leptin receptor, partial [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ObR_Ig super family | cl39908 | Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ... |
2-41 | 8.12e-06 | ||
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity. The actual alignment was detected with superfamily member pfam18589: Pssm-ID: 465812 Cd Length: 105 Bit Score: 38.48 E-value: 8.12e-06
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| Name | Accession | Description | Interval | E-value | ||
| ObR_Ig | pfam18589 | Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ... |
2-41 | 8.12e-06 | ||
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity. Pssm-ID: 465812 Cd Length: 105 Bit Score: 38.48 E-value: 8.12e-06
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| Name | Accession | Description | Interval | E-value | ||
| ObR_Ig | pfam18589 | Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ... |
2-41 | 8.12e-06 | ||
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity. Pssm-ID: 465812 Cd Length: 105 Bit Score: 38.48 E-value: 8.12e-06
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