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Conserved domains on  [gi|158257648|dbj|BAF84797|]
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unnamed protein product [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA N(3)-methylcytidine methyltransferase METTL6

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 201-305 7.33e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.01  E-value: 7.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  201 LEVGCGAGNSVFPILNTLensPESFLYCCDFASGAVEL----VKSHSPYRATQCFAFVHDVcDDGLPYPFpdgilDVILL 276
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDL-GELDPGSF-----DVVVA 71

                          90       100
                  ....*....|....*....|....*....
gi 158257648  277 VFVLSsiHPDRMQGVVNRLSKLLKPGGML 305
Cdd:pfam08242  72 SNVLH--HLADPRAVLRNIRRLLKPGGVL 98
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 201-305 7.33e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.01  E-value: 7.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  201 LEVGCGAGNSVFPILNTLensPESFLYCCDFASGAVEL----VKSHSPYRATQCFAFVHDVcDDGLPYPFpdgilDVILL 276
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDL-GELDPGSF-----DVVVA 71

                          90       100
                  ....*....|....*....|....*....
gi 158257648  277 VFVLSsiHPDRMQGVVNRLSKLLKPGGML 305
Cdd:pfam08242  72 SNVLH--HLADPRAVLRNIRRLLKPGGVL 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 199-319 2.92e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.56  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKSHSPYRATQcfafVHDVCDDGLPYPFPDGILDVILLVF 278
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 158257648 279 VLSSIhPDRmQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLR 319
Cdd:COG2226   96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 199-307 8.74e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 8.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSPYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 278
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*....
gi 158257648 279 VLSSIHPDrMQGVVNRLSKLLKPGGMLLF 307
Cdd:cd02440   75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
PRK08317 PRK08317
hypothetical protein; Provisional
 190-303 1.31e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 190 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShspyRATQCFAFVHDVCDDGLPYPFPDG 269
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 158257648 270 ILDVILLVFVLSsiHPDRMQGVVNRLSKLLKPGG 303
Cdd:PRK08317  87 SFDAVRSDRVLQ--HLEDPARALAEIARVLRPGG 118
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 201-305 7.33e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 67.01  E-value: 7.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  201 LEVGCGAGNSVFPILNTLensPESFLYCCDFASGAVEL----VKSHSPYRATQCFAFVHDVcDDGLPYPFpdgilDVILL 276
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAarerLAALGLLNAVRVELFQLDL-GELDPGSF-----DVVVA 71

                          90       100
                  ....*....|....*....|....*....
gi 158257648  277 VFVLSsiHPDRMQGVVNRLSKLLKPGGML 305
Cdd:pfam08242  72 SNVLH--HLADPRAVLRNIRRLLKPGGVL 98
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 200-303 1.31e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.05  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  200 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSPYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 279
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 158257648  280 LSSIHPDRMQGVVNRLSKLLKPGG 303
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 199-319 2.92e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.56  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKSHSPYRATQcfafVHDVCDDGLPYPFPDGILDVILLVF 278
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 158257648 279 VLSSIhPDRmQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLR 319
Cdd:COG2226   96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 190-352 9.37e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 60.70  E-value: 9.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 190 LFPGSNATFRILEVGCGAGNSVFPILNTLEnspeSFLYCCDFASGAVEL-VKSHSPYRATQCFAFVHDVCDdglPYPFPD 268
Cdd:COG0500   20 LLERLPKGGRVLDLGCGTGRNLLALAARFG----GRVIGIDLSPEAIALaRARAAKAGLGNVEFLVADLAE---LDPLPA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 269 GILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLF--------RDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAY 340
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLsasdaaaaLSLARLLLLATASLLELLLLLRLLALELYLRAL 172

                        170
                 ....*....|..
gi 158257648 341 FFTKGEVHSMFC 352
Cdd:COG0500  173 LAAAATEDLRSD 184
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 201-307 2.78e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.90  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  201 LEVGCGAGNSVFPILNTLENspesfLYCCDFASGAVELVKSHSPYRAtqcfafVHDVCDDGLPYPFPDGILDVILLVFVL 280
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-----VTGVDISPEMLELAREKAPREG------LTFVVGDAEDLPFPDNSFDLVLSSEVL 69

                          90       100
                  ....*....|....*....|....*..
gi 158257648  281 SsiHPDRMQGVVNRLSKLLKPGGMLLF 307
Cdd:pfam08241  70 H--HVEDPERALREIARVLKPGGILII 94
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
199-307 4.74e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 4.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNSVFPILntlENSPESFLYCCDFASGAVELVKSHSPyRATqcfaFVH-DVCDDGLPYPFpdgilDVILLV 277
Cdd:COG4106    4 RVLDLGCGTGRLTALLA---ERFPGARVTGVDLSPEMLARARARLP-NVR----FVVaDLRDLDPPEPF-----DLVVSN 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 158257648 278 FVLSsiHPDRMQGVVNRLSKLLKPGGMLLF 307
Cdd:COG4106   71 AALH--WLPDHAALLARLAAALAPGGVLAV 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 199-307 8.74e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.82  E-value: 8.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSPYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 278
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*....
gi 158257648 279 VLSSIHPDrMQGVVNRLSKLLKPGGMLLF 307
Cdd:cd02440   75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 199-310 1.08e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 53.10  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNSVFPILNTLENspesfLYCCDFASGAVELVKSHSPYRAtqcfafVHDVCDDGLPYPFPDGILDVILLVF 278
Cdd:COG2227   27 RVLDVGCGTGRLALALARRGAD-----VTGVDISPEALEIARERAAELN------VDFVQGDLEDLPLEDGSFDLVICSE 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 158257648 279 VLssIHPDRMQGVVNRLSKLLKPGGMLLFRDY 310
Cdd:COG2227   96 VL--EHLPDPAALLRELARLLKPGGLLLLSTP 125
PRK08317 PRK08317
hypothetical protein; Provisional
 190-303 1.31e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 190 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShspyRATQCFAFVHDVCDDGLPYPFPDG 269
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 158257648 270 ILDVILLVFVLSsiHPDRMQGVVNRLSKLLKPGG 303
Cdd:PRK08317  87 SFDAVRSDRVLQ--HLEDPARALAEIARVLRPGG 118
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
199-313 8.69e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 8.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 199 RILEVGCGAGNSVFPILntlensPESF-LYCCDFASGAVELVKSHSPYRATqcfaFVHDVCDDglpyPFPDGILDVILLV 277
Cdd:COG4976   49 RVLDLGCGTGLLGEALR------PRGYrLTGVDLSEEMLAKAREKGVYDRL----LVADLADL----AEPDGRFDLIVAA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 158257648 278 FVLSsiHPDRMQGVVNRLSKLLKPGGMLLF-----RDYGRY 313
Cdd:COG4976  115 DVLT--YLGDLAAVFAGVARALKPGGLFIFsvedaDGSGRY 153
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 190-351 9.56e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.42  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  190 LFPGSNATFRILEVGCGAGNsvfpilNTLENSPESFLYCcdfasgAVELvkshSPYRATQCFAFVHDVCDDGLPYPFPDG 269
Cdd:pfam13489  16 LLPKLPSPGRVLDFGCGTGI------FLRLLRAQGFSVT------GVDP----SPIAIERALLNVRFDQFDEQEAAVPAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  270 ILDVILLVFVLSSIHPdrMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENfyvrgdGTRAYFFTKGEVHS 349
Cdd:pfam13489  80 KFDVIVAREVLEHVPD--PPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARSLKR 151


                  ..
gi 158257648  350 MF 351
Cdd:pfam13489 152 LL 153
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 199-351 3.85e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.48  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648  199 RILEVGCGAGNSVFpILNTLENsPESFLYCCDFASGAVELVKSHspyRATQCFAFVH-DVCD-DGLPYPFPDGILDVILL 276
Cdd:pfam13847   6 RVLDLGCGTGHLSF-ELAEELG-PNAEVVGIDISEEAIEKAREN---AQKLGFDNVEfEQGDiEELPELLEDDKFDVVIS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 158257648  277 VFVLSSIhPDrMQGVVNRLSKLLKPGGMLLFRDYGRydktqLRFKKGHCLSENFYVRGDGTRAYffTKGEVHSMF 351
Cdd:pfam13847  81 NCVLNHI-PD-PDKVLQEILRVLKPGGRLIISDPDS-----LAELPAHVKEDSTYYAGCVGGAI--LKKKLYELL 146
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 230-323 5.25e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 37.36  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158257648 230 DFASGAVELVKSHSPYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIhPDRMQGvVNRLSKLLKPGGMLLFRD 309
Cdd:PLN02232   4 DFSSEQLAVAATRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNV-VDRLRA-MKEMYRVLKPGSRVSILD 81

                         90
                 ....*....|....
gi 158257648 310 YGRYDKTQLRFKKG 323
Cdd:PLN02232  82 FNKSNQSVTTFMQG 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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