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Conserved domains on  [gi|15778144|dbj|BAB68519|]
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hatching enzyme EHE14 [Anguilla japonica]

Protein Classification

zinc metalloprotease; M10 family metallopeptidase domain-containing protein( domain architecture ID 10136819)

zinc metalloprotease may be a member of the astacin-like protease family or the adamalysin/reprolysin-like protease family; M10 family metallopeptidase domain-containing protein is a metalloendopeptidase similar to matrix metalloproteinases that may be endopeptidases that degrade various components of the extracellular matrix

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
84-265 1.21e-124

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


:

Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 352.34  E-value: 1.21e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  84 NGLVEVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQRDYISIQSRGGCYSYLGRTGGKQVVSLARYGCVYHGI 163
Cdd:cd04283   1 NGIVYVPYVISPQYSENERAVIEKAMQEFETLTCVRFVPRTTERDYLNIESRSGCWSYIGRQGGRQTVSLQKQGCMYKGI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 164 IQHELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQNTNNLHTPYDYTSIMHYGKTAFSTNGKDTITTIPNPKQ 243
Cdd:cd04283  81 IQHELLHALGFYHEQTRSDRDKYVRINWENIIPDQLYNFDKQDTNNLGTPYDYSSVMHYGRYAFSINGKPTIVPIPDPNV 160
                       170       180
                ....*....|....*....|..
gi 15778144 244 SIGQRRSMSRWDILRIKKLYNC 265
Cdd:cd04283 161 PIGQRQGMSNLDILRINKLYNC 182
 
Name Accession Description Interval E-value
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
84-265 1.21e-124

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 352.34  E-value: 1.21e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  84 NGLVEVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQRDYISIQSRGGCYSYLGRTGGKQVVSLARYGCVYHGI 163
Cdd:cd04283   1 NGIVYVPYVISPQYSENERAVIEKAMQEFETLTCVRFVPRTTERDYLNIESRSGCWSYIGRQGGRQTVSLQKQGCMYKGI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 164 IQHELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQNTNNLHTPYDYTSIMHYGKTAFSTNGKDTITTIPNPKQ 243
Cdd:cd04283  81 IQHELLHALGFYHEQTRSDRDKYVRINWENIIPDQLYNFDKQDTNNLGTPYDYSSVMHYGRYAFSINGKPTIVPIPDPNV 160
                       170       180
                ....*....|....*....|..
gi 15778144 244 SIGQRRSMSRWDILRIKKLYNC 265
Cdd:cd04283 161 PIGQRQGMSNLDILRINKLYNC 182
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
88-265 3.51e-73

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 222.16  E-value: 3.51e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144    88 EVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPR--SRQRDYISIQSRGGCYSYLGRTGGKQVVSLARyGCVYHGIIQ 165
Cdd:pfam01400   7 PIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERtpAPDNNYLFFFKGDGCYSYVGRVGGRQPVSIGD-GCDKFGIIV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144   166 HELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQN---TNNLHTPYDYTSIMHYGKTAFSTNG-KDTITTIPNP 241
Cdd:pfam01400  86 HELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYDpseVDSYGVPYDYGSIMHYGPNAFSKNGsLPTIVPKDND 165
                         170       180
                  ....*....|....*....|....*
gi 15778144   242 KQS-IGQRRSMSRWDILRIKKLYNC 265
Cdd:pfam01400 166 YQAtIGQRVKLSFYDIKKINKLYKC 190
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
75-218 3.86e-41

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 138.64  E-value: 3.86e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144     75 NRCLWKKssnglVEVPYTV-SRQFSYYQRKRIVKAMKTFNTQTCIRFVPR-SRQRDYISIQSR--GGCYSYLGRTGGKQV 150
Cdd:smart00235   1 GSKKWPK-----GTVPYVIdSSSLSPEEREAIAKALAEWSDVTCIRFVERtGTADIYISFGSGdsGCTLSHAGRPGGDQH 75
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15778144    151 VSLARyGCVYHGIIQHELSHALGFYHEHTRSDRNEYVRINWENVAPRsiyNFQKQNTNNLHTPYDYTS 218
Cdd:smart00235  76 LSLGN-GCINTGVAAHELGHALGLYHEQSRSDRDNYMYINYTNIDTR---NFDLSEDDSLGIPYDYGS 139
 
Name Accession Description Interval E-value
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
84-265 1.21e-124

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 352.34  E-value: 1.21e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  84 NGLVEVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQRDYISIQSRGGCYSYLGRTGGKQVVSLARYGCVYHGI 163
Cdd:cd04283   1 NGIVYVPYVISPQYSENERAVIEKAMQEFETLTCVRFVPRTTERDYLNIESRSGCWSYIGRQGGRQTVSLQKQGCMYKGI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 164 IQHELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQNTNNLHTPYDYTSIMHYGKTAFSTNGKDTITTIPNPKQ 243
Cdd:cd04283  81 IQHELLHALGFYHEQTRSDRDKYVRINWENIIPDQLYNFDKQDTNNLGTPYDYSSVMHYGRYAFSINGKPTIVPIPDPNV 160
                       170       180
                ....*....|....*....|..
gi 15778144 244 SIGQRRSMSRWDILRIKKLYNC 265
Cdd:cd04283 161 PIGQRQGMSNLDILRINKLYNC 182
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
89-263 3.66e-88

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 259.81  E-value: 3.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  89 VPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQRDYISIQSRGGCYSYLGRTGGKQVVSLARyGCVYHGIIQHEL 168
Cdd:cd04280   4 VPYVIDGSFDESDRSLILRAMREIESNTCIRFVPRTTEKDYIRIVKGSGCWSYVGRVGGRQVVSLGS-GCFSLGTIVHEL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 169 SHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQN---TNNLHTPYDYTSIMHYGKTAFSTNGKDTITTIPNPKQSI 245
Cdd:cd04280  83 MHALGFYHEQSRPDRDDYVTINWENIQPGYEHNFDKYSpdtVTTYGVPYDYGSVMHYGPTAFSKNGKPTIVPKDPGYQII 162
                       170
                ....*....|....*...
gi 15778144 246 GQRRSMSRWDILRIKKLY 263
Cdd:cd04280 163 GQREGLSFLDIKKINKMY 180
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
88-265 3.51e-73

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 222.16  E-value: 3.51e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144    88 EVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPR--SRQRDYISIQSRGGCYSYLGRTGGKQVVSLARyGCVYHGIIQ 165
Cdd:pfam01400   7 PIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERtpAPDNNYLFFFKGDGCYSYVGRVGGRQPVSIGD-GCDKFGIIV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144   166 HELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQKQN---TNNLHTPYDYTSIMHYGKTAFSTNG-KDTITTIPNP 241
Cdd:pfam01400  86 HELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYDpseVDSYGVPYDYGSIMHYGPNAFSKNGsLPTIVPKDND 165
                         170       180
                  ....*....|....*....|....*
gi 15778144   242 KQS-IGQRRSMSRWDILRIKKLYNC 265
Cdd:pfam01400 166 YQAtIGQRVKLSFYDIKKINKLYKC 190
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
89-265 1.53e-51

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 167.23  E-value: 1.53e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  89 VPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQRDYISIQSRG-GCYSYLGRTG-GKQVVSLARyGCVYHGIIQH 166
Cdd:cd04281  15 IPYVIDGNFTGSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPcGCCSYVGRRGnGPQAISIGK-NCDKFGIVVH 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 167 ELSHALGFYHEHTRSDRNEYVRINWENVAPRSIYNFQK---QNTNNLHTPYDYTSIMHYGKTAFSTNGK-DTITTIPNP- 241
Cdd:cd04281  94 ELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKmepEEVDSLGEPYDFDSIMHYARNTFSRGMFlDTILPKRDPn 173
                       170       180
                ....*....|....*....|....*.
gi 15778144 242 --KQSIGQRRSMSRWDILRIKKLYNC 265
Cdd:cd04281 174 gvRPEIGQRTRLSEGDIIQANKLYKC 199
ZnMc_meprin cd04282
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted ...
27-265 1.96e-50

Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as osteopontin, and proteins such as collagen IV, fibronectin, casein and gelatin. Meprins may also be able to release proteins from the cell surface. Closely related meprin alpha- and beta-subunits form homo- and hetero-oligomers; these complexes are found on epithelial cells of the intestine, for example, and are also expressed in certain cancer cells.


Pssm-ID: 239809 [Multi-domain]  Cd Length: 230  Bit Score: 165.34  E-value: 1.96e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  27 GEDENEIEDPDDLDIttrimqsNNGSIEMLMEGDLLV--SNTRNAMkcRNNRCLWKKSsnglveVPYTVSRQFSYYQRKR 104
Cdd:cd04282   1 ENDADEGIDQDIFEI-------NLGAGLDLFEGDILLdeGQSRNGL--IGDTYRWPFP------IPYILDDSLDLNAKGV 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 105 IVKAMKTFNTQTCIRFVPRSRQRDYISIQSRGGCYSYLGRTGGKQVVSLARyGCVYHGIIQHELSHALGFYHEHTRSDRN 184
Cdd:cd04282  66 ILKAFEMYRLKSCVDFKPYEGESNYIFFFKGSGCWSMVGDQQGGQNLSIGA-GCDYKATVEHEFLHALGFYHEQSRSDRD 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 185 EYVRINWENVAPRSIYNFQKQN---TNNLHTPYDYTSIMHYGKTAFSTNGKD-TITT-IPNPKQSIGQRRSMSRWDILRI 259
Cdd:cd04282 145 DYVKIWWDQILSGREHNFNKYDdsfSTDLNTPYDYESVMHYSPFSFNKGASEpTITTkIPEFNDIIGQRLDFSDIDLERL 224

                ....*.
gi 15778144 260 KKLYNC 265
Cdd:cd04282 225 NRMYNC 230
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
75-218 3.86e-41

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 138.64  E-value: 3.86e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144     75 NRCLWKKssnglVEVPYTV-SRQFSYYQRKRIVKAMKTFNTQTCIRFVPR-SRQRDYISIQSR--GGCYSYLGRTGGKQV 150
Cdd:smart00235   1 GSKKWPK-----GTVPYVIdSSSLSPEEREAIAKALAEWSDVTCIRFVERtGTADIYISFGSGdsGCTLSHAGRPGGDQH 75
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15778144    151 VSLARyGCVYHGIIQHELSHALGFYHEHTRSDRNEYVRINWENVAPRsiyNFQKQNTNNLHTPYDYTS 218
Cdd:smart00235  76 LSLGN-GCINTGVAAHELGHALGLYHEQSRSDRDNYMYINYTNIDTR---NFDLSEDDSLGIPYDYGS 139
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
87-263 1.39e-26

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 101.83  E-value: 1.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  87 VEVPYTVSR--------QFSYYQRKRIVKAMKTFNTQTCIRFVPR--SRQRDYISIQS-------RGGCYSYLGRT--GG 147
Cdd:cd00203   1 KVIPYVVVAddrdveeeNLSAQIQSLILIAMQIWRDYLNIRFVLVgvEIDKADIAILVtrqdfdgGTGGWAYLGRVcdSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 148 KQVVSLARYGCV---YHGIIQHELSHALGFYHEHTRSDRNEYVRINWENVAprsiynfqkqntnnlhTPYDYTSIMHYGK 224
Cdd:cd00203  81 RGVGVLQDNQSGtkeGAQTIAHELGHALGFYHDHDRKDRDDYPTIDDTLNA----------------EDDDYYSVMSYTK 144
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15778144 225 TAFstngkdtittipnpkqSIGQRRSMSRWDILRIKKLY 263
Cdd:cd00203 145 GSF----------------SDGQRKDFSQCDIDQINKLY 167
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
88-263 3.24e-24

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 95.26  E-value: 3.24e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144  88 EVPYTVSRQFSYYQRKRIVKAMKTFNTQTCIRFVPRSRQR-DYISI------QSRGGCYSYLGRT--GGKQVVSLARYGC 158
Cdd:cd04268   3 PITYYIDDSVPDKLRAAILDAIEAWNKAFAIGFKNANDVDpADIRYsvirwiPYNDGTWSYGPSQvdPLTGEILLARVYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 159 ----------VYHGIIQHELSHALGFYHEHTRSDRneyvrinwenvaprsiynfqKQNTNNLHTPYDYTSIMHYGKTAFS 228
Cdd:cd04268  83 yssfveysgaRLRNTAEHELGHALGLRHNFAASDR--------------------DDNVDLLAEKGDTSSVMDYAPSNFS 142
                       170       180       190
                ....*....|....*....|....*....|....*
gi 15778144 229 TNGKDtittipnpkqsiGQRRSMSRWDILRIKKLY 263
Cdd:cd04268 143 IQLGD------------GQKYTIGPYDIAAIKKLY 165
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
101-222 2.10e-08

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 53.15  E-value: 2.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15778144 101 QRKRIVKAMKTFNTQTCIRFVpRSRQRD---YISIQSRGGCYSYLGR----------TGGKQVVSLARYGCVYHGIIQHE 167
Cdd:cd04327  21 LKDKVRAAAREWLPYANLKFK-FVTDADadiRISFTPGDGYWSYVGTdalligadapTMNLGWFTDDTPDPEFSRVVLHE 99
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15778144 168 LSHALGFYHEHTRSDRNeyVRINWENVAP--RSIYN-----------FQKQN-TNNLHTPYDYTSIMHY 222
Cdd:cd04327 100 FGHALGFIHEHQSPAAN--IPWDKEAVYAyfSGPPNwdretvinhnvFAKLDdGDVAYSPYDPDSIMHY 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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