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Conserved domains on  [gi|1376610644|gb|AVY03718|]
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capsular polysaccharide phosphotransferase [Actinobacillus pleuropneumoniae]

Protein Classification

stealth family protein( domain architecture ID 11246895)

stealth family protein is involved in the biosynthesis of exopolysaccharides and helps pathogens elude the host innate immune system; similar to capsular polysaccharide phosphotransferase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 103-208 1.13e-49

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 463267  Cd Length: 108  Bit Score: 162.25  E-value: 1.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376610644 103 RFEDHNELYYSVHAVLKYMPWVRHIFIITDNQKPKWLDeTRQEKITLIDHQDIIDKEY-LPTFNSHVIEAFLHKIPNLSE 181
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLN-TSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSE 79

                          90       100
                  ....*....|....*....|....*..
gi 1376610644 182 NFIYFNDDVFIARELQAEHFFQANGIA 208
Cdd:pfam11380  80 HFLYFNDDMFLGRPVKPEDFFTPDGLP 106
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 65-90 1.41e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....*.
gi 1376610644  65 IDVVFTWVDGSDPSWQAKYSQYAPNY 90
Cdd:pfam17101   3 IDVVYTWVNGSDPEWQAKKAKYLGKL 28
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 103-208 1.13e-49

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 162.25  E-value: 1.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376610644 103 RFEDHNELYYSVHAVLKYMPWVRHIFIITDNQKPKWLDeTRQEKITLIDHQDIIDKEY-LPTFNSHVIEAFLHKIPNLSE 181
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLN-TSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSE 79

                          90       100
                  ....*....|....*....|....*..
gi 1376610644 182 NFIYFNDDVFIARELQAEHFFQANGIA 208
Cdd:pfam11380  80 HFLYFNDDMFLGRPVKPEDFFTPDGLP 106
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 65-90 1.41e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....*.
gi 1376610644  65 IDVVFTWVDGSDPSWQAKYSQYAPNY 90
Cdd:pfam17101   3 IDVVYTWVNGSDPEWQAKKAKYLGKL 28
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 103-208 1.13e-49

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 162.25  E-value: 1.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376610644 103 RFEDHNELYYSVHAVLKYMPWVRHIFIITDNQKPKWLDeTRQEKITLIDHQDIIDKEY-LPTFNSHVIEAFLHKIPNLSE 181
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLN-TSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSE 79

                          90       100
                  ....*....|....*....|....*..
gi 1376610644 182 NFIYFNDDVFIARELQAEHFFQANGIA 208
Cdd:pfam11380  80 HFLYFNDDMFLGRPVKPEDFFTPDGLP 106
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 65-90 1.41e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....*.
gi 1376610644  65 IDVVFTWVDGSDPSWQAKYSQYAPNY 90
Cdd:pfam17101   3 IDVVYTWVNGSDPEWQAKKAKYLGKL 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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