIIASTIsvvnqIYGYF---VLGHPLCIVEGYTVSLC 136
Cdd:PHA02638  106 IIIFILGLFGN--AAIIMILFcKKIKTITDIYIFNLAISDLIFVIDFPFI-----IYNEFdqwIFGDFMCKVISASYYIG 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 137 GITGLWSLAIISWERWLVVCKPFGNMRFDA-KLAIAGITFSWVWSAVWTAPP--IFGWSRYWPHGLKTSCGPDVFSGSSY 213
Cdd:PHA02638  179 FFSNMFLITLMSIDRYFAILYPISFQKYRTfNIGIILCIISWILSLIITSPAyfIFEASNIIFSAQDSNETISNYQCTLI 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 214 PGVQSYMIVLMTTCC---------IVPLSVIVLCYLQVWLAIravaKQQKESESTQKaekevTRMVVVMILAYCFCWGPY 284
Cdd:PHA02638  259 EDNEKNNISFLGRILqfeinilgmFIPIIIFAFCYIKIILKL----KQLKKSKKTKS-----IIIVSIIIICSLICWIPL 329
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375379927 285 AFFACFAAAHPGYAFHPLVAALPAYFAK-------------SATIYNPIIYVFMNRQFRNCILQLFGR 339
Cdd:PHA02638  330 NIVILFATMYSFKGFNSIISEHICGFIKlgyammlaeaislTHCCINPLIYTLIGENFRMHLLMIFRN 397
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
63-331 6.88e-03

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 37.81  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADL--AETIIASTISVVNQiygyFVLGHPLCIVEGYTVSLCGITG 140
Cdd:cd15184    10 VFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLlfLLTLPFWAHYAANE----WVFGNAMCKLLTGLYHIGFFSG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 141 LWSLAIISWERWLVVCKPFGNMRfdAKLAIAGITFSWV-WS-AVWTAPPIFGWSRYWPHGLKTSCGPDvFSGSSYPGVQS 218
Cdd:cd15184    86 IFFIILLTIDRYLAIVHAVFALK--ARTVTFGVVTSVVtWVvAVFASLPGIIFTKSQKEGSHYTCSPH-FPPSQYQFWKN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 219 YMIVLMTTCCIV-PLSVIVLCYLQVwlaIRAVAKQQKEsestqKAEKEVTRMVVVMILAYCFCWGPYAFFACFAAAHPGY 297
Cdd:cd15184   163 FQTLKMNILGLVlPLLVMIICYSGI---LKTLLRCRNE-----KKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFF 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1375379927 298 AFHPLVAALPAYFAKSAT--------IYNPIIYVFMNRQFRN 331
Cdd:cd15184   235 GLNNCSSSNRLDQAMQVTetlgmthcCINPVIYAFVGEKFRS 276
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
60-159 7.29e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.92  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCIVEGYTVSLCGIT 139
Cdd:cd15957     7 MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTA 86
                          90       100
                  ....*....|....*....|
gi 1375379927 140 GLWSLAIISWERWLVVCKPF 159
Cdd:cd15957    87 SIETLCVIAVDRYFAITSPF 106
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
63-284 8.37e-03

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 37.72  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  63 VVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAETIiASTISVVNQIYGY-FVLGHPLCIVEGYTVSLCGITGL 141
Cdd:cd15159    10 ILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTL-ALPGRIAYYALGFdWPFGDWLCRLTALLFYINTYAGV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927 142 WSLAIISWERWLVVCKPFGNMRF-DAKLAIAGITFSWVWSAVWTAPPIFGwSRYWPHGLKTSCgpdvFSGSSYPGVQSYM 220
Cdd:cd15159    89 NFMTCLSVDRYIAVVHPLRRHRLrKVKVVRYICVFVWVLVFLQTLPLLFM-PMTKEMGGRITC----MEYPNFEKIKRLP 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375379927 221 IVLMTTCCI---VPLSVIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTrMVVVMILAYCFCWGPY 284
Cdd:cd15159   164 LILLGACVIgfgVPVGIILFCYSQITLKLCRTAKENPLTEKSGHHKKACN-VILLVLLVFVVCFSPY 229
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
60-158 9.67e-03

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 37.46  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375379927  60 MIFVVIASVFTNGLVLVATMRFKKLRHPLNWILVNLAVADLAetiiaSTISVVNQIYGYF-----VLGHPLCIVEGYTVS 134
Cdd:cd15428     7 FLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELC-----YTTTVVPQMLVHLlserkIISFIRCAAQLYFFL 81
                          90       100
                  ....*....|....*....|....
gi 1375379927 135 LCGITGLWSLAIISWERWLVVCKP 158
Cdd:cd15428    82 SFGITECALLSVMSYDRYVAICLP 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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