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Conserved domains on  [gi|943491483|dbj|BAT23938|]
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group 1 glycosyl transferase [Klebsiella sp. 1303/50]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133545)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 413-786 3.27e-79

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


:

Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 259.22  E-value: 3.27e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 413 KLLVDISVLVEHdaKTGIQRVSRSILSELLKSGVAgYTVSAVYYRPGECYRYANEY--LNTHFNGAFGPDVPVLFTKDDI 490
Cdd:cd03809    1 KILIDGRSLAQR--LTGIGRYTRELLKALAKNDPD-ESVLAVPPLPGELLRLLREYpeLSLGVIKIKLWRELALLRWLQI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 491 LVATDLTAHLFPeLTVQLDFIRLSGAKVCFVVHDILPLRRPEWSDEGMQRVFPIWLSCIAQHADRLICVSASVAEDVKAW 570
Cdd:cd03809   78 LLPKKDKPDLLH-SPHNTAPLLLKGCPQVVTIHDLIPLRYPEFFPKRFRLYYRLLLPISLRRADAIITVSEATRDDIIKF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 571 IAENSHWVkpnplltvSNFHLGADLDASVPstgmPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNY 650
Cdd:cd03809  157 YGVPPEKI--------VVIPLGVDPSFFPP----ESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 651 NLFIIGKQGWHVDDLCERLRHhPQLNKKLFWLQNISDEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPV 730
Cdd:cd03809  225 KLVIVGGKGWEDEELLDLVKK-LGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISV 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 943491483 731 FKEIAQEHAWYFSGEAPADIAKAVED-WLALYEQNAHPRSENIN--WLTWKQSAEFLLK 786
Cdd:cd03809  304 LPEVAGDAALYFDPLDPESIADAILRlLEDPSLREELIRKGLERakKFSWEKTAEKTLE 362
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 56-356 7.32e-70

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


:

Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 234.18  E-value: 7.32e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  56 IANINPDVVFIINFYEGFDDSYTvsipqttvpwKTVCVCHDLIPLLNKERY-LGEPNFRQYYYDKLAqyERADAIFAISR 134
Cdd:cd03809   80 PKKDKPDLLHSPHNTAPLLLKGC----------PQVVTIHDLIPLRYPEFFpKRFRLYYRLLLPISL--RRADAIITVSE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 135 SSMQEVIDYTSIPAEKIINISSGVSDSFKIKDYThdeiKDLRNKYHLPQEFILSLAMIEPRKNIEALIHAYSLLPhALQQ 214
Cdd:cd03809  148 ATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESA----AVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLK-KQGG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 215 SYPLVLAYKISTDEKERLYRVAENygLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSN 294
Cdd:cd03809  223 DLKLVIVGGKGWEDEELLDLVKKL--GLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASN 300

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943491483 295 VTSLPEVIGMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDHTAQLALK 356
Cdd:cd03809  301 ISVLPEVAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKGLERAKKFSWEKTAEKTLE 362
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 413-786 3.27e-79

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 259.22  E-value: 3.27e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 413 KLLVDISVLVEHdaKTGIQRVSRSILSELLKSGVAgYTVSAVYYRPGECYRYANEY--LNTHFNGAFGPDVPVLFTKDDI 490
Cdd:cd03809    1 KILIDGRSLAQR--LTGIGRYTRELLKALAKNDPD-ESVLAVPPLPGELLRLLREYpeLSLGVIKIKLWRELALLRWLQI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 491 LVATDLTAHLFPeLTVQLDFIRLSGAKVCFVVHDILPLRRPEWSDEGMQRVFPIWLSCIAQHADRLICVSASVAEDVKAW 570
Cdd:cd03809   78 LLPKKDKPDLLH-SPHNTAPLLLKGCPQVVTIHDLIPLRYPEFFPKRFRLYYRLLLPISLRRADAIITVSEATRDDIIKF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 571 IAENSHWVkpnplltvSNFHLGADLDASVPstgmPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNY 650
Cdd:cd03809  157 YGVPPEKI--------VVIPLGVDPSFFPP----ESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 651 NLFIIGKQGWHVDDLCERLRHhPQLNKKLFWLQNISDEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPV 730
Cdd:cd03809  225 KLVIVGGKGWEDEELLDLVKK-LGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISV 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 943491483 731 FKEIAQEHAWYFSGEAPADIAKAVED-WLALYEQNAHPRSENIN--WLTWKQSAEFLLK 786
Cdd:cd03809  304 LPEVAGDAALYFDPLDPESIADAILRlLEDPSLREELIRKGLERakKFSWEKTAEKTLE 362
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 56-356 7.32e-70

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 234.18  E-value: 7.32e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  56 IANINPDVVFIINFYEGFDDSYTvsipqttvpwKTVCVCHDLIPLLNKERY-LGEPNFRQYYYDKLAqyERADAIFAISR 134
Cdd:cd03809   80 PKKDKPDLLHSPHNTAPLLLKGC----------PQVVTIHDLIPLRYPEFFpKRFRLYYRLLLPISL--RRADAIITVSE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 135 SSMQEVIDYTSIPAEKIINISSGVSDSFKIKDYThdeiKDLRNKYHLPQEFILSLAMIEPRKNIEALIHAYSLLPhALQQ 214
Cdd:cd03809  148 ATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESA----AVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLK-KQGG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 215 SYPLVLAYKISTDEKERLYRVAENygLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSN 294
Cdd:cd03809  223 DLKLVIVGGKGWEDEELLDLVKKL--GLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASN 300

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943491483 295 VTSLPEVIGMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDHTAQLALK 356
Cdd:cd03809  301 ISVLPEVAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKGLERAKKFSWEKTAEKTLE 362
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 183-341 1.98e-29

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 114.68  E-value: 1.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  183 QEFILSLAMIEPRKNIEALIHAYSLLPhALQQSYPLVLAYKIstDEKERLYRVAENYGLsRNQLIFTGFLNDSDLIALYN 262
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFALLK-EKNPNLKLVIAGDG--EEEKRLKKLAEKLGL-GDNVIFLGFVSDEDLPELLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  263 LCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKAHAPA 340
Cdd:pfam00534  78 IADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETgfLVKPNNAEALAEAIDKLLEDEELRERLGENARK 157


                  .
gi 943491483  341 Q 341
Cdd:pfam00534 158 R 158
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 123-355 6.81e-23

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 101.32  E-value: 6.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  123 YERADAIFAISRSSMQEVIDYTSIPAEKIINissGVsDSFKIKDYTHDEIKDLRNKYHL---PqeFILSLAMIEPRKNIE 199
Cdd:TIGR04047 136 IVEADAVLCVSAAWAAELRAEWGIDATVVPN---GV-DAARFSPAADAADAALRRRLGLrggP--YVLAVGGIEPRKNTI 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  200 ALIHAYSLLPHALQQSyPLVLAYKIS----TDEKERLYRVAENYGLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEG 275
Cdd:TIGR04047 210 DLLEAFALLRARRPQA-QLVIAGGATlfdyDAYRREFRARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEG 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  276 FGLPPLEAMRCGAATLGSNVTSLPEVIGMEEALF-NPLDVPDICRVMQRALtDSEFYSALKAHAPAQAAKFTWDHTAQLA 354
Cdd:TIGR04047 289 FGLVVLEALASGIPVVASDIAPFTEYLGRFDAAWaDPSDPDSIADALALAL-DPARRPALRAAGPELAARYTWDASARAH 367


                  .
gi 943491483  355 L 355
Cdd:TIGR04047 368 L 368
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 621-774 2.21e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 94.26  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  621 FIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKQGWhvDDLCERLRHHPQLNKKLFWLQNISDEFLTKLYSQSSAL 700
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEE--EKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 943491483  701 IFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEH--AWYFSGEAPADIAKAVEDWLALYEQNAHPRSENINW 774
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGetGFLVKPNNAEALAEAIDKLLEDEELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 259-362 9.39e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 85.43  E-value: 9.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 259 ALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKA 336
Cdd:COG0438   16 ALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETglLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|....*..
gi 943491483 337 HAPAQAA-KFTWDHTAQLALKGFERLV 362
Cdd:COG0438   96 AARERAEeRFSWEAIAERLLALYEELL 122
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 687-786 5.90e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 57.69  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 687 DEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQ--EHAWYFSGEAPADIAKAVEDWLALYE-- 762
Cdd:COG0438   11 DLLLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEdgETGLLVPPGDPEALAEAILRLLEDPElr 90

                         90       100
                 ....*....|....*....|....*...
gi 943491483 763 ----QNAHPRSEniNWLTWKQSAEFLLK 786
Cdd:COG0438   91 rrlgEAARERAE--ERFSWEAIAERLLA 116
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 247-347 1.00e-06

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 52.02  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 247 IFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA-----LFNPLDVPDICRVM 321
Cdd:PLN02871 315 VFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIPPDQEgktgfLYTPGDVDDCVEKL 394

                         90       100
                 ....*....|....*....|....*.
gi 943491483 322 QRALTDSEFYSALKAHAPAQAAKFTW 347
Cdd:PLN02871 395 ETLLADPELRERMGAAAREEVEKWDW 420
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 413-786 3.27e-79

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 259.22  E-value: 3.27e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 413 KLLVDISVLVEHdaKTGIQRVSRSILSELLKSGVAgYTVSAVYYRPGECYRYANEY--LNTHFNGAFGPDVPVLFTKDDI 490
Cdd:cd03809    1 KILIDGRSLAQR--LTGIGRYTRELLKALAKNDPD-ESVLAVPPLPGELLRLLREYpeLSLGVIKIKLWRELALLRWLQI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 491 LVATDLTAHLFPeLTVQLDFIRLSGAKVCFVVHDILPLRRPEWSDEGMQRVFPIWLSCIAQHADRLICVSASVAEDVKAW 570
Cdd:cd03809   78 LLPKKDKPDLLH-SPHNTAPLLLKGCPQVVTIHDLIPLRYPEFFPKRFRLYYRLLLPISLRRADAIITVSEATRDDIIKF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 571 IAENSHWVkpnplltvSNFHLGADLDASVPstgmPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNY 650
Cdd:cd03809  157 YGVPPEKI--------VVIPLGVDPSFFPP----ESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 651 NLFIIGKQGWHVDDLCERLRHhPQLNKKLFWLQNISDEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPV 730
Cdd:cd03809  225 KLVIVGGKGWEDEELLDLVKK-LGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISV 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 943491483 731 FKEIAQEHAWYFSGEAPADIAKAVED-WLALYEQNAHPRSENIN--WLTWKQSAEFLLK 786
Cdd:cd03809  304 LPEVAGDAALYFDPLDPESIADAILRlLEDPSLREELIRKGLERakKFSWEKTAEKTLE 362
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 56-356 7.32e-70

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 234.18  E-value: 7.32e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  56 IANINPDVVFIINFYEGFDDSYTvsipqttvpwKTVCVCHDLIPLLNKERY-LGEPNFRQYYYDKLAqyERADAIFAISR 134
Cdd:cd03809   80 PKKDKPDLLHSPHNTAPLLLKGC----------PQVVTIHDLIPLRYPEFFpKRFRLYYRLLLPISL--RRADAIITVSE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 135 SSMQEVIDYTSIPAEKIINISSGVSDSFKIKDYThdeiKDLRNKYHLPQEFILSLAMIEPRKNIEALIHAYSLLPhALQQ 214
Cdd:cd03809  148 ATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESA----AVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLK-KQGG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 215 SYPLVLAYKISTDEKERLYRVAENygLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSN 294
Cdd:cd03809  223 DLKLVIVGGKGWEDEELLDLVKKL--GLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASN 300

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943491483 295 VTSLPEVIGMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDHTAQLALK 356
Cdd:cd03809  301 ISVLPEVAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKGLERAKKFSWEKTAEKTLE 362
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 44-352 2.77e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 146.53  E-value: 2.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  44 RSVAATLARELAIANI--NPDVVFIINFYEGFDDSYTVSIPQTtvpwKTVCVCHDLIPLLNKERYLGEPNFRQYYydkLA 121
Cdd:cd03801   64 LLRARRLLRELRPLLRlrKFDVVHAHGLLAALLAALLALLLGA----PLVVTLHGAEPGRLLLLLAAERRLLARA---EA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 122 QYERADAIFAISRSSMQEVIDYTSIPAEKIINISSGVSDSFkikdythdEIKDLRNKYHLPQE--FILSLAMIEPRKNIE 199
Cdd:cd03801  137 LLRRADAVIAVSEALRDELRALGGIPPEKIVVIPNGVDLER--------FSPPLRRKLGIPPDrpVLLFVGRLSPRKGVD 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 200 ALIHAYSLLPHALQQsYPLVLAYKiSTDEKERLyrVAENYGLSRNqLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLP 279
Cdd:cd03801  209 LLLEALAKLLRRGPD-VRLVIVGG-DGPLRAEL--EELELGLGDR-VRFLGFVPDEELPALYAAADVFVLPSRYEGFGLV 283

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 943491483 280 PLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQ-AAKFTWDHTAQ 352
Cdd:cd03801  284 VLEAMAAGLPVVATDVGGLPEVVEDGEGglVVPPDDVEALADALLRLLADPELRARLGRAARERvAERFSWERVAE 359
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 183-341 1.98e-29

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 114.68  E-value: 1.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  183 QEFILSLAMIEPRKNIEALIHAYSLLPhALQQSYPLVLAYKIstDEKERLYRVAENYGLsRNQLIFTGFLNDSDLIALYN 262
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFALLK-EKNPNLKLVIAGDG--EEEKRLKKLAEKLGL-GDNVIFLGFVSDEDLPELLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  263 LCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKAHAPA 340
Cdd:pfam00534  78 IADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETgfLVKPNNAEALAEAIDKLLEDEELRERLGENARK 157


                  .
gi 943491483  341 Q 341
Cdd:pfam00534 158 R 158
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 429-786 4.17e-29

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 119.56  E-value: 4.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 429 GIQRVSRSILSELLKsgvAGYTVSAVYYRPGECYRYANEYLNTHFNGAFGPDVPVL------------FTKDDILVATDL 496
Cdd:cd03801   15 GAERHVRELARALAA---RGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRArrllrelrpllrLRKFDVVHAHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 497 TAHLFPELTVqldfiRLSGAKVCFVVHDILPLRRPEWSDeGMQRVFPIWLScIAQHADRLICVSASVAEDVKAWiaensH 576
Cdd:cd03801   92 LAALLAALLA-----LLLGAPLVVTLHGAEPGRLLLLLA-AERRLLARAEA-LLRRADAVIAVSEALRDELRAL-----G 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 577 WVKPNPLLTVSNfhlGADLDAsvpstgMPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIG 656
Cdd:cd03801  160 GIPPEKIVVIPN---GVDLER------FSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 657 KQGWHVDDLCERLRHhpqLNKKLFWLQNISDEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQ 736
Cdd:cd03801  231 GDGPLRAELEELELG---LGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 943491483 737 --EHAWYFSGEAPADIAKAVEDWL---ALYEQ-NAHPRSENINWLTWKQSAEFLLK 786
Cdd:cd03801  308 dgEGGLVVPPDDVEALADALLRLLadpELRARlGRAARERVAERFSWERVAERLLD 363
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 123-354 1.19e-25

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 110.02  E-value: 1.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 123 YERADAIFAISRSSMQEVIDYTSIPAEKIINISSGVS-DSFkikdYTHDEIKDLRNKYHLPQE--FILSLAMIEPRKNIE 199
Cdd:cd03800  161 LEAADRVIASTPQEADELISLYGADPSRINVVPPGVDlERF----FPVDRAEARRARLLLPPDkpVVLALGRLDPRKGID 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 200 ALIHAYSLLPHaLQQSYPLVLA----YKISTDEKERLYRVAENYGLSrNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEG 275
Cdd:cd03800  237 TLVRAFAQLPE-LRELANLVLVggpsDDPLSMDREELAELAEELGLI-DRVRFPGRVSRDDLPELYRAADVFVVPSLYEP 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 276 FGLPPLEAMRCGAATLGSNVTSLPEVI--GMEEALFNPLDVPDICRVMQRALTDSEFYSAL--KAHAPAQaAKFTWD-HT 350
Cdd:cd03800  315 FGLTAIEAMACGTPVVATAVGGLQDIVrdGRTGLLVDPHDPEALAAALRRLLDDPALWQRLsrAGLERAR-AHYTWEsVA 393


                 ....
gi 943491483 351 AQLA 354
Cdd:cd03800  394 DQLL 397
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 123-355 6.81e-23

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 101.32  E-value: 6.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  123 YERADAIFAISRSSMQEVIDYTSIPAEKIINissGVsDSFKIKDYTHDEIKDLRNKYHL---PqeFILSLAMIEPRKNIE 199
Cdd:TIGR04047 136 IVEADAVLCVSAAWAAELRAEWGIDATVVPN---GV-DAARFSPAADAADAALRRRLGLrggP--YVLAVGGIEPRKNTI 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  200 ALIHAYSLLPHALQQSyPLVLAYKIS----TDEKERLYRVAENYGLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEG 275
Cdd:TIGR04047 210 DLLEAFALLRARRPQA-QLVIAGGATlfdyDAYRREFRARAAELGVDPGPVVITGPVPDADLPALYRCADAFAFPSLKEG 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  276 FGLPPLEAMRCGAATLGSNVTSLPEVIGMEEALF-NPLDVPDICRVMQRALtDSEFYSALKAHAPAQAAKFTWDHTAQLA 354
Cdd:TIGR04047 289 FGLVVLEALASGIPVVASDIAPFTEYLGRFDAAWaDPSDPDSIADALALAL-DPARRPALRAAGPELAARYTWDASARAH 367


                  .
gi 943491483  355 L 355
Cdd:TIGR04047 368 L 368
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 621-774 2.21e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 94.26  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  621 FIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKQGWhvDDLCERLRHHPQLNKKLFWLQNISDEFLTKLYSQSSAL 700
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEE--EKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 943491483  701 IFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEH--AWYFSGEAPADIAKAVEDWLALYEQNAHPRSENINW 774
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGetGFLVKPNNAEALAEAIDKLLEDEELRERLGENARKR 158
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 123-361 2.48e-22

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 99.76  E-value: 2.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 123 YERADAIFAISRSsMQEVIDYTSIPAEKIINISSGVsdsfkikDYTHDEIKDLRNKYHLPQEFILSLAMIEPRKNIEALI 202
Cdd:cd03798  148 LRRAARVIAVSKA-LAEELVALGVPRDRVDVIPNGV-------DPARFQPEDRGLGLPLDAFVILFVGRLIPRKGIDLLL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 203 HAYSLLPHALQqsyPLVLayKISTD--EKERLYRVAENYGLsRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPP 280
Cdd:cd03798  220 EAFARLAKARP---DVVL--LIVGDgpLREALRALAEDLGL-GDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVL 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 281 LEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALtdsefYSALKAHAPAQAAK-----FTWDHTAQL 353
Cdd:cd03798  294 LEAMACGLPVVATDVGGIPEVVGDPETglLVPPGDADALAAALRRAL-----AEPYLRELGEAARArvaerFSWVKAADR 368


                 ....*...
gi 943491483 354 ALKGFERL 361
Cdd:cd03798  369 IAAAYRDV 376
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 56-337 1.60e-20

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 93.96  E-value: 1.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  56 IANINPDVVFIINFYegfdDSYTVSIPqTTVPWKTVCVCHDLipllnkerYLGEPNFRQYYYDKLAQYERADAIFAISRS 135
Cdd:cd03811   79 LKRAKPDVVISFLGF----ATYIVAKL-AAARSKVIAWIHSS--------LSKLYYLKKKLLLKLKLYKKADKIVCVSKG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 136 SMQEVIDYTSIPAEKIINISSGVSDSFKIKDYTHDEIKDLRNKyhlpqEFILSLAMIEPRKNIEALIHAYSLLPhALQQS 215
Cdd:cd03811  146 IKEDLIRLGPSPPEKIEVIYNPIDIDRIRALAKEPILNEPEDG-----PVILAVGRLDPQKGHDLLIEAFAKLR-KKYPD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 216 YPLVLAYKIstDEKERLYRVAENYGLSrNQLIFTGFLndSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNV 295
Cdd:cd03811  220 VKLVILGDG--PLREELEKLAKELGLA-ERVIFLGFQ--SNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDC 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 943491483 296 TSLPEVIGMEEALF-----NPLDVPDICRVMQRALTDSEFYSALKAH 337
Cdd:cd03811  295 PGPREILDDGENGLlvpdgDAAALAGILAALLQKKLDAALRERLAKA 341
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
191-327 6.63e-20

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 86.41  E-value: 6.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  191 MIEPRKNIEALIHAyslLPHALQQSYPLVLaYKISTDEKERLYRVAENYglsRNQLIFTGFLNDsdLIALYNLCKIFVFP 270
Cdd:pfam13692  10 LHPNVKGVDYLLEA---VPLLRKRDNDVRL-VIVGDGPEEELEELAAGL---EDRVIFTGFVED--LAELLAAADVFVLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 943491483  271 SIHEGFGLPPLEAMRCGAATLGSNVTSLPEVI-GMEEALFNPLDVPDICRVMQRALTD 327
Cdd:pfam13692  81 SLYEGFGLKLLEAMAAGLPVVATDVGGIPELVdGENGLLVPPGDPEALAEAILRLLED 138
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 259-362 9.39e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 85.43  E-value: 9.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 259 ALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKA 336
Cdd:COG0438   16 ALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETglLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|....*..
gi 943491483 337 HAPAQAA-KFTWDHTAQLALKGFERLV 362
Cdd:COG0438   96 AARERAEeRFSWEAIAERLLALYEELL 122
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 187-302 1.05e-17

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 83.22  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 187 LSLAMIEPRKNIEALIHAYSLLPHALQqsyPLVLAYKISTDEKERLYRVAENYGLSRNQLIFTGFLNDSDLIALYNLCKI 266
Cdd:cd01635  114 VSVGRLVPEKGIDLLLEALALLKARLP---DLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADV 190

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 943491483 267 FVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVI 302
Cdd:cd01635  191 FVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFV 226
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 124-344 7.70e-16

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 80.09  E-value: 7.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 124 ERADAIFAISRSSMQEVIDYTSiPAEKIINISSGV-SDSFKIKDYTHDEikdlRNKYHLPQE-FILSLAMIEPRKNIEAL 201
Cdd:cd04962  140 NKSDRVTAVSSSLRQETYELFD-VDKDIEVIHNFIdEDVFKRKPAGALK----RRLLAPPDEkVVIHVSNFRPVKRIDDV 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 202 IHAYsllpHALQQSYPLVLAYKISTDEKERLYRVAENYGLsRNQLIFTGflNDSDLIALYNLCKIFVFPSIHEGFGLPPL 281
Cdd:cd04962  215 VRVF----ARVRRKIPAKLLLVGDGPERVPAEELARELGV-EDRVLFLG--KQDDVEELLSIADLFLLPSEKESFGLAAL 287

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 943491483 282 EAMRCGAATLGSNVTSLPEVI--GMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAK 344
Cdd:cd04962  288 EAMACGVPVVSSNAGGIPEVVkhGETGFLSDVGDVDAMAKSALSILEDDELYNRMGRAARKRAAE 352
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 123-349 1.11e-15

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 79.65  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 123 YERADAIFAISRSSMQEVidyTSIPAEKIINISSGV-SDSFkikdytHDEIKD--LRNKYHLPQEFILS----LAmiePR 195
Cdd:cd03814  143 HNPFDTTLVPSPSIAREL---EGHGFERVRLWPRGVdTELF------HPSRRDaaLRRRLGPPGRPLLLyvgrLA---PE 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 196 KNIEALIHAYSllphALQQSYPLVLAykISTDEKERlyrvaenYGLSRNQL--IFTGFLNDSDLIALYNLCKIFVFPSIH 273
Cdd:cd03814  211 KNLEALLDADL----PLAASPPVRLV--VVGDGPAR-------AELEARGPdvIFTGFLTGEELARAYASADVFVFPSRT 277

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943491483 274 EGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEE--ALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDH 349
Cdd:cd03814  278 ETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGtgALVEPGDAAAFAAALRALLEDPELRRRMAARARAEAERYSWEA 355
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 105-351 4.31e-15

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 77.40  E-value: 4.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 105 RYLGEPNFRQYYYDKLAqyeRADAIFAISRSSMQEVIDYTSIPAEKIINISSGVSDsfkikDYTHDEIKDLRNKYHLPQE 184
Cdd:cd03819  109 SYLATYHPKDFALAVRA---RGDRVIAVSELVRDHLIEALGVDPERIRVIPNGVDT-----DRFPPEAEAEERAQLGLPE 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 185 ---FILSLAMIEPRKNIEALIHAYSLLPHALQQsyplvlAYKISTD--EKERLYRVAENYGLsRNQLIFTGFlnDSDLIA 259
Cdd:cd03819  181 gkpVVGYVGRLSPEKGWLLLVDAAAELKDEPDF------RLLVAGDgpERDEIRRLVERLGL-RDRVTFTGF--REDVPA 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 260 LYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVI--GMEEALFNPLDVPDICRVMQRALTDsefysaLKAH 337
Cdd:cd03819  252 ALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVvhGRTGLLVPPGDAEALADAIRAAKLL------PEAR 325

                        250
                 ....*....|....
gi 943491483 338 APAQAAKFTWDHTA 351
Cdd:cd03819  326 EKLQAAAALTEAVR 339
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 88-342 2.91e-14

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 75.06  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  88 WKTVC-VChdliPLLNKERYLGEPNFRQYYYDKLAQYERADAIF-AISRSSMQEVIDYTSIPAEKIINISSGVS-DSFKi 164
Cdd:cd03825  102 WKTGCgNC----PNLNSYPPAKKDLSRQLFRRKREALAKKRLTIvAPSRWLADMVRRSPLLKGLPVVVIPNGIDtEIFA- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 165 kdyTHDEiKDLRNKYHLPQEFILSLAMIE----PRKNIEALIHAYSLLPHalQQSYPLVLAYKIStdekerlyrvaENYG 240
Cdd:cd03825  177 ---PVDK-AKARKRLGIPQDKKVILFGAEsvtkPRKGFDELIEALKLLAT--KDDLLLVVFGKND-----------PQIV 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 241 LSRNQLIFTGFL-NDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDI 317
Cdd:cd03825  240 ILPFDIISLGYIdDDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTgyLVPPGDVQAL 319

                        250       260
                 ....*....|....*....|....*
gi 943491483 318 CRVMQRALTDSEFYSALKAHAPAQA 342
Cdd:cd03825  320 AEAIEWLLANPKERESLGERARALA 344
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 172-348 3.11e-14

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 75.01  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 172 IKDLRNKYHLPQEF--ILSLAMIEPRKNIEALIHAYSLLPHAlqqsYPLVLAYKISTDEKERLYRVAENYGLSRNqLIFT 249
Cdd:cd03817  188 NTEERRKLGLPPDEpiLLYVGRLAKEKNIDFLLRAFAELKKE----PNIKLVIVGDGPEREELKELARELGLADK-VIFT 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 250 GFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPdICRVMQRALTD 327
Cdd:cd03817  263 GFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENgfLFEPNDET-LAEKLLHLREN 341

                        170       180
                 ....*....|....*....|.
gi 943491483 328 SEFYSALKAHAPAQAAKFTWD 348
Cdd:cd03817  342 LELLRKLSKNAEISAREFAFA 362
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 505-729 1.15e-13

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 73.16  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 505 TVQLDFIRLSGAKVCFVVHDILPLRRPEWSdegmqrvFPIWLSCIAQHADRLICVSasvaEDVKAWIAENShWVKPNPLL 584
Cdd:cd03811   95 TYIVAKLAAARSKVIAWIHSSLSKLYYLKK-------KLLLKLKLYKKADKIVCVS----KGIKEDLIRLG-PSPPEKIE 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 585 TVSNfhlGADLDASVPSTgmpdnAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGkQGwhvdD 664
Cdd:cd03811  163 VIYN---PIDIDRIRALA-----KEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILG-DG----P 229

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 943491483 665 LCERLRhhpQLNKKLfwlqNISDEFLT--------KLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIP 729
Cdd:cd03811  230 LREELE---KLAKEL----GLAERVIFlgfqsnpyPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCP 295
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 119-329 1.84e-13

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 72.63  E-value: 1.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 119 KLAQYeRADAIFAISRSSMQEVIDYTSIPAEKIINI-SSGVSdsfkIKDYTHDEIKDLRNKYHlpqefILSLAMIEPRKN 197
Cdd:cd03808  134 KLALL-FTDKVIFVNEDDRDLAIKKGIIKKKKTVLIpGSGVD----LDRFQYSPESLPSEKVV-----FLFVARLLKDKG 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 198 IEALIHAYSLLPhalqQSYP---LVLAYkiSTDEKERLYRVAENYGLSRNqLIFTGFLndSDLIALYNLCKIFVFPSIHE 274
Cdd:cd03808  204 IDELIEAAKILK----KKGPnvrFLLVG--DGELENPSEILIEKLGLEGR-IEFLGFR--SDVPELLAESDVFVLPSYRE 274

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 275 GFGLPPLEAMRCGAATLGSNVTSLPEVI-----GMeeaLFNPLDVPDICRVMQRALTDSE 329
Cdd:cd03808  275 GLPRSLLEAMAAGRPVITTDVPGCRELVidgvnGF---LVPPGDVEALADAIEKLIEDPE 331
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
619-759 2.91e-13

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 67.54  E-value: 2.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  619 PSFIMVGTM-EPRKGHAQTLAAFEELWLQGKNYNLFIIGkqgwhvDDLCERLR-HHPQLNKKLFWLQNISDefLTKLYSQ 696
Cdd:pfam13692   2 PVILFVGRLhPNVKGVDYLLEAVPLLRKRDNDVRLVIVG------DGPEEELEeLAAGLEDRVIFTGFVED--LAELLAA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 943491483  697 SSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQ-EHAWYFSGEAPADIAKAVEDWLA 759
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDgENGLLVPPGDPEALAEAILRLLE 137
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 126-352 3.70e-13

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 72.02  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 126 ADAIFAISRSSMQEVidYTSIPAEKIINISSGVSDSFKIKDythdeIKDLRNKYHLPQE-FILSLAMIEPRKNIEALIHA 204
Cdd:cd03821  153 AALVHFTSEQEADEL--RRFGLEPPIAVIPNGVDIPEFDPG-----LRDRRKHNGLEDRrIILFLGRIHPKKGLDLLIRA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 205 YSLLPHAlQQSYPLVLAykiSTDEKERLYRVAE--NYGLsRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLE 282
Cdd:cd03821  226 ARKLAEQ-GRDWHLVIA---GPDDGAYPAFLQLqsSLGL-GDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAE 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 943491483 283 AMRCGAATLGSNVTSLPEVIGMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAA---KFTWDHTAQ 352
Cdd:cd03821  301 ALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRARQveeNFSWEAVAG 373
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 544-763 1.14e-12

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 70.42  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 544 IWLSCIAQHADRL-ICVSASVAEDVKAWiaenshWVKPNPLLTVSNfhlGADLDASVPSTGMPDNAQALLAAMAAAPSFI 622
Cdd:cd03807  124 RKLCLLLSKFSPAtVANSSAVAEFHQEQ------GYAKNKIVVIYN---GIDLFKLSPDDASRARARRRLGLAEDRRVIG 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 623 MVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKQGWHVDDLCERLRHHPQLNKKLfwLQNISDefLTKLYSQSSALIF 702
Cdd:cd03807  195 IVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHL--LGERSD--VPALLPAMDIFVL 270

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943491483 703 ASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHA-WYFSGEAPADIAKAVEDWLALYEQ 763
Cdd:cd03807  271 SSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDGTgFLVPAGDPQALADAIRALLEDPEK 332
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 124-338 3.68e-12

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 68.45  E-value: 3.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 124 ERADAIFAISRSSMQEVIDYTSIpAEKIINISSGVSdsfkIKDYTHDEIKDLRNKYHLPQE-FILSLAMIEPRKNIEALI 202
Cdd:cd03795  136 RRADRIIATSPNYVETSPTLREF-KNKVRVIPLGID----KNVYNIPRVDFENIKREKKGKkIFLFIGRLVYYKGLDYLI 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 203 HAysllphALQQSYPLVLAYkiSTDEKERLYRVAEnYGLSRNqLIFTGFLNDSDLIALYNLCKIFVFPSI--HEGFGLPP 280
Cdd:cd03795  211 EA------AQYLNYPIVIGG--EGPLKPDLEAQIE-LNLLDN-VKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVL 280

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 943491483 281 LEAMRCGAATLGSNV-TSLPEVI--GMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHA 338
Cdd:cd03795  281 LEAMMCGKPVISTNIgTGVPYVNnnGETGLVVPPKDPDALAEAIDKLLSDEELRESYGENA 341
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 127-338 7.84e-12

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 67.73  E-value: 7.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 127 DAIFAISRSSMQEVIDYtSIPAEKIINISSGV-----SDSFKIKDYTHDEIKDLRNKYHlpqefILSLAMIEPRKNIEAL 201
Cdd:cd03807  135 PATVANSSAVAEFHQEQ-GYAKNKIVVIYNGIdlfklSPDDASRARARRRLGLAEDRRV-----IGIVGRLHPVKDHSDL 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 202 IHAYSLLPHALQQsYPLVLAYKisTDEKERLYRVAENYGLsRNQLIFTGflNDSDLIALYNLCKIFVFPSIHEGFGLPPL 281
Cdd:cd03807  209 LRAAALLVETHPD-LRLLLVGR--GPERPNLERLLLELGL-EDRVHLLG--ERSDVPALLPAMDIFVLSSRTEGFPNALL 282

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 943491483 282 EAMRCGAATLGSNVTSLPEVIG-MEEALFNPLDVPDICRVMQRALTDSEFYSALKAHA 338
Cdd:cd03807  283 EAMACGLPVVATDVGGAAELVDdGTGFLVPAGDPQALADAIRALLEDPEKRARLGRAA 340
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 55-349 9.78e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 67.26  E-value: 9.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  55 AIANINPDVVFiinfyeGFDDSYTVSIPQTTVPWKTVCVCHdliplLNKERYLGEpnFRQYYYDKLAqYERADAIFAISR 134
Cdd:cd03820   82 YLKNNKPDVVI------SFRTSLLTFLALIGLKSKLIVWEH-----NNYEAYNKG--LRRLLLRRLL-YKRADKIVVLTE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 135 SsmqEVIDYTSIPAEKIINISSGVSDSFkikdytHDEIKDLRNKYhlpqefILSLAMIEPRKNIEALIHAYSLLphalQQ 214
Cdd:cd03820  148 A---DKLKKYKQPNSNVVVIPNPLSFPS------EEPSTNLKSKR------ILAVGRLTYQKGFDLLIEAWALI----AK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 215 SYPlvlAYKI----STDEKERLYRVAENYGLSrNQLIFTGFlnDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAAT 290
Cdd:cd03820  209 KHP---DWKLriygDGPEREELEKLIDKLGLE-DRVKLLGP--TKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPI 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943491483 291 LGSNVTSLPE--VIGMEEA-LFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDH 349
Cdd:cd03820  283 ISFDCPTGPSeiIEDGENGlLVPNGDVDALAEALLRLMEDEELRKKMGKNARKNAERFSIEK 344
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 621-737 4.29e-11

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 63.58  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 621 FIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKQGWHVDDL-CERLRHHPQLNKKLFWLqnISDEFLTKLYSQSSA 699
Cdd:cd01635  113 KVSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEaLAAALGLLERVVIIGGL--VDDEVLELLLAAADV 190

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 943491483 700 LIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQE 737
Cdd:cd01635  191 FVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVD 228
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 126-303 1.89e-10

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 63.23  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 126 ADAIFAISRSSMQEVIDYTSIPAEKIINISSGVS-DSFKikdYTHDEIKDLRNKYHLP-QEF-ILSLAMIEPRKNIEALI 202
Cdd:cd04951  131 CDITTNVSREALDEFIAKKAFSKNKSVPVYNGIDlNKFK---KDINVRLKIRNKLNLKnDEFvILNVGRLTEAKDYPNLL 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 203 HAYSLLpHALQQSYPLVLAYKisTDEKERLYRVAENYGLSRNqLIFTGFLndSDLIALYNLCKIFVFPSIHEGFGLPPLE 282
Cdd:cd04951  208 LAISEL-ILSKNDFKLLIAGD--GPLRNELERLICNLNLVDR-VILLGQI--SNISEYYNAADLFVLSSEWEGFGLVVAE 281

                        170       180
                 ....*....|....*....|.
gi 943491483 283 AMRCGAATLGSNVTSLPEVIG 303
Cdd:cd04951  282 AMACERPVVATDAGGVAEVVG 302
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 103-303 4.88e-10

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 62.74  E-value: 4.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 103 KERYLGEPNFR---QYYYDKLAQ---------YERADAIFAISRSSMQEVIDYTSiPAEKIINISSGVsdsfKIKDYthd 170
Cdd:cd03813  210 RERKIEILQSTwimGYIKKLWIRfferlgklaYQQADKIISLYEGNRRRQIRLGA-DPDKTRVIPNGI----DIQRF--- 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 171 eiKDLRNKYHLPQEFILSLAM-IEPRKNIEALIHAYSLLPHALqqsyPLVLAYKISTDEKERLY-----RVAENYGLsRN 244
Cdd:cd03813  282 --APAREERPEKEPPVVGLVGrVVPIKDVKTFIRAFKLVRRAM----PDAEGWLIGPEDEDPEYaqeckRLVASLGL-EN 354

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 943491483 245 QLIFTGFLNDSDLIALYNLckiFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIG 303
Cdd:cd03813  355 KVKFLGFQNIKEYYPKLGL---LVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIY 410
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 687-786 5.90e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 57.69  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 687 DEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQ--EHAWYFSGEAPADIAKAVEDWLALYE-- 762
Cdd:COG0438   11 DLLLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEdgETGLLVPPGDPEALAEAILRLLEDPElr 90

                         90       100
                 ....*....|....*....|....*...
gi 943491483 763 ----QNAHPRSEniNWLTWKQSAEFLLK 786
Cdd:COG0438   91 rrlgEAARERAE--ERFSWEAIAERLLA 116
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 619-729 1.27e-09

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 60.69  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 619 PSFIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGkqGWHVDDLCERLRHHPQLNKKLFWLQNISDefLTKLYSQSS 698
Cdd:cd03808  190 VVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVG--DGELENPSEILIEKLGLEGRIEFLGFRSD--VPELLAESD 265

                         90       100       110
                 ....*....|....*....|....*....|.
gi 943491483 699 ALIFASLGEGFGLPLIEAAQKKLPVIIRDIP 729
Cdd:cd03808  266 VFVLPSYREGLPRSLLEAMAAGRPVITTDVP 296
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 89-352 1.38e-09

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 60.82  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  89 KTVCVCHDLIPLLNKERYLGEPNFRQYYYDKL--AQYERADAIFAISRsSMQEVIDYTSIPAEKIINISSGVSDSFkIKD 166
Cdd:cd03794  125 PFILDVRDLWPESLIALGVLKKGSLLKLLKKLerKLYRLADAIIVLSP-GLKEYLLRKGVPKEKIIVIPNWADLEE-FKP 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 167 ythDEIKDLRNKYHLPQEFILSLA-MIEPRKNIEALIHAYSLlphaLQQSYPLVLAYKISTDEKERLYRVAENYGLSRNq 245
Cdd:cd03794  203 ---PPKDELRKKLGLDDKFVVVYAgNIGKAQGLETLLEAAER----LKRRPDIRFLFVGDGDEKERLKELAKARGLDNV- 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 246 lIFTGFLNDSDLIALYNLCKIFVFP---SIHEGFGLP--PLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDIC 318
Cdd:cd03794  275 -TFLGRVPKEEVPELLSAADVGLVPlkdNPANRGSSPskLFEYMAAGKPILASDDGGSDLAVEINGCglVVEPGDPEALA 353

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 943491483 319 RVMQRALTDSEFYSALKAHAPAQAA-KFTWDHTAQ 352
Cdd:cd03794  354 DAILELLDDPELRRAMGENGRELAEeKFSREKLAD 388
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 498-724 5.37e-09

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 58.93  E-value: 5.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 498 AH-LFPELTVQLDFIRLSGAKVCFVVH--DILPLRRPEWsdegmQRVFPIWlscIAQHADRLICVSASVAEDVKA--WIA 572
Cdd:cd03798  101 AHfAYPAGFAAALLARLYGVPYVVTEHgsDINVFPPRSL-----LRKLLRW---ALRRAARVIAVSKALAEELVAlgVPR 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 573 ENSHwVKPNPLLTvSNFHlGADLDASVPSTGmpdnaqallaamaaaPSFIMVGTMEPRKGHAQTLAAFEELWLQGKNYNL 652
Cdd:cd03798  173 DRVD-VIPNGVDP-ARFQ-PEDRGLGLPLDA---------------FVILFVGRLIPRKGIDLLLEAFARLAKARPDVVL 234

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 943491483 653 FIIG--KQGWHVDDLCERLRhhpqLNKKLFWLQNISDEFLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVI 724
Cdd:cd03798  235 LIVGdgPLREALRALAEDLG----LGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVV 304
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 429-730 4.24e-08

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 56.09  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 429 GIQRVSRSILSELLKsgvAGYTVSAVY-YRPGECYRYA------NEYLNTHFNGAFGPDVPVLF-----------TKDDI 490
Cdd:cd03820   14 GAERVAINLANHLAK---KGYDVTIISlDSAEKPPFYElddnikIKNLGDRKYSHFKLLLKYFKkvrrlrkylknNKPDV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 491 LVATDltahlfPELTVQLDFIRLsGAKVCFVVHdILPLRRPEWSDEGMQRVFpiwlscIAQHADRLICVSASVAEdvkaw 570
Cdd:cd03820   91 VISFR------TSLLTFLALIGL-KSKLIVWEH-NNYEAYNKGLRRLLLRRL------LYKRADKIVVLTEADKL----- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 571 iaeNSHWVKPNPLLTVSNFhlgADLDASVPSTGMPDNAqallaamaaapsFIMVGTMEPRKGHAQTLAAFEELWLQGKNY 650
Cdd:cd03820  152 ---KKYKQPNSNVVVIPNP---LSFPSEEPSTNLKSKR------------ILAVGRLTYQKGFDLLIEAWALIAKKHPDW 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 651 NLFIIGKqGwhvdDLCERLRH----HpQLNKKLFWL---QNISDEfltklYSQSSALIFASLGEGFGLPLIEAAQKKLPV 723
Cdd:cd03820  214 KLRIYGD-G----PEREELEKlidkL-GLEDRVKLLgptKNIAEE-----YANSSIFVLSSRYEGFPMVLLEAMAYGLPI 282


                 ....*..
gi 943491483 724 IIRDIPV 730
Cdd:cd03820  283 ISFDCPT 289
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 98-344 1.19e-07

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 54.77  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  98 IPLL----------NKERYLGEPNFRQYY--YDKLAQyERADAIFAISRSSMQEVIDyTSIPAEKIINISSGVsDSFKIK 165
Cdd:cd05844  105 VPLVvtfhgfdittSRAWLAASPGWPSQFqrHRRALQ-RPAALFVAVSGFIRDRLLA-RGLPAERIHVHYIGI-DPAKFA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 166 DYTHDEikdlrnkyhlPQEFILSLAMIEPRKNIEALIHAYSLLPHALQQSyPLVLAykisTDEKERLYRVAENYGLSRnq 245
Cdd:cd05844  182 PRDPAE----------RAPTILFVGRLVEKKGCDVLIEAFRRLAARHPTA-RLVIA----GDGPLRPALQALAAALGR-- 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 246 LIFTGFLNDSDLIALYNLCKIFVFPSI------HEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDI 317
Cdd:cd05844  245 VRFLGALPHAEVQDWMRRAEIFCLPSVtaasgdSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETgfLVPEGDVDAL 324

                        250       260
                 ....*....|....*....|....*..
gi 943491483 318 CRVMQRALTDSEFYSALKAHAPAQAAK 344
Cdd:cd05844  325 ADALQALLADRALADRMGGAARAFVCE 351
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 512-760 6.02e-07

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 52.36  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 512 RLSGAKVCFVVHDILPLRrpewsdegMQRVFPIWLSCIAqhADRLICVSASVAEdvkawIAENSHWVKPNPLLTVSNfhl 591
Cdd:cd03819   96 RLTGVPLVTTVHGSYLAT--------YHPKDFALAVRAR--GDRVIAVSELVRD-----HLIEALGVDPERIRVIPN--- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 592 GADLDASVPSTgmPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWLQgKNYNLFIIGKQgwHVDDLCERLRH 671
Cdd:cd03819  158 GVDTDRFPPEA--EAEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELKDE-PDFRLLVAGDG--PERDEIRRLVE 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 672 HPQLNKKLFWLQNISDefLTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEI--AQEHAWYFSGEAPAD 749
Cdd:cd03819  233 RLGLRDRVTFTGFRED--VPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIvvHGRTGLLVPPGDAEA 310

                        250
                 ....*....|.
gi 943491483 750 IAKAVEDWLAL 760
Cdd:cd03819  311 LADAIRAAKLL 321
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 192-360 8.67e-07

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 51.95  E-value: 8.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 192 IEPRKNIEALIHAYSLLPHalqQSYPLVLAykistdEKERLYRVAENYGLSRNQLIftGFLNDSDLIALYNLCKIFVFPS 271
Cdd:cd03823  200 LTEEKGIDLLVEAFKRLPR---EDIELVIA------GHGPLSDERQIEGGRRIAFL--GRVPTDDIKDFYEKIDVLVVPS 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 272 I-HEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA--LFNPLDVPDICRVMQRALTDSEFYSALKAHApaqAAKFTWD 348
Cdd:cd03823  269 IwPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNglLFAPGDAEDLAAAMRRLLTDPALLERLRAGA---EPPRSTE 345

                        170
                 ....*....|..
gi 943491483 349 HTAQLALKGFER 360
Cdd:cd03823  346 SQAEEYLKLYRD 357
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 621-751 9.55e-07

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 51.68  E-value: 9.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 621 FIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGkQGWHVDDLCERLRHHpQLNKKLFWLQNISDefLTKLYSQSSAL 700
Cdd:cd04951  191 ILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG-DGPLRNELERLICNL-NLVDRVILLGQISN--ISEYYNAADLF 266

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 943491483 701 IFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPADIA 751
Cdd:cd04951  267 VLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPVSDPQLLA 317
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 247-347 1.00e-06

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 52.02  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 247 IFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEA-----LFNPLDVPDICRVM 321
Cdd:PLN02871 315 VFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIPPDQEgktgfLYTPGDVDDCVEKL 394

                         90       100
                 ....*....|....*....|....*.
gi 943491483 322 QRALTDSEFYSALKAHAPAQAAKFTW 347
Cdd:PLN02871 395 ETLLADPELRERMGAAAREEVEKWDW 420
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 624-750 3.80e-06

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 49.98  E-value: 3.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 624 VGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKqgwhvDDLCERLRHHPQ---LNKKLFWLQNISDefLTKLYSQSSAL 700
Cdd:cd03812  197 VGRFNEQKNHSFLIDIFEELKKKNPNVKLVLVGE-----GELKEKIKEKVKelgLEDKVIFLGFRND--VSEILSAMDVF 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 943491483 701 IFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPADI 750
Cdd:cd03812  270 LFPSLYEGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFLPLNETPST 319
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 127-302 1.16e-05

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 48.61  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 127 DAIFAISRSSMQEVIDYTSIPAEKIINISSGVSDSFKIKDYTHDEikDLRnkyhlpqefILSLAMIEPRKNIEALIHAys 206
Cdd:cd04946  179 DAVFLISKEGKDYLQKCYPAYKEKIFVSRLGVSDKEQYSKVKKEG--DLR---------LVSCSSIVPVKRIDLIIET-- 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 207 llphaLQQSYPLVLAYKIS------TDEKERLYRVAENygLSRN-QLIFTGFLNDSDLIALY--NLCKIFVFPSIHEGFG 277
Cdd:cd04946  246 -----LNSLCVAHPSICISwthiggGPLKERLEKLAEN--KLENvKVNFTGEVSNKEVKQLYkeNDVDVFVNVSESEGIP 318

                        170       180
                 ....*....|....*....|....*
gi 943491483 278 LPPLEAMRCGAATLGSNVTSLPEVI 302
Cdd:cd04946  319 VSIMEAISFGIPVIATNVGGTREIV 343
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 112-316 2.05e-05

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 47.67  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 112 FRQYYYDKLAQYERA-DAIFAISRSSMQEVIdYTSIPAEKIINIssgvsdsfkikdythDEIKDLRNKYHLPQ-EFIL-S 188
Cdd:cd03812  133 IERLSTKYLACSEDAgEWLFGEVENGKFKVI-PNGIDIEKYKFN---------------KEKRRKRRKLLILEdKLVLgH 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 189 LAMIEPRKNIEALIHAYSLLpHALQQSYPLVLAYKISTDEKERLYrvAENYGLSRNqLIFTGFLND-SDLialYNLCKIF 267
Cdd:cd03812  197 VGRFNEQKNHSFLIDIFEEL-KKKNPNVKLVLVGEGELKEKIKEK--VKELGLEDK-VIFLGFRNDvSEI---LSAMDVF 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 943491483 268 VFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEALFnPLDVPD 316
Cdd:cd03812  270 LFPSLYEGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFL-PLNETP 317
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 185-287 2.76e-05

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 47.20  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 185 FILSLAMIEPRKNIEALIHAYSLLPHALQQSYP--LVLA--YkistDEK--------ERLYRVAENYGLSRNQLIFTGFL 252
Cdd:cd03805  213 FFLSINRFERKKNIALAIEAFAKLKQKLPEFENvrLVIAggY----DPRvaenveylEELQRLAEELLNVEDQVLFLRSI 288

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 943491483 253 NDSDLIALYNLCKIFVFPSIHEGFGLPPLEAMRCG 287
Cdd:cd03805  289 SDSQKEQLLSSALALLYTPSNEHFGIVPLEAMYAG 323
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 621-768 3.36e-05

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 46.88  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 621 FIMVGTMEPRKGHAQTLAAfeelwLQGKNYNLFIIGKqGWHVDDLCERLRHHpqLNKKLFWLQNISDEFLTKLYSQSSAL 700
Cdd:cd03795  194 FLFIGRLVYYKGLDYLIEA-----AQYLNYPIVIGGE-GPLKPDLEAQIELN--LLDNVKFLGRVDDEEKVIYLHLCDVF 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 701 IFASL--GEGFGLPLIEAAQKKLPVIIRDIP---VFKEIAQEHAWYFSGEAPADIAKAVeDWL----ALYEQ---NAHPR 768
Cdd:cd03795  266 VFPSVlrSEAFGIVLLEAMMCGKPVISTNIGtgvPYVNNNGETGLVVPPKDPDALAEAI-DKLlsdeELRESygeNAKKR 344
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 619-754 7.01e-05

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 45.82  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 619 PSFIMVGTMEPRKGHAQTLAAFEELWLQGKNYNLFIIGKqgwhvDDLCERLRHHPQ----LNKKLFWLQNISDEFLTKLY 694
Cdd:cd03821  205 RIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGP-----DDGAYPAFLQLQsslgLGDRVTFTGPLYGEAKWALY 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 695 SQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPADIAKAV 754
Cdd:cd03821  280 ASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEAL 339
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 146-359 1.75e-04

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 44.68  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 146 IPAEKIINISSGVSDSFKIKDYTHDEIKDLRNKYhlpqeFILSLAMIEPRKNIEALIHAYSLLPHALQQSYPLVLAYKIS 225
Cdd:cd03822  155 IPAVNIEVIPHGVPEVPQDPTTALKRLLLPEGKK-----VILTFGFIGPGKGLEILLEALPELKAEFPDVRLVIAGELHP 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 226 TDEKER----LYRVAENYGLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSIHEGFGLPplEAMRCGAATlGSNVTSLP-- 299
Cdd:cd03822  230 SLARYEgeryRKAAIEELGLQDHVDFHNNFLPEEEVPRYISAADVVVLPYLNTEQSSS--GTLSYAIAC-GKPVISTPlr 306

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 943491483 300 ----EVIGMEEALFNPLDVPDICRVMQRALTDSEFYSALKAHAPAQAAKFTWDHTAQLALKGFE 359
Cdd:cd03822  307 haeeLLADGRGVLVPFDDPSAIAEAILRLLEDDERRQAIAERAYAYARAMTWESIADRYLRLFN 370
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 112-295 2.15e-04

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 44.21  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 112 FRQYYYDKLAQYERADAIFAIS---RSSMQEVIDYTsipaEKIINISSGVSDSFKIKDYTHDeikdlRNKYHlpqefILS 188
Cdd:cd04949  100 IKNFYKYVFENLNKYDAIIVSTeqqKQDLSERFNKY----PPIFTIPVGYVDQLDTAESNHE-----RKSNK-----IIT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 189 LAMIEPRKNIEALIHAYSLlphALQQSYPLVLAYKISTDEKERLYRVAENYGLSrNQLIFTGFLNDsdLIALYNLCKIFV 268
Cdd:cd04949  166 ISRLAPEKQLDHLIEAVAK---AVKKVPEITLDIYGYGEEREKLKKLIEELHLE-DNVFLKGYHSN--LDQEYQDAYLSL 239

                        170       180
                 ....*....|....*....|....*..
gi 943491483 269 FPSIHEGFGLPPLEAMRCGAATLGSNV 295
Cdd:cd04949  240 LTSQMEGFGLTLMEAIGHGLPVVSYDV 266
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 182-302 2.41e-04

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 44.20  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 182 PQEFILSLAMIEPRKNIEALIHAysllphALQQSYPLVLAYKIstDEKERLYRVAENYGLSRNQliFTGFLNDSDLIALY 261
Cdd:cd03802  168 PEDYLAFLGRIAPEKGLEDAIRV------ARRAGLPLKIAGKV--RDEDYFYYLQEPLPGPRIE--FIGEVGHDEKQELL 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 943491483 262 NLCKIFVFPSI-HEGFGLPPLEAMRCGAATLGSNVTSLPEVI 302
Cdd:cd03802  238 GGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVI 279
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
41-158 3.01e-04

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 42.13  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483   41 NHPRSVAATLARELAIANINPDVVfIINFYEGFDDSYTVSIPQTTVPwkTVCVCHDLIPLlnKERYLGEPNFRQYYYDKL 120
Cdd:pfam13439  52 RLLRSLAFLRRLRRLLRRERPDVV-HAHSPFPLGLAALAARLRLGIP--LVVTYHGLFPD--YKRLGARLSPLRRLLRRL 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 943491483  121 AQ--YERADAIFAISRSSMQEVIDYTSIPAEKIINISSGV 158
Cdd:pfam13439 127 ERrlLRRADRVIAVSEAVADELRRLYGVPPEKIRVIPNGV 166
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 51-299 4.60e-04

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 43.46  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  51 ARELAIANINPDVVFIinfyegfDDSYTVSIP----QTTVPWktVCVCHDLIpllnkERYLGEPNFRQYYYdkLAQY-ER 125
Cdd:cd03792   78 ASRYPLLDGDADVVVI-------HDPQPALLPkikkKRDRKW--IWRCHIDI-----STPLTEPQPRVWDF--LWNYiEG 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 126 ADA-IFAISRSSMQEV-IDYTSIPAEkiINISSGvsdsfKIKDYTHDEIKDLRNKYHL--PQE-FILSLAMIEPRKNIEA 200
Cdd:cd03792  142 YDLfVFHPPEFVPPQVpPPKFYIPPS--IDPLSG-----KNKDLSPADIRYYLEKPFVidPERpYILQVARFDPSKDPLG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 201 LIHAYSLLpHALQQSYPLVLAYKISTD--EKERLYR-VAENYGLSRNqlIFTGFLNDSDLI--ALYNLCKIFVFPSIHEG 275
Cdd:cd03792  215 VIDAYKLF-KRRAEEPQLVICGHGAVDdpEGSVVYEeVMEYAGDDHD--IHVLRLPPSDQEinALQRAATVVLQLSTREG 291

                        250       260
                 ....*....|....*....|....
gi 943491483 276 FGLPPLEAMRCGAATLGSNVTSLP 299
Cdd:cd03792  292 FGLTVSEALWKGKPVIATPAGGIP 315
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 690-729 2.34e-03

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 40.75  E-value: 2.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 943491483 690 LTKLYSQSSALIFASLGEGFGLPLIEAAQKKLPVIIRDIP 729
Cdd:cd04949  228 LDQEYQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVK 267
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 183-287 2.98e-03

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 40.73  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 183 QEFILSLAMIEPRKNIEALIHAYSLLPhalqqsYPLVLaykISTDEKERLYRvaenyGLSRNQLIFTGFLNDSDLIALYN 262
Cdd:cd03804  199 EDYYLTASRLVPYKRIDLAVEAFNELP------KRLVV---IGDGPDLDRLR-----AMASPNVEFLGYQPDEVLKELLS 264

                         90       100
                 ....*....|....*....|....*
gi 943491483 263 LCKIFVFPSiHEGFGLPPLEAMRCG 287
Cdd:cd03804  265 KARAFVFAA-EEDFGIVPVEAQACG 288
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 240-344 3.23e-03

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 40.81  E-value: 3.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 240 GLSRNQLIFTGFLNDSDLIALYNLCKIFVFPSihEGF----GLppLEAMRCGAATLGSNVTSLPEVI-GMEEALFNPLDV 314
Cdd:cd03818  277 GVDLERVHFVGKVPYDQYVRLLQLSDAHVYLT--YPFvlswSL--LEAMACGCPVIGSDTAPVREVIrDGRNGLLVDFFD 352

                         90       100       110
                 ....*....|....*....|....*....|.
gi 943491483 315 PD-ICRVMQRALTDSEFYSALKAHAPAQAAK 344
Cdd:cd03818  353 PDaLAAAVLELLEDPDRAAALRRAARRTVER 383
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
497-596 3.80e-03

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 39.05  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483  497 TAHLFPELTVQLDFIRLSGAKVCFVVHDILPLRRPEWSDEGMQRVFPIWLSC-IAQHADRLICVSASVAEDVKAWiaens 575
Cdd:pfam13439  77 AHSPFPLGLAALAARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRRLERrLLRRADRVIAVSEAVADELRRL----- 151

                          90       100
                  ....*....|....*....|.
gi 943491483  576 HWVKPNPLLTVSNfhlGADLD 596
Cdd:pfam13439 152 YGVPPEKIRVIPN---GVDLE 169
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 266-373 5.39e-03

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 39.91  E-value: 5.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943491483 266 IFVFPSIHEGFGLPPLEAMRCGAATLGSNVTSLPEVIGMEEALFNPLDVPDICRVMQRALTD--------SEFYSALKAH 337
Cdd:cd03796  272 IFLNTSLTEAFCIAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISIlrtgkhdpWSFHNRVKKM 351

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 943491483 338 apaqaakFTWDHTAqlalKGFERLVDNASTSEPLDI 373
Cdd:cd03796  352 -------YSWEDVA----RRTEKVYDRILSTPNRPF 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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