NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1407423166|gb|AWW01303|]
View 

dissimilatory sulfite reductase subunit B, partial [uncultured sulfate-reducing bacterium]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
dsrB super family cl31167
sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes ...
 1-122 3.77e-61

sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the beta subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


The actual alignment was detected with superfamily member TIGR02066:

Pssm-ID: 131121 [Multi-domain]  Cd Length: 341  Bit Score: 190.44  E-value: 3.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407423166   1 NIVHTQGWAHCHSAATDSSPIVKALMDELYGYFTSMKLPGKIRVSLACCINMCGAVHCSDLAIVGVHTKIPKVNHEKVAA 80
Cdd:TIGR02066 103 NIVHTQGWLHCHIPAIDASGIVKAVMDELYEYFTDHKLPAMVRISLSCCANMCGGVHASDIAIVGIHRKPPKINHEAVRN 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1407423166  81 ICEIPTVMASCPTGAIRRHPDKEVKSVVIREDLCMFCGNCYT 122
Cdd:TIGR02066 183 VCEIPSVVAACPTGALKPRRDGKNKSLEVDVEKCIYCGNCYT 224
 
Name Accession Description Interval E-value
dsrB TIGR02066
sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes ...
 1-122 3.77e-61

sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the beta subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 131121 [Multi-domain]  Cd Length: 341  Bit Score: 190.44  E-value: 3.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407423166   1 NIVHTQGWAHCHSAATDSSPIVKALMDELYGYFTSMKLPGKIRVSLACCINMCGAVHCSDLAIVGVHTKIPKVNHEKVAA 80
Cdd:TIGR02066 103 NIVHTQGWLHCHIPAIDASGIVKAVMDELYEYFTDHKLPAMVRISLSCCANMCGGVHASDIAIVGIHRKPPKINHEAVRN 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1407423166  81 ICEIPTVMASCPTGAIRRHPDKEVKSVVIREDLCMFCGNCYT 122
Cdd:TIGR02066 183 VCEIPSVVAACPTGALKPRRDGKNKSLEVDVEKCIYCGNCYT 224
NIR_SIR pfam01077
Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the ...
 1-73 2.05e-19

Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully. They are also both important for the dissimilation of oxidized anions for energy transduction.


Pssm-ID: 426031 [Multi-domain]  Cd Length: 153  Bit Score: 78.08  E-value: 2.05e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1407423166   1 NIVHTQGWAHCHSAATDSSPIVKALMDELYGYFTSMKLPGKIRVSLACCINMCGAVHCSDLAIVGVHTKIPKV 73
Cdd:pfam01077   6 NVTLCPGAGLCPEELLDTRPLAKAIEDEFEPDYGFPYLPRKFKIAVSGCPNNCVAAHANDIGFVGVWKDGGEI 78
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 82-120 2.53e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 38.14  E-value: 2.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRHPDKEvksVVIREDLCMFCGNC 120
Cdd:cd04410    53 CEDPPCVKACPTGAIYKDEDGI---VLIDEDKCIGCGSC 88
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 62-122 5.56e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.80  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1407423166  62 AIVGVHtkIPKVNHEKVAAIceiPTVMASCPTGAIRRhpdkEVKSVVIREDLCMFCGNCYT 122
Cdd:COG2221     3 GIIGTW--PPKIDEEKCIGC---GLCVAVCPTGAISL----DDGKLVIDEEKCIGCGACIR 54
 
Name Accession Description Interval E-value
dsrB TIGR02066
sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes ...
 1-122 3.77e-61

sulfite reductase, dissimilatory-type beta subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the beta subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 131121 [Multi-domain]  Cd Length: 341  Bit Score: 190.44  E-value: 3.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1407423166   1 NIVHTQGWAHCHSAATDSSPIVKALMDELYGYFTSMKLPGKIRVSLACCINMCGAVHCSDLAIVGVHTKIPKVNHEKVAA 80
Cdd:TIGR02066 103 NIVHTQGWLHCHIPAIDASGIVKAVMDELYEYFTDHKLPAMVRISLSCCANMCGGVHASDIAIVGIHRKPPKINHEAVRN 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1407423166  81 ICEIPTVMASCPTGAIRRHPDKEVKSVVIREDLCMFCGNCYT 122
Cdd:TIGR02066 183 VCEIPSVVAACPTGALKPRRDGKNKSLEVDVEKCIYCGNCYT 224
NIR_SIR pfam01077
Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the ...
 1-73 2.05e-19

Nitrite and sulphite reductase 4Fe-4S domain; Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully. They are also both important for the dissimilation of oxidized anions for energy transduction.


Pssm-ID: 426031 [Multi-domain]  Cd Length: 153  Bit Score: 78.08  E-value: 2.05e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1407423166   1 NIVHTQGWAHCHSAATDSSPIVKALMDELYGYFTSMKLPGKIRVSLACCINMCGAVHCSDLAIVGVHTKIPKV 73
Cdd:pfam01077   6 NVTLCPGAGLCPEELLDTRPLAKAIEDEFEPDYGFPYLPRKFKIAVSGCPNNCVAAHANDIGFVGVWKDGGEI 78
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 82-120 2.53e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 38.14  E-value: 2.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRHPDKEvksVVIREDLCMFCGNC 120
Cdd:cd04410    53 CEDPPCVKACPTGAIYKDEDGI---VLIDEDKCIGCGSC 88
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 82-120 5.10e-04

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 37.75  E-value: 5.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRhpdKEVKSVVIREDLCMFCGNC 120
Cdd:cd10560    81 CTDAGCLEACPTGAIFR---TEFGTVYIQPDICNGCGYC 116
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 62-122 5.56e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.80  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1407423166  62 AIVGVHtkIPKVNHEKVAAIceiPTVMASCPTGAIRRhpdkEVKSVVIREDLCMFCGNCYT 122
Cdd:COG2221     3 GIIGTW--PPKIDEEKCIGC---GLCVAVCPTGAISL----DDGKLVIDEEKCIGCGACIR 54
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 82-120 1.43e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 36.08  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRHPDkevkSVVIREDLCMFCGNC 120
Cdd:cd10554    59 CEDAPCANVCPVGAISQEDG----VVQVDEERCIGCKLC 93
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 91-120 1.54e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 34.72  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1407423166  91 CPTGAIRRHPDKEVKSVVIREDLCMFCGNC 120
Cdd:COG1143    14 CPVDAITIEDGEPGKVYVIDPDKCIGCGLC 43
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 82-120 1.58e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 35.63  E-value: 1.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRhpDKEVKSVVIREDLCMFCGNC 120
Cdd:cd10550    52 CEDAPCVEACPVGAISR--DEETGAVVVDEDKCIGCGMC 88
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
82-120 2.97e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 35.02  E-value: 2.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1407423166  82 CEIPTVMASCPTGAIRRHPDkevkSVVIREDLCMFCGNC 120
Cdd:COG1142    55 CEDAPCAEVCPVGAITRDDG----AVVVDEEKCIGCGLC 89
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 82-122 5.44e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 34.68  E-value: 5.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1407423166  82 CEIPTVMASCPTGAIRRHPDkevKSVVIREDLCMFCGNCYT 122
Cdd:cd16366    73 CTDAGCLAACPTGAIIRTET---GTVVVDPETCIGCGYCVN 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH