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Conserved domains on  [gi|1836651091|dbj|BBO93537|]
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acyltransferase 3 [Actinobacillus pleuropneumoniae]

Protein Classification

acyltransferase( domain architecture ID 10004639)

acyltransferase catalyzes the acylation of various substrates including peptidoglycan and sugars; similar to Exopolysaccharide production protein ExoZ required for the acetyl modification of the third sugar (glucose) of the octasaccharide subunit of succinoglycan (EPS I)

EC:  2.3.-.-
Gene Ontology:  GO:0016747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
 2-159 2.59e-18

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441440  Cd Length: 309  Bit Score: 79.30  E-value: 2.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091   2 ITSIQYLRGIAALFVVLFHMkwmlnNVYVEKNLGDIFFISGNFGVDLFFVISGFVICLSTERE---TLHSVKEFFIRRFF 78
Cdd:COG1835     8 LPSLDGLRGLAALLVVLYHA-----FLLFPPGPLGGLLSGGFLGVDVFFVLSGFLITRSLLRRlerGGFSLRRFYLRRFL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091  79 RIYPLLLLSVCtiyilgdfkihelilsmipihldysspspvfgynILVSAWTITYEISFYIIFVLSLMINHRFRCELTIL 158
Cdd:COG1835    83 RIYPAYLVVLL----------------------------------LTGHLWSLSVELQFYLLFPLLLLLLRRLRRRLLAL 128


                  .
gi 1836651091 159 F 159
Cdd:COG1835   129 L 129
 
Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
 2-159 2.59e-18

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441440  Cd Length: 309  Bit Score: 79.30  E-value: 2.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091   2 ITSIQYLRGIAALFVVLFHMkwmlnNVYVEKNLGDIFFISGNFGVDLFFVISGFVICLSTERE---TLHSVKEFFIRRFF 78
Cdd:COG1835     8 LPSLDGLRGLAALLVVLYHA-----FLLFPPGPLGGLLSGGFLGVDVFFVLSGFLITRSLLRRlerGGFSLRRFYLRRFL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091  79 RIYPLLLLSVCtiyilgdfkihelilsmipihldysspspvfgynILVSAWTITYEISFYIIFVLSLMINHRFRCELTIL 158
Cdd:COG1835    83 RIYPAYLVVLL----------------------------------LTGHLWSLSVELQFYLLFPLLLLLLRRLRRRLLAL 128


                  .
gi 1836651091 159 F 159
Cdd:COG1835   129 L 129
Acyl_transf_3 pfam01757
Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain ...
 2-152 3.20e-06

Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyze the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans.


Pssm-ID: 426413 [Multi-domain]  Cd Length: 330  Bit Score: 45.62  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091   2 ITSIQYLRGIAALFVVLFHMKWMLNNVYVEKNLGDIFF---ISGNFGVDLFFVISGFVICLSTERetLHSVKEFFIRRFF 78
Cdd:pfam01757   1 IAYLDLLRGIAILLVVIGHVLLAFGYGGFGLPLELALLflvFLGRFGVPLFFFISGYLLAALRRR--RRSLFKFIKKRLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1836651091  79 RIYPLLLLSVCTIYILGDFKIHElILSMIPIHLDYSSPSPVFGYNILVSAWTITYEISFYIIFVLSLMINHRFR 152
Cdd:pfam01757  79 RLLIPYLLWSLLYALLLLLVAGL-SVGGALLLLLLLNNGPLFFLGVNGHLWFLSALFVFYLLLPLLLRLLRKLK 151
 
Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
 2-159 2.59e-18

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441440  Cd Length: 309  Bit Score: 79.30  E-value: 2.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091   2 ITSIQYLRGIAALFVVLFHMkwmlnNVYVEKNLGDIFFISGNFGVDLFFVISGFVICLSTERE---TLHSVKEFFIRRFF 78
Cdd:COG1835     8 LPSLDGLRGLAALLVVLYHA-----FLLFPPGPLGGLLSGGFLGVDVFFVLSGFLITRSLLRRlerGGFSLRRFYLRRFL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091  79 RIYPLLLLSVCtiyilgdfkihelilsmipihldysspspvfgynILVSAWTITYEISFYIIFVLSLMINHRFRCELTIL 158
Cdd:COG1835    83 RIYPAYLVVLL----------------------------------LTGHLWSLSVELQFYLLFPLLLLLLRRLRRRLLAL 128


                  .
gi 1836651091 159 F 159
Cdd:COG1835   129 L 129
Acyl_transf_3 pfam01757
Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain ...
 2-152 3.20e-06

Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyze the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans.


Pssm-ID: 426413 [Multi-domain]  Cd Length: 330  Bit Score: 45.62  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1836651091   2 ITSIQYLRGIAALFVVLFHMKWMLNNVYVEKNLGDIFF---ISGNFGVDLFFVISGFVICLSTERetLHSVKEFFIRRFF 78
Cdd:pfam01757   1 IAYLDLLRGIAILLVVIGHVLLAFGYGGFGLPLELALLflvFLGRFGVPLFFFISGYLLAALRRR--RRSLFKFIKKRLL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1836651091  79 RIYPLLLLSVCTIYILGDFKIHElILSMIPIHLDYSSPSPVFGYNILVSAWTITYEISFYIIFVLSLMINHRFR 152
Cdd:pfam01757  79 RLLIPYLLWSLLYALLLLLVAGL-SVGGALLLLLLLNNGPLFFLGVNGHLWFLSALFVFYLLLPLLLRLLRKLK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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