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Conserved domains on  [gi|193786491|dbj|BAG51774|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.99e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 2.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  50 NERSLTSVPLGIPEGVTVLYLHDNQINNAGFPAELHNVQSVHTVYLYGNQLAEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 193786491 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491   282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 193786491   359 S 359
Cdd:TIGR00864   77 D 77
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 426-488 3.12e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193786491  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRST 488
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTE 68
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.07e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 193786491   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.99e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 2.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  50 NERSLTSVPLGIPEGVTVLYLHDNQINNAGFPAELHNVQSVHTVYLYGNQLAEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 193786491 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-265 9.14e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.28  E-value: 9.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  31 SKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHDNQINNagFPAELHNvqSVHTVYLYGNQLAEFPMNLPKN 110
Cdd:PRK15370 209 NELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITE--LPERLPS--ALQSLDLFHNKISCLPENLPEE 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 111 VRVLHLQENNIQTISRAALAQLLkleELHLDDNSIStvgvedgAFREAI--SLKLLFLSKNHLSSVPVGLPVDLQELRVD 188
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLT-------ALPETLppGLKTLEAGENALTSLPASLPPELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 189 ENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHLIRLYLQDNQ 263
Cdd:PRK15370 355 KNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQPTRIIVEYNP 426


                 ..
gi 193786491 264 IN 265
Cdd:PRK15370 427 FS 428
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 1.24e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  89 SVHTVYLYGNQLAEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340   77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193786491 246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340  125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.31e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.31e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491   282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 193786491   359 S 359
Cdd:TIGR00864   77 D 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.05e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 193786491   310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 3.01e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 3.01e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 193786491    35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
fn3 pfam00041
Fibronectin type III domain;
426-488 3.12e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193786491  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRST 488
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTE 68
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.07e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 193786491   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.29e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 193786491  336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-310 2.99e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 2.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  50 NERSLTSVPLGIPEGVTVLYLHDNQINNAGFPAELHNVQSVHTVYLYGNQLAEFPMNLP--KNVRVLHLQENNIQTISrA 127
Cdd:COG4886   75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 128 ALAQLLKLEELHLDDNSISTVGVEdgaFREAISLKLLFLSKNHLSSVPVGL--PVDLQELRVDENRIAVISDmAFQNLTS 205
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 206 LERLIVDGNLLTNkgIAEgtFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISN 285
Cdd:COG4886  230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        250       260
                 ....*....|....*....|....*
gi 193786491 286 NQLRMLTQGVFDNLSNLKQLTARNN 310
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-316 3.19e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  48 YCNERSLTSVPLGIPE--GVTVLYLHDNQINNagFPAELHNVQSVHTVYLYGNQLAEFPMNL--PKNVRVLHLQENNIQT 123
Cdd:COG4886  142 DLSNNQLTDLPEPLGNltNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 124 ISrAALAQLLKLEELHLDDNSISTVGvedgAFREAISLKLLFLSKNHLSSVPVGLPVD-LQELRVDENRIAVIsdmafqN 202
Cdd:COG4886  220 LP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDL------K 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 203 LTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEfSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLD 282
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLL-TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                        250       260       270
                 ....*....|....*....|....*....|....
gi 193786491 283 ISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDC 316
Cdd:COG4886  368 TLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-265 9.14e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 81.28  E-value: 9.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  31 SKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHDNQINNagFPAELHNvqSVHTVYLYGNQLAEFPMNLPKN 110
Cdd:PRK15370 209 NELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITE--LPERLPS--ALQSLDLFHNKISCLPENLPEE 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 111 VRVLHLQENNIQTISRAALAQLLkleELHLDDNSIStvgvedgAFREAI--SLKLLFLSKNHLSSVPVGLPVDLQELRVD 188
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLT-------ALPETLppGLKTLEAGENALTSLPASLPPELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 189 ENRIAVISDMAFQNLTSLErliVDGNLLTNkgIAEGTFSHLtKLKEFSivRNSLSHPPPDLP-----GTHLIRLYLQDNQ 263
Cdd:PRK15370 355 KNQITVLPETLPPTITTLD---VSRNALTN--LPENLPAAL-QIMQAS--RNNLVRLPESLPhfrgeGPQPTRIIVEYNP 426


                 ..
gi 193786491 264 IN 265
Cdd:PRK15370 427 FS 428
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-310 8.03e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 8.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 105 MNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQE 184
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 185 LRVDEnRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAegtFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQ 263
Cdd:COG4886   95 LTNLT-ELDLSGNEELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNlTNLKSLDLSNNQ 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 193786491 264 INHIPlTAFSNLRKLERLDISNNQLRMLTQgVFDNLSNLKQLTARNN 310
Cdd:COG4886  171 LTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-311 1.24e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  89 SVHTVYLYGNQLAEFP-MNLPKNVRVLHLQENNIQTISraALAQLLKLEELHLDDNSISTVGVEDGafreAISLKLLFLS 167
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLEN----LVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 168 KNHLSSVpVGL--PVDLQELRVDEnriavisdmafQNLTSLERLIVDGNLLTNkgiaegtfshltklkefsiVRNSLSHp 245
Cdd:cd21340   77 GNRISVV-EGLenLTNLEELHIEN-----------QRLPPGEKLTFDPRSLAA-------------------LSNSLRV- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193786491 246 ppdlpgthlirLYLQDNQINHipLTAFSNLRKLERLDISNNQLRMLTQ--GVFDNLSNLKQLTARNNP 311
Cdd:cd21340  125 -----------LNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-246 1.79e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  47 VYCNERSLTSVP-LGIPEGVTVLYLHDNQINNAgfpAELHNVQSVHTVYLYGNQLAEFPM--NLpKNVRVLHLQENNIQT 123
Cdd:cd21340    7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEKIENleNL-VNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 124 ISraALAQLLKLEELHL-------------DDNSISTVgvedgafreAISLKLLFLSKNHLSsvpvglpvDLQELrvden 190
Cdd:cd21340   83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNID--------SLEPL----- 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193786491 191 riavisdmafQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Cdd:cd21340  139 ----------APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
200-311 3.51e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 3.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 200 FQNLTSLERLIVDGNLltnkgiaegTFSHLTKLKEFSIVRNSLSHPPPDLPG-THLIRLYLQDNQINHIPlTAFSNLRKL 278
Cdd:COG4886   92 LGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDLP-EPLGNLTNL 161

                         90       100       110
                 ....*....|....*....|....*....|...
gi 193786491 279 ERLDISNNQLRMLTQgVFDNLSNLKQLTARNNP 311
Cdd:COG4886  162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-295 2.93e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  54 LTSVPLGIPEGVTVLYLhDNqinnagfpaelhnvqsvhtvylygNQLAEFPMNLPKNVRVLHLQENNIQTISrAALAQll 133
Cdd:PRK15370 190 LTTIPACIPEQITTLIL-DN------------------------NELKSLPENLQGNIKTLYANSNQLTSIP-ATLPD-- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 134 KLEELHLDDNSISTVgvedgAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAV--------ISDMAFQN--L 203
Cdd:PRK15370 242 TIQEMELSINRITEL-----PERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTlpahlpsgITHLNVQSnsL 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 204 T--------SLERLIVDGNLLTNkgIAEgtfSHLTKLKEFSIVRNSLSHPPPDLPGThLIRLYLQDNQINHIPltafSNL 275
Cdd:PRK15370 317 TalpetlppGLKTLEAGENALTS--LPA---SLPPELQVLDVSKNQITVLPETLPPT-ITTLDVSRNALTNLP----ENL 386

                        250       260
                 ....*....|....*....|.
gi 193786491 276 -RKLERLDISNNQLRMLTQGV 295
Cdd:PRK15370 387 pAALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
252-311 2.31e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.31e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  252 THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNP 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-223 1.18e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.96  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  65 VTVLYLHDNQINNAGFPA---ELHNVQSVHTVYLYGNQLAEFPMNL-------PKNVRVLHLQENNIQTISRAALAQLLK 134
Cdd:COG5238  238 LTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQIGAEGAIAlakalqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 135 ----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISdmAFQNLTSL 206
Cdd:COG5238  318 gnktLHTLNLAYNGIGAQGAI--ALAKALqentTLHSLDLSDNQIG---------------DEGAIALAK--YLEGNTTL 378

                        170
                 ....*....|....*..
gi 193786491 207 ERLIVDGNLLTNKGIAE 223
Cdd:COG5238  379 RELNLGKNNIGKQGAEA 395
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-289 5.41e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 110 NVRVLHLQENNIQTISRAALAQLLK----LEELHLDDN----SISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGL--- 178
Cdd:cd00116   24 CLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVles 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 179 ---PVDLQELRVDENRIAvisDMAFQNLT--------SLERLIVDGNLLTNKGIAE--GTFSHLTKLKEFSIVRNSLSHP 245
Cdd:cd00116  104 llrSSSLQELKLNNNGLG---DRGLRLLAkglkdlppALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDA 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 193786491 246 -----PPDLPG-THLIRLYLQDNQINHIPLTA----FSNLRKLERLDISNNQLR 289
Cdd:cd00116  181 giralAEGLKAnCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLT 234
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 282-359 1.13e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.56  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491   282 DISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKyiPSSLNVR---GFMCQGPEQVRGMAVreLNMNLL 358
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRqpeAALCAGPGALAGQPL--LGIPLL 76


                   .
gi 193786491   359 S 359
Cdd:TIGR00864   77 D 77
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
23-268 1.26e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 58.25  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  23 SLGLYSQVSKLLACPSVCRCDRNfvyCNERSLTSVPLGIPEGVTVLYLHDNQINN-AGFPAELhnvqsvHTVYLYGNQLA 101
Cdd:PRK15387 185 SRGRAAVVQKMRACLNNGNAVLN---VGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPEL------RTLEVSGNQLT 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 102 EFPMnLPKNVRVLHLQENNIQTISR--AALAQLL--------------KLEELHLDDNSISTVgvedgafrEAISLKL-- 163
Cdd:PRK15387 256 SLPV-LPPGLLELSIFSNPLTHLPAlpSGLCKLWifgnqltslpvlppGLQELSVSDNQLASL--------PALPSELck 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 164 LFLSKNHLSSVPVgLPVDLQELRVDENRIAVISDM--------AFQN-LTS-------LERLIVDGNLLTNKGIAEgtfs 227
Cdd:PRK15387 327 LWAYNNQLTSLPT-LPSGLQELSVSDNQLASLPTLpselyklwAYNNrLTSlpalpsgLKELIVSGNRLTSLPVLP---- 401

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 193786491 228 hlTKLKEFSIVRNSLSHPPPdLPgTHLIRLYLQDNQINHIP 268
Cdd:PRK15387 402 --SELKELMVSGNRLTSLPM-LP-SGLLSLSVYRNQLTRLP 438
LRR_8 pfam13855
Leucine rich repeat;
204-288 1.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  204 TSLERLIVDGNLLTNkgIAEGTFSHLTKLKEfsivrnslshpppdlpgthlirLYLQDNQINHIPLTAFSNLRKLERLDI 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKV----------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 193786491  284 SNNQL 288
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-242 3.90e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193786491  182 LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTnkGIAEGTFSHLTKLKEFSIVRNSL 242
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-171 8.38e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 8.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193786491  110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTvgVEDGAFREAISLKLLFLSKNHL 171
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
310-361 1.05e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 193786491   310 NPWFCDCSIKWVTEWL---KYIPSSLNVRgfmCQGPEQVRGmAVRELNMNLLSCP 361
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVDLR---CASPSSLRG-PLLELLHSEFKCP 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-192 2.90e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  52 RSLTSVPlgipEGVTVLYLHDNQINNAGFPA---ELHNVQSVHTVYLYGNQLAE---------FPMNlpKNVRVLHLQEN 119
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLEGASCEAlakALRANRDLKELNLANNGIGDagiralaegLKAN--CNLEVLDLNNN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 120 -----NIQTISrAALAQLLKLEELHLDDNSISTVGVE---DGAFREAISLKLLFLSKNHLSSVPV-----GLP--VDLQE 184
Cdd:cd00116  204 gltdeGASALA-ETLASLKSLEVLNLGDNNLTDAGAAalaSALLSPNISLLTLSLSCNDITDDGAkdlaeVLAekESLLE 282


                 ....*...
gi 193786491 185 LRVDENRI 192
Cdd:cd00116  283 LDLRGNKF 290
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 129-310 3.01e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 3.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 129 LAQLLKLEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSSVPVGL---------PVDLQELRVDENRIAVI 195
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEEAAK--ALASALrpqpSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALGPD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 196 SDMAFQNLTSLERLivdGNL-LTNKGIAEGTFSHLTKlkefsivrnSLSHPPPDLPgthliRLYLQDNQINHIPLT---- 270
Cdd:cd00116   97 GCGVLESLLRSSSL---QELkLNNNGLGDRGLRLLAK---------GLKDLPPALE-----KLVLGRNRLEGASCEalak 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 193786491 271 AFSNLRKLERLDISNNQL-----RMLTQGVFDNlSNLKQLTARNN 310
Cdd:cd00116  160 ALRANRDLKELNLANNGIgdagiRALAEGLKAN-CNLEVLDLNNN 203
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-206 4.15e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  47 VYCNerSLTSVPLGIPEGVTVLYLHDNQINnaGFPAELHNvqSVHTVYLYGNQLAEFPMNLPKNVRVLHLQENNIQTISr 126
Cdd:PRK15370 269 LFHN--KISCLPENLPEELRYLSVYDNSIR--TLPAHLPS--GITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLP- 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 127 AALAQLLK-------------------LEELHLDDNSISTVGVEDGAfreaiSLKLLFLSKNHLSSVPVGLPVDLQElRV 187
Cdd:PRK15370 342 ASLPPELQvldvsknqitvlpetlpptITTLDVSRNALTNLPENLPA-----ALQIMQASRNNLVRLPESLPHFRGE-GP 415

                        170       180
                 ....*....|....*....|...
gi 193786491 188 DENRIAV----ISDMAFQNLTSL 206
Cdd:PRK15370 416 QPTRIIVeynpFSERTIQNMQRL 438
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-288 5.66e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 5.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  81 PAELHNVQSVHTVYLYGNQLA-EFPMNL--PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSIStvGVEDGAFRE 157
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 158 AISLKLLFLSKNHLSSvpvGLPVDLQElrvdENRIAVIsDMAFQNLTSlerLIVDGnlLTNKGiaegtfsHLTKLKEFSi 237
Cdd:PLN00113 331 LPRLQVLQLWSNKFSG---EIPKNLGK----HNNLTVL-DLSTNNLTG---EIPEG--LCSSG-------NLFKLILFS- 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 193786491 238 vrNSL-SHPPPDLPGTH-LIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
Cdd:PLN00113 390 --NSLeGEIPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-288 5.95e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 5.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  53 SLTSVPLGIPEGVTVLYLHDNQINNAGFPAELHNVQSVHTVYLYGNQLAEFP-------MNLPKNVRVLHLQENNIQTIS 125
Cdd:COG5238  145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGieelaeaLTQNTTVTTLWLKRNPIGDEG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 126 RAALAQLLK----LEELHLDDNSISTVGVEdgAFREAI----SLKLLFLSKNHLSsvpvglpvdlqelrvDENRIAVISd 197
Cdd:COG5238  225 AEILAEALKgnksLTTLDLSNNQIGDEGVI--ALAEALknntTVETLYLSGNQIG---------------AEGAIALAK- 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 198 mAFQNLTSLERLIVDGNLLTNKG---IAEGtfshltklkefsivrnslshpppdLPGTHLIR-LYLQDNQINH---IPL- 269
Cdd:COG5238  287 -ALQGNTTLTSLDLSVNRIGDEGaiaLAEG------------------------LQGNKTLHtLNLAYNGIGAqgaIALa 341

                        250
                 ....*....|....*....
gi 193786491 270 TAFSNLRKLERLDISNNQL 288
Cdd:COG5238  342 KALQENTTLHSLDLSDNQI 360
LRR_8 pfam13855
Leucine rich repeat;
134-216 7.47e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  134 KLEELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvglpvdlqelrvdenriavISDMAFQNLTSLERLIVDG 213
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 193786491  214 NLL 216
Cdd:pfam13855  59 NRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
35-66 3.01e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 3.01e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 193786491    35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVT 66
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-242 3.03e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 112 RVLHLQENNI-----QTISRAALAQLLKLEELHLDDNSISTVGVED--GAFREAISLKLLFLSKNHLS-----SVPVGLP 179
Cdd:cd00116  111 QELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGdagirALAEGLK 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193786491 180 VD--LQELRVDENRI----AVISDMAFQNLTSLERLIVDGNLLTNKGIAE---GTFSHLTKLKEFSIVRNSL 242
Cdd:cd00116  191 ANcnLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAAlasALLSPNISLLTLSLSCNDI 262
fn3 pfam00041
Fibronectin type III domain;
426-488 3.12e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 3.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193786491  426 QLSIHFVNDTSIQVSWLSLFT----VMAYKLTWVKMGHslvGGIVQERIVSGEKQHLSLVNLEPRST 488
Cdd:pfam00041   5 NLTVTDVTSTSLTVSWTPPPDgngpITGYEVEYRPKNS---GEPWNEITVPGTTTSVTLTGLKPGTE 68
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-145 3.77e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  65 VTVLYLHDNQINNAGFPAELHNVQ---SVHTVYLYGNQ--------LAEFPMNLPkNVRVLHLQENNIQTISRAALAQLL 133
Cdd:COG5238  322 LHTLNLAYNGIGAQGAIALAKALQentTLHSLDLSDNQigdegaiaLAKYLEGNT-TLRELNLGKNNIGKQGAEALIDAL 400

                         90
                 ....*....|....*
gi 193786491 134 KLEELH---LDDNSI 145
Cdd:COG5238  401 QTNRLHtliLDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
109-145 3.88e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 193786491  109 KNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
Cdd:pfam13855  25 SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 35-62 4.07e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 193786491   35 ACPSVCRCDRNFVYCNERSLTSVPLGIP 62
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 195-306 8.10e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  195 ISDMAFQNlTSLERLIVDGNLLTnkgIAEGTFSHLTKLKEFSIvrnslshpPPDLP--------GTHLIRLYLQDNqINH 266
Cdd:pfam13306   3 IGSYAFYN-CSLTSITIPSSLTS---IGEYAFSNCTSLKSITL--------PSSLTsigsyafyNCSLTSITIPSS-LTS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 193786491  267 IPLTAFSNLRKLERLDISNNqLRMLTQGVFDNlSNLKQLT 306
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN-CSLKSIT 107
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-309 8.22e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 8.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491  59 LGIPEGVTVLYLHDNQINNAgFPAELHNVQSVHTVYLYGNQL-AEFPMNLP--KNVRVLHLQENNIQTISRAALAQLLKL 135
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLeGEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLV 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 136 EELHLDDNSIStvGVEDGAFREAISLKLLFLSKNHLSSvpvGLP-----VDLQELRVDENRIAVISDMAFQNLTSLERLI 210
Cdd:PLN00113 431 YFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193786491 211 VDGNLLTNKgIAEgtfshltklkEFSIVRNslshpppdlpgthLIRLYLQDNQIN-HIPLTaFSNLRKLERLDISNNQlr 289
Cdd:PLN00113 506 LSENKLSGE-IPD----------ELSSCKK-------------LVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQ-- 558

                        250       260
                 ....*....|....*....|
gi 193786491 290 mLTQGVFDNLSNLKQLTARN 309
Cdd:PLN00113 559 -LSGEIPKNLGNVESLVQVN 577
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 336-361 9.29e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 33.95  E-value: 9.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 193786491  336 GFMCQGPEQVRGMAVRELNMNLLSCP 361
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSCS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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