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Conserved domains on  [gi|290463271|sp|B0B7Q0|]
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RecName: Full=Pyruvate kinase; Short=PK

Protein Classification

pyruvate kinase( domain architecture ID 11490147)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


:

Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 702.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271    4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   83 KVQPGDRLTLVSKEI--LGSKESGVTLYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIK 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDYKG-LTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  161 DIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  241 IARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  321 VHAVKTMRSIIQETEKTFDYHAFFQlNDKNSALKVSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 290463271  401 IAVTPNRNVYYRLAVEWGVYPMLT--LESNRTVWRHQACVYGVEKGILSNYDKILVFSRG--AGMQDTNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdeEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 702.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271    4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   83 KVQPGDRLTLVSKEI--LGSKESGVTLYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIK 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDYKG-LTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  161 DIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  241 IARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  321 VHAVKTMRSIIQETEKTFDYHAFFQlNDKNSALKVSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 290463271  401 IAVTPNRNVYYRLAVEWGVYPMLT--LESNRTVWRHQACVYGVEKGILSNYDKILVFSRG--AGMQDTNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdeEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-459 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 651.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   1 MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  81 -PIKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSI 159
Cdd:PRK05826  82 gKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 160 KDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGI 239
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 240 MIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAH 319
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 320 PVHAVKTMRSIIQETEKTFDYHAFF-----QLNDKNSALKVSPYLEAIGFSGIqiaekasaKAIIVYTQTGGSPMFLSKY 394
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSINLSKhrldrQFDRIDEAIAMSAMYAANHLKGV--------KAIVALTESGRTARLISRF 393

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290463271 395 RPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLES-NRTVWRHQACVYGVEKGILSNYDKILVFSRGA 459
Cdd:PRK05826 394 RPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-454 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 608.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   1 MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQV-E 79
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFkE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  80 SPIKVQPGDRLTLVSKEILGSKES-GVTlYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLS 158
Cdd:COG0469   81 GPVELKKGDTFTLTTDDVEGDAERvSVT-YPE-LPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 159 IKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIARAADG 238
Cdd:COG0469  159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 239 IMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGA 318
Cdd:COG0469  238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 319 HPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSpylEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYL 398
Cdd:COG0469  318 YPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT---DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKV 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 290463271 399 PIIAVTPNRNVYYRLAVEWGVYPMLTLESNRT-VWRHQACVYGVEKGILSNYDKILV 454
Cdd:COG0469  395 PILALTPNERTARRLALVWGVYPVLVDDVESTdEMIEEAVEALLEEGLVKPGDLVVI 451
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 4-472 2.33e-167

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 480.66  E-value: 2.33e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVE--SP 81
Cdd:cd00288    3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKggKD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  82 IKVQPGD--RLTLVSKEILGSKES-GVTlYPScVFPYVRERAPVLIDDGYIQAVVVNAQ-EHMVEIEFQNSGEIKSNKSL 157
Cdd:cd00288   83 ISLKAGDkfLVTTDPAAKKGTKEKiYVD-YKN-LTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 158 SIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIARAAD 237
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 238 GIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASG 317
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 318 AHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPyLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPY 397
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTST-TEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 398 LPIIAVTPNRNVYYRLAVEWGVYPMLT-----LESNRTVWRHQACV-YGVEKGILSNYDKILVFSRG-AGMQDTNNLTLT 470
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLFeepkpGWQEDTDARLKAAVnVAKEKGLLKKGDLVVVVQGWpVGSGSTNTMRIL 478


                 ..
gi 290463271 471 TV 472
Cdd:cd00288  479 TV 480
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 4-344 6.10e-133

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 388.26  E-value: 6.10e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271    4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVE---S 80
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKdgkK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   81 PIKVQPGDRLTLVSKEILGSKESGVTL---YPScVFPYVRERAPVLIDDGYIQAVVVNA-QEHMVEIEFQNSGEIKSNKS 156
Cdd:pfam00224  83 DIELKAGDEMIVSTDAKYKGACDDEMIyvdYKN-IVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  157 LSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGrPNMPIIAKIENHLGVQNFQEIARAA 236
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  237 DGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETAS 316
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330       340
                  ....*....|....*....|....*...
gi 290463271  317 GAHPVHAVKTMRSIIQETEKTFDYHAFF 344
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 702.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271    4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   83 KVQPGDRLTLVSKEI--LGSKESGVTLYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIK 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDYKG-LTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  161 DIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  241 IARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  321 VHAVKTMRSIIQETEKTFDYHAFFQlNDKNSALKVSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 290463271  401 IAVTPNRNVYYRLAVEWGVYPMLT--LESNRTVWRHQACVYGVEKGILSNYDKILVFSRG--AGMQDTNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVdeEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-459 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 651.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   1 MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  81 -PIKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSI 159
Cdd:PRK05826  82 gKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 160 KDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGI 239
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 240 MIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAH 319
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 320 PVHAVKTMRSIIQETEKTFDYHAFF-----QLNDKNSALKVSPYLEAIGFSGIqiaekasaKAIIVYTQTGGSPMFLSKY 394
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSINLSKhrldrQFDRIDEAIAMSAMYAANHLKGV--------KAIVALTESGRTARLISRF 393

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290463271 395 RPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLES-NRTVWRHQACVYGVEKGILSNYDKILVFSRGA 459
Cdd:PRK05826 394 RPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-454 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 608.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   1 MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQV-E 79
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFkE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  80 SPIKVQPGDRLTLVSKEILGSKES-GVTlYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLS 158
Cdd:COG0469   81 GPVELKKGDTFTLTTDDVEGDAERvSVT-YPE-LPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 159 IKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIARAADG 238
Cdd:COG0469  159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 239 IMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGA 318
Cdd:COG0469  238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 319 HPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSpylEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYL 398
Cdd:COG0469  318 YPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT---DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKV 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 290463271 399 PIIAVTPNRNVYYRLAVEWGVYPMLTLESNRT-VWRHQACVYGVEKGILSNYDKILV 454
Cdd:COG0469  395 PILALTPNERTARRLALVWGVYPVLVDDVESTdEMIEEAVEALLEEGLVKPGDLVVI 451
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 4-472 2.33e-167

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 480.66  E-value: 2.33e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVE--SP 81
Cdd:cd00288    3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKggKD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  82 IKVQPGD--RLTLVSKEILGSKES-GVTlYPScVFPYVRERAPVLIDDGYIQAVVVNAQ-EHMVEIEFQNSGEIKSNKSL 157
Cdd:cd00288   83 ISLKAGDkfLVTTDPAAKKGTKEKiYVD-YKN-LTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 158 SIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIARAAD 237
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK-DIKIIAKIENQEGVNNFDEILEASD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 238 GIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASG 317
Cdd:cd00288  240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 318 AHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPyLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPY 397
Cdd:cd00288  320 KYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTST-TEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 398 LPIIAVTPNRNVYYRLAVEWGVYPMLT-----LESNRTVWRHQACV-YGVEKGILSNYDKILVFSRG-AGMQDTNNLTLT 470
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLFeepkpGWQEDTDARLKAAVnVAKEKGLLKKGDLVVVVQGWpVGSGSTNTMRIL 478


                 ..
gi 290463271 471 TV 472
Cdd:cd00288  479 TV 480
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-450 6.53e-157

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 458.24  E-value: 6.53e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   1 MIARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES 80
Cdd:PRK06354   6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFED 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  81 -PIKVQPGDRLTLVSKEILGSKE-SGVTlYPSCVfPYVRERAPVLIDDGYIQAVV--VNAQEHMVEIEFQNSGEIKSNKS 156
Cdd:PRK06354  86 gPIELKTGDEFILTSREVLGTQEkFSVT-YDGLA-DEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKKG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 157 LSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAA 236
Cdd:PRK06354 164 VNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELC 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 237 DGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETAS 316
Cdd:PRK06354 244 DGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 317 GAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSalkvSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRP 396
Cdd:PRK06354 324 GDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFT----TTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRP 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 290463271 397 YLPIIAVTPNRNVYYRLAVEWGVYPMLTLESNRTVWRHQACV-YGVEKGILSNYD 450
Cdd:PRK06354 400 KTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAInVAQESGLLKQGD 454
PRK06247 PRK06247
pyruvate kinase; Provisional
 4-424 5.53e-140

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 410.86  E-value: 5.53e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQ-VESPI 82
Cdd:PRK06247   6 RVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRfADGKV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  83 KVQPGDRLTLVSKEILGSKESGVTLYPScVFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDI 162
Cdd:PRK06247  86 QLANGQTFRLDVDDAPGDHDRVSLPHPE-IAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 163 DVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLEsfGRpnMPIIAKIENHLGVQNFQEIARAADGIMIA 242
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIG--GR--VPVMAKIEKPQAIDRLEAIVEASDAIMVA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 243 RGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVH 322
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 323 AVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSpylEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIA 402
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKR---DAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397

                        410       420
                 ....*....|....*....|..
gi 290463271 403 VTPNRNVYYRLAVEWGVYPMLT 424
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVV 419
PRK09206 PRK09206
pyruvate kinase PykF;
2-430 1.13e-137

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 404.82  E-value: 1.13e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   2 IARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRlgqvesP 81
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIR------T 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  82 IKVQPGDRLTLVS---------KEILGSKESGVTLYPScvfpYVRERAP---VLIDDGYIQAVVVNAQEHMVEIEFQNSG 149
Cdd:PRK09206  75 MKLEGGNDVSLKAgqtftfttdKSVVGNKERVAVTYEG----FTADLSVgntVLVDDGLIGMEVTAITGNEVICKVLNNG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 150 EIKSNKSLSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNF 229
Cdd:PRK09206 151 DLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 230 QEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVM 309
Cdd:PRK09206 231 DEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVM 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 310 LSGETASGAHPVHAVKTMRSIIQETEKTFdyHAFFQLNDKNSALKVSpylEAIGFSGIQIAEKASAKAIIVYTQTGGSPM 389
Cdd:PRK09206 311 LSGESAKGKYPLEAVSIMATICERTDRVM--NSRLESNNDNRKLRIT---EAVCRGAVETAEKLDAPLIVVATQGGKSAR 385

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 290463271 390 FLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLESNRT 430
Cdd:PRK09206 386 SVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEIAST 426
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 4-344 6.10e-133

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 388.26  E-value: 6.10e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271    4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVE---S 80
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKdgkK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   81 PIKVQPGDRLTLVSKEILGSKESGVTL---YPScVFPYVRERAPVLIDDGYIQAVVVNA-QEHMVEIEFQNSGEIKSNKS 156
Cdd:pfam00224  83 DIELKAGDEMIVSTDAKYKGACDDEMIyvdYKN-IVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  157 LSIKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGrPNMPIIAKIENHLGVQNFQEIARAA 236
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  237 DGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETAS 316
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330       340
                  ....*....|....*....|....*...
gi 290463271  317 GAHPVHAVKTMRSIIQETEKTFDYHAFF 344
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKALPHRNLF 348
PLN02461 PLN02461
Probable pyruvate kinase
 2-403 1.87e-123

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 369.69  E-value: 1.87e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   2 IARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVES- 80
Cdd:PLN02461  20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDg 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  81 -PIKVQPGDRLTLVSK-EILGSKESGVTLYPSCVFPyVRERAPVLIDDGYIQAVVV--NAQEHMVEIEFQNSGEIKSNKS 156
Cdd:PLN02461 100 kPVQLKQGQEITITTDySIKGDENMIAMSYKKLAVD-VKPGSVILCADGTITLTVLscDVEAGTVRCRCENSAMLGERKN 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 157 LSIKDIDVALPFMTEKDIAD-LKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIARA 235
Cdd:PLN02461 179 VNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK-SILLISKVENQEGLDNFDDILAE 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 236 ADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETA 315
Cdd:PLN02461 258 SDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETA 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 316 SGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPyLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYR 395
Cdd:PLN02461 338 AGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSP-LESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYR 416


                 ....*...
gi 290463271 396 PYLPIIAV 403
Cdd:PLN02461 417 PAVPILSV 424
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 4-419 4.48e-114

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 345.98  E-value: 4.48e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKR-QVPLAIMLDTKGPEIRLGQVES-- 80
Cdd:PTZ00066  39 KTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLKNhk 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  81 PIKVQPGDRLTLVSK-EILGSKESgvtlyPSCVFPY----VRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNK 155
Cdd:PTZ00066 119 PITLKEGQTLKITTDyTFLGDETC-----ISCSYKKlpqsVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERK 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 156 SLSIKDIDVALPFMTEKDIAD-LKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRpNMPIIAKIENHLGVQNFQEIAR 234
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR-HIKIIPKIENIEGLINFDEILA 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 235 AADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGET 314
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 315 ASGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYlEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKY 394
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQ-EAVARSAVETAEDINAKLIIALTETGNTARLISKY 431

                        410       420
                 ....*....|....*....|....*
gi 290463271 395 RPYLPIIAVTPNRNVYYRLAVEWGV 419
Cdd:PTZ00066 432 RPSCTILALSASPSVVKSLSVARGV 456
PLN02623 PLN02623
pyruvate kinase
 4-422 1.44e-104

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 323.80  E-value: 1.44e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELR-EKRQVPLAIMLDTKGPEIRLGQVESPI 82
Cdd:PLN02623 111 KTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNaQSKDNVIAIMLDTKGPEVRSGDLPQPI 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  83 KVQPGDRLTLVSKEILGSKESGVTLYPSCVFPyVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDI 162
Cdd:PLN02623 191 MLEEGQEFTFTIKRGVSTEDCVSVNYDDFVND-VEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGK 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 163 DVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGrPNMPIIAKIENHLGVQNFQEIARAADGIMIA 242
Cdd:PLN02623 270 SATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCN-ADIHVIVKIESADSIPNLHSIITASDGAMVA 348

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 243 RGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVH 322
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 323 AVKTMRSIIQETEKTF-------DYHAFFQlndknsalkvSPYLEAIGFSGIQIAEKASAkAIIVYTQTGGSPMFLSKYR 395
Cdd:PLN02623 429 AVKVMHTVALRTEATLpegttppNLGQAFK----------NHMSEMFAFHATMMANTLGT-SIIVFTRTGFMAILLSHYR 497

                        410       420
                 ....*....|....*....|....*..
gi 290463271 396 PYLPIIAVTPNRNVYYRLAVEWGVYPM 422
Cdd:PLN02623 498 PSGTIFAFTNEKRIQQRLALYQGVCPI 524
PRK06739 PRK06739
pyruvate kinase; Validated
 8-356 3.96e-96

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 294.16  E-value: 3.96e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   8 ICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQvplaIMLDTKGPEIRLGQVESP-IKVQP 86
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIK----ILGDVQGPKIRLGEIKGEqITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  87 GDRLTLVSKEILGSKESGVTLYPSCVFPyVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVAL 166
Cdd:PRK06739  82 GDSFILHTQPVTGSSTEASVDYEGIAND-VKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 167 PFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIMIARGDL 246
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 247 GIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVHAVKT 326
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320

                        330       340       350
                 ....*....|....*....|....*....|
gi 290463271 327 MRsIIQETEKTFDYHAFFQLNDKNSALKVS 356
Cdd:PRK06739 321 LR-LVSEFAEHVKKDGPFVMKDVLELLHKS 349
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 29-419 2.71e-93

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 290.41  E-value: 2.71e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  29 MNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQ-VESPIKVQPGDRLTLVSK---EILGSKESG 104
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLfVGGEAVMERGATCYVTTDpafADKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 105 VTLYPScVFPYVRERAPVLIDDG-YIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKFGVEQ 183
Cdd:PTZ00300  81 YIDYQN-LSKVVRPGGYIYIDDGiLILHVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 184 ELDLIAASFVRCNEDIDSMRKVLESFGRPNMpIIAKIENHLGVQNFQEIARAADGIMIARGDLGIELSIVEVPGLQKFMA 263
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIM-IICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 264 RASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAF 343
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 290463271 344 FQLNDKNSALKVSPYlEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGV 419
Cdd:PTZ00300 319 FNSIKKLQPIPMSAE-EAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGV 393
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 4-428 2.47e-88

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 279.32  E-value: 2.47e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQ--VESP 81
Cdd:PLN02762  26 RTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDlgGASS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  82 IKVQPGDRLTLVSKEILGSKesgvtlyPSCVFPY--------VRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKS 153
Cdd:PLN02762 106 AKAEDGEEWTFTVRKFDGSR-------PEFTIQVnydgfaedVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLP 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 154 NKSLS-------IKDIDVALPFMTEKDIADLKFGVEQELDLIAASFVRCNEDIDSMRKVLESFGR-PNMPIIAKIENHLG 225
Cdd:PLN02762 179 RANLTfwrdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRdSDIGVIAKIESLDS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 226 VQNFQEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAIYDGT 305
Cdd:PLN02762 259 LKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 306 SAVMLSGETASGAHPVHAVKTMRSIIQETEKTF---DYHAFFQLNDKNSAL--KVSpylEAIGFSGIQIAEKASAKAIIV 380
Cdd:PLN02762 339 DALMLSGESAMGLYPEKALSVLRSVSLRMELWSreeKRHEALELPQLSSSLsdRIS---EEICNSAAKMANNLGVDAIFV 415

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 290463271 381 YTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPML-----TLESN 428
Cdd:PLN02762 416 YTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRldfsdDMESN 468
PLN02765 PLN02765
pyruvate kinase
 3-457 4.09e-80

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 258.45  E-value: 4.09e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   3 ARTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIR-LGQVESP 81
Cdd:PLN02765  28 ALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQvINKTEKP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  82 IKVQPGDRLTLVSKEilgSKESGVTLYP-------------SCVF--PYV---RERAPVliddgYIQAVVVNAQEhmVEI 143
Cdd:PLN02765 108 ISLKAGNTVTLTPDQ---SKEASSEVLPinfpglakavkpgDTIFvgQYLftgSETTSV-----WLEVDEVKGDD--VVC 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 144 EFQNSGEIKSNK-SLSIKDIDVALPFMTEKDIADLK-FGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIE 221
Cdd:PLN02765 178 TVKNSATLAGSLfTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIE 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 222 NHLGVQNFQEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITaTQMLESMIRNPLPTRAEVSDVANAI 301
Cdd:PLN02765 258 NVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAV 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 302 YDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAFFQlndknsalKVSPY-------LEAIGFSGIQIAEKAS 374
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFK--------KTVKYvgepmshLESIASSAVRAAIKVK 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 375 AKAIIVYTQTGGSPMFLSKYRPYLPIIAVtpnrnVYYRL---AVEW---------------GVYPML---------TLES 427
Cdd:PLN02765 409 ASVIIVFTSSGRAARLIAKYRPTMPVLSV-----VIPRLktnQLKWsftgafqarqclivrGLFPMLadprhsaesTSAT 483

                        490       500       510
                 ....*....|....*....|....*....|
gi 290463271 428 NRTVWRHqACVYGVEKGILSNYDKILVFSR 457
Cdd:PLN02765 484 NESVLKV-ALDHGKAAGVIKSHDRVVVCQK 512
PRK08187 PRK08187
pyruvate kinase; Validated
 4-332 2.38e-47

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 170.58  E-value: 2.38e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271   4 RTKIICTI-GPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAIMLDTKGPEIRLGQVESPI 82
Cdd:PRK08187 134 RTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPL 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  83 ---KVQPGDRLTLVSKEILGSKES---GVTLYPSCVFPYVRERAPVLIDDGYIQAVV--VNAQEHMVEIEF--QNSGEIK 152
Cdd:PRK08187 214 gktRLYTGDRLALVAQGPPRRIDEehfQVTCTLPEILARLAVGARVWIDDGKLGARVerVGPGGALLEVTHarPKGLKLK 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 153 SNKSLSIKDIDVALPFMTEKDIADLKFgVEQELDLIAASFVRCNEDIDSMRKVLESFG---RPNMPIIAKIENHLGVQNF 229
Cdd:PRK08187 294 PEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRpddWRKLGLVLKIETPRAVANL 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 230 QE-IARAAD----GIMIARGDLGIELsivevpGLQKfMARASRETGRFC-------ITATQMLESMIRNPLPTRAEVSDV 297
Cdd:PRK08187 373 PElIVQAAGrqpfGVMIARGDLAVEI------GFER-LAEMQEEILWLCeaahvpvIWATQVLEGLVKKGLPSRAEMTDA 445

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 290463271 298 ANAiyDGTSAVMLSgetaSGAHPVHAVKTMRSIIQ 332
Cdd:PRK08187 446 AMA--ARAECVMLN----KGPYLVEAVTFLDDLLA 474
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
274-431 1.41e-46

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 164.30  E-value: 1.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 274 ITATQMLESMIRNPLPTRAEVSDVANAIYDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSAL 353
Cdd:COG3848   10 ITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRVPRAKESST 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 290463271 354 KVspyLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLESNRTV 431
Cdd:COG3848   90 TI---TDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESASTD 164
PRK14725 PRK14725
pyruvate kinase; Provisional
 75-330 5.85e-44

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 163.58  E-value: 5.85e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  75 LGQVESPIKVQPGDRLTLVSKEILGSKESGVTLYP--SC----VFPYVRERAPVLIDDGYIQAVVVNAQEHMVEIEFQNS 148
Cdd:PRK14725 326 LPPVEQKLRLKVGDRLVLTRDDAPGDPAQGDAPPAriSCtlpeAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHA 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 149 GE----IKSNKSLSIKDIDVALPFMTEKDIADLKFgVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHL 224
Cdd:PRK14725 406 RPggskLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRR 484

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271 225 GVQNFQEI-----ARAADGIMIARGDLGIELS---IVEVPGLQKFMARASRETgrfCITATQMLESMIRNPLPTRAEVSD 296
Cdd:PRK14725 485 AFENLPRIlleamRHPRFGVMIARGDLAVEVGferLAEVQEEILWLCEAAHVP---VIWATQVLESLAKKGLPSRAEITD 561

                        250       260       270
                 ....*....|....*....|....*....|....
gi 290463271 297 VANAIYdgTSAVMLSgetaSGAHPVHAVKTMRSI 330
Cdd:PRK14725 562 AAMALR--AECVMLN----KGPHIVEAVRVLDDI 589
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 360-454 2.12e-21

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 89.08  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290463271  360 EAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYPMLTLESNRTVWR-HQACV 438
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMlRRAVK 80

                          90
                  ....*....|....*.
gi 290463271  439 YGVEKGILSNYDKILV 454
Cdd:pfam02887  81 VAKEAGLVKKGDLVVI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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