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Conserved domains on  [gi|16551945|dbj|BAB71203|]
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unnamed protein product, partial [Homo sapiens]

Protein Classification

RST1 family protein( domain architecture ID 10576052)

RST1 family protein is a DUF3730 domain-containing protein similar to Arabidopsis thaliana protein RST1, which is required for the synthesis of alkanes from wax precursors and may play a role in acyl-CoA reduction to aldehydes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
 490-714 4.70e-83

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


:

Pssm-ID: 463619  Cd Length: 227  Bit Score: 266.45  E-value: 4.70e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   490 IPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRFMA 566
Cdd:pfam12530   1 LPELLYALEKSSNPELVLLLLKGLPSLARHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPFLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   567 VSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCIRS 646
Cdd:pfam12530  81 FSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDFSS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16551945   647 TWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQNKD-PIVANAAYRSL 714
Cdd:pfam12530 159 AWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENSNDdARVASAAFEAL 227
 
Name Accession Description Interval E-value
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
 490-714 4.70e-83

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


Pssm-ID: 463619  Cd Length: 227  Bit Score: 266.45  E-value: 4.70e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   490 IPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRFMA 566
Cdd:pfam12530   1 LPELLYALEKSSNPELVLLLLKGLPSLARHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPFLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   567 VSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCIRS 646
Cdd:pfam12530  81 FSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDFSS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16551945   647 TWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQNKD-PIVANAAYRSL 714
Cdd:pfam12530 159 AWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENSNDdARVASAAFEAL 227
 
Name Accession Description Interval E-value
DUF3730 pfam12530
Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals ...
 490-714 4.70e-83

Focadhesin/RST1, DUF3730; This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.


Pssm-ID: 463619  Cd Length: 227  Bit Score: 266.45  E-value: 4.70e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   490 IPVLMFKLGRPLEPILYNDILYTLPKLGVHKVCIGQILRIIQLLGT---TPRLRAVTLRLLTSLWEKQDRVYPELQRFMA 566
Cdd:pfam12530   1 LPELLYALEKSSNPELVLLLLKGLPSLARHKVCVPLVLPFIQPLSSrdaSPLLQAVALRLLCKLWKGMDRVYPFLQPFLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16551945   567 VSDvPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQaTPAALVLQGLHALCQAEVVCIRS 646
Cdd:pfam12530  81 FSK-SSSSAFARSLIESLASLAASLRDICKHRPDQHGEDLVDAYSACLNECESEVP-EVQALGLELLDALCEAEVVDFSS 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16551945   647 TWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTTEYENFKVQVLSFLWTHTQNKD-PIVANAAYRSL 714
Cdd:pfam12530 159 AWDVIQKKLGLDYRPLVLKSLCSLFALLPQLEVDHEQYEELKLDIILILWKLENSNDdARVASAAFEAL 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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