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Conserved domains on  [gi|2637|emb|CAA26663|]
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unnamed protein product, partial [Wickerhamomyces anomalus]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637801)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0003700
PubMed:  9290251|16959962

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 194-238 4.42e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 54.67  E-value: 4.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2637        194 KGNPNPCDHCRRRQIKCITVPNlsNCVQCETKGIKCTHSESPSNP 238
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKP--PCSNCIKLGLECTYSDSKKRK 43
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 357-412 9.57e-07

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 50.52  E-value: 9.57e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2637     357 PHGQSLVNTYFKIIHPSFPILHRKVFLEKYARSYREFSAP------LLAAVYSLAIQWWDQD 412
Cdd:cd12148   4 EVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspaslaLLLAVLALAALSLPDS 65
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 194-238 4.42e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 54.67  E-value: 4.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2637        194 KGNPNPCDHCRRRQIKCITVPNlsNCVQCETKGIKCTHSESPSNP 238
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKP--PCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 197-232 3.46e-07

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 46.12  E-value: 3.46e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 2637     197 PNPCDHCRRRQIKCITVPNlsNCVQCETKGIKCTHS 232
Cdd:cd00067   3 RRACDRCRRRKIKCDGEKP--PCSNCIKLGLECTYS 36
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 357-412 9.57e-07

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 50.52  E-value: 9.57e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2637     357 PHGQSLVNTYFKIIHPSFPILHRKVFLEKYARSYREFSAP------LLAAVYSLAIQWWDQD 412
Cdd:cd12148   4 EVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspaslaLLLAVLALAALSLPDS 65
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
199-238 2.46e-05

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 41.13  E-value: 2.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2637       199 PCDHCRRRQIKCITvpNLSNCVQCETKGIKCTHSESPSNP 238
Cdd:pfam00172   2 ACDNCRKRKVKCDG--KKPACSRCIKNGLECTYSRKSKKS 39
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 363-412 6.19e-05

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 44.40  E-value: 6.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2637       363 VNTYFKIIHPSFPILHRKVFLEKYARSYREFSAP----LLAAVYSLAIQWWDQD 412
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNYasplLLLAILALGALFSESP 54
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 194-238 4.42e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 54.67  E-value: 4.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2637        194 KGNPNPCDHCRRRQIKCITVPNlsNCVQCETKGIKCTHSESPSNP 238
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKP--PCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 197-232 3.46e-07

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 46.12  E-value: 3.46e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 2637     197 PNPCDHCRRRQIKCITVPNlsNCVQCETKGIKCTHS 232
Cdd:cd00067   3 RRACDRCRRRKIKCDGEKP--PCSNCIKLGLECTYS 36
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 357-412 9.57e-07

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 50.52  E-value: 9.57e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2637     357 PHGQSLVNTYFKIIHPSFPILHRKVFLEKYARSYREFSAP------LLAAVYSLAIQWWDQD 412
Cdd:cd12148   4 EVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspaslaLLLAVLALAALSLPDS 65
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
199-238 2.46e-05

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 41.13  E-value: 2.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2637       199 PCDHCRRRQIKCITvpNLSNCVQCETKGIKCTHSESPSNP 238
Cdd:pfam00172   2 ACDNCRKRKVKCDG--KKPACSRCIKNGLECTYSRKSKKS 39
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 363-412 6.19e-05

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 44.40  E-value: 6.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2637       363 VNTYFKIIHPSFPILHRKVFLEKYARSYREFSAP----LLAAVYSLAIQWWDQD 412
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNYasplLLLAILALGALFSESP 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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