TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 60360274   1059 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1102
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 60360274   1422 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 1466
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274    723 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 758
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 60360274    904 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 944
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274    557 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 592
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274   1806 CSQSPKPCNFICKNTEGSYQCSCPRGYVLQEDGKTC 1841
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 60360274    1245 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1279
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 60360274    1482 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 1523
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 60360274  121 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 156
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 60360274    1367 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 1407
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 60360274     426 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 460
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 60360274    1925 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 1954
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 60360274 1838 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 1874
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 60360274 1198 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1240
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 60360274      79 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 120
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 60360274     802 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 837
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 60360274   1605 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 1637
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 60360274    1882 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 1924
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 60360274   1059 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1102
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 60360274   1422 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 1466
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274    723 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 758
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 60360274    904 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 944
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274    557 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 592
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 60360274   1806 CSQSPKPCNFICKNTEGSYQCSCPRGYVLQEDGKTC 1841
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 60360274 1800 CVDLDECSQSPKPCNFICKNTEGSYQCSCPRGYVLQEDGKT 1840
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 60360274    216 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 246
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60360274 1161 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1195
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 60360274 1245 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1278
Cdd:cd00054    1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 60360274  551 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 591
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 60360274     961 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 993
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 60360274     469 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 501
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 60360274    1367 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 1407
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 60360274   1161 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1192
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 60360274    1284 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1326
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 60360274 1482 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 1523
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 60360274     843 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 874
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 60360274     511 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 543
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 60360274  961 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 994
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 60360274    1119 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1151
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60360274  678 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGWVG 712
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60360274 1367 DINECdEDPNICLF-GSCTNTPGGFQCICPPGFVL 1400
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 60360274  843 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 875
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 60360274    266 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 296
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 60360274   1482 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 1512
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 60360274  802 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 836
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 60360274    426 DIDECRISPDLC-GSGICVNTPGSFECECFEG 456
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 60360274   1605 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 1637
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 60360274     678 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGW 710
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 60360274    1882 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 1924
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 60360274    1802 DLDECSqSPKPC--NFICKNTEGSYQCSCPRGYvlqEDGKTCK 1842
Cdd:smart00179    1 DIDECA-SGNPCqnGGTCVNTVGSYRCECPPGY---TDGRNCE 39

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 60360274   1059 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1102
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 60360274   1422 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 1466
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44