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Conserved domains on  [gi|1905442724|emb|CAD5311236|]
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hypothetical protein STMLT2P22_CBEKMEGD_04682 (plasmid) [Salmonella enterica subsp. enterica serovar Typhimurium]

Protein Classification

thioredoxin domain-containing protein( domain architecture ID 144)

thioredoxin domain-containing protein may function as a thiol disulfide oxidoreductase that catalyzes the oxidation or reduction of protein disulfide bonds using an active site dithiol, present in a CXXC motif

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thioredoxin_like super family cl00388
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; The thioredoxin ...
 2-94 1.50e-07

Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; The thioredoxin (TRX)-like superfamily is a large, diverse group of proteins containing a TRX fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of target proteins via the reversible oxidation of their active site dithiol. The PDO members of this superfamily include the families of TRX, protein disulfide isomerase (PDI), tlpA, glutaredoxin, NrdH redoxin, and bacterial Dsb proteins (DsbA, DsbC, DsbG, DsbE, DsbDgamma). Members of the superfamily that do not function as PDOs but contain a TRX-fold domain include phosducins, peroxiredoxins, glutathione (GSH) peroxidases, SCO proteins, GSH transferases (GST, N-terminal domain), arsenic reductases, TRX-like ferredoxins and calsequestrin, among others.


The actual alignment was detected with superfamily member cd03023:

Pssm-ID: 469754 [Multi-domain]  Cd Length: 154  Bit Score: 46.05  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905442724   2 FKYWPTFVQQWENslkAAQKGLEIWKSArADAWLAYHNGIFATShyeGALTSEDISSAAAAA---LKGHKIRGGNVNTKS 78
Cdd:cd03023    41 FKEFPILGESSVL---AARVALAVWKNG-PGKYLEFHNALMATR---GRLNEESLLRIAKKAgldEAKLKKDMDDPEIEA 113

                          90
                  ....*....|....*.
gi 1905442724  79 ILDGSNRLAHTLALQG 94
Cdd:cd03023   114 TIDKNRQLARALGITG 129
 
Name Accession Description Interval E-value
DsbA_Com1_like cd03023
DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer ...
 2-94 1.50e-07

DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC motif, assumed to be imbedded in a DsbA-like structure. Its homology to DsbA suggests that the protein is a protein disulfide oxidoreductase. The role of such a protein in pathogenesis is unknown.


Pssm-ID: 239321 [Multi-domain]  Cd Length: 154  Bit Score: 46.05  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905442724   2 FKYWPTFVQQWENslkAAQKGLEIWKSArADAWLAYHNGIFATShyeGALTSEDISSAAAAA---LKGHKIRGGNVNTKS 78
Cdd:cd03023    41 FKEFPILGESSVL---AARVALAVWKNG-PGKYLEFHNALMATR---GRLNEESLLRIAKKAgldEAKLKKDMDDPEIEA 113

                          90
                  ....*....|....*.
gi 1905442724  79 ILDGSNRLAHTLALQG 94
Cdd:cd03023   114 TIDKNRQLARALGITG 129
 
Name Accession Description Interval E-value
DsbA_Com1_like cd03023
DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer ...
 2-94 1.50e-07

DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC motif, assumed to be imbedded in a DsbA-like structure. Its homology to DsbA suggests that the protein is a protein disulfide oxidoreductase. The role of such a protein in pathogenesis is unknown.


Pssm-ID: 239321 [Multi-domain]  Cd Length: 154  Bit Score: 46.05  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905442724   2 FKYWPTFVQQWENslkAAQKGLEIWKSArADAWLAYHNGIFATShyeGALTSEDISSAAAAA---LKGHKIRGGNVNTKS 78
Cdd:cd03023    41 FKEFPILGESSVL---AARVALAVWKNG-PGKYLEFHNALMATR---GRLNEESLLRIAKKAgldEAKLKKDMDDPEIEA 113

                          90
                  ....*....|....*.
gi 1905442724  79 ILDGSNRLAHTLALQG 94
Cdd:cd03023   114 TIDKNRQLARALGITG 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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