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Conserved domains on  [gi|194387764|dbj|BAG61295|]
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unnamed protein product [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-231 1.31e-126

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17342:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 399  Bit Score: 363.94  E-value: 1.31e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  20 HVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPLEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGL 99
Cdd:cd17342    1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 100 FISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342   81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194387764 180 GLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSP 231
Cdd:cd17342  161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP 212
 
Name Accession Description Interval E-value
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 20-231 1.31e-126

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 363.94  E-value: 1.31e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  20 HVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPLEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGL 99
Cdd:cd17342    1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 100 FISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342   81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194387764 180 GLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSP 231
Cdd:cd17342  161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP 212
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
84-229 2.66e-16

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 77.06  E-value: 2.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:PRK11663  60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSV-LQYGYEYAFLVtasvqfAGGIVIFFGLLV 229
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMI------AGIIAIVVGLFL 194
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-230 1.17e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.21  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF------WQLLLLRFLLGLGEAGFFPAAL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVL-QYGYEYAFLVTASVQFAGGIVIFFGLLVS 230
Cdd:COG2271  121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPGLLLALLRFWLLALA 188
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 84-229 6.51e-14

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 70.10  E-value: 6.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764   84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764  164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTasvqFAGGIVIFFGLLV 229
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFI----VPGIIAIIVSLIC 167
MFS_1 pfam07690
Major Facilitator Superfamily;
84-233 3.64e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 3.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764   84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194387764  164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVL-QYGYEYAFLVTASVQFAGGIVIFFGLLVSPEE 233
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178
 
Name Accession Description Interval E-value
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 20-231 1.31e-126

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 363.94  E-value: 1.31e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  20 HVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPLEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGL 99
Cdd:cd17342    1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 100 FISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342   81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194387764 180 GLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSP 231
Cdd:cd17342  161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP 212
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
 23-231 1.13e-54

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 180.21  E-value: 1.13e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  23 VFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPLEIWSSNHLFpSAEKATLFLGTLDTIFLFSYAVGLFIS 102
Cdd:cd17344    4 ILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNIVLNNTTWCGWAPF-DGKNGTELLGALDSAFLFAYAIGMFFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 103 GIVGDRLNLRWVLSFGMCSSALVVFVFGaLTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLW 182
Cdd:cd17344   83 GHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGIW 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 194387764 183 SACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSP 231
Cdd:cd17344  162 NSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP 210
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 20-231 1.36e-51

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 171.30  E-value: 1.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  20 HVVVFLLTFFSYSLLHASRKTFSNVKVSISEQwtpsafntsvelpleiwssnhlfpsAEKATLFLGTLDTIFLFSYAVGL 99
Cdd:cd17312    1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEE-------------------------IGLSKDDLGIIGSAFLIAYAVGK 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 100 FISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEwlrfynKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17312   56 FISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS------LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVY 129

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194387764 180 GLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGLLVSP 231
Cdd:cd17312  130 GIWSTSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
84-229 2.66e-16

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 77.06  E-value: 2.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:PRK11663  60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSV-LQYGYEYAFLVtasvqfAGGIVIFFGLLV 229
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMI------AGIIAIVVGLFL 194
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 84-235 8.36e-16

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 75.74  E-value: 8.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrFYNKWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:cd17345   40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA--TSSVGLMFILLFLNGWFQGMGWPPSG 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEY----AFLVTASVQFAGGIVIFFGLLVSPEEIG 235
Cdd:cd17345  118 RTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGwwrgAFIFPAIIAIIVAVIVLFLGKDTPESEG 193
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 94-236 1.10e-15

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 75.06  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  94 SYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGAltewlrFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKA 173
Cdd:cd17343   50 AYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSG------SSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPS 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194387764 174 GRGVVFGLWSACASVGNILGACLASSV-LQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGK 236
Cdd:cd17343  124 QFGTWWSVLSTSMNLAGSLGPILATLLaLSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGL 187
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-230 1.17e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.21  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF------WQLLLLRFLLGLGEAGFFPAAL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVL-QYGYEYAFLVTASVQFAGGIVIFFGLLVS 230
Cdd:COG2271  121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPGLLLALLRFWLLALA 188
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 84-229 6.51e-14

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 70.10  E-value: 6.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764   84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764  164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTasvqFAGGIVIFFGLLV 229
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFI----VPGIIAIIVSLIC 167
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 84-234 6.56e-14

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 69.74  E-value: 6.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:cd17488   40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSS------SLWAFAVLWTLNAFFQGWGWPPCA 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSV-LQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEI 234
Cdd:cd17488  114 RLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAaLTYGWRAGMYVPGIIAILMGIVLCWRLRDRPPYI 185
MFS_1 pfam07690
Major Facilitator Superfamily;
84-233 3.64e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 3.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764   84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194387764  164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVL-QYGYEYAFLVTASVQFAGGIVIFFGLLVSPEE 233
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 89-232 1.32e-09

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 57.26  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  89 TIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALtewlrfYNKWLYCCLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:cd17327   48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV------KNFGGLIALRFFLGLFESGVFPGFILYLGM 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194387764 169 WFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-------YGYEYAFLVTASVQFAGGIVIFFGLLVSPE 232
Cdd:cd17327  122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPS 192
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-227 1.55e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:COG2814   47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL------WLLLAARFLQGLGAGALFPAAL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQY-GYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:COG2814  121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLL 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 84-227 1.71e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:cd17325  237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF------WLLLLLLALLGLGLGLVFPATL 310

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLLR 375
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
81-235 3.30e-08

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 53.51  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  81 TLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRfYNKWLYCCLWIVNGLLQSTGWP 160
Cdd:PRK09556  63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGS-VSLGLMIALWALSGFFQSTGGP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLA---SSVLQYGYEYAFLVTASVqfAGGIVIFFGLLV---SPEEI 234
Cdd:PRK09556 142 CSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVAlwgANYFFDGHVIGMFIFPSI--IALIIGFIGLRYgsdSPEEL 219


                 .
gi 194387764 235 G 235
Cdd:PRK09556 220 G 220
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
84-232 4.74e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.88  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY------WLLLLLGLLLGIGGGGSFAVGI 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGLLVSPE 232
Cdd:COG2223  116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPA 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 82-227 4.83e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  82 LFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPC 161
Cdd:cd17325   31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFLQGLASAAVWPA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194387764 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17325  105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL 171
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 84-225 6.51e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.11  E-value: 6.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYnkwlycCLWIVNGLLQSTGWPCVV 163
Cdd:cd17319   40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY------VLRFLLGVAEAGFFPGAI 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQY-GYEYAFLVTASVQFAGGIVIFF 225
Cdd:cd17319  114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAFIIEGLLGLLLAVLWWF 176
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 81-225 6.97e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.35  E-value: 6.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  81 TLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWP 160
Cdd:cd06174   30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------WLLLLGRFLLGLGSGLIDP 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194387764 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQY---GYEYAFLVTASVQFAGGIVIFF 225
Cdd:cd06174  104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAALALLAAILLLL 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 85-227 1.83e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  85 GTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVVA 164
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP------WLFAIALVLTGFGGGLFEPASEA 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194387764 165 VMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17329  112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 25-215 1.71e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.84  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  25 LLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPLEIWSSNHLFPSAEKATlflGTLDTIFLFSYAVGLFISGI 104
Cdd:cd17318    2 ILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQ---GIILSSFFYGYILTQIPGGY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 105 VGDRLNLRWVLSFGMCSSALVVFvfgaLTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSA 184
Cdd:cd17318   79 LAEKYGAKRVLGYSILITALLTL----LTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYS 154

                        170       180       190
                 ....*....|....*....|....*....|..
gi 194387764 185 CASVGNILGACLASSVLQY-GYEYAFLVTASV 215
Cdd:cd17318  155 GSQFGTVIAMPLSGFLCESlGWPSIFYIFGGL 186
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 83-214 1.85e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.77  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  83 FLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFvfgaLTEWLRFYNKWLYCCLWIVNGLLQSTGWPCV 162
Cdd:cd17380   35 DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL----LTPLLAYSSLPLLILSRILLGLGEGVHFPSM 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194387764 163 VAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVL-QYGYEYAFLVTAS 214
Cdd:cd17380  111 TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLeYYGWPSVFYFFGL 163
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 84-227 2.76e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.45  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:cd17328   36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF------WQLLLFRALVGIGEASYSPIAP 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSV--LQYGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17328  110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLFV 175
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 84-227 3.24e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLrfynkWLYCCLwIVNGLLQSTGWPCVV 163
Cdd:cd17475   33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP-----VLLVLL-FLVGAGYGSVQPGGG 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764 164 -AVMGnWFGKAGRGVVFGLWSACASVGNILGACLASSV-LQYGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17475  107 rAIMR-WFPPRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFY 171
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-225 3.26e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  83 FLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGalteWLRFYNKWLYCCLWIVNGLLQSTGWPCV 162
Cdd:COG2211  265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF----FLGPGNLWLLLVLAALAGIGLGAILVLP 340

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194387764 163 VAVMGN-------WFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFF 225
Cdd:COG2211  341 WAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAlFGYVAGAAQSPSALTGIRLLFFL 411
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
89-225 3.66e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  89 TIFLFSYAVGLFISGIVGDRLN--LRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQSTGWPCVVAVM 166
Cdd:COG2271  223 SLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLP------SPALAIALLFLAGFGLGGAFGLLWALA 296

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 167 GNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFF 225
Cdd:COG2271  297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDaTGYQAAFLLLAALALLAALLALL 356
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 81-224 3.97e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  81 TLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWP 160
Cdd:cd17478  229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI------WSYILLVLAGFLLFASFPV 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764 161 CVVAVMGNWFGKAG--RGVVFGLwsaCASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIF 224
Cdd:cd17478  303 TVVLAQELLPGNVGlaSGLMMGL---SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 84-237 8.04e-04

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 40.01  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764   84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYnkwlycCLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00893  31 YGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLY------ILRVLLGAAEAPFFPGII 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194387764  164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGKL 237
Cdd:TIGR00893 105 LIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIhFSWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKWL 179
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 84-225 8.49e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.79  E-value: 8.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP------SPELLIAARALQGIGAGGLMPGAL 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQY-GYEYAFLVTASVQFAGGIVIFF 225
Cdd:COG0477  125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPLGLLALVLRLR 187
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-192 1.17e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  85 GTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVVA 164
Cdd:COG2814  246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL------WLLLLALFLLGFGFGLLFPLLQA 319

                         90       100
                 ....*....|....*....|....*...
gi 194387764 165 VMGNWFGKAGRGVVFGLWSACASVGNIL 192
Cdd:COG2814  320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 82-225 1.53e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  82 LFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLwIVNGLLQSTGWPC 161
Cdd:cd06173   34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFFGPA 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194387764 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFF 225
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLF 177
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 84-225 2.09e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVV 163
Cdd:cd06173  246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL------WLLLAALFLLGLAGGLFNVPLN 319

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194387764 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTASVQFAGGIVIFF 225
Cdd:cd06173  320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGALLLLAALLLLL 382
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
76-230 4.48e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 37.53  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  76 SAEKATLFLgtldTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTewlrfyNKWLYCCLWIVNGLLQ 155
Cdd:COG0738  244 SEATAALGL----SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP------GPWLALIGLALVGLGL 313

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387764 156 STGWPCVVAVMGNWFGKAGrGVVFGLWSACASVGNILGACLASSVLQ-YGYEYAFLVTAsvqFAGGIVIFFGLLVS 230
Cdd:COG0738  314 SLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADaFGLRAAFLVPL---VCYLLILLLALALK 385
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
84-233 6.25e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 37.14  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  84 LGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLrfynkWLYCCLWIV---NGLLQSTGWP 160
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLglgLGLLDVAANP 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194387764 161 CVVAVmgnwfGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYE----YAFLVTASVQFAGGIVIFFGLLVSPEE 233
Cdd:COG0738  120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLILAVLLLLLALLFLRSKLPEIEE 191
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 103-227 6.84e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 37.24  E-value: 6.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764 103 GIVGDRLNLRWVLSFGMCSSALVVFVFGALTE-----WLRFynkwlycclwiVNGLLQSTGWPCVVAVMGNWFGKAGRGV 177
Cdd:cd17391  261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTpwqlgILRF-----------LLGLATGGLLPAINSLLAKITPKEVAGR 329

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194387764 178 VFGLWSACASVGNILGACLASSV-LQYGYEYAFLVTASVQFAGGIVIFFGL 227
Cdd:cd17391  330 IFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 89-225 9.02e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 36.80  E-value: 9.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387764  89 TIFLFSYAVGL----FISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWlrfynkWLYCCLWIVNGLLQSTGWPCVVA 164
Cdd:cd17489  230 GLFFTVYAIALllsrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP------WMLLLAAVLYGLGFGLLFPALQA 303

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194387764 165 VMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQY-GYEYAFLVTASVQFAGGIVIFF 225
Cdd:cd17489  304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLYIF 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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