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Conserved domains on  [gi|1388116475|gb|AWI67078|]
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Methyltransferase [Piromyces sp.]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 64-176 4.96e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 111.62  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  64 EKALSGIEENFNGKLLDVPVGTGVLTVPLYSilKDADITCVDYSDEMLNQAKEKAEKLQLtNTKFQQGDVGHLEFEDNSF 143
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1388116475 144 DIVLSMNGFHAFPDKEAAYNETYRVLKTGGKFC 176
Cdd:COG2226    89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLV 121
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 64-176 4.96e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 111.62  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  64 EKALSGIEENFNGKLLDVPVGTGVLTVPLYSilKDADITCVDYSDEMLNQAKEKAEKLQLtNTKFQQGDVGHLEFEDNSF 143
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1388116475 144 DIVLSMNGFHAFPDKEAAYNETYRVLKTGGKFC 176
Cdd:COG2226    89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLV 121
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 79-173 2.18e-28

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 103.03  E-value: 2.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTVPLYSILKdADITCVDYSDEMLNQAKEKAEKLQLtNTKFQQGDVGHLEFEDNSFDIVLSMNGFHAF--P 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpdP 79

                          90
                  ....*....|....*..
gi 1388116475 157 DKEAAYNETYRVLKTGG 173
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 64-175 3.68e-22

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 90.78  E-value: 3.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  64 EKALSGIEENFNGKLLDVPVGTGVLTVPLY-SILKDADITCVDYSDEMLNQAKEKAEKLQltNTKFQQGDVGHLEFEDNS 142
Cdd:TIGR01934  29 RRAVKLIGVFKGQKVLDVACGTGDLAIELAkSAPDRGKVTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNS 106

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1388116475 143 FDIVLSMNGFHAFPDKEAAYNETYRVLKTGGKF 175
Cdd:TIGR01934 107 FDAVTIAFGLRNVTDIQKALREMYRVLKPGGRL 139
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 77-175 9.29e-22

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 89.83  E-value: 9.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPLY-SILKDADITCVDYSDEMLNQAKEKAEKLQL-TNTKFQQGDVGHLEFEDNSFDIVlSMngfhA 154
Cdd:PRK00216   54 KVLDLACGTGDLAIALAkAVGKTGEVVGLDFSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAV-TI----A 128

                          90       100
                  ....*....|....*....|....*.
gi 1388116475 155 F-----PDKEAAYNETYRVLKTGGKF 175
Cdd:PRK00216  129 FglrnvPDIDKALREMYRVLKPGGRL 154
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 77-181 4.29e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 71.31  E-value: 4.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPLYSiLKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEF-EDNSFDIVLS-MNGFHA 154
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISdPPLHHL 79

                          90       100
                  ....*....|....*....|....*..
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKFCGCFYI 181
Cdd:cd02440    80 VEDLARFLEEARRLLKPGGVLVLTLVL 106
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 64-176 4.96e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 111.62  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  64 EKALSGIEENFNGKLLDVPVGTGVLTVPLYSilKDADITCVDYSDEMLNQAKEKAEKLQLtNTKFQQGDVGHLEFEDNSF 143
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFPDGSF 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1388116475 144 DIVLSMNGFHAFPDKEAAYNETYRVLKTGGKFC 176
Cdd:COG2226    89 DLVISSFVLHHLPDPERALAEIARVLKPGGRLV 121
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 79-173 2.18e-28

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 103.03  E-value: 2.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTVPLYSILKdADITCVDYSDEMLNQAKEKAEKLQLtNTKFQQGDVGHLEFEDNSFDIVLSMNGFHAF--P 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpdP 79

                          90
                  ....*....|....*..
gi 1388116475 157 DKEAAYNETYRVLKTGG 173
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 79-176 2.14e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 92.73  E-value: 2.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTVPLYSILkdADITCVDYSDEMLNQAKEKAEKLQLTntkFQQGDVGHLEFEDNSFDIVLSMNGFHAFPDK 158
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG--ARVTGVDISPEMLELAREKAPREGLT---FVVGDAEDLPFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*...
gi 1388116475 159 EAAYNETYRVLKTGGKFC 176
Cdd:pfam08241  76 ERALREIARVLKPGGILI 93
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 64-175 3.68e-22

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 90.78  E-value: 3.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  64 EKALSGIEENFNGKLLDVPVGTGVLTVPLY-SILKDADITCVDYSDEMLNQAKEKAEKLQltNTKFQQGDVGHLEFEDNS 142
Cdd:TIGR01934  29 RRAVKLIGVFKGQKVLDVACGTGDLAIELAkSAPDRGKVTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNS 106

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1388116475 143 FDIVLSMNGFHAFPDKEAAYNETYRVLKTGGKF 175
Cdd:TIGR01934 107 FDAVTIAFGLRNVTDIQKALREMYRVLKPGGRL 139
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 75-176 7.23e-22

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 87.86  E-value: 7.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSIL-KDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLE--FEDNSFDIVLSMNG 151
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFDVVISNCV 83

                          90       100
                  ....*....|....*....|....*
gi 1388116475 152 FHAFPDKEAAYNETYRVLKTGGKFC 176
Cdd:pfam13847  84 LNHIPDPDKVLQEILRVLKPGGRLI 108
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 77-175 9.29e-22

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 89.83  E-value: 9.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPLY-SILKDADITCVDYSDEMLNQAKEKAEKLQL-TNTKFQQGDVGHLEFEDNSFDIVlSMngfhA 154
Cdd:PRK00216   54 KVLDLACGTGDLAIALAkAVGKTGEVVGLDFSEGMLAVGREKLRDLGLsGNVEFVQGDAEALPFPDNSFDAV-TI----A 128

                          90       100
                  ....*....|....*....|....*.
gi 1388116475 155 F-----PDKEAAYNETYRVLKTGGKF 175
Cdd:PRK00216  129 FglrnvPDIDKALREMYRVLKPGGRL 154
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 75-175 6.74e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 84.68  E-value: 6.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSilKDADITCVDYSDEMLNQAKEKAEKLQLTntkFQQGDVGHLEFEDNSFDIVLSMNGFHA 154
Cdd:COG2227    25 GGRVLDVGCGTGRLALALAR--RGADVTGVDISPEALEIARERAAELNVD---FVQGDLEDLPLEDGSFDLVICSEVLEH 99

                          90       100
                  ....*....|....*....|.
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKF 175
Cdd:COG2227   100 LPDPAALLRELARLLKPGGLL 120
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
62-176 4.80e-19

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 81.20  E-value: 4.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  62 IIEKALSGIEENFNGKLLDVPVGTGVLTVPLysILKDADITCVDYSDEMLNQAKEKAeklqlTNTKFQQGDVGHLEFEDN 141
Cdd:COG4976    34 LAEELLARLPPGPFGRVLDLGCGTGLLGEAL--RPRGYRLTGVDLSEEMLAKAREKG-----VYDRLLVADLADLAEPDG 106

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1388116475 142 SFDIVLSMNGFHAFPDKEAAYNETYRVLKTGGKFC 176
Cdd:COG4976   107 RFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI 141
arsM PRK11873
arsenite methyltransferase;
104-175 7.99e-17

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 77.30  E-value: 7.99e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1388116475 104 VDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEFEDNSFDIVLS---MNgfhAFPDKEAAYNETYRVLKTGGKF 175
Cdd:PRK11873  108 VDMTPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISncvIN---LSPDKERVFKEAFRVLKPGGRF 179
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
75-175 1.12e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 72.93  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKaeklqLTNTKFQQGDVGHLEFEDnSFDIVLSMNGFHA 154
Cdd:COG4106     2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR-----LPNVRFVVADLRDLDPPE-PFDLVVSNAALHW 75

                          90       100
                  ....*....|....*....|.
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKF 175
Cdd:COG4106    76 LPDHAALLARLAAALAPGGVL 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 77-181 4.29e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 71.31  E-value: 4.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPLYSiLKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEF-EDNSFDIVLS-MNGFHA 154
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISdPPLHHL 79

                          90       100
                  ....*....|....*....|....*..
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKFCGCFYI 181
Cdd:cd02440    80 VEDLARFLEEARRLLKPGGVLVLTLVL 106
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 79-175 4.37e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 71.24  E-value: 4.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEFED-NSFDIVLSMNGFHAFPD 157
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDpGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 1388116475 158 KEAAYNETYRVLKTGGKF 175
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 75-176 1.06e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 73.03  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSILKdADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHL-EFEDNSFDIVLSMNGFH 153
Cdd:COG0500    27 GGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELdPLPAESFDLVVAFGVLH 105

                          90       100
                  ....*....|....*....|....*
gi 1388116475 154 AFPDKE--AAYNETYRVLKTGGKFC 176
Cdd:COG0500   106 HLPPEEreALLRELARALKPGGVLL 130
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
77-175 6.40e-15

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 71.32  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPLY-SILKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEFEDNSFDIVLSMNGFHAF 155
Cdd:pfam01209  45 KFLDVAGGTGDWTFGLSdSAGSSGKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRNF 124

                          90       100
                  ....*....|....*....|
gi 1388116475 156 PDKEAAYNETYRVLKTGGKF 175
Cdd:pfam01209 125 PDYLKVLKEAFRVLKPGGRV 144
PRK08317 PRK08317
hypothetical protein; Provisional
 79-174 1.45e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 70.35  E-value: 1.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTVPL-YSILKDADITCVDYSDEMLNQAKEKAEKLqLTNTKFQQGDVGHLEFEDNSFDIVLSMNGFHAFPD 157
Cdd:PRK08317   24 LDVGCGPGNDARELaRRVGPEGRVVGIDRSEAMLALAKERAAGL-GPNVEFVRGDADGLPFPDGSFDAVRSDRVLQHLED 102

                          90
                  ....*....|....*..
gi 1388116475 158 KEAAYNETYRVLKTGGK 174
Cdd:PRK08317  103 PARALAEIARVLRPGGR 119
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 75-176 2.99e-11

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 62.22  E-value: 2.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKAEklqLTNTKFQQGDVGHLEFEDNSFDIVLSMNGFHA 154
Cdd:PLN02490  114 NLKVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEP---LKECKIIEGDAEDLPFPTDYADRYVSAGSIEY 190

                          90       100
                  ....*....|....*....|..
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKFC 176
Cdd:PLN02490  191 WPDPQRGIKEAYRVLKIGGKAC 212
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 77-175 5.11e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.48  E-value: 5.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  77 KLLDVPVGTGVLTVPL---YsilkDADITCVDYSDEMLNQAKEKAEKLQLTNT-KFQQGDVGHLEFeDNSFDIVLSMNGF 152
Cdd:COG2230    54 RVLDIGCGWGGLALYLarrY----GVRVTGVTLSPEQLEYARERAAEAGLADRvEVRLADYRDLPA-DGQFDAIVSIGMF 128

                          90       100
                  ....*....|....*....|....*
gi 1388116475 153 HAFPDK--EAAYNETYRVLKTGGKF 175
Cdd:COG2230   129 EHVGPEnyPAYFAKVARLLKPGGRL 153
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 67-175 4.20e-09

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 54.13  E-value: 4.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  67 LSGIEENFNGKLLDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVgHLEFEDNSFDIV 146
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDV-YSGVEDGKFDLI 102

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1388116475 147 LSMNGFHAfpDKEAAYNETYR-------VLKTGGKF 175
Cdd:pfam05175 103 ISNPPFHA--GLATTYNVAQRfiadakrHLRPGGEL 136
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 67-175 6.12e-09

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 54.04  E-value: 6.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  67 LSGIEENFNGKLLDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHlEFEDNSFDIV 146
Cdd:COG2813    42 LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLS-GVPDGSFDLI 120

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1388116475 147 LSMNGFHA--FPDKEAAY---NETYRVLKTGGKF 175
Cdd:COG2813   121 LSNPPFHAgrAVDKEVAHaliADAARHLRPGGEL 154
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 67-218 2.52e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 51.87  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  67 LSGIEENfnGKLLDVPVGTGvlTVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTNTKFQQGDVGHLEFEDNSFD-I 145
Cdd:COG1041    21 LAGAKEG--DTVLDPFCGTG--TILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLADESVDaI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475 146 VLSM---NGFHAFPDK-----EAAYNETYRVLKTGGKFcgCFYikgqcsrTDKIIDTVYVKKGyftppFETLESFTERMN 217
Cdd:COG1041    97 VTDPpygRSSKISGEEllelyEKALEEAARVLKPGGRV--VIV-------TPRDIDELLEEAG-----FKVLERHEQRVH 162


                  .
gi 1388116475 218 K 218
Cdd:COG1041   163 K 163
PRK05785 PRK05785
hypothetical protein; Provisional
 76-168 5.11e-07

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 48.92  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  76 GKLLDVPVGTGVLTVPLYSILKdADITCVDYSDEMLNQAKEKAEKLQltntkfqqGDVGHLEFEDNSFDIVLSMNGFHAF 155
Cdd:PRK05785   53 KKVLDVAAGKGELSYHFKKVFK-YYVVALDYAENMLKMNLVADDKVV--------GSFEALPFRDKSFDVVMSSFALHAS 123

                          90
                  ....*....|...
gi 1388116475 156 PDKEAAYNETYRV 168
Cdd:PRK05785  124 DNIEKVIAEFTRV 136
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 78-174 1.07e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 45.27  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  78 LLDVPVGTGVLTVPLYS-ILKDADITCVDYSDEMLNQA---KEKAEKLQLTNTKFQQGDVGHLEFEDNSFDIVLSMNGFH 153
Cdd:PLN02233   77 VLDLCCGSGDLAFLLSEkVGSDGKVMGLDFSSEQLAVAasrQELKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLR 156

                          90       100
                  ....*....|....*....|.
gi 1388116475 154 AFPDKEAAYNETYRVLKTGGK 174
Cdd:PLN02233  157 NVVDRLKAMQEMYRVLKPGSR 177
PLN02244 PLN02244
tocopherol O-methyltransferase
 127-174 1.54e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 45.12  E-value: 1.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1388116475 127 KFQQGDVGHLEFEDNSFDIVLSM-NGFHaFPDKEAAYNETYRVLKTGGK 174
Cdd:PLN02244  171 SFQVADALNQPFEDGQFDLVWSMeSGEH-MPDKRKFVQELARVAAPGGR 218
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 79-174 1.74e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 44.75  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  79 LDVPVGTGVLTvpLYSILKDADITCVDYSDEMLNQAKEkaeklQLTNTKFQQGDVGHLEFEDNSFDIVLSMNGFHAFPDK 158
Cdd:PRK10258   47 LDAGCGPGWMS--RYWRERGSQVTALDLSPPMLAQARQ-----KDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNL 119

                          90
                  ....*....|....*.
gi 1388116475 159 EAAYNETYRVLKTGGK 174
Cdd:PRK10258  120 STALRELYRVVRPGGV 135
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
138-175 3.56e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 42.93  E-value: 3.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1388116475 138 FEDNSFDIVLSMNGFHAFPDKEA--AYNETYRVLKTGGKF 175
Cdd:COG4627    42 FPDNSVDAIYSSHVLEHLDYEEAplALKECYRVLKPGGIL 81
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 60-161 7.68e-05

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 42.52  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  60 DTIIEKALSGIEENFNGK---LLDVPVGTGVLTVPLYSilKDADITCVDYSDEMLNQAKEKA-EKLQLTNTKFQQGDvgh 135
Cdd:PRK07580   46 QRMRDTVLSWLPADGDLTglrILDAGCGVGSLSIPLAR--RGAKVVASDISPQMVEEARERApEAGLAGNITFEVGD--- 120

                          90       100
                  ....*....|....*....|....*.
gi 1388116475 136 LEFEDNSFDIVLSMNGFHAFPDKEAA 161
Cdd:PRK07580  121 LESLLGRFDTVVCLDVLIHYPQEDAA 146
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 75-176 1.60e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 41.67  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTN-TKFQQGDVGHL--EFEDNSFDIVLS--- 148
Cdd:COG4123    38 GGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFaaELPPGSFDLVVSnpp 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1388116475 149 ---MNGFHAFPD--KEAAYNETY-----------RVLKTGGKFC 176
Cdd:COG4123   118 yfkAGSGRKSPDeaRAIARHEDAltledliraaaRLLKPGGRFA 161
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 65-173 9.28e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 39.57  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  65 KALSGIEENFNGKLLDvpVGTGVLTVPLYSILK-DADITCVDYSDEMLNQAKEKAEklQLTNTKFQQGDVGHLEFEDNSF 143
Cdd:PTZ00098   43 KILSDIELNENSKVLD--IGSGLGGGCKYINEKyGAHVHGVDICEKMVNIAKLRNS--DKNKIEFEANDILKKDFPENTF 118

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1388116475 144 DIVLSMNGFHAFP--DKEAAYNETYRVLKTGG 173
Cdd:PTZ00098  119 DMIYSRDAILHLSyaDKKKLFEKCYKWLKPNG 150
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 75-175 1.83e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.79  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  75 NGKLLDVPVGTGVLTVPLYsiLKDADITCVDYSDEMLNQAKEKAeklqltntKFQQGDVGHLEFEDNSFDIVLSMNGFHA 154
Cdd:pfam13489  23 PGRVLDFGCGTGIFLRLLR--AQGFSVTGVDPSPIAIERALLNV--------RFDQFDEQEAAVPAGKFDVIVAREVLEH 92

                          90       100
                  ....*....|....*....|.
gi 1388116475 155 FPDKEAAYNETYRVLKTGGKF 175
Cdd:pfam13489  93 VPDPPALLRQIAALLKPGGLL 113
PRK14968 PRK14968
putative methyltransferase; Provisional
 57-147 1.84e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.96  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475  57 EDNDTIIEKALsgieENFNGKLLDVPVGTGVltVPLYSILKDADITCVDYSDEMLNQAKEKAEKLQLTNT--KFQQGDVg 134
Cdd:PRK14968   10 EDSFLLAENAV----DKKGDRVLEVGTGSGI--VAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNgvEVIRSDL- 82

                          90
                  ....*....|....
gi 1388116475 135 hLE-FEDNSFDIVL 147
Cdd:PRK14968   83 -FEpFRGDKFDVIL 95
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 98-174 7.61e-03

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 37.04  E-value: 7.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116475  98 DADITCVDYSDEMLNQAKEKAEKLQLTnTKFQQGDVGHLEFEDNSFDIVLSMNGFHAFPDKEAAYNETYRVLKTGGK 174
Cdd:PLN02336  289 DVHVVGIDLSVNMISFALERAIGRKCS-VEFEVADCTKKTYPDNSFDVIYSRDTILHIQDKPALFRSFFKWLKPGGK 364
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
101-180 7.76e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 36.48  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116475 101 ITCVDYSDEMLNQAKEKAEKLQLT-NTKFQQG---DVG-HLEfedNSFDIVLsmngFHA----FPDKEAAYNETYRVLKT 171
Cdd:PRK11036   69 VILCDLSAEMIQRAKQAAEAKGVSdNMQFIHCaaqDIAqHLE---TPVDLIL----FHAvlewVADPKSVLQTLWSVLRP 141


                  ....*....
gi 1388116475 172 GGKFCGCFY 180
Cdd:PRK11036  142 GGALSLMFY 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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