|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
8-426 |
6.48e-168 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 477.44 E-value: 6.48e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGG 87
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 88 LGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADA--------E 159
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAggadwlgaE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 160 AWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwvRP 239
Cdd:cd17359 161 GWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG--------------------------------------------KP 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 240 ALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISL 319
Cdd:cd17359 197 ILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 320 IVLALVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEA 399
Cdd:cd17359 277 LLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAA 356
|
410 420
....*....|....*....|....*..
gi 225185403 400 IGISYLFLIYAAIGIMAFLFVRFKVTE 426
Cdd:cd17359 357 FGLAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
11-439 |
3.35e-123 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 366.21 E-value: 3.35e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMK-----------KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAA 79
Cdd:pfam00083 3 LVAALGGFLFGYDTGVIGAFLTLIDffknfglsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 80 ALLFCIGGLGVALAPNT---GVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFA 156
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGKwsvYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 157 ---DAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDIKEAEKQDEGG----L 229
Cdd:pfam00083 163 ktsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAekasW 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 230 KELFDPW-VRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFgnSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLL 308
Cdd:pfam00083 243 KELFSTKtRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 309 LFGNAGMVISLIVLALVNLFF-DNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTL 387
Cdd:pfam00083 321 LLGAAGMAICFVILGIVALLGvSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANF 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 225185403 388 IVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDL 439
Cdd:pfam00083 401 LIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
12-426 |
2.70e-115 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 342.63 E-value: 2.70e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALYGYDTGVISGAILFMKKEL--GLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLG 89
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 90 VALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFA--DAEAWRWMLGL 167
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsPPGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 168 AAVPSLLLLIGILFMPESprwlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwvrPALIAGLGL 247
Cdd:cd17315 161 AAVPALLQLLLMFFLPES-----------------------------------------------------RALLVGVGL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 248 AFLQQFIGTNTIIYYAPKTFTNVGfGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNL 327
Cdd:cd17315 188 QLLQQLTGINAVMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 328 FFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFL 407
Cdd:cd17315 267 LPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFI 346
|
410
....*....|....*....
gi 225185403 408 IYAAIGIMAFLFVRFKVTE 426
Cdd:cd17315 347 FFAAVCLLALVFVFFFVPE 365
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
1-435 |
3.11e-113 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 341.63 E-value: 3.11e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 1 MKKQSNIWLYFFG----ALGGALYGYDTGVISGAILFMKKEL--------GLNAFTEGLVVSSLLVGAILGSGAAGKLTD 68
Cdd:TIGR00879 17 AGLGSTYWKVALLsliaAIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAGWLSD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 69 RFGRKKAIMAAALLFCIGGLG---VALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGI 145
Cdd:TIGR00879 97 RFGRKKSLLIIALLFVIGAILmglAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 146 LLSYIVNY---IFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDIKEAE 222
Cdd:TIGR00879 177 LVAYGFGSgkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 223 K-----------QDEGGLKELFdPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLM 291
Cdd:TIGR00879 257 DikrsiekrsvqPSWGSLFSST-RRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 292 TLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNT--PAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLH 369
Cdd:TIGR00879 336 TFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGssKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLS 415
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 370 VRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEI 435
Cdd:TIGR00879 416 LRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
12-435 |
5.36e-110 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 330.08 E-value: 5.36e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALYGYDTGVISGAILFMKKEL-------GLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFC 84
Cdd:cd17362 1 FPALGGLLFGYDIGATSGALLSITSPAlsgtdwyNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 85 IGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAE-AWRW 163
Cdd:cd17362 81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVgGWRY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 164 MLGLAAVPSLLLLIGILFMPESPRWlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfDPWVRPALIA 243
Cdd:cd17362 161 MYGLAAPPALLLGIGMWFLPPSPRW---------------------------------------------QGNYRKPLII 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 244 GLGLAFLQQFIGTNTIIYYAPKTFTNVGF-GNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVL 322
Cdd:cd17362 196 GLGLVLFQQITGQPSVLYYAATIFKSAGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFLL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 323 ALVNLFFDNTPAA-SWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIG 401
Cdd:cd17362 276 AAYNLFVQMGPAGlAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIG 355
|
410 420 430
....*....|....*....|....*....|....
gi 225185403 402 ISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEI 435
Cdd:cd17362 356 LPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
11-434 |
7.26e-105 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 318.75 E-value: 7.26e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKKE----LGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17358 5 FVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAdaeaWRWMLG 166
Cdd:cd17358 85 WLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 167 LAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTK-DIDQEIHDIKEAEKQ-----DEGGLKELFDPWVRPA 240
Cdd:cd17358 161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDaDISKEAAEIQEELAElekeaKESSFSDLFQRKYLKP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 241 LIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASIlGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLI 320
Cdd:cd17358 241 LVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNT-ATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 321 VLALVNLFFDNTPAA---SWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILM 397
Cdd:cd17358 320 ALGLYFYLQEHGALLssvSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLT 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 225185403 398 EAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEE 434
Cdd:cd17358 400 LAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
12-426 |
1.69e-102 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 309.97 E-value: 1.69e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALYGYDTGVISGAILFMKKELGLNAFTEG---LVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGL 88
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 89 GVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAE-AWRWMLGL 167
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPgGWRWMLGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 168 AAVPSLLLLIGILFMPESPRWlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfdPWVRPALIAGLGL 247
Cdd:cd17360 161 AAVPAVLQFIGLLFLPESPRW----------------------------------------------PSTRRALIVGCGL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 248 AFLQQFIGTNTIIYYAPKTFTNVGF-GNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvn 326
Cdd:cd17360 195 QAFQQFSGINTVMYYSATILQMAGFkDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLAV-- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 327 lffdntpaasWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLF 406
Cdd:cd17360 273 ----------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTF 342
|
410 420
....*....|....*....|
gi 225185403 407 LIYAAIGIMAFLFVRFKVTE 426
Cdd:cd17360 343 LLFAGLAVLGLIFIYFCVPE 362
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
1-436 |
4.37e-99 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 305.08 E-value: 4.37e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 1 MKKQSNIwLYFFG-----ALGGALYGYDTGVISGAILFMKK--------ELGLNAFTEGLVVSSLLVGAILGSGAAGKLT 67
Cdd:PRK10077 1 MNTQYNS-SYIFSitlvaTLGGLLFGYDTAVISGTVESLNTvfvapqnlSESAANSLLGFCVASALIGCIIGGALGGYCS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 68 DRFGRKKAIMAAALLFCIGGLGVAL---------APNTGVM---VLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSS 135
Cdd:PRK10077 80 NRFGRRDSLKIAAVLFFISALGSAWpefgftsigPDNTGYVpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 136 LNQLMITVGILLSYIVNYIFADAEA--------WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRG 207
Cdd:PRK10077 160 FNQFAIIFGQLVVYFVNYFIARSGDaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 208 TKDIDQEIHDIKEAEKQDEGGLKELFDPWVRPALIaGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTV 287
Cdd:PRK10077 240 NTLATQALQEIKHSLDHGRKTGGKLLMFGVGVIVI-GVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIVGVI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 288 NVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVnlffDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFP 367
Cdd:PRK10077 319 NLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTA----FYTQAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFP 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225185403 368 LHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAI--------GISYlfLIYAAIGIMAFLFVRFKVTETKGRSLEEIE 436
Cdd:PRK10077 395 NAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSwlvahfhnGFSY--WIYGCMGVLAALFMWKFVPETKGKTLEEME 469
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
14-430 |
9.57e-88 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 274.91 E-value: 9.57e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGAL-YGYDTGVISGAILFMKK------------ELGLNAFTE--GLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMA 78
Cdd:cd17357 5 AFGGSFqFGYNIGVVNAPQEVFKEfindtlvdryglNLSDSELDLlwSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 79 AALLFCIGGL--GVALAPNTGVMVLF-RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVN--Y 153
Cdd:cd17357 85 SNALLVVSSLlmFLSKSAKSPELLIFgRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGlpS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 154 IFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTN-GEESKAKKILEKLRGTKDID----QEIHDIKEAEKQDEGG 228
Cdd:cd17357 165 VLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEEEAEKSLKFLRGIEDDVdqelEEIKKESEQMGDQKQV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 229 -LKELF-DPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKP 306
Cdd:cd17357 245 sLMQLLrDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 307 LLLFGNAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGT 386
Cdd:cd17357 325 LLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSN 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 225185403 387 LIVSLTYPILMEAIGIsYLFLIYAAIGIMAFLFVRFKVTETKGR 430
Cdd:cd17357 405 FIVGMAFPPLQSIGGG-FVFIIFAIPCALFLLYLYRYLPETKGR 447
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
12-435 |
1.37e-85 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 267.34 E-value: 1.37e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVA 91
Cdd:cd17437 1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 92 LAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA---WRWMLGLA 168
Cdd:cd17437 81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLhvgWRLMLGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 169 AVPSLLLLIGILFMPESPRWlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfDPWVRPALIAGLGLA 248
Cdd:cd17437 161 AVPSLFLAIGVLAMPESPRW---------------------------------------------TPAVRRMLIAALGIH 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 249 FLQQFIGTNTIIYYAPKTFTNVGFGNSASILG-TVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNL 327
Cdd:cd17437 196 FFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLaTVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSLT 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 328 FFDNTP----AASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGIS 403
Cdd:cd17437 276 FIDRNGggltWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTG 355
|
410 420 430
....*....|....*....|....*....|..
gi 225185403 404 YLFLIYAAIGIMAFLFVRFKVTETKGRSLEEI 435
Cdd:cd17437 356 GTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
8-438 |
3.09e-79 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 251.40 E-value: 3.09e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFGALGGALYGYDTGVISGAI---LFMKKEL------GLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMA 78
Cdd:cd17356 1 LLCAFVSLGGFLFGYDTGSISGILnmkSFQKYFAdntgtyYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 79 AALLFCIGG-LGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFA- 156
Cdd:cd17356 81 GCVIYIIGAiIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHk 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 157 --DAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfd 234
Cdd:cd17356 161 ldGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL--------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 235 pwvrPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAG 314
Cdd:cd17356 196 ----YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 315 MVISLIVLALVNLFF--------DNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGT 386
Cdd:cd17356 272 MSICLFIYAAVGVRYlipnpqsgTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWN 351
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 225185403 387 LIVSLTYPILMEAIGiSYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQD 438
Cdd:cd17356 352 FLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDEL 402
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
11-430 |
1.03e-78 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 251.49 E-value: 1.03e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGA----ILFMKKELGlNAFTE-----------GLVVSSLLVGAILGSGAAGKLTDRFGRKKA 75
Cdd:cd17431 4 FVAVLGSLQFGYNTGVINAPqkviEEFYNKTLG-DRYGEpispetlttlwSLSVAIFSVGGMIGSFSVGLFVNRFGRRNS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 76 IMAAALLFCIGG--LGVA-LAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYI-- 150
Cdd:cd17431 83 MLYNNLLAFAGAalMGLSkLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIfg 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 151 VNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTN-GEESKAKKILEKLRGTKDIDQEIHDIKE----AEKQD 225
Cdd:cd17431 163 LEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINrNEEEEAKSVLKKLRGTTDVSEDIQEMKEesrqMMREK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 226 EGGLKELF-DPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSasILGTVGIGTVNVLMTLVAIKIIDKIGR 304
Cdd:cd17431 243 KVTILELFrSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQP--VYATIGAGVVNTIFTVVSLFLVERAGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 305 KPLLLFGNAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHV 384
Cdd:cd17431 321 RTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 225185403 385 GTLIVSLTYPILMEAIGiSYLFLIYAAIGIMAFLFVRFKVTETKGR 430
Cdd:cd17431 401 SNFIVGMCFQYIANLCG-PYVFIIFTVFLLTFFIFTYFKVPETKGK 445
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
14-435 |
3.82e-74 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 237.39 E-value: 3.82e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd17435 7 AVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAD-AEAWRWMLGLAAVPS 172
Cdd:cd17435 87 VSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANvSNGWKYMFGLVIPLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 173 LLLLIGILFMPESPRWLFTNGEeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwVRPALIAGLGLAFLQQ 252
Cdd:cd17435 167 ALQAIAMYFLPPSPRFLVMKDN------------------------------------------MRARLLIGLTLVFFVQ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 253 FIGTNTIIYYAPKTFTNVGF-GNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdn 331
Cdd:cd17435 205 ITGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGL------- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 332 tpaasWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAA 411
Cdd:cd17435 278 -----WLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGLPWVCFIYTA 352
|
410 420
....*....|....*....|....
gi 225185403 412 IGIMAFLFVRFKVTETKGRSLEEI 435
Cdd:cd17435 353 MSLASLVFVIMFVPETKGCSLEQI 376
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
13-426 |
6.35e-72 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 232.14 E-value: 6.35e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 13 GALGGALYGYDTGVISG-------------AILFMKKELGLNAF------TEGLVVSSLLVGAILGSGAAGKLTDRFGRK 73
Cdd:cd17361 2 AALGGLIFGYDIGISGGvtsmdpflekffpSVYEKKKGASENNYckyddqLLQLFTSSLYLAGLVASLLASYVTRKWGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 74 KAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNY 153
Cdd:cd17361 82 PSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 154 IFADAEA--WRWMLGLAAVPSLLLLIGILFMPESPrwlftngeeskakkileklrgtkdidqeihdikeaekqdegglke 231
Cdd:cd17361 162 GTSKIKPngWRLSLGLAAVPALILLLGSLFLPETP--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 232 lfdpwVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFG 311
Cdd:cd17361 197 -----NSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 312 NAGMVISLIVLA-LVNLFFDNTP----AASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGT 386
Cdd:cd17361 272 GVQMLASQVAIGiLLAVKFGDGGelpkAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVNFLFT 351
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 225185403 387 LIVSLTYPILMEAIGiSYLFLIYAAIGIMAFLFVRFKVTE 426
Cdd:cd17361 352 FVIAQAFLSMLCAMK-FGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
15-435 |
8.37e-70 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 226.22 E-value: 8.37e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 15 LGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAP 94
Cdd:cd17436 8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 95 NTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAD-AEAWRWMLGLAAVPSL 173
Cdd:cd17436 88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNvLTGWRYMFGLAIIPAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 174 LLLIGILFMPESPRWLFTNGEeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwVRPALIAGLGLAFLQQF 253
Cdd:cd17436 168 IQFASILLLPKKPEVLNIKDN------------------------------------------MRRRTLVGLGLVLFQQF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 254 IGTNTIIYYAPKTFTNVGF-GNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdnt 332
Cdd:cd17436 206 TGQPNVLCYASTIFRSVGFqSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL-------- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 333 paasWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAI 412
Cdd:cd17436 278 ----WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYGVV 353
|
410 420
....*....|....*....|...
gi 225185403 413 GIMAFLFVRFKVTETKGRSLEEI 435
Cdd:cd17436 354 GVAGVVFIYLFVPETKGQSLEEI 376
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
11-434 |
5.15e-69 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 225.53 E-value: 5.15e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKK----ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17433 5 FAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAdaeaWRWMLG 166
Cdd:cd17433 85 FTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD----WRWLAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 167 LAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTK-DIDQEIHDIKEAEKQDEGGLK--ELFDPWVRPALIA 243
Cdd:cd17433 161 LGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDqGWEWECIGIEQSFHLEEQSFSlaLLKQPGIYKPLII 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 244 GLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSAsiLGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISlivla 323
Cdd:cd17433 241 GVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS--VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS----- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 324 lvnlffdnTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGIS 403
Cdd:cd17433 314 --------TAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSY 385
|
410 420 430
....*....|....*....|....*....|.
gi 225185403 404 YLFLIYAAIGIMAFLFVRFKVTETKGRSLEE 434
Cdd:cd17433 386 GTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
11-435 |
8.90e-67 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 220.57 E-value: 8.90e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGA-LYGYDTGVISGAILFMKK--------------ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKA 75
Cdd:cd17432 3 LAAAFGSSfQYGYNLSVVNSPTPYIQNfynetwterygtplEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 76 IMAAALLFCIGGLGVALAPNTG---VMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVN 152
Cdd:cd17432 83 LLLNNIFAIVAAILMGLSKIAKsfeMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 153 --YIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRW-LFTNGEESKAKKILEKLRGTKDIDQEIHDIkEAEKQDEGGL 229
Cdd:cd17432 163 lrELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRGKEDVDDEMEEM-LEEQRAEKGV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 230 K-----ELF-DPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIG 303
Cdd:cd17432 242 GtvsvlELFrDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 304 RKPLLLFGNAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLH 383
Cdd:cd17432 322 RRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNW 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 225185403 384 VGTLIVSLTYPILMEAIGiSYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEI 435
Cdd:cd17432 402 LSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
11-434 |
2.32e-48 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 171.17 E-value: 2.32e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKKE----LGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17434 5 FSAVLGNFSFGYALVYTSPVIPALEQGddprLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAdaeaWRWMLG 166
Cdd:cd17434 85 YLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLP----WRWLAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 167 LAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTK-DIDQEIHDIKEAEKQDEGGLK--ELFDPWV-RPALI 242
Cdd:cd17434 161 AGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNtDYMTEFEQIKDNIRKQSSRLSwaELKTPSYyKPILI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 243 AgLGLAFLQQFIGTNTIIYYAPKTFTNVGF----GNSASIlgtvgIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVIS 318
Cdd:cd17434 241 A-VVMRFLQQLTGITPILVYLEPIFHLTAVilepKYDAAL-----VGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 319 LIVLALVNLffdntpaaswttvICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILME 398
Cdd:cd17434 315 NLSMGLIPL-------------IAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVV 381
|
410 420 430
....*....|....*....|....*....|....*.
gi 225185403 399 AIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEE 434
Cdd:cd17434 382 TFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-385 |
2.05e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 147.81 E-value: 2.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSL 173
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLAL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 174 LLLIGILF-MPESPRwlftngeeskakkileklrgtkdidqeihdikeaeKQDEGGLKELFDPWVRPALIAGLGLAFLQQ 252
Cdd:COG2814 176 LALLLLLRlLPESRP-----------------------------------AARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 253 FIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdnt 332
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-------- 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 225185403 333 pAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVG 385
Cdd:COG2814 293 -AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-420 |
7.29e-39 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 143.90 E-value: 7.29e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKKE--LGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGL 88
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 89 GVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGI----LLSYIVNYIFADAEAWRWM 164
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGAllaaLVASLLIPLLSGDWGWRIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 165 LGLAAVPSLLLLigilfmpesprwlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpWVRPALIAG 244
Cdd:cd17316 162 FLIGALPALLAL-----------------------------------------------------------LLRRRTLLL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 245 LGLAFLqQFIGTNTIIYYAPKTFTNV-GFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLA 323
Cdd:cd17316 183 ILLWFF-ISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 324 LVnlffdntPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGIS 403
Cdd:cd17316 262 YL-------LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
410
....*....|....*..
gi 225185403 404 YLFLIYAAIGIMAFLFV 420
Cdd:cd17316 335 GVPALILALLAIVALIV 351
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
41-434 |
2.59e-37 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 142.85 E-value: 2.59e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 41 NAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLY 120
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 121 LSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKK 200
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 201 ILEKLRGT--KDIDQEIHDI----KEAEKQDEGGLKELF-DPWVRPALIAGLGLAFlqqfigTNTIIYYAPKTFTNVGFG 273
Cdd:TIGR00898 282 ILQRIAKIngKKLPAEVLSLslekDLSSSKKQYSFLDLFrTPNLRKTTLCLMMLWF------TTAFSYYGLVLDLGNLGG 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 274 NSASILgtVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLivlaLVNLFFDNTPAASWTTVICLGVFIVVFAVS 353
Cdd:TIGR00898 356 NIYLDL--FISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVAL----LLLLFVPVDLYFLRTALAVLGKFGITSAFQ 429
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 354 wgpVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSltypiLMEAIGISYLFL---IYAAIGIMAFLFVRFkVTETKGR 430
Cdd:TIGR00898 430 ---MVYLYTAELYPTVVRNLGVGVCSTMARVGSIISP-----FLVYLGEKWLFLplvLFGGLALLAGILTLF-LPETKGV 500
|
....
gi 225185403 431 SLEE 434
Cdd:TIGR00898 501 PLPE 504
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-428 |
2.84e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 123.06 E-value: 2.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGG 87
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 88 LGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGL 167
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 168 AAVPSLLLLIgilfmpesprwlftngeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwvrpALIAGLGL 247
Cdd:COG2271 170 LGLPGLLLAL--------------------------------------------------------------LRFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 248 AFLQQFIGTNTIIYYAPKTFTNV-GFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGR--KPLLLFGNAGMVISLIVLAL 324
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 325 VNlffdntpaaSWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISY 404
Cdd:COG2271 268 LP---------SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
410 420
....*....|....*....|....
gi 225185403 405 LFLIYAAIGIMAFLFVRFKVTETK 428
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-190 |
5.07e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 118.37 E-value: 5.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 1 MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAA 80
Cdd:COG0477 7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 81 LLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA 160
Cdd:COG0477 87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180 190
....*....|....*....|....*....|
gi 225185403 161 WRWMLGLAAVPSLLLLIGILFMPESPRWLF 190
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLL 196
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-419 |
5.93e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.84 E-value: 5.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA--WRWMLGLAAVP 171
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 172 SLLLLIGILFMPESPRWLFTNGEESKAKKILeklrgtkdidqeihdikeaekqdeggLKELFDPWVRPALIAGLGLAFLQ 251
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSV--------------------------LKLLKRVLKNPGLWLLLLAIFLV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 252 QFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDK-IGRKPLLLFGNAGMVISLIVLALvnlffd 330
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLL------ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 331 ntpAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTY-PILMEAIGISYLFLIY 409
Cdd:cd06174 290 ---APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLVL 366
|
410
....*....|
gi 225185403 410 AAIGIMAFLF 419
Cdd:cd06174 367 AVLLLLAAIL 376
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
11-427 |
8.43e-27 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 111.24 E-value: 8.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGV 90
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 91 ALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNY----IFADAEAWRWMLG 166
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAllfpLLPPEIAWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 167 LAAVPSLLLLIGILFMPESPRWlftngeeskakkileklrgtkdidqEIHDIKEAEKQDEGGLKELFDP-WVRPALIAGL 245
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQW-------------------------QAARAARRHFADRPSLRELFSPpLLRTTLLASL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 246 GLAFLQqfigtntIIYYAPKTFTNVgFGNSASILGTVGIGTVNVLMTLVAI-------KIIDKIGRKPLLLFGNAGMVIS 318
Cdd:cd17371 217 LATGAL-------GGYYGITTWLPS-YLTGERGLSFEGSAGYLVVTILGGFlgylaggFLADRIGRRNNFALFALGSAIS 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 319 LivlaLVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPvvwvMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILME 398
Cdd:cd17371 289 I----LLYFFLPLSPTLILILGFPLGFFASGPFSGMGA----YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAT 360
|
410 420
....*....|....*....|....*....
gi 225185403 399 AIGISYLFLIYAAIGIMAFLFVRFKVTET 427
Cdd:cd17371 361 SGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-388 |
1.11e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.20 E-value: 1.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAI-LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVAL 92
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 93 APNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPS 172
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 173 LLLLIGILFMPESPRwlftngeeskakkileklrgtkdiDQEIHDIKEAEKQDEGGLKELFDPWVRPALIaglglAFLQQ 252
Cdd:pfam07690 162 LLAAVLLLLPRPPPE------------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLL-----ALLLF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 253 FIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnLFFDNT 332
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL--LSLTLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 333 PAASWTTVICLGVFIVVFAvswgPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLI 388
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVF----PALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
36-424 |
1.19e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.36 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 36 KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTT 115
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 116 IVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRwlftNGEE 195
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR----PPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 196 SKAKKILEKLRGTKDIdqeihdikeaekqdegglkeLFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKtftnvgFGNS 275
Cdd:cd17325 180 KRAVSAARLRSGLRLL--------------------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL------GGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 276 ASILGTV--GIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFfdntpaasWTTVICLGVFIVVFAVS 353
Cdd:cd17325 234 PAQIGLLfgAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--------WLLLLLLALLGLGLGLV 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 354 WgPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKV 424
Cdd:cd17325 306 F-PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-422 |
1.16e-24 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 104.94 E-value: 1.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 1 MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 81 LLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLnQLMITVGILLSYIV--NYIFADA 158
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLggLLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 159 EA-WRWMLGLAAVPSLLLLIGILFMPesprwlftngeeskakkileklrgtkdidqeIHDIKEAEKQDEGGLKELFDPWV 237
Cdd:COG0738 160 SLsWHLPYLILAVLLLLLALLFLRSK-------------------------------LPEIEEEEEEAAGSAASLKSLLK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 238 RPALIAGLGLAFL----QQFIGTNTIIYYApktfTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNA 313
Cdd:COG0738 209 NPRLLLGGLAIFLyvgaEGAIGDWLPLYLK----DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 314 GMVISLIVLALVnlffdNTPAASWTTVICLGVFIvvfAVSWgPVVWVMLPELFPLHVRGIGTGVSTLMLhVGTLIVSLTY 393
Cdd:COG0738 285 LAAVGLLLALLA-----PGPWLALIGLALVGLGL---SLMF-PTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLI 354
|
410 420
....*....|....*....|....*....
gi 225185403 394 PILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:COG0738 355 GFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-431 |
2.25e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.19 E-value: 2.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 26 VISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRII 105
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 106 LGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGI-LFMPE 184
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAwLFLRD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 185 SPrwlftngeeskakkileklrgtkdidqeiHDIKEAEKQDEGGLKELF---DPWVrpaliagLGLAFLQQFIGTNTIIY 261
Cdd:COG2223 183 PP-----------------------------AGAAAAAKASLRDQLEALrdpRFWL-------LSLLYFGTFGSFIGFSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 262 YAPKTFTNVgFGNSASILGTV--GIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdntPAASWTT 339
Cdd:COG2223 227 WLPPYLVDQ-FGLSAATAGLLaaLFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL--------ALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 340 VICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIG-ISYLFLIYAAIGIMAFL 418
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALV 377
|
410
....*....|...
gi 225185403 419 FVRFKVTETKGRS 431
Cdd:COG2223 378 LTLLLYRRPRRAA 390
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
13-428 |
1.72e-23 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 101.99 E-value: 1.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 13 GALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAI------LGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17367 4 GSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVgflmrpIGGWLFGRLADRIGRRAALTLSVSLMAAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPN---TGVM-----VLFRIILGLAVG----TSTTivplYLSELAPKHKRGALSSLNQLMITVGILL----SYI 150
Cdd:cd17367 84 SLVIAVTPTyatIGIWapiilLLARLLQGLSVGgeygTSAT----YLSEVAPPGRRGFYSSFQYVTLIGGQLLalgvLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 151 VNYIFADAE----AWRWMLGLAAVPSLLLLIGILFMPESprwlftngEESKAkkileklrgtkdidqeihdIKEAEKQDE 226
Cdd:cd17367 160 LQHTLGEDQmaawGWRIPFLLGGVLAVVVLWLRRGLEET--------ESFEA-------------------IAESNEASA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 227 GGLKELFDPWVRPALIAGLGLAFlqqfigtnTIIYYAPKTF------TNVGFGNSASILGTVGIGTVNVLMTLVAIKIID 300
Cdd:cd17367 213 GTLRELRRHPRELLLVVGLTAGG--------TLAFYTWTTYlqkflvNTAGFSKGDATWITTAALLVFMLLQPLGGRLSD 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 301 KIGRKPLLL-FGNAGMVISLIVLALVnlffDNTPaaSWTT---VICLGVFIVVFAVSWGPVVWVmlpELFPLHVRGIGTG 376
Cdd:cd17367 285 RIGRRPLLLfFGIGGTLATVPLLSAL----DHTD--SPYTafaLVLVGLVFLSGYTSINAVVKA---ELFPTHVRALGVG 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 377 VS---TLMLHVGTLIVSLTYpilMEAIGISYLFLIYAAIGIMAFLFVRFKVTETK 428
Cdd:cd17367 356 LPyalAVAIFGGTAPYVALW---LKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-420 |
1.85e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.39 E-value: 1.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSL 173
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 174 LLLIGILF-MPesprwlftngeeskakkileklrgtkdidqeihDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQ 252
Cdd:cd17324 165 LAALLLWRlLP---------------------------------SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 253 FIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLfgnAGMVISLIVLALvnlffdnT 332
Cdd:cd17324 212 GGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI---ALLLLAAALLLL-------T 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 333 PAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAI 412
Cdd:cd17324 282 LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL 361
|
....*...
gi 225185403 413 GIMAFLFV 420
Cdd:cd17324 362 LLLALLLA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-424 |
7.02e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 93.81 E-value: 7.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 36 KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTT 115
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 116 IVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPEsprwlftngee 195
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 196 skakkileklrgtkdidqEIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNS 275
Cdd:cd17489 173 ------------------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 276 ASILGTvgigtvnVLMTLVAIKIIDKIGRKPLLLFGnagmvISLIVLALVNLFFDNTPAAswttvicLGVFIVVFAVSWG 355
Cdd:cd17489 235 VYAIAL-------LLSRPFSGKLSDRKGPKTVIIPG-----LLLLALGLLLLSFAGSPWM-------LLLAAVLYGLGFG 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 356 ---PVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKV 424
Cdd:cd17489 296 llfPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
21-396 |
2.36e-20 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 92.42 E-value: 2.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 21 GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMV 100
Cdd:TIGR00895 30 GYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 101 LFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAV-PSLLLLIGI 179
Cdd:TIGR00895 110 ILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLM 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 180 LFMPESPRWLFTNGEEsKAKKILEKLRGTKDIDQEIHdiKEAEKQDEGGLKELFDPWVRPALIAG---LGLAFLQQFIGT 256
Cdd:TIGR00895 190 RFLPESIDFLVSKRPE-TVRRIVNAIAPQMQAEAQSA--LPEQKSTQGTKRSVFKALFQGKTARItvlLWLLYFMLLVGV 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 257 NTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNlffdntpaaS 336
Cdd:TIGR00895 267 YFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLF---------S 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 337 WTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVstlMLHVGTLiVSLTYPIL 396
Cdd:TIGR00895 338 PTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGW---AIGIGRL-GAIIGPIL 393
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-422 |
1.22e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 90.32 E-value: 1.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 25 GVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRI 104
Cdd:cd17474 16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 105 ILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAeAWRWMLGLAAVPSLLLLIGILFMPE 184
Cdd:cd17474 96 LQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 185 SPRwlfTNGEESKAKKILEKLRGtkdidqeihdikeaekqdegglkelfdpwVRPALIAGLGLAFLQQFIGTNTIIYYAP 264
Cdd:cd17474 175 EPK---EKAKSSSATKLRDLKKA-----------------------------LRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 265 kTFTNVGFGNSASILGTVgIGTVNVLMTLVAI----KIIDKIGRKPLLLFGNAGMVISLIVLALVNLFfdntpaasWTTV 340
Cdd:cd17474 223 -FLLELLYGISPIIIGLL-FAGWSVLLALGSLfvgrLLKKRFGARRILVIGLLLYALSLLLLGFVPSL--------ALLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 341 ICLGVFIVVFAVSwGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFV 420
Cdd:cd17474 293 IAIVLFGLGLGLN-LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
..
gi 225185403 421 RF 422
Cdd:cd17474 372 AL 373
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
44-435 |
1.28e-19 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 91.33 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 44 TEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNT------GVMVLFRIILGLAVGTSTTIV 117
Cdd:TIGR00887 57 VSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSspksvmATLCFWRFWLGVGIGGDYPLS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 118 PLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYI--------------FADAEA---------WRWMLGLAAVPSLL 174
Cdd:TIGR00887 137 AIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALIvlagfkhsleaaadEASCTGscvpavdymWRILIGFGAVPALL 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 175 LLIGILFMPESPRWLFTNGEESK------AKKILEKLRGTKDIDQEIHDIKEAEKQDEGGLKELFDPWVRPALIAG---- 244
Cdd:TIGR00887 217 ALYFRLTIPETPRYTADVAKDVEqaasdmSAVLQVKIEAEPDEVEKASTAVEVPKASWSDFFTHFFKWRHGKHLLGtags 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 245 ---LGLAFLQQFIGTNTI---IYYAPKTFTNVGFgnsaSILGTVGIGtvNVLMTL--------VAIKIIDKIGRKPLLLF 310
Cdd:TIGR00887 297 wflLDIAFYGVNLNQKVIlsaIGYSPPAATNNAY----EELYKTAVG--NLIIALagtvpgywVTVFLVDIIGRKPIQLM 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 311 GNAGMVISLIVLALvnlffdntPAASWTTVICLGVF-IVVFAVSWGP--VVWVMLPELFPLHVRGIGTGVSTLMLHVGTL 387
Cdd:TIGR00887 371 GFFILTVLFFVLGF--------AYNHLSTHGFLAIYvLAQFFANFGPnaTTFIVPGEVFPTRYRSTAHGISAASGKAGAI 442
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 388 IVSLTYPILME----------AIGISYLFLIYAAIGIMAFLFVrFKVTETKGRSLEEI 435
Cdd:TIGR00887 443 IGQFGFLYLAQhgdptkgyptGIWMGHVLEIFALFMFLGILFT-LLIPETKGKSLEEL 499
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-420 |
2.74e-19 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 88.80 E-value: 2.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 21 GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMV 100
Cdd:cd17365 12 GFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 101 LFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIgil 180
Cdd:cd17365 92 LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP--- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 181 fmpesprwlftngeeskakkileKLRGTkdidqeihdikeaekqdegglkelfdpwvrpALIAGLGLAFLQQFIGTNTii 260
Cdd:cd17365 169 -----------------------LLRGT-------------------------------LLLWVTFFMGLLLVYLLNS-- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 261 yYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlfFDNTPAASWTTV 340
Cdd:cd17365 193 -WLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGV----SPASLVLLYVLV 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 341 ICLGVFIVVFAVswgpVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEA-IGISYLFLIYAAIGIMAFLF 419
Cdd:cd17365 268 FLAGACVNGAQV----GLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAgLGPESVFLALAIPAALGALA 343
|
.
gi 225185403 420 V 420
Cdd:cd17365 344 V 344
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
21-427 |
6.05e-19 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 88.10 E-value: 6.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 21 GYDTGVISGAILFMKKELG-----LNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPN 95
Cdd:cd17364 12 AYDLFSISLVTKILGRLYYggkgsLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 96 T---GVMV---LFRIILGLAVG----TSTTIVplylSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADA------- 158
Cdd:cd17364 92 StplGVMGwliFFRFLLGIGIGgdypLSATIM----SEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIfehplpa 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 159 -------EAWRWMLGLAAVPSLLLLIgilfmpesPRWLftngeeskakkilekLRGTkdidqeihdikeaekqdeGGLKE 231
Cdd:cd17364 168 gtyhhadLVWRIVLGLGAIPALSVLY--------FRKH---------------LLGT------------------AGTWF 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 232 LFDpwvrpalIAGLGLAFLQQFIgTNTIIYYAPKTFTNVGFGNSASILGTVGIGTvnVLMTLVAIKIIDKIGRKPLLLFG 311
Cdd:cd17364 207 LLD-------IAFYGQNLFQSTI-ISAIGFSKTMNAYQELFNIAVGQLIIALAGT--VPGYWFTVFLIDRIGRKKIQMMG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 312 NAGMVISLIVLAlvnLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSL 391
Cdd:cd17364 277 FFGMTIFLLILA---GPYDHWKISTIGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSF 353
|
410 420 430
....*....|....*....|....*....|....*.
gi 225185403 392 TYPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTET 427
Cdd:cd17364 354 LFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-419 |
3.12e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.92 E-value: 3.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 46 GLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELA 125
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 126 PKHKRGALSSLNQLMITVGILLSYIVNYIFADAeAWRWMLGLAAVPSLLLLIGILFMPESPRwlftngeeskakkilekl 205
Cdd:cd17473 118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPAR------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 206 rgtkdidqeihdiKEAEKQDEGGLKELFDPWVRPALIAGLGLAflqQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIG 285
Cdd:cd17473 179 -------------KSKSAASPGAATAAALPWKRVLPIYFLAFL---AMLLFYVIPIQLPFLLQERGGGSAALIGLALAIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 286 TV-NVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdntpAASWTTVIcLGVFIVVFAVSW-GPVVWVMLP 363
Cdd:cd17473 243 SLaGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL---------ASGLWVVL-LGAILAGLGFGLlLPTLNSWAM 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 225185403 364 ELFPLHVRGIGTGVSTLMLHVGTLIVSL-TYPILMEAIGISYLFLIYAAIGIMAFLF 419
Cdd:cd17473 313 SLVPPELRGRAMGIVTSAFFLGQFLSPLvLGPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
58-419 |
5.18e-16 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 79.49 E-value: 5.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 58 LGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTG--------VMVLFRIILGLAVGTSTTIVPLYLSELAPKHK 129
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAqigilapiLLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 130 RGALSSLNQLMITVGILLSYIVNYIFA--------DAEAWRWMLGLAAVpslLLLIGI---LFMPESPrwLFTngeeska 198
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATGVFLLLSallsdeafLSWGWRIPFLLSAV---LVAVGLyirLRLEETP--VFR------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 199 kkileklrgtkdidqeihDIKEAEKQDEGGLKELFDPWVRPALIaGLGLAFLQQ---FIGTNTIIYYAPKTftnVGFGNS 275
Cdd:cd17369 207 ------------------RAKEAGQVVRAPLVEVLRRHWRALLL-AIGLRLAENvlfYLFTTFALSYATQT---LGVDRS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 276 ASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLivLALVNLFFDNTPAASWTTVICLGVFIV--VFAVs 353
Cdd:cd17369 265 TVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFA--FPFFWLLDTGSTWLIVLAAVVVLGVLHgmMYGP- 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225185403 354 WGPvvwvMLPELFPLHVRGIGTGVSTlmlHVGTLIVSLTYPILMEAI--------GISYLFLIYAAIGIMAFLF 419
Cdd:cd17369 342 QAA----FLAELFPTRVRYTGASLGY---QLGAILGGGFAPLIATALvaatgswwPVALYLAALAVISLVAALF 408
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-422 |
6.69e-16 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 78.39 E-value: 6.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 47 LVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAP 126
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 127 KHKRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMPesprwlftngeeskaKKILeklr 206
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWLP---------------RRTI---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 207 gtkdidqeihdikeaekqdegglkelfdpwvrpaliaGLGLAFLqqfigTNTIIYYApKTFTNVGFGNSAsILGTVGIGT 286
Cdd:cd17317 167 -------------------------------------IVGLIWF-----VTSLVYYG-LSLNSSNLGGNL-YLNFFLSGL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 287 VNVLMTLVAIKIIDKIGRKPLLLfgnAGMVISLIVLALVNLFFDNTPAAsWTTVICLGVFIVvfAVSWGpVVWVMLPELF 366
Cdd:cd17317 203 VEIPAYFLALLLLDRLGRRWTLS---GSLLLAGLACLVTALLPDDENTL-ALTLALVGKFAI--SAAFS-VIYLYTAELY 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 367 PLHVRGIGTGVSTLMLHVGTLIVSLTypILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17317 276 PTVVRNTGVGLCSTVARVGAILAPFI--VLLGKIGPLLPLIIFGVLALLGGLLTLL 329
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
37-418 |
3.30e-15 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 76.78 E-value: 3.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 37 ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTI 116
Cdd:cd17441 28 EWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 117 VPLYlSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTngees 196
Cdd:cd17441 108 VTLY-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYWTT----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 197 kakkILeklrgtkdidqeIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA 276
Cdd:cd17441 182 ----IL------------LWFIWFSNAFSYYGLVLLTTELFQAGDVCSGSSGKKVEGKCSLECEYLTTSDYMDLLWTTLS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 277 SILGtvgigtvnvlmTLVAIKIIDKIGRKPLllfgnagMVISLIVLALVNLFFDNTPAASWTTVIclgVFIVVFAVSWG- 355
Cdd:cd17441 246 EFPG-----------LLVTLWIIDRFGRKKT-------MALCFFVFSFCTLLLFSCVGRFSLTVL---LFIARAFISGGf 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 356 PVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAiGISYLFLIYAAIGIMAFL 418
Cdd:cd17441 305 QAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLES-SVYLTLSVYSGCCLLAAI 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-445 |
6.24e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 76.48 E-value: 6.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 5 SNIWLYFFGALGGALYGydTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTD----RFGRKKA-IMAA 79
Cdd:COG2211 10 KEKLAYGLGDLGLNLAF--GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPwILIG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 80 ALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTI----VPLY--LSELAP-KHKRGALSSLNQLMITVGILLSYIVN 152
Cdd:COG2211 88 AIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYtlvnIPYSalGAELTPdYEERTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 153 YIFAD------AEAWRWMLGLAAVPSLLL-LIGILFMPESPRwlfTNGEESKAKKILEKLRGTKdidqeihdikeaekqd 225
Cdd:COG2211 168 PPLVAafggdaALGYRLTALIFAVLGLLAfLLTFFGTKERPV---PEEEKVSLKESLKALLKNR---------------- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 226 egglkelfdPWVRpaliagLGLAFLQQFIGTNTIIYYAPKTFTNVgFGNSASILGTVGIGT--VNVLMTLVAIKIIDKIG 303
Cdd:COG2211 229 ---------PFLL------LLLAYLLFFLALALVAALLLYYFKYV-LGLSAALVGLLLALYflAALLGAPLWPRLAKRFG 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 304 RKPLLLFGNAGMVISLIVLALVnlffdntPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLH-------VRGIGTG 376
Cdd:COG2211 293 KKKAFIIGLLLAALGLLLLFFL-------GPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 377 VSTLMLHVGTLIVSLTYPILMEAIG--------------ISYLFLIYAAIG--IMAFLFVRFKVTEtkgRSLEEIEQDLR 440
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltgIRLLFFLLPAVLllLAALLLLFYPLTR---ERHAEIRAELA 442
|
....*
gi 225185403 441 DKNGQ 445
Cdd:COG2211 443 ARRAA 447
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
37-399 |
1.42e-14 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 74.88 E-value: 1.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 37 ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTI 116
Cdd:cd17372 28 EWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 117 VPLYLsELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWL----FTN 192
Cdd:cd17372 108 ASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTTLLLwviwFGN 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 193 GEESKAKKILE-KLRGTKDIDQEIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGlaflqQFIGtntiiyyapktftnvg 271
Cdd:cd17372 187 AFAYYGVVLLTtELNNSHNVCGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATFA-----EFPG---------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 272 fgnsasilgtvgigtvnvlmTLVAIKIIDKIGRKplllfgnAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVFA 351
Cdd:cd17372 246 --------------------LLISAAMIDRLGRK-------ASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISA 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 225185403 352 VSwgPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEA 399
Cdd:cd17372 299 AF--TVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHG 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-422 |
3.53e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 73.77 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGtsttIVPLYLS---ELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAV 170
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA----VFPLAFAlvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 171 PSLLLLIGILFMP----ESPRWLFTNGeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwvrPALIAGLG 246
Cdd:cd17504 158 VAVLLAALVPLIDlrllRRRNVLLANI---------------------------------------------TALLAGFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 247 LAFLQQFIgtntIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVn 326
Cdd:cd17504 193 MFMVFQLL----PQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALL- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 327 lffdntPAASWTTVICLGVFIVVFAVSWGPVVWVMLpELFPLHVRGIGTGVSTLMLHVGT---------LIVSLTYPILM 397
Cdd:cd17504 268 ------HSSLWALVVALLLIGIGLGLAFASLPNIVV-ESVPPDRTGIATGMNTVLRTIGSaigpaiagaILTTYTVSITS 340
|
410 420
....*....|....*....|....*....
gi 225185403 398 EAI----GISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17504 341 GGVptegAYVLAFLIGAALALAALLLSLL 369
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
34-376 |
5.11e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 73.46 E-value: 5.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 34 MKKELGLNAFTEGLVVSS----LLVGAILGsgaaGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLA 109
Cdd:PRK11551 41 MAQEFGLDVAQMGWAFSAgilgLLPGALLG----GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 110 VGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWR---WMLGLAavPSLLLLIGILFMPESP 186
Cdd:PRK11551 117 LGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRhifYVGGVG--PLLLVPLLMRWLPESR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 187 RWLftngeeskakkileklrgtkdidqeihDIKEAEKQDEGGLKELFDPWVRPALIAgLGLAFLqqfiGTNTIIYY---- 262
Cdd:PRK11551 195 AFA---------------------------QAAGAGKQRAPVLRALFGEGRATATLL-LWISYF----FTLIVLYFllnw 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 263 -----APKTFTNVGFG------NSASILGTVGIGtvnVLMtlvaikiiDKIGRKPLLLFGNAGMVISLIVLALvnlffdn 331
Cdd:PRK11551 243 lpsllVGQGLSRSQAGlvqiafNIGGALGSLLIG---ALM--------DRLRPRRVVLLIYAGILASLAALAA------- 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 225185403 332 tpAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTG 376
Cdd:PRK11551 305 --APSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVG 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-183 |
6.57e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 6.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 6 NIWLYFFGALGGALYGYdtGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGR--KKAIMAAALLF 83
Cdd:COG2271 181 RFWLLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 84 CIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRW 163
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|
gi 225185403 164 MLGLAAVPSLLLLIGILFMP 183
Cdd:COG2271 339 AFLLLAALALLAALLALLLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-187 |
8.17e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.60 E-value: 8.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 34 MKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTS 113
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 114 TTIVPLYLSELAPkHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLL-LLIGILFMPESPR 187
Cdd:COG2807 124 NVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLaLLLWLPLLRRRPA 197
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
12-208 |
1.30e-13 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 72.52 E-value: 1.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALY--GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLG 89
Cdd:cd17363 1 FFVLGLALMadGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 90 VALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGA-LSSLNQLMITVGILLSYIV---------------NY 153
Cdd:cd17363 81 SSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEhLSWLCMFWMIGGLYASAMAwaiiphygwgfsmgtAY 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 154 IFadaEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGT 208
Cdd:cd17363 161 QF---HSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDT 212
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-145 |
1.67e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.54 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 3 KQSNIWLYFFGALGGALYGYdtGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALL 82
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFF--ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 83 FCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGI 145
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-420 |
1.79e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.44 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 9 LYFFGALGGALYGYDTGVISgaiLFMKKElGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGL 88
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLS---LRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 89 GVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVnYIFADAEAWRWmLGLA 168
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALP-FLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 169 AVPSLLLLIGILFMPESPrwlftngeeskakkileklrgtkdidqeihdiKEAEKQDEGGLKELFDPwVRPALIAGLGLA 248
Cdd:cd17477 155 AVLLLLALVPLLLTRRAA--------------------------------PEIEEAESISLRRLLRI-APLALLGAFVAG 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 249 FLQQFIGTNTIIYyapktFTNVGFGNS--ASILGTVGIGtvNVLMTLVAIKIIDKIGRKPLLLfgnaGMVISLIVLALVN 326
Cdd:cd17477 202 FLEGAFYSLLPLY-----GLRLGLSVAqaALLLAAFVLG--GLLLQWPLGWLADRFDRRRVLL----GCALLGALAALLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 327 LFFDNTPAASWTTVICLGVFIVVFAvswgPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLF 406
Cdd:cd17477 271 PLVPGLPLALLVLLFLWGGAAGPLY----TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLF 346
|
410
....*....|....
gi 225185403 407 LIYAAIGIMAFLFV 420
Cdd:cd17477 347 LFLAAVALLFLLFL 360
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
8-188 |
1.97e-13 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 72.04 E-value: 1.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFGA-LGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:PRK03893 19 WKAFSAAwLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPNTGVMVLFRIILGLAV----GTSTTivplYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWR 162
Cdd:PRK03893 99 TLACGFAPGYWTLFIARLVIGMGMageyGSSAT----YVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR 174
|
170 180
....*....|....*....|....*.
gi 225185403 163 WMLGLAAVPSLLLLIGILFMPESPRW 188
Cdd:PRK03893 175 ALFFIGILPIIFALWLRKNLPEAEDW 200
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-423 |
3.59e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 3.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 30 AILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTG-----VMVLFRI 104
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslslwLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 105 ILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPE 184
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 185 SPRwlftngeeskakkileklrgtkdiDQEIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAP 264
Cdd:cd06173 181 PPP------------------------AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 265 KTF--TNVGFGnsaSILGTVGIGTvnVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFdntpaASWTTVIC 342
Cdd:cd06173 237 EVLggGAAGYG---LLLAAFGVGA--LLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLW-----LLLAALFL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 343 LGVFIVVFAVSWGpvvwVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd06173 307 LGLAGGLFNVPLN----TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
.
gi 225185403 423 K 423
Cdd:cd06173 383 L 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-418 |
3.68e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.68 E-value: 3.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 30 AILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLA 109
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 110 VGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWR---WMLGLAAVpsLLLLIGILFMPESP 186
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifVFLALLGL--LLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 187 rwlftngeesKAKKILEKLRGTkdidqeIHDIKEAekqdegglkeLFDP-WVRPALIAGLGLAFLQQFIGTNTIIYYAPK 265
Cdd:cd17320 179 ----------PEEKRKPLLSSL------LRAYKRV----------LKNRrFLGYALALGLSFAGLFAYLAAAPFIYIEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 266 TFTNVGFGNSASIlgtvgIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPAASWttvicLGV 345
Cdd:cd17320 233 GLSPAQFGLLFAL-----NAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLV-----APL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225185403 346 FIVVFAVSW-GPVVWVMLPELFPlHVRGIGTGVSTLMlhvGTLIVSLTYPILMEAIGISyLFLIYAAIGIMAFL 418
Cdd:cd17320 303 FLIFFGFGLiFPNATSLALEPFP-HVAGTASALLGFL---QFLIGALAGALVGLLPNGT-ALPMGLLILVLGLL 371
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
15-187 |
4.81e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 70.34 E-value: 4.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 15 LGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAP 94
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 95 NTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA-WRWMLGLAAVPSL 173
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgWRWAFRVTGVLGV 165
|
170
....*....|....
gi 225185403 174 LLLIGILFMPESPR 187
Cdd:cd17328 166 LLAILLLLFVREPP 179
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
12-208 |
8.63e-13 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 69.95 E-value: 8.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALY--GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLG 89
Cdd:cd17438 1 FFVLGLALMadGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 90 VALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGA-LSSLNQLMITVGILLSYI---------------VNY 153
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEhLSWLCMFWMIGGLYASAMawsiiphygwgfsmgTNY 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 154 IFadaEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGT 208
Cdd:cd17438 161 HF---HSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDT 212
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-182 |
1.53e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.80 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 25 GVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRI 104
Cdd:cd06173 226 ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 105 ILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFM 182
Cdd:cd06173 306 LLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
8-208 |
1.90e-12 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 69.24 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFgALGGALY--GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAimaaaLLFCI 85
Cdd:TIGR01299 166 WALFF-VLGLALMadGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQC-----LLICL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 86 GGLGV-----ALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGA-LSSLNQLMITVGILLS---------YI 150
Cdd:TIGR01299 240 SVNGFfaffsSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhLSWLCMFWMIGGIYAAamawaiiphYG 319
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 151 VNYIFADA---EAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGT 208
Cdd:TIGR01299 320 WSFQMGSAyqfHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDT 380
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
54-377 |
3.26e-12 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 67.78 E-value: 3.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 54 VGAILgsgaAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPN--------TGVMVLFRIILGLAVGTSTTIVPLYLSELA 125
Cdd:cd17368 55 IGAIV----LGAYADRIGRKPAMTLTLAIMALGTLLIALAPTyatigiaaPLLVLLARLLQGFAAGGEVGGVTAYLVEAA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 126 PKHKRGALSSLN----QLMITVGILLSYIVNYIFADA--EAWRWMLGLAAVpslLLLIGILFmpesprWLFTNGEESKAk 199
Cdd:cd17368 131 PPGRRGFYTSWQsasqQVAIVAGALVGYLLSLTLTAEalAEWGWRIPFFIG---LLIIPLGL------WLRRSLEETEA- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 200 kileklrgtkdidqEIHDIKEAEKQDEGGLkeLFDPWvrPALIAGLGLAFLQQfIGTNTIIYYAPkTFTNVGFGNSA--S 277
Cdd:cd17368 201 --------------FLERKARPTRRELFAL--LANNR--RIILLGMLLVAGST-VTFYFTTVYTP-TYAKTVLGLSArdS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 278 ILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGmviSLIVLALVNLFFDNTPAASWTTVIcLGVFIVVFAVSWGPV 357
Cdd:cd17368 261 FLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLA---ALVTLYPVFAWLTAAPSFGRLLLV-LLVLSFFFGMYGGAM 336
|
330 340
....*....|....*....|
gi 225185403 358 VwVMLPELFPLHVRGIGTGV 377
Cdd:cd17368 337 V-VALVELFPVRVRSTGFSL 355
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-182 |
3.83e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.21 E-value: 3.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 23 DTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF 102
Cdd:cd17319 18 DRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 103 RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFM 182
Cdd:cd17319 98 RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
23-348 |
9.14e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.45 E-value: 9.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 23 DTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF 102
Cdd:cd17503 11 DTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 103 RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLgLAAVPslLLLIGILFM 182
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF-YINLP--IGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 183 PESPRWLFTNgeeskakkileklrgtkdidqeihdikeaekqdegglkelfdpwvrPALIAGLGLAFLQQFiGTNTIIYY 262
Cdd:cd17503 168 PLLDLRLFKD----------------------------------------------RNFTLGLLLSFLLGL-GLFGAMFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 263 APkTFTNVGFGNSASILGTVGI--GTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPAASWTTV 340
Cdd:cd17503 201 LP-LYLQNVLGYSAFESGLVLApgGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFI 279
|
....*...
gi 225185403 341 ICLGVFIV 348
Cdd:cd17503 280 RGLGMGLV 287
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
26-183 |
3.21e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 64.52 E-value: 3.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 26 VISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRII 105
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 106 LGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
46-185 |
4.82e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 60.36 E-value: 4.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 46 GLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELA 125
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 126 PKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILF-MPES 185
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFlLPET 141
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
39-183 |
7.56e-11 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 63.08 E-value: 7.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 39 GLNAFTEGLVVSSLLVGAILGsgaaGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV-GTSTTIV 117
Cdd:cd17374 35 SLKSVAQSIFMAGLLVGALIF----GHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTL 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 118 PLYLSELAPKHkRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17374 111 ILGTEWTTPRH-RALAITLTSCFFSIGQMLLAGLAYAIRD---WRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
41-183 |
8.71e-11 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 63.14 E-value: 8.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 41 NAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLY 120
Cdd:cd17379 31 DAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVL 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 121 LSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17379 111 VTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPH---WRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
11-424 |
1.00e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 63.41 E-value: 1.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 11 FFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGV 90
Cdd:PRK12307 21 FSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 91 ALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAV 170
Cdd:PRK12307 101 GLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 171 PSLLLLIGILFMPESPRWlftngeeskakkILEKLRGTKDIDQeihdikEAEKQDEGGLKELFDpwvRPALIAGLgLAFL 250
Cdd:PRK12307 181 PVLLVIYIRARAPESKEW------------EEAKLSGKGKHSQ------SAWSVFSLSMKGLFN---RAQFPLTL-CVFI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 251 QQF--IGTNTIIY-YAPKTFTNVGF--GNSASILGTVGIGTV--NVLMTLVAikiiDKIGRKPLLLFgnaGMVISLIVla 323
Cdd:PRK12307 239 VLFsiFGANWPIFgLLPTYLAGEGFdtGVVSNLMTAAAFGTVlgNIVWGLCA----DRIGLKKTFSI---GLLMSFLF-- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 324 LVNLFFDNTPAASWTTVICLGVFIVVFAVswGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSL--TYPILMEAIG 401
Cdd:PRK12307 310 IFPLFRIPQDNYLLLGACLFGLMATNVGV--GGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMaaTWLGITMGLG 387
|
410 420
....*....|....*....|...
gi 225185403 402 ISyLFLIYAAIGIMAFLFVRFKV 424
Cdd:PRK12307 388 AA-LTFIVAFWTATILLIIGLSI 409
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
33-399 |
1.12e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.03 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 33 FMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGT 112
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 113 STTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVpsLLLLIGILFMpespRWLftn 192
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGL--VSILAAVLFW----LFY--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 193 geeskakkileklrgtKDIDQEIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYapKTFTNVGF 272
Cdd:cd17475 172 ----------------REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFL--HDHLGLSV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 273 GNSASILGTVGIGtvNVLMTLVAIKIIDKIG---RKPLLLFGNAGMVISLIVLALvnlffdntPAASWTTVICLGVFIV- 348
Cdd:cd17475 234 VAAGALLAVAQLG--GALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSL--------LSPGTPLWLLVLLLILl 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 225185403 349 -VFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEA 399
Cdd:cd17475 304 gLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
15-182 |
2.56e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.43 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 15 LGGALYGYDTGVISGAILFMKKELG-LNAFteGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGgLSLV--SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRW---------M 164
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWcfyinlpigG 160
|
170
....*....|....*...
gi 225185403 165 LGLAAVPSLLLLIGILFM 182
Cdd:cd17502 161 LALALLRTILLSSIFGFL 178
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-421 |
2.69e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 61.86 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVG 111
Cdd:cd17329 24 IYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 112 TSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILL-SYIVNYIFADAEAWRWMLGlAAVPSLLLLIGILFMPESPRWLF 190
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIgPLLGGLLLLYSFRLLFLAA-AVLFLLAALVLLFLLPETRPKRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 191 TNGEESKAKKILEKLRgtkdidqeihdikeaekqdegglkelfDPWVRPALIAGLGLAFLQQFIGTNTIIYYapktftNV 270
Cdd:cd17329 183 AAEKTEILRGYKIVLR---------------------------DRAFLLFLLASFLISLIYFQLESTLPVYV------VE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 271 GFGNSASILGTVGI--GTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdntpAASWTTVICLGVFIV 348
Cdd:cd17329 230 ILGLGESLLGLLLAlnALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF---------ANTLAVLILAMIVLT 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 349 VFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVR 421
Cdd:cd17329 301 LGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
234-441 |
3.20e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.53 E-value: 3.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 234 DPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNA 313
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 314 GMVISLIVLALvnlffdntpAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTY 393
Cdd:COG2814 84 LFALGSLLCAL---------APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 225185403 394 PILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRD 441
Cdd:COG2814 155 GLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE 202
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
64-418 |
9.11e-10 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 60.59 E-value: 9.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 64 GKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGV--------MVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSS 135
Cdd:PRK10406 84 GRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 136 LNQLMITVGILLSYIV----NYIFADAE----AWRWMLGLAAVPSLLLLigilfmpesprWLFTNGEESKakkileklrg 207
Cdd:PRK10406 164 FQYVTLIGGQLLALLVvvvlQQTLEDAElrewGWRIPFALGAVLAVVAL-----------WLRRQLDETS---------- 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 208 tkdiDQEIHDIKEAekqdeGGLKELFDPwvRPALIAGLGlaflqqFIGTNTIIYYAPKTF-------TNVGFGNSASILG 280
Cdd:PRK10406 223 ----QQETRALKEA-----GSLKGLWRN--RRAFIMVLG------FTAAGSLCFYTFTTYmqkylvnTAGMHANVASGIM 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 281 TVGIGTVNVLMTLVAiKIIDKIGRK-PLLLFGNAGMVISL-IVLALVNLffdNTPAASWTTVIClGVFIVVFAVSwgpVV 358
Cdd:PRK10406 286 TAALFVFMLIQPLIG-ALSDKIGRRtSMLCFGSLAALFTVpILSALQNV---SSPYAAFGLVMC-ALLIVSFYTS---IS 357
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 359 WVMLPELFPLHVRGIGTGVSTLMLHvGTLIVSLTYPIL-MEAIGISYLFLIY-AAIGIMAFL 418
Cdd:PRK10406 358 GILKAEMFPAQVRALGVGLSYAVAN-ALFGGSAEYVALsLKSIGMETAFFWYvTLMAVVAFL 418
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
10-208 |
1.06e-09 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 60.43 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 10 YFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLG 89
Cdd:cd17439 1 YFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 90 VALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGA-LSSLNQLMITVGILLSYIVNYIFA------------ 156
Cdd:cd17439 81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEhLSWLCMFWMIGGIYASAMAWAIIPhygwsfqmgsay 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 225185403 157 DAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGT 208
Cdd:cd17439 161 QFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDT 212
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
58-421 |
1.53e-09 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 59.29 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 58 LGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPN---TGV-----MVLFRIILGLAVGTSTTIVPLYLSELAPKHK 129
Cdd:cd17366 55 LGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTyatIGVwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 130 RGALSSLNQLMITVGILLSYIVNYIF------ADAEAWRWMLG-LAAVPslLLLIGIlfmpesprwlftngeeskakkil 202
Cdd:cd17366 135 RGFLGSWLEFGTLAGFILGAGLVTLLtlllteAQMLDWGWRIPfLIAAP--LGLVGL----------------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 203 eklrgtkdidqeihdikeaekqdegglkelfdpWVRPALIAGLGLaflqqFIGTNTIIY----YAPKTFTNV-GFGNSAS 277
Cdd:cd17366 190 ---------------------------------YLRRPLLICIGL-----VLVFNVTNYmllsYMPSYLEETlGYSETHG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 278 ILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnLFFDNTPAASWTTVICLGVFIVVFAVSWGPV 357
Cdd:cd17366 232 LLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL--LMNSGSIAAIFIGLLVLGLLLSCYTATMAST 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 358 vwvmLPELFPLHVR----GIGTGVSTLML-----HVGTLIVSLTYPILMEAigisYLFLIYAAIGIMAFLFVR 421
Cdd:cd17366 310 ----LPALFPTHVRysalAIAFNISVSLFggttpLVASWLVSATGNPLMPA----YYLMVAAVVGLVAVLFLT 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-179 |
2.27e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.72 E-value: 2.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 14 ALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALA 93
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSL 173
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
....*.
gi 225185403 174 LLLIGI 179
Cdd:cd17321 162 VALLLA 167
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-188 |
3.13e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 3.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 9 LYFFGALGGALY-GYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGG 87
Cdd:COG0738 211 RLLLGGLAIFLYvGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 88 LGVALAPNTGVMVLFRIILGLAVGtstTIVPL---YLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIfADAEAWRWM 164
Cdd:COG0738 291 LLALLAPGPWLALIGLALVGLGLS---LMFPTifsLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL-ADAFGLRAA 366
|
170 180
....*....|....*....|....
gi 225185403 165 LGLAAVPSLLLLIGILFMPESPRW 188
Cdd:COG0738 367 FLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-181 |
3.35e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 58.79 E-value: 3.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 26 VISGAILFMKKELGlNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRII 105
Cdd:cd06179 16 LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225185403 106 LGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIF-ADAEAWRWMLGLAAVPSLLLLIGILF 181
Cdd:cd06179 95 IGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeANAAGWRWIFYINAIFNALALILLFF 171
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-420 |
4.47e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.95 E-value: 4.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 24 TGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFR 103
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 104 IILGLAVGTSTTIVPLYLSELAPKhKRGALSSLNQLMITVG-----ILLSYIVNYIFadAEAWRWMLGLAAVPSLLLLIg 178
Cdd:cd17478 92 ALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGfalgpLIAAALVALFG--GLGLLILLIIPGLAVALLLL- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 179 ilfmpespRWLFTNGEESKAKKILEKLRGTKDIdqeihdikeaekqdegglkelfdpwVRPALIAGLGLAFLQQFIGTNT 258
Cdd:cd17478 168 --------RLRPLKKPEAKKAAAKSSARSTLKG-------------------------VWRALLLLLIIVFLRSWVLSSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 259 IIYYAP----KTFTNVGFGNSASI-LGTVGIGtvnvlmTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFfdntp 333
Cdd:cd17478 215 TTFLPFylvqRGYSLVFAGLLLSLfLFAGAIG------TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI----- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 334 aASWTTVICLGVFIvvfaVSWGPVVWVMLPELFPLHVrGIGTGVS-TLMLHVGTLIVSLTyPILMEAIGISYLFLIYAAI 412
Cdd:cd17478 284 -WSYILLVLAGFLL----FASFPVTVVLAQELLPGNV-GLASGLMmGLSFGLGGIGAPVL-GALADAFGLESVLLILALL 356
|
....*...
gi 225185403 413 GIMAFLFV 420
Cdd:cd17478 357 PLLGALLA 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-187 |
4.90e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.97 E-value: 4.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 7 IWLYFFGALGGALygydtGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:COG2223 210 LSLLYFGTFGSFI-----GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAP-NTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVG-ILLSYIVNYIFADAEAWRWM 164
Cdd:COG2223 285 LLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGgFLGPLLFGALLDATGSYTAA 364
|
170 180
....*....|....*....|...
gi 225185403 165 LGLAAVPSLLLLIGILFMPESPR 187
Cdd:COG2223 365 FLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
36-420 |
5.09e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 36 KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFC-IGGLGVALAPNTGVMVLFRII--LGLAVGT 112
Cdd:cd17370 27 VVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSaLAKPLLALAGSWQLVLLLRILerLGKGIRT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 113 STTIVplYLSELAPKHKRGALSSLNQLMITVG----ILLSYIVNYIFAdaEAWRWMLGLAAVPSLLLLIGILFMPESPRW 188
Cdd:cd17370 107 PPRDA--LLADATPPSGRGKAFGLHRALDTLGavlgPLLAALLLYLLG--GNYRTIFLLAAIPALLALLILLFVVKEYPR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 189 LFTNGEESKakkileklrgtkdidqeihdikeaeKQDEGGLKELFDPWVRPALIAGLGLAFLQqfigtnTIIYYApktfT 268
Cdd:cd17370 183 PPKLRKKSK-------------------------KTSLKKLPKAFWLYLLAVALFALGNFSFA------FLILRA----Q 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 269 NVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGnagMVISLIVLALvnLFFDNTPAASWTTVICLGVFIV 348
Cdd:cd17370 228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG---YLSLALAYLG--FALGSSLWLLLLGFILWGLYMG 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 349 VfavsWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFV 420
Cdd:cd17370 303 A----QESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-183 |
1.22e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 7 IWLYFFGALGGALyGYDTGVISGAiLFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17473 199 VLPIYFLAFLAML-LFYVIPIQLP-FLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLS-YIVNYIFADAEAWRWML 165
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSpLVLGPLVNLTGGLSGAF 356
|
170
....*....|....*...
gi 225185403 166 GLAAVPSLLLLIGILFMP 183
Cdd:cd17473 357 LILGVLALVLAIVLLLLR 374
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
43-183 |
1.28e-08 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 56.60 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 43 FTEGLVVSSLLVGAILGSGAAGKLTD-RFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYL 121
Cdd:cd17378 33 FLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 122 SELAPKHKRGALSSLNQLMITVGILLSYIVNYIfaDAEAWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17378 113 TEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYL--NGSSWRVLYFWTSIPALIYCILVYLFA 172
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-422 |
2.01e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.08 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 40 LNAFTEGLVVSSLLVGAILGS-GAA--------GKLTDRFGRKKAIMAAALLFCI-GGLGVALAPNTGVMVLFRIILGLA 109
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAyGISqmllriplGILSDRIGKRKLFIIIGLLFTVlASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 110 VGTSTTIVPLYLSELAPKHKRGALSSLNQLMiTVGILLSYIVNYIFADAEAWR---WMLGLAAVPSLLLLIGIlfmpesp 186
Cdd:cd17490 99 AATWVSFTVLYASYFPPDEAAKAMGLINLVN-NLGQLIAFLIGGLIAEHFGMRapfLLAALAGVLGFILSLFI------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 187 rwlftngEESKAKKileklrgtkdidqeihdikeaeKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKT 266
Cdd:cd17490 171 -------KEERREK----------------------KPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 267 FTNVGFGNSA-SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVlalvnlffdnTPAASWTTVICLGV 345
Cdd:cd17490 222 AKQLGASSFQlGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFL----------IPFAPNLTLLYLLQ 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 346 FIVVFAVSWG-PVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17490 292 ALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
46-208 |
2.09e-08 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 56.07 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 46 GLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELA 125
Cdd:cd17440 37 GWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 126 PKHKRGA-LSSLNQLMITVGILLSYIV-------NYIFADAEA-----WRWMLGLAAVPSLLLLIGILFMPESPRWLFTN 192
Cdd:cd17440 117 AREKRGEhLSWLCMFWMIGGIYASAMAwaiiphyGWSFSMGSAyqfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEV 196
|
170
....*....|....*.
gi 225185403 193 GEESKAKKILEKLRGT 208
Cdd:cd17440 197 GKHDEAWMILKQIHDT 212
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-422 |
1.14e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 31 ILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV 110
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 111 GTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIgilfmpespRWLF 190
Cdd:cd17333 99 GILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAI---------LILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 191 TNGEEskakkilekLRGTKDIDQEIHDIKEAEKQDEGGLKELFdpwvrpaliagLGLAFLQQFIGTNTIIYYAPKTFTNV 270
Cdd:cd17333 170 TLFPE---------LPSARNPQQSVGAFSASASRLLRNPSIIL-----------GALALFLYVGAETAFSSWVPSYLVEK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 271 GF-GNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNlffdnTPAASWTTVICLGVFIvv 349
Cdd:cd17333 230 KHvSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAP-----TLVVGLVATALLGLFM-- 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 350 favswGPVVWVMLP---ELFPLHVrGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17333 303 -----AALFPTILSlgiSNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-148 |
1.32e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 10 YFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLG 89
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 90 VALAPNTGVMVLFR---IILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLS 148
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
47-185 |
1.95e-07 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 52.89 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 47 LVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV-GTSTTIVplYLSELA 125
Cdd:cd17442 40 LVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVsGHSQGLI--IKTEFL 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 126 PKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPES 185
Cdd:cd17442 118 PTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIPRT 177
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
15-391 |
2.47e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 52.76 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 15 LGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGrKKAIMAAALLFC-IGGLGVALA 93
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSN-PRVFLPIGLILCaIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 94 PNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRG-ALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPS 172
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGtWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 173 LLL-LIGILFMPESPRwlftngeeSKAKKILEKLRGtKDIDQEIHDIKEAEKQDEGGLKELfdpwVRPALIAGLGLAFLQ 251
Cdd:TIGR00881 161 IIVsLICFLLLRDSPQ--------SCGLPPAEEMPN-EEPDGDAEKKEEELTKKQIFLQYV----LLNKVLWYISLGYVF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 252 QFIGTNTIIYYAPKTFTNV-GFGNSASILGTVGIGTVNVLMTLVAIKIIDKI---GRKPLLLFGNAGMVISLIVLALvnl 327
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEkGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWL--- 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 328 ffdnTPAASWTTVICLGvFIVVFAVsWGPV--VWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSL 391
Cdd:TIGR00881 305 ----NPAANPLMDLICL-FALGFLV-YGPQmlIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGL 364
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
31-180 |
2.66e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 31 ILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV 110
Cdd:cd17370 222 LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYM 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 111 GTSTTIVPLYLSELAPKHKRGalSSLNQLMITVGILL---SYIVNYIFaDAEAWRWMLGLAAVPSLLLLIGIL 180
Cdd:cd17370 302 GAQESIERAAVADLVPAELRG--TAYGLFNTVVGIGWllaSLIAGYLW-DLISPSAAFLFSAVLALIALLLLL 371
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-181 |
5.45e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 51.61 E-value: 5.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 23 DTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF 102
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225185403 103 RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILF 181
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFF 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
37-182 |
8.66e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 8.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 37 ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTI 116
Cdd:COG2807 244 DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPL 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 117 VPLYLSELAPKHKR-GALSSlnqLMITVGILLS----YIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFM 182
Cdd:COG2807 324 ALTLIGLRARTPAEaAALSG---MAQSVGYLLAalgpLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-355 |
8.84e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.10 E-value: 8.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 9 LYFFGALGGALYGYDtgvisgAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGL 88
Cdd:cd17327 13 LYFLQYLDKSNISNA------AVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 89 GVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSL----NQLMITVGILLSYIVNYIFADA--EAWR 162
Cdd:cd17327 87 LTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFfyaaAGLGSIFGGLLAYGVFKILGVGglAGWR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 163 WMLGLAAVPSLLL-LIGILFMPESP--RWLFTNGEESKAKKILEKlRGTKDIDQEIH--DIKEAEKqdegglkelfDPWV 237
Cdd:cd17327 167 WLFIIEGLITIIIgLVIFFWLPDNPskAWFLTEEEKELAVERLRA-NQTGKGDQKFKwkQIKEAFK----------DPRT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 238 RPaliagLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRK-PLLLFGNAGMV 316
Cdd:cd17327 236 WL-----LFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRgLFAIFACVLAL 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 225185403 317 ISLIVLalvnLFFDNTPAASWTTVICLGVFIVVFAVSWG 355
Cdd:cd17327 311 VGSIIL----LAAPNPPGAYFAAYILGGGSYAGFPILLS 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-177 |
1.09e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.50 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 3 KQSNIWLYFFGALggALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDR-FGRKKAIMAAAL 81
Cdd:cd06174 201 KNPGLWLLLLAIF--LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 82 LFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVG-ILLSYIVNYIFADAEA 160
Cdd:cd06174 279 LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGgAIGPLLAGFLLAATFG 358
|
170
....*....|....*..
gi 225185403 161 WRWMLGLAAVPSLLLLI 177
Cdd:cd06174 359 LTGAFLVLAVLLLLAAI 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
245-434 |
1.15e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.50 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 245 LGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLAL 324
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 325 vnlffdntpAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGIS- 403
Cdd:cd06174 81 ---------APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGw 151
|
170 180 190
....*....|....*....|....*....|..
gi 225185403 404 -YLFLIYAAIGIMAFLFVRFKVTETKGRSLEE 434
Cdd:cd06174 152 rAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
42-182 |
1.16e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 50.34 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 42 AFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYL 121
Cdd:cd17391 239 AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 122 SELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLglaAVPSLLLLIGILFM 182
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF---VVTALLVLLNAIWS 376
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
54-183 |
1.21e-06 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 50.11 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 54 VGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV-GTSTTIVPLYLSELAPKHkRGA 132
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALtGFSIISMVLCVEWVDIEH-RTV 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 225185403 133 LSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17447 125 AGVLISLFWTVGNMLLALVAYLIRD---WRWLILAVTLPCAPGIITWWWVP 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-182 |
1.29e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLV--VSSLLVgaILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLA 109
Cdd:cd17329 225 VYVVEILGLGESLLGLLlaLNALLI--VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 225185403 110 VGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFM 182
Cdd:cd17329 303 EMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
1-131 |
1.95e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.77 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 1 MKKQSNIWLYFfgaLGGALY--GYDTgVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMA 78
Cdd:COG2270 234 LRRYRDLLRFL---LAYFFYrdGVQT-VIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 225185403 79 AALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRG 131
Cdd:COG2270 310 SLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREA 362
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
50-183 |
2.06e-06 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 49.72 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 50 SSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV-GTSTTIVPLYLsELAPKH 128
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALsGIVLNSVSLNV-EWMPTR 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 129 KRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17446 119 VRAVVGTLLGYCYTLGQLILAGVAYAIRD---WRWLQLAVSLPFFIFFLYSWWFP 170
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
7-176 |
2.17e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 49.64 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 7 IWLYFFGALGgaLYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRK-------KAIMAA 79
Cdd:cd17343 218 LWLLSLGYLV--VFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKhgsssrgNPRMPL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 80 ALLFCIGglgvalapNTGVMVLFRI------------ILGLAVGTST----TIVPLYLSELAPKHKRGALSSLNQLMITV 143
Cdd:cd17343 296 ALVFMAG--------LTVSLHLFRVhitsdsselfilLLGFLIGFSLygpiAIFGVIANESAPSHLCGTSHAIVALAANV 367
|
170 180 190
....*....|....*....|....*....|....*..
gi 225185403 144 GILLS-YIVNYIfADAEAWR---WMLGLAAVPSLLLL 176
Cdd:cd17343 368 GGVLAgLPFSYI-AKHYDWRtafLLLEILCAITVVIL 403
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
245-437 |
2.50e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 245 LGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLAL 324
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 325 vnlffdntpAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISY 404
Cdd:pfam07690 82 ---------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180 190
....*....|....*....|....*....|...
gi 225185403 405 LFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQ 437
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEE 185
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
33-177 |
3.82e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 3.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 33 FMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGV--MVLFRIILGLAV 110
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPtlLLLLLFILSFFV 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225185403 111 GTSTTIVPLYLSELAPKHKRGALSSL-NQLMITVGILLSYIVNYIFADAE---AWRWMLGLAAVPSLLLLI 177
Cdd:cd17316 283 GGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGgtgVPALILALLAIVALIVAL 353
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-157 |
4.56e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.80 E-value: 4.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 46 GLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSElA 125
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQ-T 117
|
90 100 110
....*....|....*....|....*....|..
gi 225185403 126 PKHKRGALSSLNQLMITVGILLSYIVNYIFAD 157
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAGTLIGPLLGGFLAD 149
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-148 |
4.70e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 4.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNT---GVMVLFRIILGL 108
Cdd:cd17321 193 LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGL 272
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 225185403 109 AVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLS 148
Cdd:cd17321 273 GLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
36-130 |
6.45e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 47.99 E-value: 6.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 36 KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLaVGTSTT 115
Cdd:cd17390 24 RSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-FKHTQS 102
|
90
....*....|....*
gi 225185403 116 IVPLYLSELAPKHKR 130
Cdd:cd17390 103 LCKAYLSDLVSEQER 117
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
6-163 |
7.35e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.14 E-value: 7.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 6 NIWLYFFGALggALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDR-FGRKKA----IMAAA 80
Cdd:TIGR00881 217 VLWYISLGYV--FVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGplavFFMAL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 81 LLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVG-ILLSYIVNYIfadAE 159
Cdd:TIGR00881 295 IIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGgILAGLPLGYL---AD 371
|
....
gi 225185403 160 AWRW 163
Cdd:TIGR00881 372 GFGW 375
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-188 |
7.49e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 7.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 26 VISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTG--VMVLFR 103
Cdd:cd17380 17 NMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSlpLLILSR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 104 IILGLAVG----TSTTIvplyLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIgI 179
Cdd:cd17380 97 ILLGLGEGvhfpSMTSL----FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWAL-V 171
|
....*....
gi 225185403 180 LFMPESPRW 188
Cdd:cd17380 172 WLIYLPPVW 180
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
38-183 |
7.97e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.96 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 38 LGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVM-VLFRIILGLAVGTSTTI 116
Cdd:cd17504 212 FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWAlVVALLLIGIGLGLAFAS 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 117 VPLYLSELAPKHKRGALSSLNQLMITVG----------ILLSYIVNYI---FADAEAWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17504 292 LPNIVVESVPPDRTGIATGMNTVLRTIGsaigpaiagaILTTYTVSITsggVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
42-183 |
9.76e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 47.47 E-value: 9.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 42 AFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYL 121
Cdd:cd17377 38 AYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLL 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225185403 122 SELAPKHKRGALSSLNQLMITVGILLSYIVNYIFadaEAWRWMLGLAAVPSLLLLIGILFMP 183
Cdd:cd17377 118 NECVGKSYWALAGSLGGLFFAVGIAQYALLGYFI---RSWRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
51-177 |
1.00e-05 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 47.51 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 51 SLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKR 130
Cdd:cd17373 33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR 112
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 225185403 131 GALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVPSLLLLI 177
Cdd:cd17373 113 LMITMVASLVAVAGQFLMPGLAALCRD---WRVLQALIICPFLLMLL 156
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
31-422 |
1.77e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.87 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 31 ILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV 110
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 111 GTSTTIVPLYLSELAPKHKRGALSSLN---QLMITVGILLSYIVnyIFADAEAWRWMLGLAAVPSLLLLIGILFMPEspr 187
Cdd:cd17393 102 GALDVAMNAQGVAVERAYGRPIMSSLHamwSLGGLAGALLGAAA--IGAGVSPGVHLLAAAVLLLLAALVAIRALLP--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 188 wlftngeeskakkileklrgtkdidqeiHDIKEAEKQDEGGLKELFDPWvrPALIAGLGLAFLQQFIGTNTIIYYAPKTF 267
Cdd:cd17393 177 ----------------------------GTGEAAEDRPDGAGKPGFLLP--NRLLLLLGLLALAAALAEGAAADWSALYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 268 TNV-GFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVnlffdNTPAASWTTVICLGVF 346
Cdd:cd17393 227 RDVlGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLA-----PSVWVALAGFALMGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 347 IVVFAvswgPVVWVMLPELFPLHvRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17393 302 LSVVV----PLAFSAAGALPGLA-AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARA 372
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
36-192 |
1.82e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.80 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 36 KELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTT 115
Cdd:cd17330 27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 116 IVPlYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLL-LLIGILFMPESPRWLFTN 192
Cdd:cd17330 107 AQA-YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLnLVLVLFFLPPLRRLLLVY 183
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
30-185 |
1.85e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.61 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 30 AILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLA 109
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225185403 110 VGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWR---WMLGLAAVpsLLLLIGILFMPES 185
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHaifAFLSLAGI--LLSALIFFILPET 183
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-182 |
2.47e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.39 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSsllvgaiLGSG-------AAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRI 104
Cdd:cd17471 224 LYVTNELGGSESWVGLLFG-------LAAAleipimlLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQL 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 105 ILGLAVGTSTTIVPLYLSELAPKHkRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVpslLLLIGILFM 182
Cdd:cd17471 297 LNAIFIGITAGLGISYFQDLMPGQ-PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAV---LALLALVLL 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-182 |
3.10e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 12 FGALGGALYGYdtgvISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVA 91
Cdd:cd17320 210 LGLSFAGLFAY----LAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 92 LAPNTGVMVLFRIILGLA-----VGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADaeaWRWMLG 166
Cdd:cd17320 286 LAALLGGLSLWPLVAPLFliffgFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNG---TALPMG 362
|
170
....*....|....*.
gi 225185403 167 LAAVPSLLLLIGILFM 182
Cdd:cd17320 363 LLILVLGLLALLLLIL 378
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-176 |
3.86e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 23 DTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGA-AGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVL 101
Cdd:cd17330 190 FAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVL 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 102 FRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVN---YIFADAEAWRWMLGLAAVPSLLLL 176
Cdd:cd17330 270 AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAgplYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
287-441 |
4.91e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 287 VNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALvnlffdntpAASWTTVICLGVFI-VVFAVSWGPVVwVMLPEL 365
Cdd:COG2223 52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL---------AVSYWLLLLLGLLLgIGGGGSFAVGI-ALVSKW 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 366 FPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRD 441
Cdd:COG2223 122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD 197
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
48-422 |
5.39e-05 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 45.42 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 48 VVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPK 127
Cdd:cd17396 40 VISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 128 HKrGALSSLNQLMITVG-ILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPrwlftngeeskakkilEKLR 206
Cdd:cd17396 120 AS-GSANILVKAFVSFGqFLLPFIIAFLAANNLWYGWSFIVPAAVLVLNALLLLKLSFPP----------------QTVT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 207 GTKDIDQEIHDIKEaekqdegglkelfdpwvRPALIAGLGLAFLQQFIGTNT---IIYYAPKTFTNVGFGNSASILGTVG 283
Cdd:cd17396 183 AANTKQKEIPVKRE-----------------KPKFLIEGIALILIGFTSTATfylFSQWMPKYGSAVAGMGEAESLKLIS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 284 IGTVNVLMTLVAIKIIDKIGRKPL-LLFGNAgmVISLIVLALvnLFFDNTPaaswtTVICLGVFIVVFAVSWGpvVW--- 359
Cdd:cd17396 246 YYSMGSLVCVFITAVLLKRYVRPIwILVLYP--IISLLALFV--LYLVPSP-----DVCILGAFVIGFFAAGG--VLqlg 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225185403 360 -VMLPELFPlHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17396 315 lTLMAEFFP-KGKGKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLLAIF 377
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
7-183 |
6.15e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.86 E-value: 6.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 7 IWLYFFGALGGALYgydTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:cd17502 170 LLSSIFGFLFGGAL---FGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGV--ALAPNTGVMVL--FRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAdaeawr 162
Cdd:cd17502 247 GAGLltTLTLDTSKWLLigYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFL------ 320
|
170 180
....*....|....*....|.
gi 225185403 163 wmlgLAAVPSLLLLIGILFMP 183
Cdd:cd17502 321 ----VALALAALAFLLSLFLP 337
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
43-205 |
8.66e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 45.04 E-value: 8.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 43 FTEGLVVSSLLVGailgsgaagKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTiVPLYLS 122
Cdd:pfam06609 87 WTMGQAVSILMMG---------RLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGA-SPLFIG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 123 EL-APKHKRGALSSLNQLMITVGILLSYIVNYIfADAEAWRWMLGLAAVPSLL--LLIGILFMPESPRWLftNGEESKAK 199
Cdd:pfam06609 157 ELmSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL-AIQGNWRWIFYIYIIMSAIavLLIIIWYHPPSFAQL--HGKKARKR 233
|
....*.
gi 225185403 200 KILEKL 205
Cdd:pfam06609 234 DELAKL 239
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-419 |
8.94e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.51 E-value: 8.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 64 GKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLavGTSTTIVPLYLSELAPKHKRGALSSLNQLMITV 143
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 144 GILLSYIVNYIFADAEAWRWMLGLAAVPSLL-LLIGILFMPESPRwlFTNGEESKAKKILEKLRGtkdidqeihdikeae 222
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLFFVPDPPK--IVQISEKEKKKLKKLLKN--------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 223 kqdegglKELFdpwvrpaliaGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASI---LGTVGIGTvnVLMTLvAIKII 299
Cdd:cd17472 194 -------KRLL----------RLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWkvyLPAILIGF--ILMVP-FVIYA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 300 DKIGR-KPLLLFGNAGMVISLIVLALVNLFFdntpaasWTTVICLGVFIVVFAvSWGPVVWVMLPELFPLHVRGIGTGVS 378
Cdd:cd17472 254 EKKGKmKQVFVSSILLIAVGFLLLLFAATSL-------WLLIIGLIIFFIGFN-LLEALLPSLVSKIAPKEYRGTAMGIY 325
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 225185403 379 TLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLF 419
Cdd:cd17472 326 NTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
5-176 |
9.49e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.54 E-value: 9.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 5 SNIWLYFFGalGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRF--GRKKAIMAAALL 82
Cdd:cd17475 198 RDVWLIAIA--GALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 83 FCIGGLGVALAPNTG----VMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSL----NQLMITVG-ILLSYIVNY 153
Cdd:cd17475 276 IAAAALLVLSLLSPGtplwLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLantiNFIGIAIGpPLFGLLVDA 355
|
170 180
....*....|....*....|...
gi 225185403 154 IFADAEAWRWMLGLAAVPSLLLL 176
Cdd:cd17475 356 THSYAPAWLALALLLVLAALLLL 378
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
58-432 |
1.11e-04 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 44.32 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 58 LGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTG--------VMVLFRIILGLAVGTSTTIVPLYLSELAPKHK 129
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 130 RGALSSLNQLMITVG--------ILLSYIVNYifADAEAWRWMLGL-AAVPslLLLIGILF---MPESPrwLFTNGEESK 197
Cdd:PRK10642 152 RGFMGSWLDFGSIAGfvlgagvvVLISTIVGE--ANFLDWGWRIPFfIALP--LGIIGLYLrhaLEETP--AFQQHVDKL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 198 AKKILEKLRGTKDIDqeihdikeaekqdeggLKELFDPWVRpALIAGLGLAflqqfIGTNTIIY----YAPKTFT-NVGF 272
Cdd:PRK10642 226 EQGDREGLQDGPKVS----------------FKEIATKHWR-SLLTCIGLV-----IATNVTYYmlltYMPSYLShNLHY 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 273 GNSASILGTVGIgTVNVLMTLVAIKII-DKIGRKPLLLFGNagmvISLIVLALVNLFFDNTpaaSWTTVICLGVFIVvfA 351
Cdd:PRK10642 284 SEDHGVLIIIAI-MIGMLFVQPVMGLLsDRFGRRPFVILGS----VALFVLAIPAFILINS---NVIGLIFAGLLML--A 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 352 VSWGPVVWVM---LPELFPLHVR--------GIGTGVSTLMLHVGTLIVSLTYPILMEAigisYLFLIYAAIGIMAFLFV 420
Cdd:PRK10642 354 VILNCFTGVMastLPAMFPTHIRysalaaafNISVLVAGLTPTLAAWLVESTQNLMMPA----YYLMVVAVIGLITGVTM 429
|
410
....*....|..
gi 225185403 421 RfkvtETKGRSL 432
Cdd:PRK10642 430 K----ETANRPL 437
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
7-182 |
1.36e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 44.22 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 7 IWLYFFGALGGALYGydtgviSGAILFMKKELGlNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG 86
Cdd:pfam13347 230 LASFLLAALAMGVLN------GLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAG 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 87 GLGVALAP--NTGVMVLFRIILGLAVGTSTTIVPLYLSELA-------PKHKRGALSSLNQLMITVGILLS-----YIVN 152
Cdd:pfam13347 303 FALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVdygelrtGKRREGTFFAMWSFISKLATGVGlgvsgLLLS 382
|
170 180 190
....*....|....*....|....*....|....*...
gi 225185403 153 YIFADAEA--------WRWMLGLAAVPSLLLLIGILFM 182
Cdd:pfam13347 383 AFGYNAGDsvqspqavTAIRLLYAVLPAVLFLVALLLL 420
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-182 |
1.49e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRF---GRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGL 108
Cdd:cd17319 204 TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGF 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225185403 109 AVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITV-GILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFM 182
Cdd:cd17319 284 GIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLgGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-182 |
2.63e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.01 E-value: 2.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNT-GVMVLFRIILGLAV 110
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSyWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225185403 111 GTSTTIVPlYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAE-------AWRWMLGLAAVPSLLLLIGILFM 182
Cdd:cd17341 103 ANFASGQP-WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVPGILLAIAAVLVLLF 180
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-144 |
3.49e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIG-GLGVALAPNTGVMVLFRIILGLAV 110
Cdd:cd17503 203 LYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGtLLLAFLTPDTSLWLIILPLFIRGL 282
|
90 100 110
....*....|....*....|....*....|....*.
gi 225185403 111 GTSTTIVPLYLSELA--PKHKRGALSSLNQLMITVG 144
Cdd:cd17503 283 GMGLVFMPLNTLALNslPPEQIGDATALFNTIRQLG 318
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
31-182 |
3.51e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 42.56 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 31 ILFMKKELGlNAFTEGLvvSSLLVGAILGSG-----AAGKLTDRF-GRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRI 104
Cdd:cd17346 26 ILYLTAQLG-DGFSEAD--AASIYGAYTALVyltpiIGGWLADKVlGARRTVFIGGILMALGYLLLALSPFSVSMLYLGL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 105 ILgLAVGTS--TTIVPLYLSELAPK--HKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGIL 180
Cdd:cd17346 103 AL-IIVGNGlfKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHYGFGLAAVGMLLGLLIFL 181
|
..
gi 225185403 181 FM 182
Cdd:cd17346 182 LG 183
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
300-422 |
5.36e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 300 DKIGRKPLLLFGNAGMVISLIVLALVnlffdntpaaswTTVICLGVFIVVFAVSWG---PVVWVMLPELFPLHVRGIGTG 376
Cdd:COG0477 74 DRYGRKRVLLIGLLLFGLASLLCGLA------------PSPELLIAARALQGIGAGglmPGALALIAELFPARERGRALG 141
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 225185403 377 VSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:COG0477 142 LWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
6-177 |
6.46e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.86 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 6 NIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCI 85
Cdd:cd17393 198 NRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 86 GGLGVALAPNTGVMVLFRIILGLAVgtsTTIVPLYLSELA--PKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRW 163
Cdd:cd17393 278 GLLLALLAPSVWVALAGFALMGLGL---SVVVPLAFSAAGalPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRT 354
|
170
....*....|....
gi 225185403 164 MLGLAAVPSLLLLI 177
Cdd:cd17393 355 AFLVVALLALLVAL 368
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
47-174 |
6.79e-04 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 41.68 E-value: 6.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 47 LVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAvGTSTTIVPLYL-SELA 125
Cdd:cd17376 39 LTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMG-QISNYVVAFVLgTEIL 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 225185403 126 PKhkrgalsSLNQLMITVGILLSYIVNYIFADAEA-----WRWMLGLAAVPSLL 174
Cdd:cd17376 118 GK-------SVRILFSTLGVCIFYAIGYMLLPLFAyfirdWRMLLLALTLPGVL 164
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
10-365 |
7.50e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 7.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 10 YFFGALGGALYgydTGVISGAIL-FMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDR-----FGRKKAIMAAALLF 83
Cdd:cd17332 4 YGLGDFGNNLI---FQIVSTYLLfFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRtrsrwGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 84 CIGGLGVALAPNTGVMVLFRIILG--LAVGTSTTIVPLYLSELAP-----KHKRGALSSLNQLMITVGILLSYIVNYIF- 155
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALItyILLDLLYTLVNIPYTALIPeltddPEERTSLTSWRMFFATIGGLLVTVLPPPLv 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 156 ------ADAEAWRWMLGLAAVPSLLLLIGILFmpesprwlftngeeskakkileklrGTKdidqEIHDIKEAEKQDEGGL 229
Cdd:cd17332 161 ayfgggNASRGYFLTALIIGIIGIILLLICFF-------------------------GTR----ERVVPPEEEKSKLPLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 230 KELFDPWVRPALIaGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLL 309
Cdd:cd17332 212 KSLKALLKNRPFL-ILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 225185403 310 FGNAGMVISLIVLALVnlffdnTPAASWTTVICLGVFIVVFAVSWgPVVWVMLPEL 365
Cdd:cd17332 291 IGLLLAILGLLLLFFL------PPGNLVLILVLAVLAGIGYGGAN-LLPWAMLADV 339
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
275-440 |
7.57e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 7.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 275 SASILGTV--GIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFfdntpaasWTTVICLGVFIVVFAV 352
Cdd:cd17329 33 SASIVGLVlaLSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP--------WLFAIALVLTGFGGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 353 SWgPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYpILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSL 432
Cdd:cd17329 105 FE-PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRR 182
|
....*...
gi 225185403 433 EEIEQDLR 440
Cdd:cd17329 183 AAEKTEIL 190
|
|
| MFS_SLC22A31 |
cd17443 |
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ... |
51-177 |
9.83e-04 |
|
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 41.30 E-value: 9.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 51 SLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVgtSTTIVPLYLS--ELAPKH 128
Cdd:cd17443 44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTL--AGVFLSLYIArlELCDPS 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 225185403 129 KRGALSSLNQLMITVGILLsyiVNYIFADAEAWRWMLGLAAVPSLLLLI 177
Cdd:cd17443 122 HRLMVSMGAGFFSVAGELL---LPGLAVLCRDWRVLQGVGTLPLLLLLL 167
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
8-181 |
1.33e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 8 WLYFFGALGGALYGYDTGVISG--AILFMKKELGL--NAFTEGLVVSSLLvgAILGSGAAGKLTDRFGRKKAIMAAALLF 83
Cdd:cd17369 227 WRALLLAIGLRLAENVLFYLFTtfALSYATQTLGVdrSTVLLAVLIASVV--AAITIPLFGWLSDRVGRRPVYLAGALLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 84 CIGGLGVALAPNTG----VMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLM--ITVGILLSYIVNYIFAD 157
Cdd:cd17369 305 ALFAFPFFWLLDTGstwlIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLgaILGGGFAPLIATALVAA 384
|
170 180
....*....|....*....|....
gi 225185403 158 AEAWRWMLGLAAVPSLLLLIGILF 181
Cdd:cd17369 385 TGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
273-440 |
1.48e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 273 GNSASILGTVGIGTV--NVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVF 350
Cdd:cd06173 30 TGSALLVGLVLAAFFlpFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 351 avswGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYA---AIGIMAFLFVRFKVTET 427
Cdd:cd06173 110 ----GPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlsfLLSALLLLFIRRPPPAA 185
|
170
....*....|...
gi 225185403 428 KGRSLEEIEQDLR 440
Cdd:cd06173 186 PGESSSLLLRDLR 198
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
32-137 |
1.52e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVS-SLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAV 110
Cdd:cd17331 232 LVAMDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGG 311
|
90 100
....*....|....*....|....*..
gi 225185403 111 GTSTTIVPLYLSELAPKHKRGALSSLN 137
Cdd:cd17331 312 SVLYTVITSLLTKAVPPEDTGTALGLS 338
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
32-181 |
1.65e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 40.89 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVG 111
Cdd:pfam05977 243 LVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWI 322
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 112 TSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVpsLLLLIGILF 181
Cdd:pfam05977 323 TALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAA--ALLAGAAAG 390
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
19-125 |
1.73e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 19 LYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAP--NT 96
Cdd:cd17332 232 LYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNL 311
|
90 100
....*....|....*....|....*....
gi 225185403 97 GVMVLFRIILGLAVGTSTTIVPLYLSELA 125
Cdd:cd17332 312 VLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
32-115 |
1.86e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNT--------GVMVLFR 103
Cdd:PRK05122 40 GYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGLLaawpvlslLLLLLGR 119
|
90
....*....|....*
gi 225185403 104 IILGLA---VGTSTT 115
Cdd:PRK05122 120 LLLGIGeslAGTGSI 134
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
53-179 |
2.02e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 40.14 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 53 LVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGA 132
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 225185403 133 LSSLNQLMITVGILLSYIVNYIFADaeaWRWMLGLAAVP-SLLLLIGI 179
Cdd:cd17445 126 VAMAGGLTMVGGHFLLLGLALGCGS---WRVLQGTITAPlSLFLCYGC 170
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
63-182 |
2.26e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 63 AGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGtstTIVPLYLSELA----PKHKRGALSSLNQ 138
Cdd:cd17476 53 FGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPA---FLLPNAMALLGrtypPGPRKNIVFSLFG 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 225185403 139 LMITVGILLSYIVNYIFADAEAWRWMLG-LAAVPSLLLLIGILFM 182
Cdd:cd17476 130 ATAPLGFALGGVFGGLFAQLAWWPWIFWfLAILAAIVAVAAIFWT 174
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
32-109 |
2.53e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 40.04 E-value: 2.53e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 32 LFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLA 109
Cdd:PRK12382 40 LFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYLLAAILPVSAPFKFALLVV 117
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
37-422 |
3.54e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.53 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 37 ELGLNAFTEGLV-----VSSLLVGAILGSgAAGKLTDRFGRKKAIMAAALLfcIGGLGVALAPNTG-------------- 97
Cdd:cd17313 28 TLGLSHALIGFVwtlgpILGLFVQPLVGS-LSDRCNSRIGRRRPFILVGAP--LAALGLILIPNAAdiglalgdgprtwa 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 98 VMVLFRIILGLAVGTSTTIVPL--YLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLG--------L 167
Cdd:cd17313 105 LVLFVLGIVLLDFAMNVCQGPVraLLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGgnlkvpfyI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 168 AAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRgtkdidqeihDIKEAEKQDEGGLKELFdpwvrpaliaglgL 247
Cdd:cd17313 185 GAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLK----------SLLKLLKIMPRSLLRLL-------------L 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 248 AFLQQFIGTNTIIYYA------------PKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGM 315
Cdd:cd17313 242 VIFFWWIAFFPFELFFtdymgeevyhgtSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 316 VISLIVLALVNlffdntpaaswtTVICLGVFIVVFAVSWGPVVWV---MLPELFPLHVRGIGT--GVSTLMLHVGTLIVS 390
Cdd:cd17313 322 AVGMALMALVH------------NVTVALVLFALGGIGWATININpypLVSDYHSESGRGQGTdtGLLNLAISLAQILVS 389
|
410 420 430
....*....|....*....|....*....|..
gi 225185403 391 LTYPILMEAIGISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17313 390 LLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
33-187 |
3.77e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 33 FMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGT 112
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225185403 113 STTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFAdAEAWRWM---LGLAAVPSLLLLIGILFMPESPR 187
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGL-GGGLSWRagwLALALLSAVLLLLSFLLLRRGPS 180
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
31-177 |
5.57e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.77 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 31 ILFMKKELGLNAFTEG--LVVSSLLVGAILGsGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGL 108
Cdd:cd17388 230 VLFTEDRFDWSPTMVGlsLAVFGLLHALFQA-FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLAL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225185403 109 AvGTSTTIVPLYLSELAPKHKR----GALSSLNQLMITVGILL-SYIVNYIFADAEAWRWMLGLAAVPSLLLLI 177
Cdd:cd17388 309 G-GIAGPALQGLLSRQVPENEQgelqGVLTSLTSLTSIIGPLLfTGIFAASPATWPGLAWIIGAALYLICLVLA 381
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
37-422 |
6.14e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.64 E-value: 6.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 37 ELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGG---LGVALAP-NTGVMVLFRIILGLAVgt 112
Cdd:cd17337 26 DLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEvlfLAFGLPShNYPLMLLTYGLRGFGY-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 113 sttivPLY-------LSELAPKHKRGALSSLNQLMITVGI------LLSYIVNYIFADAEAWrwmLGLAAVpSLLLLIGI 179
Cdd:cd17337 104 -----PLFaysflvwITYRTPAERLGSAVGWFWFAFTGGLpvlgsyLASFTIPVIGEIGTLW---LSLVFV-ALGGLIAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 180 LFMPESPRWLFTNGEESKAKKILeklrgtkdidqeihdikeaekqdeggLKELFDPWVRPALiaglGLAFLQQFIgtNTI 259
Cdd:cd17337 175 FLVRDRTGEQPLANPSEEPLKEL--------------------------LSGITILFRNPKI----AIGGIVRII--NTL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 260 IYYA-----PKTFTN-VGFGNS--ASILGTVGIgtVNVLMTLVAIKIIDKIG-RKPLLLFGNAGMVISLIVLALVNLFFD 330
Cdd:cd17337 223 SQFGfpvfmPLYFTDtGGFSTSqwLQIWGIIFL--VNIFFNLIFGILGDKIGwRRTVRWFGGVGCAISTLLFYYVPQLFG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 331 NTPAASWTTVICLGVFIVVFavswgpvvwVMLPELFPLHV---RG-------IGTGVSTLmlhVGTLIVSLTYPilmeAI 400
Cdd:cd17337 301 HNYWAALIAAILFGIGLAGF---------VPLSALMPSLApehKGaamsilnLGAGLSNF---VGPAIVTLFLG----SF 364
|
410 420
....*....|....*....|..
gi 225185403 401 GISYLFLIYAAIGIMAFLFVRF 422
Cdd:cd17337 365 GAGGVVWIFAGLYLLSAVLTLF 386
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
9-182 |
7.84e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 9 LYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAG-KLTDRFGRKKAIMAAALLFCIGG 87
Cdd:cd17490 196 LLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYC 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 88 LGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGL 167
Cdd:cd17490 276 FLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFV 355
|
170
....*....|....*
gi 225185403 168 AAVPSLLLLIGILFM 182
Cdd:cd17490 356 IGVIALLAAILSLAY 370
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
33-130 |
9.19e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.11 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 33 FMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRI---ILGLA 109
Cdd:cd17366 219 YLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIgllVLGLL 298
|
90 100
....*....|....*....|.
gi 225185403 110 VGTSTTIVPLYLSELAPKHKR 130
Cdd:cd17366 299 LSCYTATMASTLPALFPTHVR 319
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
20-109 |
9.31e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 38.35 E-value: 9.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225185403 20 YGYDTGVIsgAILFMkkeLGLnafteglvVSSLLVGAILGSgaagkLTDRFGRKKAIMAAALLFCIGGLgVALAPNTGVM 99
Cdd:cd17487 33 YGFSEEQI--AILFV---TGF--------GSSVVFGTFVGS-----LADKFGRKRACLLFCVLYSLSCL-TKHSPNFGVL 93
|
90
....*....|
gi 225185403 100 VLFRIILGLA 109
Cdd:cd17487 94 LLGRVLGGIS 103
|
|
| |
