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Conserved domains on  [gi|21754031|dbj|BAC04447|]
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unnamed protein product [Homo sapiens]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIP49_C super family cl48131
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 1-94 1.32e-21

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


The actual alignment was detected with superfamily member pfam12260:

Pssm-ID: 463512  Cd Length: 188  Bit Score: 85.03  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754031     1 MFGVFSNGHLFIRDASAVGVIDKQEGSQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLLQGR 78
Cdd:pfam12260  92 NFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLLRGP 170

                          90
                  ....*....|....*.
gi 21754031    79 fPSPVQDDIDSILVQC 94
Cdd:pfam12260 171 -PSPLPEELEKLLQEC 185
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 1-94 1.32e-21

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 85.03  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754031     1 MFGVFSNGHLFIRDASAVGVIDKQEGSQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLLQGR 78
Cdd:pfam12260  92 NFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLLRGP 170

                          90
                  ....*....|....*.
gi 21754031    79 fPSPVQDDIDSILVQC 94
Cdd:pfam12260 171 -PSPLPEELEKLLQEC 185
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 1-94 1.32e-21

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 85.03  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754031     1 MFGVFSNGHLFIRDASAVGVIDKQEGSQEANRAGENKD--IFSCLvSGCQAQLPSCESISEKQSLVLVCQKLLPRLLQGR 78
Cdd:pfam12260  92 NFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQKVCQKLLDYLLRGP 170

                          90
                  ....*....|....*.
gi 21754031    79 fPSPVQDDIDSILVQC 94
Cdd:pfam12260 171 -PSPLPEELEKLLQEC 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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