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Conserved domains on  [gi|1127023|dbj|BAA07400|]
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pancreatic GP2 [Homo sapiens]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 10443513)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
76-325 3.45e-67

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 213.24  E-value: 3.45e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     76 CGPREIKVKVDKCLQGGLGFPEEV-IAYLRDPNCSSILQTEERNWVSVTSPVqaSACRNILERNQTHAIYKNTLSL---V 151
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSSLsLLGGLDPSCKPVSNTNGSPAVLFEFPL--TGCGTTVQVNGTHIIYSNTLYSstdL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    152 NDFIIRDTI-LNINFQCAYPLDMKVSLQAALQPivSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVG 230
Cdd:pfam00100  79 RSGIIRRTItRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    231 AILEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDST--IHVEENGQSSESRFSVQMFMFAGHY-DLVFLH 307
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236
                         250
                  ....*....|....*...
gi 1127023    308 CEIHLCDSLNEQCQPSCS 325
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
76-325 3.45e-67

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 213.24  E-value: 3.45e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     76 CGPREIKVKVDKCLQGGLGFPEEV-IAYLRDPNCSSILQTEERNWVSVTSPVqaSACRNILERNQTHAIYKNTLSL---V 151
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSSLsLLGGLDPSCKPVSNTNGSPAVLFEFPL--TGCGTTVQVNGTHIIYSNTLYSstdL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    152 NDFIIRDTI-LNINFQCAYPLDMKVSLQAALQPivSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVG 230
Cdd:pfam00100  79 RSGIIRRTItRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    231 AILEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDST--IHVEENGQSSESRFSVQMFMFAGHY-DLVFLH 307
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236
                         250
                  ....*....|....*...
gi 1127023    308 CEIHLCDSLNEQCQPSCS 325
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
76-327 1.86e-60

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 195.68  E-value: 1.86e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023      76 CGPREIKVKVDKCLQGGLGFpEEVIAYLRDPNCSSILQTEERNWVSVTSPVQAsaCRNILERNQTHAIYKNTL---SLVN 152
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGI-NVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLvvsPFHP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     153 DFIIRDTILNINFQCAYPLDMKVSLQAALQPIVSSLNVSVdGNGEFIVRMALFQDQNYTNPYEGDAVELsvESVLYVGAI 232
Cdd:smart00241  79 GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYHEWE 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     233 LEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQR--DSTIHVEENgQSSESRFSVQMFMFAGhYDLVFLHCEI 310
Cdd:smart00241 156 CDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGylDSTIPYNSN-PLHRARFSVKVFKFAD-RSLVYFHCQI 233
                          250
                   ....*....|....*....
gi 1127023     311 HLCDSL--NEQCQPSCSRS 327
Cdd:smart00241 234 RLCDKDdgSSCDGPACSSR 252
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
76-325 3.45e-67

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 213.24  E-value: 3.45e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     76 CGPREIKVKVDKCLQGGLGFPEEV-IAYLRDPNCSSILQTEERNWVSVTSPVqaSACRNILERNQTHAIYKNTLSL---V 151
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSSLsLLGGLDPSCKPVSNTNGSPAVLFEFPL--TGCGTTVQVNGTHIIYSNTLYSstdL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    152 NDFIIRDTI-LNINFQCAYPLDMKVSLQAALQPivSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVG 230
Cdd:pfam00100  79 RSGIIRRTItRRLPFSCSYPRSSLVSLLVVAPP--SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLYVE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023    231 AILEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDST--IHVEENGQSSESRFSVQMFMFAGHY-DLVFLH 307
Cdd:pfam00100 157 VSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypVSSLSNGPSHYVRFSFKAFRFVGSSiSQVYLH 236
                         250
                  ....*....|....*...
gi 1127023    308 CEIHLCDSLNEQCQPSCS 325
Cdd:pfam00100 237 CSVSVCSSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
76-327 1.86e-60

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 195.68  E-value: 1.86e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023      76 CGPREIKVKVDKCLQGGLGFpEEVIAYLRDPNCSSILQTEERNWVSVTSPVQAsaCRNILERNQTHAIYKNTL---SLVN 152
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGI-NVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLvvsPFHP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     153 DFIIRDTILNINFQCAYPLDMKVSLQAALQPIVSSLNVSVdGNGEFIVRMALFQDQNYTNPYEGDAVELsvESVLYVGAI 232
Cdd:smart00241  79 GFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYHEWE 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127023     233 LEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQR--DSTIHVEENgQSSESRFSVQMFMFAGhYDLVFLHCEI 310
Cdd:smart00241 156 CDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGylDSTIPYNSN-PLHRARFSVKVFKFAD-RSLVYFHCQI 233
                          250
                   ....*....|....*....
gi 1127023     311 HLCDSL--NEQCQPSCSRS 327
Cdd:smart00241 234 RLCDKDdgSSCDGPACSSR 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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