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Conserved domains on  [gi|1033478218|dbj|BAV13198|]
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c-type lysozyme [Aulonocara sp. 'yellow']

Protein Classification

lysozyme family protein; lytic transglycosylase domain-containing protein( domain architecture ID 11261915)

lysozyme family protein; lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
17-142 6.47e-73

Alpha-lactalbumin / lysozyme C;


:

Pssm-ID: 197612  Cd Length: 127  Bit Score: 213.69  E-value: 6.47e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218   17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIR-SANGCNIDC 95
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNGGSTDYGIFQINSKYWCNDGKTPgSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1033478218   96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQGQDLRPYLSGCG 142
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCQGEDLSQWIRGCG 127
 
Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
17-142 6.47e-73

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 213.69  E-value: 6.47e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218   17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIR-SANGCNIDC 95
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNGGSTDYGIFQINSKYWCNDGKTPgSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1033478218   96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQGQDLRPYLSGCG 142
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCQGEDLSQWIRGCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 17-141 1.23e-72

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 213.28  E-value: 1.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIRSANGCNIDCN 96
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPDGSTDYGIFQINSRYWCNDGKTPSKNLCHISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1033478218  97 VLLTDDVTPAINCAKRIVRE-QGITAWVAWRTRCQGQDLRPYLSGC 141
Cdd:cd16897    81 DLLNDDITDDIKCAKKIVKDpQGMGAWVAWRLHCEGRDLSRWLDGC 126
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 17-139 5.74e-59

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 178.38  E-value: 5.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNtDGSTDFGIFQINSRWWCNDRRIRSA-NGCNIDC 95
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYN-NGSTDYGIFQINDKYWCKDGKTPQSvNICGISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1033478218  96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQgQDLRPYLS 139
Cdd:pfam00062  80 DKLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCS-EDLEQWIG 122
PRK15328 PRK15328
type III secretion system invasion protein IagB;
5-76 7.10e-05

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 40.62  E-value: 7.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1033478218   5 FVFLLLITVASAKVFERCdWARKLKANGMDGYGGVSLANwvcltkHESNYNTKATNRNTDGSTDFGIFQINS 76
Cdd:PRK15328    4 FFIIVIWLLSINTAWADC-WLQAEKMFNIESELLYAIAQ------QESAMKPGAIGHNRDGSTDLGLMQINS 68
 
Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
17-142 6.47e-73

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 213.69  E-value: 6.47e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218   17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIR-SANGCNIDC 95
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNGGSTDYGIFQINSKYWCNDGKTPgSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1033478218   96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQGQDLRPYLSGCG 142
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCQGEDLSQWIRGCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 17-141 1.23e-72

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 213.28  E-value: 1.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIRSANGCNIDCN 96
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPDGSTDYGIFQINSRYWCNDGKTPSKNLCHISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1033478218  97 VLLTDDVTPAINCAKRIVRE-QGITAWVAWRTRCQGQDLRPYLSGC 141
Cdd:cd16897    81 DLLNDDITDDIKCAKKIVKDpQGMGAWVAWRLHCEGRDLSRWLDGC 126
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 17-139 5.74e-59

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 178.38  E-value: 5.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNRNtDGSTDFGIFQINSRWWCNDRRIRSA-NGCNIDC 95
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYN-NGSTDYGIFQINDKYWCKDGKTPQSvNICGISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1033478218  96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQgQDLRPYLS 139
Cdd:pfam00062  80 DKLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCS-EDLEQWIG 122
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 17-139 8.40e-51

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 157.73  E-value: 8.40e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGmdGYGGVSLANWVCLTKHESNYNTKATNRNTDGSTDFGIFQINSRWWCNDRRIRSA-NGCNIDC 95
Cdd:cd00119     1 KVFTRCELARLLKDIG--GYGGISLPNWVCLMKHESGYDTQATNENNNGSTDYGLFQINSRYWCKDGQTPGArNICDISC 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1033478218  96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQGQdLRPYLS 139
Cdd:cd00119    79 SKLLTDDITDAIMCAKKIVDDKGIDAWVAWKNHCQNK-LRQYVS 121
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 17-141 1.34e-49

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 154.69  E-value: 1.34e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  17 KVFERCDWARKLKANGMDGyggVSLANWVCLTKHESNYNTKATNR-NTDGSTDFGIFQINSRWWCNDRRiRSANGCNIDC 95
Cdd:cd16899     1 KIFTRCELARELRKLGVPR---SQLANWVCLAEHESSFNTTAVGGpNSDGSGDYGLFQINDKYWCSPGG-GSGNGCNVKC 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1033478218  96 NVLLTDDVTPAINCAKRIVREQGITAWVAWRTRCQGQDLrPYLSGC 141
Cdd:cd16899    77 EDLLDDDISDDVKCAKKIYKEQGFNAWVGWKNKCKGKNL-PSYSDC 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 19-131 2.69e-38

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 126.01  E-value: 2.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1033478218  19 FERCDWARKLKANGMDGYGGVSLANWVCLTKHESNYNTKATNrNTDGSTDFGIFQINSRWWCNDRRI-RSANGCNIDCNV 97
Cdd:cd16898     3 FTKCELSQILKEHGLDGFNGISLPEWICVTFHTSGYDTQALV-YNNGSTEYGLFQISNKGWCDDSQEpVSRNICGISCSK 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1033478218  98 LLTDDVTPAINCAKRIVRE-QGITAWVAWRTRCQG 131
Cdd:cd16898    82 LLDDDITDDIACAKKILAIpKGIDYWKAHKPFCRE 116
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 49-79 1.80e-08

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 49.06  E-value: 1.80e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1033478218  49 KHESNYNTKATNRNTDGSTDFGIFQINSRWW 79
Cdd:cd13400    13 KVESGFNPNAINRNKNGSYDIGLMQINSIWL 43
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 43-113 1.36e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 43.17  E-value: 1.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1033478218  43 NWVCLTKHESNYNTKAtnRNTDGSTDFGIFQINSRWWCNDRRIRSANgcnidcnvllTDDVTPAINCAKRI 113
Cdd:cd00442     1 VLAAIIGQESGGNKPA--NAGSGSGAAGLFQFMPGTWKAYGKNSSSD----------LNDPEASIEAAAKY 59
PRK15328 PRK15328
type III secretion system invasion protein IagB;
5-76 7.10e-05

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 40.62  E-value: 7.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1033478218   5 FVFLLLITVASAKVFERCdWARKLKANGMDGYGGVSLANwvcltkHESNYNTKATNRNTDGSTDFGIFQINS 76
Cdd:PRK15328    4 FFIIVIWLLSINTAWADC-WLQAEKMFNIESELLYAIAQ------QESAMKPGAIGHNRDGSTDLGLMQINS 68
Phage_lysozyme2 pfam18013
Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of ...
 28-84 4.15e-03

Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.


Pssm-ID: 465617  Cd Length: 139  Bit Score: 35.35  E-value: 4.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1033478218  28 LKANGMDGYG--GVsLANWVcltkHESNYNTKATNRNTDGSTDFGIFQinsrwWCNDRR 84
Cdd:pfam18013  10 LKSKGYSKAAaaGI-LGNMQ----RESGFNPGAVEDEGGGGGGYGLVQ-----WTGGRK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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