NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|108792662|dbj|BAE95823|]
View 

hypothetical protein [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 121-256 1.07e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662  121 PQEVHGAPVVDSVQQQPIQQTSSIQPVVQPIQQQVAQPAQQTPPIQPVVRPiqqQVLQPVQQAPSTQQHLQPIQQTPPRQ 200
Cdd:pfam09770 219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRP---QSPQPDPAQPSIQPQAQQFHQQPPPV 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 108792662  201 RLQPIQ--RTPVRQQVVQPIQHLGPANASAGFAAHGGQPAQQFVNQviPEHLVHHAQP 256
Cdd:pfam09770 296 PVQPTQilQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR--QAPIITHPQQ 351
KLF1_2_4_N super family cl41729
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 201-334 3.95e-03

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


The actual alignment was detected with superfamily member cd22056:

Pssm-ID: 425360 [Multi-domain]  Cd Length: 339  Bit Score: 38.49  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662 201 RLQPIQRTPVRQQVVQPIQHLGP-------------ANASAGF-AAHGGQPAQQFVNQVIPEHLVHHAQPDGTLVTHMVP 266
Cdd:cd22056  161 ELRALPTAPPAHQPATSPPPLGYkiktepveqscmmAAGGGGFmGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGG 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108792662 267 EHLVHNIQPNLHNYQggnLNYQYQLSSPQAQYQPGGSAQQQFAPQFGQY-EPMQQQPQGAALSHPEVLS 334
Cdd:cd22056  241 PDCHLLHSSHHHHHH---HHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFrEPMRVHHQGHPGSMLTPPS 306
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 121-256 1.07e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662  121 PQEVHGAPVVDSVQQQPIQQTSSIQPVVQPIQQQVAQPAQQTPPIQPVVRPiqqQVLQPVQQAPSTQQHLQPIQQTPPRQ 200
Cdd:pfam09770 219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRP---QSPQPDPAQPSIQPQAQQFHQQPPPV 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 108792662  201 RLQPIQ--RTPVRQQVVQPIQHLGPANASAGFAAHGGQPAQQFVNQviPEHLVHHAQP 256
Cdd:pfam09770 296 PVQPTQilQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR--QAPIITHPQQ 351
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 201-334 3.95e-03

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 38.49  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662 201 RLQPIQRTPVRQQVVQPIQHLGP-------------ANASAGF-AAHGGQPAQQFVNQVIPEHLVHHAQPDGTLVTHMVP 266
Cdd:cd22056  161 ELRALPTAPPAHQPATSPPPLGYkiktepveqscmmAAGGGGFmGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGG 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108792662 267 EHLVHNIQPNLHNYQggnLNYQYQLSSPQAQYQPGGSAQQQFAPQFGQY-EPMQQQPQGAALSHPEVLS 334
Cdd:cd22056  241 PDCHLLHSSHHHHHH---HHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFrEPMRVHHQGHPGSMLTPPS 306
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 121-256 1.07e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662  121 PQEVHGAPVVDSVQQQPIQQTSSIQPVVQPIQQQVAQPAQQTPPIQPVVRPiqqQVLQPVQQAPSTQQHLQPIQQTPPRQ 200
Cdd:pfam09770 219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRP---QSPQPDPAQPSIQPQAQQFHQQPPPV 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 108792662  201 RLQPIQ--RTPVRQQVVQPIQHLGPANASAGFAAHGGQPAQQFVNQviPEHLVHHAQP 256
Cdd:pfam09770 296 PVQPTQilQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR--QAPIITHPQQ 351
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 201-334 3.95e-03

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 38.49  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108792662 201 RLQPIQRTPVRQQVVQPIQHLGP-------------ANASAGF-AAHGGQPAQQFVNQVIPEHLVHHAQPDGTLVTHMVP 266
Cdd:cd22056  161 ELRALPTAPPAHQPATSPPPLGYkiktepveqscmmAAGGGGFmGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGG 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108792662 267 EHLVHNIQPNLHNYQggnLNYQYQLSSPQAQYQPGGSAQQQFAPQFGQY-EPMQQQPQGAALSHPEVLS 334
Cdd:cd22056  241 PDCHLLHSSHHHHHH---HHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFrEPMRVHHQGHPGSMLTPPS 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH