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Conserved domains on  [gi|194385410|dbj|BAG65082|]
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unnamed protein product [Homo sapiens]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
1-481 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 762.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410    1 MEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYY 80
Cdd:pfam01153  62 MEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYY 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410   81 VVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGD 160
Cdd:pfam01153 142 RGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGRE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  161 VVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIES 240
Cdd:pfam01153 222 VVNKVSQVPLSPECTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIEN 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  241 VMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAgRISRSISESAFSAR-FRPHHPEERPTTAAGTSLDRLVTDV 319
Cdd:pfam01153 302 VIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPY-RSTRSSSPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDV 380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  320 KEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALR 399
Cdd:pfam01153 381 KEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLK 460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  400 VMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHA---------GKSANEKADSAGVRPGAQAYL 470
Cdd:pfam01153 461 IMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDGCPSDLCKGDLPFVFELTDtpatpakptTQQGTGSVDGSSTGGLPSSLL 540

                         490
                  ....*....|.
gi 194385410  471 LTVFCILFLVM 481
Cdd:pfam01153 541 LATSMLLSLVT 551
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
1-481 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 762.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410    1 MEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYY 80
Cdd:pfam01153  62 MEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYY 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410   81 VVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGD 160
Cdd:pfam01153 142 RGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGRE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  161 VVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIES 240
Cdd:pfam01153 222 VVNKVSQVPLSPECTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIEN 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  241 VMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAgRISRSISESAFSAR-FRPHHPEERPTTAAGTSLDRLVTDV 319
Cdd:pfam01153 302 VIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPY-RSTRSSSPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDV 380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  320 KEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALR 399
Cdd:pfam01153 381 KEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLK 460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  400 VMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHA---------GKSANEKADSAGVRPGAQAYL 470
Cdd:pfam01153 461 IMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDGCPSDLCKGDLPFVFELTDtpatpakptTQQGTGSVDGSSTGGLPSSLL 540

                         490
                  ....*....|.
gi 194385410  471 LTVFCILFLVM 481
Cdd:pfam01153 541 LATSMLLSLVT 551
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
1-481 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 762.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410    1 MEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYY 80
Cdd:pfam01153  62 MEEKLSNQSRREFEQLVHEASSSLQTTLTTNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYY 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410   81 VVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGD 160
Cdd:pfam01153 142 RGSNVNLEEALNEFWARLLERLFKLVNPQYHFSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGRE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  161 VVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIES 240
Cdd:pfam01153 222 VVNKVSQVPLSPECTRALMKMLYCPHCRGLPSVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIEN 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  241 VMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAgRISRSISESAFSAR-FRPHHPEERPTTAAGTSLDRLVTDV 319
Cdd:pfam01153 302 VIDSIHVKISEAIMNMQENSMKLTAKVFQGCGTPKPTPY-RSTRSSSPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDV 380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  320 KEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALR 399
Cdd:pfam01153 381 KEKLKEMKSFWSTLPDTLCSDEKMAADPTNEDKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLK 460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194385410  400 VMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHA---------GKSANEKADSAGVRPGAQAYL 470
Cdd:pfam01153 461 IMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDGCPSDLCKGDLPFVFELTDtpatpakptTQQGTGSVDGSSTGGLPSSLL 540

                         490
                  ....*....|.
gi 194385410  471 LTVFCILFLVM 481
Cdd:pfam01153 541 LATSMLLSLVT 551
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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