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Conserved domains on  [gi|17425947|dbj|BAB79107|]
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immunoglobulin heavy chain, partial [Mus musculus]

Protein Classification

immunoglobulin heavy chain variable domain-containing protein( domain architecture ID 10141748)

immunoglobulin heavy chain variable domain-containing protein similar to immunoglobulin heavy chains

CATH:  2.60.40.10
Gene Ontology:  GO:0003823
PubMed:  9571064|9541533

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-113 8.41e-68

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 199.46  E-value: 8.41e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   3 QLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTKYNEKFKSKATLTVDKPSSTAYMQ 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17425947  83 LSSLTSEDSAVYYCAR-------RWFDYWGQGTTLTVS 113
Cdd:cd04981  81 LNSLTSEDTAVYYCARglggygySYFDYWGQGTTVTVS 118
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-113 8.41e-68

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 199.46  E-value: 8.41e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   3 QLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTKYNEKFKSKATLTVDKPSSTAYMQ 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17425947  83 LSSLTSEDSAVYYCAR-------RWFDYWGQGTTLTVS 113
Cdd:cd04981  81 LNSLTSEDTAVYYCARglggygySYFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
17-98 4.35e-31

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 105.54  E-value: 4.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947     17 SVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIdPNSGGTKYNEKFKSKATLTVDKPSSTAYMQLSSLTSEDSAVYYC 96
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYI-GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 17425947     97 AR 98
Cdd:smart00406  80 AV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 5-112 8.96e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 8.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947     5 QQPGAELVKPGASVKLSCKASGY-TFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTkynEKFKSKATLTVDKPSSTAYMQL 83
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSEE---GVKKGRFSGRGDPSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 17425947    84 SSLTSEDSAVYYCARRWFD--YWGQGTTLTV 112
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGegVFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-113 8.41e-68

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 199.46  E-value: 8.41e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   3 QLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTKYNEKFKSKATLTVDKPSSTAYMQ 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17425947  83 LSSLTSEDSAVYYCAR-------RWFDYWGQGTTLTVS 113
Cdd:cd04981  81 LNSLTSEDTAVYYCARglggygySYFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
17-98 4.35e-31

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 105.54  E-value: 4.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947     17 SVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIdPNSGGTKYNEKFKSKATLTVDKPSSTAYMQLSSLTSEDSAVYYC 96
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYI-GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 17425947     97 AR 98
Cdd:smart00406  80 AV 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 5-112 4.16e-27

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 96.25  E-value: 4.16e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   5 QQPGAELVKPGASVKLSCKASGyTFTSYWMHWVKQRPGRGLEWIGRIdpNSGGTKYNEKFKSKATLTVDKpSSTAYMQLS 84
Cdd:cd00099   3 QSPRSLSVQEGESVTLSCEVSS-SFSSTYIYWYRQKPGQGPEFLIYL--SSSKGKTKGGVPGRFSGSRDG-TSSFSLTIS 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 17425947  85 SLTSEDSAVYYCARR-----WFDYWGQGTTLTV 112
Cdd:cd00099  79 NLQPEDSGTYYCAVSesggtDKLTFGSGTRLTV 111
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 4-113 1.75e-16

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 69.31  E-value: 1.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   4 LQQPGAELVKP-GASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTKYNEKFKSKATLTVDKPSSTAYMQ 82
Cdd:cd04982   1 LEQPQLSITREeSKSVTISCKVSGIDFSTTYIHWYRQKPGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTSTLT 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17425947  83 LSSLTSEDSAVYYCA--RRWFDYW----GQGTTLTVS 113
Cdd:cd04982  81 ITNLEKEDSATYYCAywESGSGYYikvfGSGTKLIVT 117
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 5-112 2.78e-16

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 68.84  E-value: 2.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   5 QQPGAELVKPGASVKLSCKASgyTFTSYWMHWVKQRPGRGLEWIGRIDPNSGgtkynEKFKSKATLTVDKPSSTAYMQLS 84
Cdd:cd04983   3 QSPQSLSVQEGENVTLNCNYS--TSTFYYLFWYRQYPGQGPQFLIYISSDSG-----NKKKGRFSATLDKSRKSSSLHIS 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 17425947  85 SLTSEDSAVYYCA-RRWFDYW----GQGTTLTV 112
Cdd:cd04983  76 AAQLSDSAVYFCAlSESGGTGkltfGKGTRLTV 108
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 5-112 4.40e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 65.77  E-value: 4.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   5 QQPGAELVKPGASVKLSC-KASGYtftsYWMHWVKQRPGRGLEWIGRIdpNSGGTKYNEKFKsKATLTVDKPSST-AYMQ 82
Cdd:cd05899   3 QSPRYLIKRRGQSVTLRCsQKSGH----DNMYWYRQDPGKGLQLLFYS--YGGGLNEEGDLP-GDRFSASRPSLTrSSLT 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17425947  83 LSSLTSEDSAVYYCA---RRWFD--YWGQGTTLTV 112
Cdd:cd05899  76 IKSAEPEDSAVYLCAsslGGGADeaYFGPGTRLTV 110
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 4-112 1.98e-14

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 64.02  E-value: 1.98e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   4 LQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRIDpNSGGTKYNEKFKSKatltvdKPSSTAYMQL 83
Cdd:cd04984   2 LTQPSSLSVSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYLIYED-KHRPSGIPDRFSGS------KSGNTASLTI 74

                        90       100       110
                ....*....|....*....|....*....|..
gi 17425947  84 SSLTSEDSAVYYCArRW--FDY-WGQGTTLTV 112
Cdd:cd04984  75 SGAQTEDEADYYCQ-VWdsNSYvFGGGTKLTV 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-112 3.34e-14

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.91  E-value: 3.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947      7 PGAELVKPGASVKLSCKASGytFTSYWMHWVKQrpgrGLEWIGridpnsggtkYNEKFkskatlTVDKPSSTAYMQLSSL 86
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG--SPPPEVTWYKQ----GGKLLA----------ESGRF------SVSRSGSTSTLTISNV 58

                           90       100
                   ....*....|....*....|....*...
gi 17425947     87 TSEDSAVYYCARR--WFDYWGqGTTLTV 112
Cdd:smart00410  59 TPEDSGTYTCAATnsSGSASS-GTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 5-112 8.96e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 8.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947     5 QQPGAELVKPGASVKLSCKASGY-TFTSYWMHWVKQRPGRGLEWIGRIDPNSGGTkynEKFKSKATLTVDKPSSTAYMQL 83
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSEE---GVKKGRFSGRGDPSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 17425947    84 SSLTSEDSAVYYCARRWFD--YWGQGTTLTV 112
Cdd:pfam07686  78 QNLTLSDSGTYTCAVIPSGegVFGKGTRLTV 108
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 4-97 6.17e-10

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 52.45  E-value: 6.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   4 LQQPGAELVKPGASVKLSCKASGYTfTSYWMHWVKQRPG----RGLEWIGRIDPnSGGTKYNEKFKS-KATLTVDKPSST 78
Cdd:cd07700   2 LQTPGSLLVQTNQTVKMSCEAKTSP-KNTRIYWLRQRQApskdSHFEFLASWDP-SKGIVYGEGVDQeKLIILSDSDSSR 79

                        90
                ....*....|....*....
gi 17425947  79 AYMQLSSLTSEDSAVYYCA 97
Cdd:cd07700  80 YILSLMSVKPEDSGTYFCM 98
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 1-112 2.48e-09

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 51.02  E-value: 2.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   1 QVQLQQPGAELVKPGASVKLSCKASGYTF-TSY--WMHWVkqrPGRGLEWIGRIDPNSGGTKynekfKSKATLTVDKPSS 77
Cdd:cd16095   1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFnTSQlsWYLWV---PGHAPLWLTSLDHISTKVS-----EDRITSSREDTNS 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17425947  78 TAYMQLSSLTSEDSAVYYCARRWFD-------YWGQGTTLTV 112
Cdd:cd16095  73 QIFLQIKGLGLRDSGQYHCARRVGYgddtdklIFGPGTDVIV 114
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 5-112 4.38e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 47.39  E-value: 4.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947   5 QQPGAELVKPGASVKLSCKASGyTFTSYWMHWVKQRPGRGLEWI------------GRIDPNSGGTKYnekfkskaTLTV 72
Cdd:cd04980   5 QSPASLSVSPGERVTISCKASQ-SISSNYLAWYQQKPGQAPKLLiyyastlhsgvpSRFSGSGSGTDF--------TLTI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17425947  73 dkpsstaymqlSSLTSEDSAVYYCARRWFDYW--GQGTTLTV 112
Cdd:cd04980  76 -----------SSVEPEDAAVYYCQQGYTFPYtfGGGTKLEI 106
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 12-112 4.75e-06

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 42.16  E-value: 4.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947  12 VKPGASVKLSCKASGYTFTSYWMHWVKQRPGRGLEWIGRidpnsGGTKYNEKFKSKATLTVDKPSSTAYMQLSSLTSEDS 91
Cdd:cd20988  10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFIYR-----EGGIYGPGFKDNFRGDIDSSNNLAVLKILEASERDE 84

                        90       100
                ....*....|....*....|....*....
gi 17425947  92 AVYYCAR------RWFD--YWGQGTTLTV 112
Cdd:cd20988  85 GSYYCASdtpgggREYDplIFGKGTYLTV 113
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 12-112 2.33e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 40.58  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947  12 VKPGASVKLSCKASgYTFTSYWMHWVKQRPGRGLEWIGRIDP---NSGGTKYNEKFKskatltvdKPSSTAYMQLSSLTS 88
Cdd:cd07706  11 VQVGEEVTLNCRYE-TSWTNYYLFWYKQLPSGEMTFLIRQDSseqNAKSGRYSVNFQ--------KAQKSISLTISALQL 81

                        90       100
                ....*....|....*....|....*....
gi 17425947  89 EDSAVYYCARRWFD-----YWGQGTTLTV 112
Cdd:cd07706  82 EDSAKYFCALSLPYdtdklIFGKGTRLTV 110
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 6-96 1.53e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.85  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17425947     6 QPGAELVKPGASVKLSCKASGYTFTSYWmhwvkqrpgrgleWigridpnsggTKYNEKFKSKATLTVDKPSSTAYMQLSS 85
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEATGSPPPTIT-------------W----------YKNGEPISSGSTRSRSLSGSNSTLTISN 63

                          90
                  ....*....|.
gi 17425947    86 LTSEDSAVYYC 96
Cdd:pfam13927  64 VTRSDAGTYTC 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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