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Conserved domains on  [gi|6683014|dbj|BAA88988|]
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beta-1,3-galactosyltransferase-4 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229488)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Galactosyl_T super family cl21608
Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose: ...
 85-308 1.10e-54

Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.


The actual alignment was detected with superfamily member pfam01762:

Pssm-ID: 473923 [Multi-domain]  Cd Length: 195  Bit Score: 178.67  E-value: 1.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014     85 NQRNAIRASWGGLREARGLRVQTLFLLGEPnaqhPVWGSQGSDLASESAAQ-GDILQAAFQDSYRNLTLKTLSGLNWAEK 163
Cdd:pfam01762   1 ARRNAIRKTWMNQGNSEGGRIKSLFLVGLS----ADTDGKVADLVMEEAKLyGDIVVVDFEDTYENLTFKTLTGLLWAVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014    164 HCPMARYVLKTDDDVYVNVPELVSELVlrggrwgQWERSTEPQREA--EQEGGQVLHSEEvpllylgrVHWRVNPSRTPG 241
Cdd:pfam01762  77 KCPSAKYIGKIDDDVYFFPDKLLSLLD-------NGNIDPSESSFYgyVMEEGPVIRNKK--------SKWYVSPSDYKC 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6683014    242 GRhrvseeqwphtwgpFPPYASGTGYVLSASAVQLILKVASRAPLLPLEDVFVGVSARRGGLAPTQC 308
Cdd:pfam01762 142 SR--------------YPPYASGPFYVLSRDAAEKLLKASKHRRFLQIEDVYVGILANDLGISRVNL 194
 
Name Accession Description Interval E-value
Galactosyl_T pfam01762
Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose: ...
 85-308 1.10e-54

Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.


Pssm-ID: 426415 [Multi-domain]  Cd Length: 195  Bit Score: 178.67  E-value: 1.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014     85 NQRNAIRASWGGLREARGLRVQTLFLLGEPnaqhPVWGSQGSDLASESAAQ-GDILQAAFQDSYRNLTLKTLSGLNWAEK 163
Cdd:pfam01762   1 ARRNAIRKTWMNQGNSEGGRIKSLFLVGLS----ADTDGKVADLVMEEAKLyGDIVVVDFEDTYENLTFKTLTGLLWAVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014    164 HCPMARYVLKTDDDVYVNVPELVSELVlrggrwgQWERSTEPQREA--EQEGGQVLHSEEvpllylgrVHWRVNPSRTPG 241
Cdd:pfam01762  77 KCPSAKYIGKIDDDVYFFPDKLLSLLD-------NGNIDPSESSFYgyVMEEGPVIRNKK--------SKWYVSPSDYKC 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6683014    242 GRhrvseeqwphtwgpFPPYASGTGYVLSASAVQLILKVASRAPLLPLEDVFVGVSARRGGLAPTQC 308
Cdd:pfam01762 142 SR--------------YPPYASGPFYVLSRDAAEKLLKASKHRRFLQIEDVYVGILANDLGISRVNL 194
PLN03133 PLN03133
beta-1,3-galactosyltransferase; Provisional
 67-305 6.31e-14

beta-1,3-galactosyltransferase; Provisional


Pssm-ID: 215596 [Multi-domain]  Cd Length: 636  Bit Score: 73.30  E-value: 6.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014    67 PGAPPFLLILVCTAPENLNQRNAIRASWGGLREARGLRVQTLFLLGEPNAQhpvwgSQGSDLASESAAQGDILQAAFQDS 146
Cdd:PLN03133 381 PKKPLDLFIGVFSTANNFKRRMAVRRTWMQYDAVRSGAVAVRFFVGLHKNQ-----MVNEELWNEARTYGDIQLMPFVDY 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014   147 YRNLTLKTLS----GLNWAEkhcpmARYVLKTDDDVYVNVPELVSELvlrggrwgqwERSTepqreaeqeggqVLHSeev 222
Cdd:PLN03133 456 YSLITWKTLAicifGTEVVS-----AKYVMKTDDDAFVRVDEVLASL----------KRTN------------VSHG--- 505

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014   223 pLLYlGRVHWRVNPSRTPGGRHRVSEEQWPHTwgPFPPYASGTGYVLS---ASAVQLILKvASRAPLLPLEDVFVGV--- 296
Cdd:PLN03133 506 -LLY-GLINSDSQPHRNPDSKWYISPEEWPEE--TYPPWAHGPGYVVSrdiAKEVYKRHK-EGRLKMFKLEDVAMGIwia 580


                 ....*....
gi 6683014   297 SARRGGLAP 305
Cdd:PLN03133 581 EMKKEGLEV 589
 
Name Accession Description Interval E-value
Galactosyl_T pfam01762
Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose: ...
 85-308 1.10e-54

Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.


Pssm-ID: 426415 [Multi-domain]  Cd Length: 195  Bit Score: 178.67  E-value: 1.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014     85 NQRNAIRASWGGLREARGLRVQTLFLLGEPnaqhPVWGSQGSDLASESAAQ-GDILQAAFQDSYRNLTLKTLSGLNWAEK 163
Cdd:pfam01762   1 ARRNAIRKTWMNQGNSEGGRIKSLFLVGLS----ADTDGKVADLVMEEAKLyGDIVVVDFEDTYENLTFKTLTGLLWAVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014    164 HCPMARYVLKTDDDVYVNVPELVSELVlrggrwgQWERSTEPQREA--EQEGGQVLHSEEvpllylgrVHWRVNPSRTPG 241
Cdd:pfam01762  77 KCPSAKYIGKIDDDVYFFPDKLLSLLD-------NGNIDPSESSFYgyVMEEGPVIRNKK--------SKWYVSPSDYKC 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6683014    242 GRhrvseeqwphtwgpFPPYASGTGYVLSASAVQLILKVASRAPLLPLEDVFVGVSARRGGLAPTQC 308
Cdd:pfam01762 142 SR--------------YPPYASGPFYVLSRDAAEKLLKASKHRRFLQIEDVYVGILANDLGISRVNL 194
PLN03133 PLN03133
beta-1,3-galactosyltransferase; Provisional
 67-305 6.31e-14

beta-1,3-galactosyltransferase; Provisional


Pssm-ID: 215596 [Multi-domain]  Cd Length: 636  Bit Score: 73.30  E-value: 6.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014    67 PGAPPFLLILVCTAPENLNQRNAIRASWGGLREARGLRVQTLFLLGEPNAQhpvwgSQGSDLASESAAQGDILQAAFQDS 146
Cdd:PLN03133 381 PKKPLDLFIGVFSTANNFKRRMAVRRTWMQYDAVRSGAVAVRFFVGLHKNQ-----MVNEELWNEARTYGDIQLMPFVDY 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014   147 YRNLTLKTLS----GLNWAEkhcpmARYVLKTDDDVYVNVPELVSELvlrggrwgqwERSTepqreaeqeggqVLHSeev 222
Cdd:PLN03133 456 YSLITWKTLAicifGTEVVS-----AKYVMKTDDDAFVRVDEVLASL----------KRTN------------VSHG--- 505

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6683014   223 pLLYlGRVHWRVNPSRTPGGRHRVSEEQWPHTwgPFPPYASGTGYVLS---ASAVQLILKvASRAPLLPLEDVFVGV--- 296
Cdd:PLN03133 506 -LLY-GLINSDSQPHRNPDSKWYISPEEWPEE--TYPPWAHGPGYVVSrdiAKEVYKRHK-EGRLKMFKLEDVAMGIwia 580


                 ....*....
gi 6683014   297 SARRGGLAP 305
Cdd:PLN03133 581 EMKKEGLEV 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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