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Conserved domains on  [gi|194386156|dbj|BAG59642|]
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unnamed protein product [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10614797)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-|2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 155-258 6.34e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.82  E-value: 6.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  155 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 234
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 194386156  235 LSSIHPDRMQGVVNRLSKLLKPGG 258
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 155-258 6.34e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.82  E-value: 6.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  155 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 234
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 194386156  235 LSSIHPDRMQGVVNRLSKLLKPGG 258
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 154-274 3.17e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.17  E-value: 3.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDGILDVILLVF 233
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARE----RAAEAGLNVEFVVGDAEDLPFPDGSFDLVISSF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 194386156 234 VLSSIhPDRmQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLR 274
Cdd:COG2226   96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 154-262 5.56e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.20  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 233
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*....
gi 194386156 234 VLSSIHPDrMQGVVNRLSKLLKPGGMLLF 262
Cdd:cd02440   75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
PRK08317 PRK08317
hypothetical protein; Provisional
 145-258 1.09e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 145 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDG 224
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194386156 225 ILDVILLVFVLSsiHPDRMQGVVNRLSKLLKPGG 258
Cdd:PRK08317  87 SFDAVRSDRVLQ--HLEDPARALAEIARVLRPGG 118
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 155-258 6.34e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.82  E-value: 6.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  155 ILEVGCGAGNSVFPILNTLENSpesfLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDdglpYPFPDGILDVILLVFV 234
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGAR----VTGVDLSPEMLERARERAAEAGLNVEFVQGDAED----LPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 194386156  235 LSSIHPDRMQGVVNRLSKLLKPGG 258
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 156-260 1.44e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 65.85  E-value: 1.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  156 LEVGCGAGNSVFPILNTLensPESFLYCCDFASGAVELVKSH-SSYRATQCFAFVHDVCDDGLPYPFPdgiLDVILLVFV 234
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAARERlAALGLLNAVRVELFQLDLGELDPGS---FDVVVASNV 74

                          90       100
                  ....*....|....*....|....*.
gi 194386156  235 LSsiHPDRMQGVVNRLSKLLKPGGML 260
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPGGVL 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 154-274 3.17e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.17  E-value: 3.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNSVFPILNTlenspESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDGILDVILLVF 233
Cdd:COG2226   25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARE----RAAEAGLNVEFVVGDAEDLPFPDGSFDLVISSF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 194386156 234 VLSSIhPDRmQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLR 274
Cdd:COG2226   96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 145-307 7.94e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 60.70  E-value: 7.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 145 LFPGSNATFRILEVGCGAGNSVFPILNTLEnspeSFLYCCDFASGAVEL-VKSHSSYRATQCFAFVHDVCDdglPYPFPD 223
Cdd:COG0500   20 LLERLPKGGRVLDLGCGTGRNLLALAARFG----GRVIGIDLSPEAIALaRARAAKAGLGNVEFLVADLAE---LDPLPA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 224 GILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLF--------RDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAY 295
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLsasdaaaaLSLARLLLLATASLLELLLLLRLLALELYLRAL 172

                        170
                 ....*....|..
gi 194386156 296 FFTKGEVHSMFC 307
Cdd:COG0500  173 LAAAATEDLRSD 184
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 156-262 5.10e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 5.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  156 LEVGCGAGNSVFPILNTLENspesfLYCCDFASGAVELVKSHSSYRAtqcfafVHDVCDDGLPYPFPDGILDVILLVFVL 235
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-----VTGVDISPEMLELAREKAPREG------LTFVVGDAEDLPFPDNSFDLVLSSEVL 69

                          90       100
                  ....*....|....*....|....*..
gi 194386156  236 SsiHPDRMQGVVNRLSKLLKPGGMLLF 262
Cdd:pfam08241  70 H--HVEDPERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 154-262 5.56e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.20  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNsvfpILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHdvCDDGLPYPFPDGILDVILLVF 233
Cdd:cd02440    1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*....
gi 194386156 234 VLSSIHPDrMQGVVNRLSKLLKPGGMLLF 262
Cdd:cd02440   75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
154-262 1.48e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 51.75  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNSVFPILntlENSPESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFpdgilDVILLVF 233
Cdd:COG4106    4 RVLDLGCGTGRLTALLA---ERFPGARVTGVDLSPEMLARARA----RLPNVRFVVADLRDLDPPEPF-----DLVVSNA 71

                         90       100
                 ....*....|....*....|....*....
gi 194386156 234 VLSsiHPDRMQGVVNRLSKLLKPGGMLLF 262
Cdd:COG4106   72 ALH--WLPDHAALLARLAAALAPGGVLAV 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 154-265 1.59e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNSVFPILNTLENspesfLYCCDFASGAVELVKSHSSYRAtqcfafVHDVCDDGLPYPFPDGILDVILLVF 233
Cdd:COG2227   27 RVLDVGCGTGRLALALARRGAD-----VTGVDISPEALEIARERAAELN------VDFVQGDLEDLPLEDGSFDLVICSE 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 194386156 234 VLssIHPDRMQGVVNRLSKLLKPGGMLLFRDY 265
Cdd:COG2227   96 VL--EHLPDPAALLRELARLLKPGGLLLLSTP 125
PRK08317 PRK08317
hypothetical protein; Provisional
 145-258 1.09e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 145 LFPGSnatfRILEVGCGAGNSVFPILNtlENSPESFLYCCDFASGAVELVKShssyRATQCFAFVHDVCDDGLPYPFPDG 224
Cdd:PRK08317  17 VQPGD----RVLDVGCGPGNDARELAR--RVGPEGRVVGIDRSEAMLALAKE----RAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194386156 225 ILDVILLVFVLSsiHPDRMQGVVNRLSKLLKPGG 258
Cdd:PRK08317  87 SFDAVRSDRVLQ--HLEDPARALAEIARVLRPGG 118
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
154-268 4.05e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.53  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 154 RILEVGCGAGNSVFPILntlensPESF-LYCCDFASGAVELVKSHSSYRATqcfaFVHDVCDDglpyPFPDGILDVILLV 232
Cdd:COG4976   49 RVLDLGCGTGLLGEALR------PRGYrLTGVDLSEEMLAKAREKGVYDRL----LVADLADL----AEPDGRFDLIVAA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 194386156 233 FVLSsiHPDRMQGVVNRLSKLLKPGGMLLF-----RDYGRY 268
Cdd:COG4976  115 DVLT--YLGDLAAVFAGVARALKPGGLFIFsvedaDGSGRY 153
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 145-306 1.14e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.03  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  145 LFPGSNATFRILEVGCGAGNsVFPILNtlENSPESFLYccDFASGAVELVKShssyratqcfaFVHDVCDDGLPYPFPDG 224
Cdd:pfam13489  16 LLPKLPSPGRVLDFGCGTGI-FLRLLR--AQGFSVTGV--DPSPIAIERALL-----------NVRFDQFDEQEAAVPAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  225 ILDVILLVFVLSSIHPdrMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENfyvrgdGTRAYFFTKGEVHS 304
Cdd:pfam13489  80 KFDVIVAREVLEHVPD--PPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARSLKR 151


                  ..
gi 194386156  305 MF 306
Cdd:pfam13489 152 LL 153
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 154-306 2.54e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.86  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156  154 RILEVGCGAGNSVFpILNTLENsPESFLYCCDFASGAVELVKSHSSYRATQCFAFVH-DVCDdgLPYPFPDGILDVILLV 232
Cdd:pfam13847   6 RVLDLGCGTGHLSF-ELAEELG-PNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQgDIEE--LPELLEDDKFDVVISN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194386156  233 FVLSSIhPDrMQGVVNRLSKLLKPGGMLLFRDYGRydktqLRFKKGHCLSENFYVRGDGTRAYffTKGEVHSMF 306
Cdd:pfam13847  82 CVLNHI-PD-PDKVLQEILRVLKPGGRLIISDPDS-----LAELPAHVKEDSTYYAGCVGGAI--LKKKLYELL 146
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 185-278 9.82e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 39.29  E-value: 9.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194386156 185 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIhPDRMQGvVNRLSKLLKPGGMLLFRD 264
Cdd:PLN02232   4 DFSSEQLAVAATRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNV-VDRLRA-MKEMYRVLKPGSRVSILD 81

                         90
                 ....*....|....
gi 194386156 265 YGRYDKTQLRFKKG 278
Cdd:PLN02232  82 FNKSNQSVTTFMQG 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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