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Conserved domains on  [gi|2245149828|sp|B8ZU60|]
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RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Short=CMK; AltName: Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11479886)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 1.13e-176

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


:

Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 490.56  E-value: 1.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  18 VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGR 97
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188   81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 178 ATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 257
Cdd:PRK03188  161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 258 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMS 317
Cdd:PRK03188  241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 1.13e-176

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 490.56  E-value: 1.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  18 VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGR 97
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188   81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 178 ATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 257
Cdd:PRK03188  161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 258 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMS 317
Cdd:PRK03188  241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 17-300 6.13e-109

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 318.22  E-value: 6.13e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  17 SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANhVPTDEHNIAWRAAELMAEHVG 96
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAG-VPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  97 RAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLS 176
Cdd:COG1947    80 IPPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 177 RATFHWVLAFADSSLLTPAVYTEFDRLRDvGNPPRLAEpgpVLAALVAADpEQLAPLLGNELQAAAVSLDPALRCALRAG 256
Cdd:COG1947   160 LPELWLVLVKPGVGVSTAEVYRALDLTRD-TPPPDIDA---LLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEAL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2245149828 257 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVR 300
Cdd:COG1947   235 LEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVAR 278
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 17-277 3.73e-48

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 163.45  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  17 SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVR---NADVLSLglvgEGANHVPTDEhNIAWRAAELMAE 93
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISvrsDDDIRLL----KGDFDVPLEE-NLAYRAAQLLKN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  94 HVGRAPD----VSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGE 169
Cdd:TIGR00154  77 FANSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 170 ELATVLSRATFHWVLAFADSSLLTPAVYTEFDRLRDvgNPPRLAEpgpVLAALVAADPEQLAPLLGNELQAAAVSLDPAL 249
Cdd:TIGR00154 157 IITPFEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRN--TPKRAKE---WLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|....*...
gi 2245149828 250 RCALRAGMEAGALAGIVSGSGPTCAFLC 277
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPCVFALF 259
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 102-160 2.40e-09

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 52.94  E-value: 2.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2245149828 102 SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRD-----LCMLAAKLGSDVPFALHGG 160
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLAleaeeLAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 1.13e-176

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 490.56  E-value: 1.13e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  18 VTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGR 97
Cdd:PRK03188    1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188   81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 178 ATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGM 257
Cdd:PRK03188  161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 258 EAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMS 317
Cdd:PRK03188  241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 17-300 6.13e-109

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 318.22  E-value: 6.13e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  17 SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANhVPTDEHNIAWRAAELMAEHVG 96
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAG-VPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  97 RAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLS 176
Cdd:COG1947    80 IPPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 177 RATFHWVLAFADSSLLTPAVYTEFDRLRDvGNPPRLAEpgpVLAALVAADpEQLAPLLGNELQAAAVSLDPALRCALRAG 256
Cdd:COG1947   160 LPELWLVLVKPGVGVSTAEVYRALDLTRD-TPPPDIDA---LLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEAL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2245149828 257 MEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVR 300
Cdd:COG1947   235 LEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVAR 278
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 17-277 3.73e-48

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 163.45  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  17 SVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVR---NADVLSLglvgEGANHVPTDEhNIAWRAAELMAE 93
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISvrsDDDIRLL----KGDFDVPLEE-NLAYRAAQLLKN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  94 HVGRAPD----VSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGE 169
Cdd:TIGR00154  77 FANSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 170 ELATVLSRATFHWVLAFADSSLLTPAVYTEFDRLRDvgNPPRLAEpgpVLAALVAADPEQLAPLLGNELQAAAVSLDPAL 249
Cdd:TIGR00154 157 IITPFEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRN--TPKRAKE---WLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260
                  ....*....|....*....|....*...
gi 2245149828 250 RCALRAGMEAGALAGIVSGSGPTCAFLC 277
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPCVFALF 259
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 13-293 1.35e-43

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 151.16  E-value: 1.35e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  13 MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMA 92
Cdd:PRK14608    2 SAMPSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALSLTVSGPFAAGLGDGDDNLVLRAARALR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  93 EHVGR-APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEEL 171
Cdd:PRK14608   82 ARVGPgLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 172 ATVLSRATFHWVLAFADSSLLTPAVY---TEFDRLRDVGNPPRLAEPGPVLAALVAAdpeqlapllGNELQAAAVSLDPA 248
Cdd:PRK14608  162 TPLPGLPSLPAVLVNPGVPVATPDVFralGLRDGPPLPGAPDPLASADALLAALAAT---------RNDLEPPALALAPV 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2245149828 249 L---RCALRAgmEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGA 293
Cdd:PRK14608  233 IgevLAALRA--QPGALLARMSGSGATCFALFADEAAAEAAAAAIAAA 278
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
23-292 5.43e-39

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 138.73  E-value: 5.43e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  23 PGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLglvgEGANHVPTDEHNIAWRAAELMAEHVGRAPDVS 102
Cdd:PRK14611    7 PAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHTLEV----KTSSPQIKEEENIVYKALRLFERYTGIDINYS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 103 IMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHW 182
Cdd:PRK14611   83 IFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLEKPISREI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 183 VLAFADSSLLTPAVYTEFDRlRDVGNPPRLAEpgpVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAgMEAGAL 262
Cdd:PRK14611  163 TLVYPNIKSSTGRVYSKVTK-QILTNKEDLNI---IISLLREGEEKKIEEVIENTLGEIALELYPEIKEVYRF-LEYLGY 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 2245149828 263 AGIVSGSGpTCAFLCASATSAIDVGAQLAG 292
Cdd:PRK14611  238 KPFVSGSG-SSVYVFGKPSEEVKKAAAVRG 266
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 17-312 2.30e-23

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 97.48  E-value: 2.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  17 SVTVQVPGKI-NLylAVG-DCCdnGyhelvtvfHAVSLVDQVTVRNADV--LSLGLVGEGANHVPTDEHNIAWRAAELMA 92
Cdd:COG0083     2 SVKVRVPATSaNL--GPGfDSL--G--------LALSLYDEVEVERSDEpgLEIEIEGEGADELPTDEDNLVYQAALALL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  93 EHVGRA-PDVSIMIDKSIPVAGGMaGGSAdAAAV--LVAMNSLWELSLPRRDLCMLAAKLGS--D--VPfALHGGTALGT 165
Cdd:COG0083    70 EKLGKEpPGLRIEIEKGIPLGRGL-GSSA-AAIVagLVAANALLGLPLSKEELLELATEGEGhpDnvAP-ALLGGLVLSR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 166 GRGEELATV--LSRATFHWVLAFADSSLLT-------PAVYTEFDRLRDVGNpprlaepgpvLAALVAA----DPEQLAP 232
Cdd:COG0083   147 SDGEPVRVVrlPVPPDLKAVVVIPDFELSTkearavlPKQVPLKDAVFNSSR----------AALLVAAlatgDYELLGR 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 233 LLGNEL-QAAAVSLDPALRCALRAGMEAGALAGIVSGSGPTCAFLCASAtSAIDVGAQL----AGAGVCRTVRVATGPVP 307
Cdd:COG0083   217 AMEDRLhEPYRAKLIPGFDEVKEAALEAGALGAGISGAGPTVLALADDE-EAEAVAEAMkaafAEAGIDARVYVLKIDNE 295


                  ....*
gi 2245149828 308 GARVV 312
Cdd:COG0083   296 GARVL 300
PRK01212 PRK01212
homoserine kinase; Provisional
 49-272 6.21e-19

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 85.20  E-value: 6.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  49 AVSLVDQVTVR----NADVLSLGLVGEGANHVPTD-EHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMaGGSAdAA 123
Cdd:PRK01212   25 ALSLYDEVLVGdvvsVEAEFSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPLGRGL-GSSA-AS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 124 AV--LVAMNSLWELSLPRRDLCMLAAKLGS--D--VPfALHGGTALG-TGRGEELATVLSRATFHWVLAFADSSLLT--- 193
Cdd:PRK01212  103 IVagLVAANELAGLPLSKEELLQLATEGEGhpDnvAP-ALLGGLVLAlEENGVISVKIPVFDDLKWVVAIPNIELSTaea 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 194 ----PAVYTEFDRLRDVGNpprlaepgpvLAALVAA----DPEQLAPLLGNEL-QAAAVSLDPALRCALRAGMEAGALAG 264
Cdd:PRK01212  182 ravlPKQYSLKDAVFNSSR----------AALLVAAlytgDYELAGRAMKDVLhEPYRAKLIPGFAEVRQAALEAGALGA 251


                  ....*...
gi 2245149828 265 IVSGSGPT 272
Cdd:PRK01212  252 GISGAGPT 259
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 25-273 3.31e-18

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 82.32  E-value: 3.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  25 KINLYLA-VGDccDNGYHELVTVFHAV-SLVDQVTVRNADVLSLGLVGegaNHVPTDEHNIAWRAAELMAEHvGRAPDV- 101
Cdd:PRK04181    8 KVNIFLKiLGK--RGNYHELISRFVLVkDLFDEIEFVPKSAESFELIG---NFDCPLEENIIYKAYQELKNK-GFSNELi 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 102 ------SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHG-GTALGTGRGEelatv 174
Cdd:PRK04181   82 effkkkAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGE----- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 175 lsratfhWVLAFADSSL-----------LTPAVYTEFDR--LRDVGNPP--RLAEPgPVLAALVAADPEQLapllgNELQ 239
Cdd:PRK04181  157 -------IVEEFEEEILnleiftpnifcSTKAVYKAYREefYDFISFNQakELLKL-SSLELLKNFKNTEL-----NDLL 223

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2245149828 240 AAAVSLDPALRCALRAGmeagalaGIVSGSGPTC 273
Cdd:PRK04181  224 APALKLYPALKDYLGED-------WFFSGSGSSF 250
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
23-270 5.97e-16

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 76.86  E-value: 5.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  23 PGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEgaNHVPTDEH--------------NIAWRAA 88
Cdd:PRK14613    4 PAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFST--NEIILEKRklydqvsergdikqNILYKTF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  89 ELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSlWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRG 168
Cdd:PRK14613   82 IKARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFS-WRNFFTSDEMQVFAKEIGSDVPFFLGEGHAFVTGKG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 169 EELATVLSRATFHwVLAFADSSLLTPAVYTEFDRL------RDVGNPprLAEpgPVLAALVAADPEQLAPLLGNELQAAA 242
Cdd:PRK14613  161 EIMEEIEVHKGQG-ILALTPQVMNTGEMYALLKKPlqesasQKNGNT--LSE--DLISSLKVGDWVSLQGRLENDFEPVA 235

                         250       260
                  ....*....|....*....|....*...
gi 2245149828 243 VSLDPALRCALRAGMEAGALAGIVSGSG 270
Cdd:PRK14613  236 FQLHPELGVLKDKFLEFGSSYCSLTGSG 263
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 49-277 4.57e-14

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 71.28  E-value: 4.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  49 AVSLVDQVTV-----RNADVLSLGLVGEGANHVPTD-EHNIAWRAAELMAEHVG-RAPDVSIMIDKSIPVAGGMAGGSAD 121
Cdd:TIGR00191  22 ALSLYLGLTVtdvvaQESDDTEIEAEGEGVEKIPTEpTDNLIYQVAKRFLDQLGiRMPPVKVTLEKNIPLGRGLGSSAAA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 122 AAAVLVAMNSLWELSLPRRDLCMLAAKL---GSDVPFALHGGTALGTGRGEELAT--VLSRATFHWVLAFADSSLLT--- 193
Cdd:TIGR00191 102 IVAALAAANELCGLPLSKERLLDYASELeghPDNVAPALLGGFQLAFVEDDKLEVlkIPIFSKLDWVLAIPNIEVSTaea 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 194 ----PAvytEFDRLRDVGNPPRLAepgPVLAALVAADPEQLAPLLGNEL-QAAAVSLDPALRCALRAGMEAGALAGIVSG 268
Cdd:TIGR00191 182 ravlPK---AYPRQDLVFNLSHLA---GLVHAIYQKKPDLGAIMMKDRIhQPYRESLIPNLFKIKQAALEKGAYGITISG 255


                  ....*....
gi 2245149828 269 SGPTCAFLC 277
Cdd:TIGR00191 256 SGPTILAMA 264
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 102-160 2.40e-09

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 52.94  E-value: 2.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2245149828 102 SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRD-----LCMLAAKLGSDVPFALHGG 160
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLAleaeeLAGGGRGGGMDVAASLYGG 64
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 84-149 2.25e-06

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 48.31  E-value: 2.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2245149828  84 AWRAAELMAEHVGRAP-DVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKL 149
Cdd:COG4542    53 ARRAAELTLEHLGLPPlGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAI 119
PTZ00299 PTZ00299
homoserine kinase; Provisional
 49-276 6.10e-06

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 47.19  E-value: 6.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  49 AVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGRA--PDVSIMIDKSIPVAGGMAGGSADAAAVL 126
Cdd:PTZ00299   29 ALSIFMELTVEHADAFSMTVEGEGSEHISTDEDNMVVQACRLAFEEYAHKsmPPLKFIMHSNIPYGCGCGSSSAAAVAGF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 127 VAMNSLWELSLP---RRDLCMLAAKL---GSDVPFALHGGTALGTGRGEELAT---VLSRATFHWVL-----AFADSSLL 192
Cdd:PTZ00299  109 VAGMKLCGLTMEtenEEALLQAIAKFeghPDNAAPAIYGGIQLVYKKDNGRFLtyrVPTPPNLSVVLfvphnKMKANTHV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828 193 TPAVYTEFDRLRD-VGNPPRLAepgPVLAALVAADPEQLAPlLGNEL--QAAAVSLDPALRCALRAGMEAGALAGIVSGS 269
Cdd:PTZ00299  189 TRNLIPTSVSLEDaVFNISRTS---ILVLALSTGDLRMLKS-CSDKLheQQRSDALFPHFRPCVKAAREAGAHYAFLSGA 264


                  ....*...
gi 2245149828 270 GPT-CAFL 276
Cdd:PTZ00299  265 GPSvCALV 272
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
25-201 1.77e-05

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 45.61  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  25 KINLYLAVGDCC-DNGYHELVTVFHAV-SLVDQVTV----RNADVLSLGlvgEGANHVPTDEHNIAWRAAELMAEHVGRA 98
Cdd:PRK05905    8 KINLGLSIYKKCkKVTKHKLESIFILVeNVYDDIEIekieKNIDDIHYF---DETNEILVYSRLILVKTLEWLRDKYNIK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245149828  99 PDVSIMIDKSIPVAGGMAGGSADAAAVlvaMNSLWELS-LPRRDLCMLAAKLGSDVPFALHG-GTALGTGRGEELATVLS 176
Cdd:PRK05905   85 NHFKIKIKKRIPIGSGLGSGSSNAAVL---MKWILEFEgINEINYKDVVNKLGSDIPFFLSGyKTAYISDYGSQVEDLIG 161

                         170       180
                  ....*....|....*....|....*
gi 2245149828 177 RATFHWVLAFADSSLLTPAVYTEFD 201
Cdd:PRK05905  162 QFKLTYKVIFMNVNVSTKKVFEKFD 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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