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Conserved domains on  [gi|308191524|sp|B4LWK0|]
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RecName: Full=Adenylosuccinate synthetase; Short=AMPSase; Short=AdSS; AltName: Full=IMP--aspartate ligase

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
29-445 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVL 108
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  109 KNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFK 188
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  189 SIVNTHLRLFPSI---KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:pfam00709 159 ALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNG 345
Cdd:pfam00709 239 TAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRING 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  346 YTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLE 425
Cdd:pfam00709 319 VTGLALTKLDVLDGLDEIKVCVAYEL-DGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIE 397

                         410       420
                  ....*....|....*....|
gi 308191524  426 SQLSVPVRWVGVGKGRESII 445
Cdd:pfam00709 398 ELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
29-445 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVL 108
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  109 KNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFK 188
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  189 SIVNTHLRLFPSI---KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:pfam00709 159 ALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNG 345
Cdd:pfam00709 239 TAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRING 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  346 YTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLE 425
Cdd:pfam00709 319 VTGLALTKLDVLDGLDEIKVCVAYEL-DGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIE 397

                         410       420
                  ....*....|....*....|
gi 308191524  426 SQLSVPVRWVGVGKGRESII 445
Cdd:pfam00709 398 ELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 27-445 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 649.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524    27 VDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDE 106
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   107 VLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKggksLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEK 186
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   187 FKSIVNTHLRLFPSI----KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:smart00788 155 LEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:smart00788 235 SNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   343 VNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:smart00788 315 INGITGLALTKLDVLDGLDEIKVCVAYKL-DGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIE 393

                          410       420
                   ....*....|....*....|...
gi 308191524   423 FLESQLSVPVRWVGVGKGRESII 445
Cdd:smart00788 394 RIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 21-448 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 627.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  21 SMYKSKVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHL 100
Cdd:PTZ00350   8 NGLKSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 101 PSLFDEVLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAE--KGGKSLGTTKKGIGPAYSSKATRNGIRVGELLg 178
Cdd:PTZ00350  88 PSLLEEIEQLTKKGI-NLLGRLYISDRAHLVFDLHQAIDGIQESEkgKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 179 DFNLFSEKFKSIVNTHLRLFPSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYP 258
Cdd:PTZ00350 166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 259 YVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLK 338
Cdd:PTZ00350 246 YVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALR 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 339 YTSLVNGYTCICITKLDILDTLPEIKVGVSYK-RSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENA 417
Cdd:PTZ00350 326 YVQMINGFDSINLTKLDVLSGLKEIKICVNYKnKGTGLEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENA 405

                        410       420       430
                 ....*....|....*....|....*....|.
gi 308191524 418 QNYVRFLESQLSVPVRWVGVGKGRESIINVH 448
Cdd:PTZ00350 406 QKYVLFIEELLGVPIVWIGVGPNRENMIVKK 436
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 27-448 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 622.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  27 VDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDE 106
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 107 VLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEK 186
Cdd:COG0104   81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 187 FKSIVNTHLRLFPSI----KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:COG0104  159 LEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:COG0104  239 SNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVR 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 343 VNGYTCICITKLDILDTLPEIKVGVSYKrSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:COG0104  319 INGLTGLALTKLDVLDGLDEIKVCVAYE-LDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVE 397

                        410       420
                 ....*....|....*....|....*.
gi 308191524 423 FLESQLSVPVRWVGVGKGRESIINVH 448
Cdd:COG0104  398 RIEELLGVPISIVSVGPDREQTIVRR 423
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 26-445 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 523.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  26 KVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFD 105
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 106 EVLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGEllgdfnlfse 185
Cdd:cd03108   81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 186 kfksivnthlrlfpsikvdvdaelarykdyvdkvrPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:cd03108  150 -----------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSSNT 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNG 345
Cdd:cd03108  195 TAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRING 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 346 YTCICITKLDIldtlpeikvgvsykrssgdkldhfpgtiselsdieveyavlpgwqtstehirnfkelpeNAQNYVRFLE 425
Cdd:cd03108  275 LTELALTKLDV-----------------------------------------------------------NAQKYIERIE 295

                        410       420
                 ....*....|....*....|
gi 308191524 426 SQLSVPVRWVGVGKGRESII 445
Cdd:cd03108  296 ELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 29-448 1.56e-180

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 510.55  E-value: 1.56e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEvL 108
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKE-M 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  109 KNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDfNLFSEKFK 188
Cdd:TIGR00184  80 EYLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAFAEKAK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  189 SIVNTHLRLF----PSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSN 264
Cdd:TIGR00184 159 NILEYLNEQLvkyyKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  265 CSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVN 344
Cdd:TIGR00184 239 TTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  345 GYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFL 424
Cdd:TIGR00184 319 GATQLALTKLDVLDGIDEIKVCVAYRM-KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERI 397

                         410       420
                  ....*....|....*....|....
gi 308191524  425 ESQLSVPVRWVGVGKGRESIINVH 448
Cdd:TIGR00184 398 EELTGVPVTIISTGPEREQTIDLR 421
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
27-345 9.03e-33

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 125.56  E-value: 9.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  27 VDVVLGAQWGDEGKGKVVDMLA--SEVDIVCRCqGGNNAGHTVV-ANGTEFDFHLLPSGVVNEKCISV-IGNGVVIHLPS 102
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAerAAPDVVVRA-AGPNAGHTYIdDEGRKFVHRMLPNGIVSPPLKQVlIGPGSEIDLEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 103 LFDEVLKNEAKGlQHLENRLIISDRAHLVfDFHQHVDgmQEAEKGGKsLGTTKKGIGPAYSSKATRNGIRVGELLGDFNL 182
Cdd:NF038379  80 LREEIEELEDAG-HDVGKRLLIHEQATVI-ELHKHVE--EEAGPMTK-IGSTKKGIGAARAAKIRRNPSTLGDAEGDFGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 183 FSEKFksivnthlrlfpsIKVDVDAELARYKDYvdkvrpyvkdticflHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:NF038379 155 GAVRD-------------QPWEIAERVVDNALY---------------DFALQAAERIQIEGTQGYSLGLHAGFYPYCTS 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQ--TIGEVIGVVKAYTTRVGD-----GPFPTE-QLNEIGdlLQTrgfEVGVTTKRKRRCGWLDI 334
Cdd:NF038379 207 RDCTPADFLADAGIPLPnvDAFKVVGTARTYPIRVAGwsgnsYPDQGEtTWEELG--LPE---ELTTVTKKVRRVGTFSA 281

                        330
                 ....*....|.
gi 308191524 335 PLLKYTSLVNG 345
Cdd:NF038379 282 EQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
29-445 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVL 108
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  109 KNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFK 188
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFREKLE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  189 SIVNTHLRLFPSI---KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:pfam00709 159 ALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNG 345
Cdd:pfam00709 239 TAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRING 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  346 YTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLE 425
Cdd:pfam00709 319 VTGLALTKLDVLDGLDEIKVCVAYEL-DGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIE 397

                         410       420
                  ....*....|....*....|
gi 308191524  426 SQLSVPVRWVGVGKGRESII 445
Cdd:pfam00709 398 ELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 27-445 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 649.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524    27 VDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDE 106
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   107 VLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKggksLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEK 186
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVLREK 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   187 FKSIVNTHLRLFPSI----KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:smart00788 155 LEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:smart00788 235 SNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVR 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   343 VNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:smart00788 315 INGITGLALTKLDVLDGLDEIKVCVAYKL-DGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIE 393

                          410       420
                   ....*....|....*....|...
gi 308191524   423 FLESQLSVPVRWVGVGKGRESII 445
Cdd:smart00788 394 RIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 21-448 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 627.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  21 SMYKSKVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHL 100
Cdd:PTZ00350   8 NGLKSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 101 PSLFDEVLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAE--KGGKSLGTTKKGIGPAYSSKATRNGIRVGELLg 178
Cdd:PTZ00350  88 PSLLEEIEQLTKKGI-NLLGRLYISDRAHLVFDLHQAIDGIQESEkgKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 179 DFNLFSEKFKSIVNTHLRLFPSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYP 258
Cdd:PTZ00350 166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 259 YVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLK 338
Cdd:PTZ00350 246 YVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALR 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 339 YTSLVNGYTCICITKLDILDTLPEIKVGVSYK-RSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENA 417
Cdd:PTZ00350 326 YVQMINGFDSINLTKLDVLSGLKEIKICVNYKnKGTGLEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENA 405

                        410       420       430
                 ....*....|....*....|....*....|.
gi 308191524 418 QNYVRFLESQLSVPVRWVGVGKGRESIINVH 448
Cdd:PTZ00350 406 QKYVLFIEELLGVPIVWIGVGPNRENMIVKK 436
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 27-448 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 622.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  27 VDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDE 106
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 107 VLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEK 186
Cdd:COG0104   81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVLREK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 187 FKSIVNTHLRLFPSI----KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:COG0104  159 LEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:COG0104  239 SNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVR 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 343 VNGYTCICITKLDILDTLPEIKVGVSYKrSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:COG0104  319 INGLTGLALTKLDVLDGLDEIKVCVAYE-LDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVE 397

                        410       420
                 ....*....|....*....|....*.
gi 308191524 423 FLESQLSVPVRWVGVGKGRESIINVH 448
Cdd:COG0104  398 RIEELLGVPISIVSVGPDREQTIVRR 423
PLN02513 PLN02513
adenylosuccinate synthase
 25-445 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 615.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  25 SKVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVV-ANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSL 103
Cdd:PLN02513   2 SQVSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 104 FDEVLKNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLF 183
Cdd:PLN02513  82 FEEIDGLESNGVS-CEGRLLVSDRAHLLFDFHQEVDGLREAELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLR-HMDTF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 184 SEKFKSIVNTHLRLFPSIKVD---VDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYV 260
Cdd:PLN02513 160 AEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 261 TSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYT 340
Cdd:PLN02513 240 TSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYS 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 341 SLVNGYTCICITKLDILDTLPEIKVGVSYKRSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNY 420
Cdd:PLN02513 320 CQINGFTSLNLTKLDVLSGLPEIKIGVAYKTPDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAY 399

                        410       420
                 ....*....|....*....|....*
gi 308191524 421 VRFLESQLSVPVRWVGVGKGRESII 445
Cdd:PLN02513 400 VERIEELVGVPVHYIGVGPGRDALI 424
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 26-448 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 599.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  26 KVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFD 105
Cdd:PRK01117   2 KNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 106 EVLKNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSE 185
Cdd:PRK01117  82 EIDELEARGVD-VRERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPETFAE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 186 KFKSIVNTHLRLFPSI----KVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVT 261
Cdd:PRK01117 160 KLEENLEYKNFLLTKYygaeAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 262 SSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTS 341
Cdd:PRK01117 240 SSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 342 LVNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYV 421
Cdd:PRK01117 320 RVNGLTGLALTKLDVLDGLEEIKICVAYEL-DGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYI 398

                        410       420
                 ....*....|....*....|....*..
gi 308191524 422 RFLESQLSVPVRWVGVGKGRESIINVH 448
Cdd:PRK01117 399 KRIEELTGVPISIISTGPDRDQTIILR 425
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 26-445 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 523.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  26 KVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFD 105
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 106 EVLKNEAKGLqHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGEllgdfnlfse 185
Cdd:cd03108   81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 186 kfksivnthlrlfpsikvdvdaelarykdyvdkvrPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:cd03108  150 -----------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSSNT 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNG 345
Cdd:cd03108  195 TAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRING 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 346 YTCICITKLDIldtlpeikvgvsykrssgdkldhfpgtiselsdieveyavlpgwqtstehirnfkelpeNAQNYVRFLE 425
Cdd:cd03108  275 LTELALTKLDV-----------------------------------------------------------NAQKYIERIE 295

                        410       420
                 ....*....|....*....|
gi 308191524 426 SQLSVPVRWVGVGKGRESII 445
Cdd:cd03108  296 ELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 29-448 1.56e-180

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 510.55  E-value: 1.56e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524   29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEvL 108
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKE-M 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  109 KNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDfNLFSEKFK 188
Cdd:TIGR00184  80 EYLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAFAEKAK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  189 SIVNTHLRLF----PSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSN 264
Cdd:TIGR00184 159 NILEYLNEQLvkyyKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  265 CSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVN 344
Cdd:TIGR00184 239 TTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  345 GYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFL 424
Cdd:TIGR00184 319 GATQLALTKLDVLDGIDEIKVCVAYRM-KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERI 397

                         410       420
                  ....*....|....*....|....
gi 308191524  425 ESQLSVPVRWVGVGKGRESIINVH 448
Cdd:TIGR00184 398 EELTGVPVTIISTGPEREQTIDLR 421
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 28-445 1.17e-124

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 368.51  E-value: 1.17e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  28 DVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEV 107
Cdd:PRK13787   4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEEC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 108 LKNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGG-KSLGTTKKGIGPAYSSKATRNGIRVGELLGdfNLFSEK 186
Cdd:PRK13787  84 DRLQKEGFP-VKDKLLLSDACHLLFPYHSQIDSARETTSSQeHKIGTTKKGIGICYADKMMRTGLRVGDLLD--KSYKRR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 187 FKSIV---NTHL-RLFPSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:PRK13787 161 LKHLVdekNRELdKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:PRK13787 241 SNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 343 VNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGtiSELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:PRK13787 321 INGITSIALTKIDILSDYDTIPVAVGYKL-NGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYIS 397

                        410       420
                 ....*....|....*....|...
gi 308191524 423 FLESQLSVPVRWVGVGKGRESII 445
Cdd:PRK13787 398 ALEKWIGVKINLVSTGPDRKDTI 420
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 30-442 2.32e-122

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 361.82  E-value: 2.32e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  30 VLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHlPSLFDEVLK 109
Cdd:PRK13788   6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVID-PFRFAEERE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 110 NEAKGlqHLENRLIISDRAHLVFDFHQHVDGmqeaekGGKSLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFKS 189
Cdd:PRK13788  85 NLRAG--GLNPKLLISERAHLVLPHHKYVDG------RKNFVGTTGRGIGPAYSDRARRVGIRFGDLL-DEAVLRERVER 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 190 IV----NTHLRLFPSIKVDVDAELARYKDYVdkvRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNC 265
Cdd:PRK13788 156 LLeakpNSTREAGWDTVEKALADLAPMREIL---LPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTSSHP 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 266 SIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRG----FEVGVTTKRKRRCGWLDIPLLKYTS 341
Cdd:PRK13788 233 TVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKYAC 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 342 LVNGYTCICITKLDILDTLPEIKVGVSYkrssgdkldhfpgtiseLSDIEVEYAVLPGWQTsTEHIRNFKELPENAQNYV 421
Cdd:PRK13788 313 EVNGFDGLVLTKLDVLSGLEKVKVCVEY-----------------DDDGQPVYKELPGWGD-LDGVKSREALPKEAQAYL 374

                        410       420
                 ....*....|....*....|.
gi 308191524 422 RFLESQLSVPVRWVGVGKGRE 442
Cdd:PRK13788 375 ELIEETTGVPVVMFSTSPRRE 395
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 29-445 6.63e-114

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 341.01  E-value: 6.63e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCIsVIGNGVVIHLPSLFDEVL 108
Cdd:PRK13786   4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 109 KNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKsLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFK 188
Cdd:PRK13786  83 MLEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRESARTEK-IGTTKRGIGFAYIDKIARDEVRMSDLV-DKERLMRRLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 189 SIVNTHLRLF------PSIKVDvDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:PRK13786 161 ELAPQKEKEIkelggdPSIVRD-EALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 342
Cdd:PRK13786 240 SSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 343 VNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVR 422
Cdd:PRK13786 320 LNGYTEIALTKLDVLTGLDPIKICVGYEL-DGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVE 398

                        410       420
                 ....*....|....*....|...
gi 308191524 423 FLESQLSVPVRWVGVGKGRESII 445
Cdd:PRK13786 399 RLEELMGVPIKYISVGPGREQTF 421
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 29-447 7.43e-112

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 335.15  E-value: 7.43e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVvaNGTEFDF--HLLPSGVVNEKCISVIGNGVVIHLPSLFDE 106
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTV--NYGDFKVvhHLLPSADFKKNVGAAIGNGVVLDLEVLVEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 107 VLKNEAKGLQhLENRLIISDRAHLVFDFHQHVDGMQEAEKGgKSLGTTKKGIGPAYSSKATRNGIRVGELlGDFNLFSEK 186
Cdd:PRK13783  82 LEELKEKFPD-YSGRIFISELAHVVLPVHKELDEIIESVRK-NAIGTTKRGIGPAYADKVMRVGVRLADL-FDEEKLREF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 187 FKSIVNTHLRLFpSIKVDVDAELARYKDYVDKVRPYVKDTIcFLHTALRNgKTILVEGANAAMLDIDFGTYPYVTSSNCS 266
Cdd:PRK13783 159 LEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPV-EIKRILEE-KSVLFEGTQGVLLDLDVGTYPYVTSSNCS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 267 IGGVLTGLGLPPQtIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNGY 346
Cdd:PRK13783 236 TTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 347 TCICITKLDILDTLPEIKVGVSYKrsSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEhiRNFKElpenaqnYVRFLES 426
Cdd:PRK13783 315 DSLVMTKADVLNGFEKIKVCVRYE--IGGKEVRDPSSLRDLEKAEPVYEEFDGWKSLED--KNFLK-------FVDFIER 383

                        410       420
                 ....*....|....*....|.
gi 308191524 427 QLSVPVRWVGVGKGRESIINV 447
Cdd:PRK13783 384 ETGRKIAYISTGPKIEEIVEV 404
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 30-445 1.30e-111

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 336.35  E-value: 1.30e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  30 VLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKcISVIGNGVVIHLPSLFDEVLK 109
Cdd:PRK13785   5 IVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDEIDA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 110 NEAKGlqhLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSL--GTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKF 187
Cdd:PRK13785  84 LRERG---LDPDVRVAERAHVILPYHRVLDGIEEEAKSDSDLevGTTGRGIGPTYEDKAGRRGVRVGDLL-DPDVLRDRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 188 KSIVNTHLRLFPSI----------KVDVDAELARYKDYVDKVRPYVKDTIC--FLHTALRNGKTILVEGANAAMLDIDFG 255
Cdd:PRK13785 160 EYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEEDMTVNAgdFLAERIDDGDNVMLEGAQGTSIDIDHG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 256 TYPYVTSSNCSIGGVLTGLGLPPQTI--GEVIGVVKAYTTRVGDGPFPTE---------------QLNEIGDLLQTRGFE 318
Cdd:PRK13785 240 NYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATYIREEGGE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 319 VGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICITKLDILDTLPEIKVGVSYKRsSGDKLDHFPGTISELSDIEVEYAVLP 398
Cdd:PRK13785 320 YGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYEL-DGEELLTMPATTERWARCEPNFRSFD 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 308191524 399 GWQT---STEHIRNFKELPENAQNYVRFLESQLSVPVRWVGVGKGRESII 445
Cdd:PRK13785 399 GWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETV 448
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 29-445 1.62e-96

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 296.55  E-value: 1.62e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  29 VVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVL 108
Cdd:PRK13784   5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 109 KNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKsLGTTKKGIGPAYSSKATRNGIRVGELLgDFNLFSEKFK 188
Cdd:PRK13784  85 RLQAKGIAISAENLFVSESCTIITSYHKLLDAVRESNTSEK-IGTTGKGIGPAYEDKVSRKGIKFKHLF-DKDLLRSRLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 189 SIVNTHLRLFPSI-KVD---VDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSN 264
Cdd:PRK13784 163 ISLAEKETLFRDLyKVEyptLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVTSSN 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 265 CSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVN 344
Cdd:PRK13784 243 TSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAKCS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 345 GYTCICITKLDILDTLPEIKVGVSYKRSSGDKLDHFPGtiseLSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFL 424
Cdd:PRK13784 323 NLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCAYPG----IDLYKVEPILVEMEPFSIDETVTKDNMPAALKTYLKTI 398

                        410       420
                 ....*....|....*....|.
gi 308191524 425 ESQLSVPVRWVGVGKGRESII 445
Cdd:PRK13784 399 ENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 27-447 5.85e-61

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 201.65  E-value: 5.85e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  27 VDVVLGAQWGDEGKGKVVDMLA--SEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLpslf 104
Cdd:PRK04293   3 CTIVVGGFFGDEGKGKIIAYLAlkDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDP---- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 105 dEVLKNEAKGLQhLENRLIISDRAHLVFDFHQhvdgmqEAEKGG----KSLGTTKKGIGPAYSSKATRNgirvgellgdf 180
Cdd:PRK04293  79 -EVLLKEVEELN-VGGRVFVDYRCGIIEEKHV------EEDRSDehlsKKIGSTGTGCGPANADRVLRR----------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 181 nlfsekfksivnthlrlfpsikvdvdAELAryKDyVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYV 260
Cdd:PRK04293 140 --------------------------LKLA--KD-VEELEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYV 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 261 TSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTE-QLNEIgdllQTRGF-EVGVTTKRKRRCGWLDIPLLK 338
Cdd:PRK04293 191 TSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTElSLEEA----EKLGLvEYGTVTGRRRRVGPFDFELAR 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 339 YTSLVNGYTCICITKLDILDtlPEIKvGVsykrssgdkldhfpgtiselsdieveyavlpgwqtstehiRNFKELPENAQ 418
Cdd:PRK04293 267 RAARINGATQIAITKLDKLD--KEAY-GV----------------------------------------TEYDKLPPEAK 303

                        410       420
                 ....*....|....*....|....*....
gi 308191524 419 NYVRFLESQLSVPVRWVGVGKGRESIINV 447
Cdd:PRK04293 304 KFIEEIEEELGVPVTLISTGPELEDTIDL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
27-345 9.03e-33

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 125.56  E-value: 9.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  27 VDVVLGAQWGDEGKGKVVDMLA--SEVDIVCRCqGGNNAGHTVV-ANGTEFDFHLLPSGVVNEKCISV-IGNGVVIHLPS 102
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAerAAPDVVVRA-AGPNAGHTYIdDEGRKFVHRMLPNGIVSPPLKQVlIGPGSEIDLEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 103 LFDEVLKNEAKGlQHLENRLIISDRAHLVfDFHQHVDgmQEAEKGGKsLGTTKKGIGPAYSSKATRNGIRVGELLGDFNL 182
Cdd:NF038379  80 LREEIEELEDAG-HDVGKRLLIHEQATVI-ELHKHVE--EEAGPMTK-IGSTKKGIGAARAAKIRRNPSTLGDAEGDFGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 183 FSEKFksivnthlrlfpsIKVDVDAELARYKDYvdkvrpyvkdticflHTALRNGKTILVEGANAAMLDIDFGTYPYVTS 262
Cdd:NF038379 155 GAVRD-------------QPWEIAERVVDNALY---------------DFALQAAERIQIEGTQGYSLGLHAGFYPYCTS 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 263 SNCSIGGVLTGLGLPPQ--TIGEVIGVVKAYTTRVGD-----GPFPTE-QLNEIGdlLQTrgfEVGVTTKRKRRCGWLDI 334
Cdd:NF038379 207 RDCTPADFLADAGIPLPnvDAFKVVGTARTYPIRVAGwsgnsYPDQGEtTWEELG--LPE---ELTTVTKKVRRVGTFSA 281

                        330
                 ....*....|.
gi 308191524 335 PLLKYTSLVNG 345
Cdd:NF038379 282 EQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 19-302 1.38e-17

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 85.49  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  19 RTSMYK----SKVDVVLGAQWGDEGKGKVVDMLASEVDIVC--RCQGGNNAGHTVVAN-GTEFDFHLLPSGVVNEKCISV 91
Cdd:PTZ00351 159 KDSLYRiveaHDVIMVAGAFFGDEGKGKTVDAVAHHPLCTCiaRVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNY 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524  92 IGNGVVIHLPSLFD-EVLKNEAKGLQHlENRLIISDRAhLVFDFHQHVDGMqeaekGGKSLGTTKKGIGPAYSSKATRNG 170
Cdd:PTZ00351 239 IGPECVMDPVSFMEkEIIQLIDAGIDY-RDRLFIGNVC-IVTPYHKLLDLL-----GSAANSSTLKGMAPVHGSKVMKRG 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 171 IRVGELLGDFNLFSEKFKSIVNTHLRLFpSIKVDVDAELARY------------KDYV------------------DKVR 220
Cdd:PTZ00351 312 IRLDHIFNDDETLRKRLEKDMDTYLGLL-KVKNLSDADVVRLcreensdgvvrvPDYViafaqakdkveflvklyrDRVR 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308191524 221 -----PYVKDTICFLHTALRNGKTILVEGANAAML-DIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVI-GVVKAY-T 292
Cdd:PTZ00351 391 hnpdfPARCDVTYELHAAVLRGEKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNFQKFKSVVlNVHKAPgS 470

                        330
                 ....*....|
gi 308191524 293 TRVGDGPFPT 302
Cdd:PTZ00351 471 SRVGIGACPS 480
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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