tRNA-nucleotidyltransferase [Homo sapiens]
CCA tRNA nucleotidyltransferase( domain architecture ID 11427658)
[cytidine(C)-cytidine(C)-adenosine (A)] tRNA nucleotidyltransferase adds the CCA sequence one nucleotide at a time onto the 3' end of tRNA
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
PcnB | COG0617 | tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
43-428 | 2.26e-91 | |||||||
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification : Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 281.70 E-value: 2.26e-91
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Name | Accession | Description | Interval | E-value | |||||||
PcnB | COG0617 | tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
43-428 | 2.26e-91 | |||||||
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 281.70 E-value: 2.26e-91
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PRK13299 | PRK13299 | tRNA CCA-pyrophosphorylase; Provisional |
38-251 | 1.68e-48 | |||||||
tRNA CCA-pyrophosphorylase; Provisional Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 170.02 E-value: 1.68e-48
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NT_ClassII-CCAase | cd05398 | Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
42-178 | 5.03e-48 | |||||||
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily. Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 160.84 E-value: 5.03e-48
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PolyA_pol | pfam01743 | Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
59-182 | 1.04e-39 | |||||||
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily. Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 138.57 E-value: 1.04e-39
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Name | Accession | Description | Interval | E-value | |||||||
PcnB | COG0617 | tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
43-428 | 2.26e-91 | |||||||
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 281.70 E-value: 2.26e-91
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PRK13299 | PRK13299 | tRNA CCA-pyrophosphorylase; Provisional |
38-251 | 1.68e-48 | |||||||
tRNA CCA-pyrophosphorylase; Provisional Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 170.02 E-value: 1.68e-48
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NT_ClassII-CCAase | cd05398 | Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
42-178 | 5.03e-48 | |||||||
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily. Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 160.84 E-value: 5.03e-48
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PolyA_pol | pfam01743 | Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
59-182 | 1.04e-39 | |||||||
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily. Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 138.57 E-value: 1.04e-39
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pcnB | PRK11623 | poly(A) polymerase I; Provisional |
54-246 | 3.06e-20 | |||||||
poly(A) polymerase I; Provisional Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 92.51 E-value: 3.06e-20
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PRK13296 | PRK13296 | CCA tRNA nucleotidyltransferase; |
58-246 | 7.52e-15 | |||||||
CCA tRNA nucleotidyltransferase; Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 75.41 E-value: 7.52e-15
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cca | PRK10885 | multifunctional CCA addition/repair protein; |
63-246 | 9.11e-14 | |||||||
multifunctional CCA addition/repair protein; Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 72.58 E-value: 9.11e-14
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PRK13297 | PRK13297 | tRNA CCA-pyrophosphorylase; Provisional |
61-286 | 5.43e-13 | |||||||
tRNA CCA-pyrophosphorylase; Provisional Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 70.02 E-value: 5.43e-13
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PRK13298 | PRK13298 | tRNA CCA-pyrophosphorylase; Provisional |
63-246 | 5.96e-13 | |||||||
tRNA CCA-pyrophosphorylase; Provisional Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 70.14 E-value: 5.96e-13
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PolyA_pol_RNAbd | pfam12627 | Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
216-270 | 1.66e-08 | |||||||
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A. Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 50.95 E-value: 1.66e-08
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PHA01806 | PHA01806 | hypothetical protein |
61-97 | 1.78e-03 | |||||||
hypothetical protein Pssm-ID: 222838 Cd Length: 200 Bit Score: 39.48 E-value: 1.78e-03
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NT_Pol-beta-like | cd05397 | Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; This ... |
42-83 | 4.82e-03 | |||||||
Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; This superfamily includes the NT domains of DNA polymerase beta and other family X DNA polymerases, as well as the NT domains of Class I and Class II CCA-adding enzymes, RelA- and SpoT-like ppGpp synthetases and hydrolases, 2'5'-oligoadenylate (2-5A)synthetases, Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), poly (A) polymerases, terminal uridylyl transferases, and Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. The Escherichia coli CCA-adding enzyme belongs to this superfamily but is not included as this enzyme lacks the N-terminal helix conserved in the remainder of the superfamily. In the majority of the Pol beta-like superfamily NTs, two carboxylates, Dx[D/E], together with a third more distal carboxylate coordinate two divalent metal cations that are essential for catalysis. These divalent metal ions are involved in a two-metal ion mechanism of nucleotide addition. Two of the three catalytic carboxylates are found in Rel-Spo enzymes, with the second carboxylate of the DXD motif missing. Evidence supports a single-cation synthetase mechanism for Rel-Spo enzymes. Pssm-ID: 143387 [Multi-domain] Cd Length: 49 Bit Score: 34.99 E-value: 4.82e-03
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Blast search parameters | ||||
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