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Conserved domains on  [gi|34535498|dbj|BAC87338|]
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unnamed protein product [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 10641050)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 1-98 5.72e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 141.33  E-value: 5.72e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34535498      1 MGGSGRCLGRVEILHQGAWGTVCDDLWDLNEAKVVCRQLGFGQAVSGPGEAHFGPGSGDIFLDNLQCTRVEHYLGQCTHL 80
Cdd:smart00202   4 VGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCPHS 83

                           90
                   ....*....|....*...
gi 34535498     81 GWSEHNCGHHEDASVICS 98
Cdd:smart00202  84 GWGSHNCSHGEDAGVVCS 101
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 126-171 2.48e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member pfam00431:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 110  Bit Score: 41.51  E-value: 2.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34535498   126 CGGVISSLSGSFSSPQYPENYPTDIQCVWEIHMGAKFHIELIIPSL 171
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDF 46
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 1-98 5.72e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 141.33  E-value: 5.72e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34535498      1 MGGSGRCLGRVEILHQGAWGTVCDDLWDLNEAKVVCRQLGFGQAVSGPGEAHFGPGSGDIFLDNLQCTRVEHYLGQCTHL 80
Cdd:smart00202   4 VGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCPHS 83

                           90
                   ....*....|....*...
gi 34535498     81 GWSEHNCGHHEDASVICS 98
Cdd:smart00202  84 GWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 3-98 6.14e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 125.95  E-value: 6.14e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34535498     3 GSGRCLGRVEILHQGAWGTVCDDLWDLNEAKVVCRQLGFGQAVSGP-GEAHFGPG-SGDIFLDNLQCTRVEHYLGQCTHL 80
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 34535498    81 GWSEHNCGHHEDASVICS 98
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
CUB pfam00431
CUB domain;
126-171 2.48e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.51  E-value: 2.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34535498   126 CGGVISSLSGSFSSPQYPENYPTDIQCVWEIHMGAKFHIELIIPSL 171
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDF 46
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 126-178 1.22e-04

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 39.70  E-value: 1.22e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 34535498 126 CGGVISSLSGSF-SSPQYPENYPTDIQCVWEIHMGAKFHIELIIPSLKVIQSKD 178
Cdd:cd00041   1 CGGTLTASTSGTiSSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN 54
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 140-173 3.41e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.14  E-value: 3.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 34535498    140 PQYPENYPTDIQCVWEIHMGAKFHIELIIPSLKV 173
Cdd:smart00042   6 PNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDL 39
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 1-98 5.72e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 141.33  E-value: 5.72e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34535498      1 MGGSGRCLGRVEILHQGAWGTVCDDLWDLNEAKVVCRQLGFGQAVSGPGEAHFGPGSGDIFLDNLQCTRVEHYLGQCTHL 80
Cdd:smart00202   4 VGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCPHS 83

                           90
                   ....*....|....*...
gi 34535498     81 GWSEHNCGHHEDASVICS 98
Cdd:smart00202  84 GWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 3-98 6.14e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 125.95  E-value: 6.14e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34535498     3 GSGRCLGRVEILHQGAWGTVCDDLWDLNEAKVVCRQLGFGQAVSGP-GEAHFGPG-SGDIFLDNLQCTRVEHYLGQCTHL 80
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 34535498    81 GWSEHNCGHHEDASVICS 98
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
CUB pfam00431
CUB domain;
126-171 2.48e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.51  E-value: 2.48e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34535498   126 CGGVISSLSGSFSSPQYPENYPTDIQCVWEIHMGAKFHIELIIPSL 171
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDF 46
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 126-178 1.22e-04

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 39.70  E-value: 1.22e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 34535498 126 CGGVISSLSGSF-SSPQYPENYPTDIQCVWEIHMGAKFHIELIIPSLKVIQSKD 178
Cdd:cd00041   1 CGGTLTASTSGTiSSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPN 54
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 140-173 3.41e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.14  E-value: 3.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 34535498    140 PQYPENYPTDIQCVWEIHMGAKFHIELIIPSLKV 173
Cdd:smart00042   6 PNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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