NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1981674398|emb|CAD7837421|]
View 

hypothetical protein [Olavius algarvensis Delta 4 endosymbiont]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-269 5.97e-38

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 132.83  E-value: 5.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  62 LNSLFYRVFFTLVRILIPACRWKID----ETVRDVRASVVVSNHISYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLA 136
Cdd:COG0204     8 LRRFRYRLVRLWARLLLRLLGVRVRveglENLPADGPVLIVANHQSWLDILLLLAALPRPVRfVAKKELFKIPLLGWLLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 137 LSGYLPSNATGHLADL-MLQRMASMpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFK 215
Cdd:COG0204    88 ALGAIPVDRSKRRAALrALRQAVEA---LKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALP 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1981674398 216 PGRFLfdtqRPNRIRVELLETIDPDYEDGSfSIHSLMERVHTLLEKHSAALEES 269
Cdd:COG0204   165 KGFLP----RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-269 5.97e-38

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 132.83  E-value: 5.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  62 LNSLFYRVFFTLVRILIPACRWKID----ETVRDVRASVVVSNHISYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLA 136
Cdd:COG0204     8 LRRFRYRLVRLWARLLLRLLGVRVRveglENLPADGPVLIVANHQSWLDILLLLAALPRPVRfVAKKELFKIPLLGWLLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 137 LSGYLPSNATGHLADL-MLQRMASMpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFK 215
Cdd:COG0204    88 ALGAIPVDRSKRRAALrALRQAVEA---LKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALP 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1981674398 216 PGRFLfdtqRPNRIRVELLETIDPDYEDGSfSIHSLMERVHTLLEKHSAALEES 269
Cdd:COG0204   165 KGFLP----RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 74-256 3.09e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 124.69  E-value: 3.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  74 VRILIPACRWKID----ETVRDVRASVVVSNHISYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLALSGYLPSNATGH 148
Cdd:cd07989     1 LRLLLRLLGVRVRveglENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRfVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 149 LADL-MLQRMASMpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKPGRFLFdtqRPN 227
Cdd:cd07989    81 RSAReALREAIEA---LKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLP---RPG 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1981674398 228 RIRVELLETIDPD-YEDGSFSIHSLMERVH 256
Cdd:cd07989   155 RVTVRIGEPIPPEgLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 96-202 4.03e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 83.17  E-value: 4.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398   96 VVVSNHISYLDPILLISLYRRH----TTIAKARLFAIPLYGNMLALSGYLPSNATGHLADLMLQRMASMpgHLADGGNLI 171
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKlgrvRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE--LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1981674398  172 IFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 85-202 3.05e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 81.24  E-value: 3.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  85 IDETVRDVRASVVVSNHISYLDPILLISLY-RRHTTIAKARLFAIPLYGNMLALSGYLP---SNATGHLADLMLQRMAsm 160
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDPLTLSAAFpPPIVFIAKKELKWIPFFGIMLWLTGAIFidrENIRAIATALKAAIEV-- 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1981674398 161 pghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:TIGR00530  86 ---LKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPI 124
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 87-202 2.14e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.47  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  87 ETVRDVRASVVVSNHISYLDPILLIS-LYRRHT---TIAKARLFAIPLYGNMLALSGYLP----SNATGHLADLMLQRMa 158
Cdd:pfam01553   8 ENLPRGGPAIVVANHQSYLDVLLLSLaLYKRGRplvFVAKKELFDIPLVGWLMRLLGCIFidrkNRKDAAGTLEYLVEL- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1981674398 159 smpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:pfam01553  87 -----LREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPI 125
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 94-218 1.21e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 73.61  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  94 ASVVVSNHISYLDPILLISLYRRHTTIAKARLFAIPLYGNMLALSGYLPSNATGHLADL-MLQRMASMpghLADGGNLII 172
Cdd:PLN02901   51 PAVYVSNHQSFLDIYTLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLeCLKRCMEL---LKKGASVFF 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1981674398 173 FPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKPGR 218
Cdd:PLN02901  128 FPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNGK 173
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-269 5.97e-38

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 132.83  E-value: 5.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  62 LNSLFYRVFFTLVRILIPACRWKID----ETVRDVRASVVVSNHISYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLA 136
Cdd:COG0204     8 LRRFRYRLVRLWARLLLRLLGVRVRveglENLPADGPVLIVANHQSWLDILLLLAALPRPVRfVAKKELFKIPLLGWLLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 137 LSGYLPSNATGHLADL-MLQRMASMpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFK 215
Cdd:COG0204    88 ALGAIPVDRSKRRAALrALRQAVEA---LKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALP 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1981674398 216 PGRFLfdtqRPNRIRVELLETIDPDYEDGSfSIHSLMERVHTLLEKHSAALEES 269
Cdd:COG0204   165 KGFLP----RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 74-256 3.09e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 124.69  E-value: 3.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  74 VRILIPACRWKID----ETVRDVRASVVVSNHISYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLALSGYLPSNATGH 148
Cdd:cd07989     1 LRLLLRLLGVRVRveglENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRfVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 149 LADL-MLQRMASMpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKPGRFLFdtqRPN 227
Cdd:cd07989    81 RSAReALREAIEA---LKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLP---RPG 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1981674398 228 RIRVELLETIDPD-YEDGSFSIHSLMERVH 256
Cdd:cd07989   155 RVTVRIGEPIPPEgLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 96-202 4.03e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 83.17  E-value: 4.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398   96 VVVSNHISYLDPILLISLYRRH----TTIAKARLFAIPLYGNMLALSGYLPSNATGHLADLMLQRMASMpgHLADGGNLI 171
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKlgrvRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVE--LLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1981674398  172 IFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 85-202 3.05e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 81.24  E-value: 3.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  85 IDETVRDVRASVVVSNHISYLDPILLISLY-RRHTTIAKARLFAIPLYGNMLALSGYLP---SNATGHLADLMLQRMAsm 160
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDPLTLSAAFpPPIVFIAKKELKWIPFFGIMLWLTGAIFidrENIRAIATALKAAIEV-- 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1981674398 161 pghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:TIGR00530  86 ---LKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPI 124
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 87-202 2.14e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.47  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  87 ETVRDVRASVVVSNHISYLDPILLIS-LYRRHT---TIAKARLFAIPLYGNMLALSGYLP----SNATGHLADLMLQRMa 158
Cdd:pfam01553   8 ENLPRGGPAIVVANHQSYLDVLLLSLaLYKRGRplvFVAKKELFDIPLVGWLMRLLGCIFidrkNRKDAAGTLEYLVEL- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1981674398 159 smpghLADGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:pfam01553  87 -----LREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPI 125
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 94-218 1.21e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 73.61  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  94 ASVVVSNHISYLDPILLISLYRRHTTIAKARLFAIPLYGNMLALSGYLPSNATGHLADL-MLQRMASMpghLADGGNLII 172
Cdd:PLN02901   51 PAVYVSNHQSFLDIYTLFHLGRPFKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLeCLKRCMEL---LKKGASVFF 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1981674398 173 FPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKPGR 218
Cdd:PLN02901  128 FPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNGK 173
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 65-217 1.77e-09

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 55.88  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  65 LFYRVFFTLVRIlipacRWKIDETVRDVRASVVVSNHISYLDPILLISLYRRHT------TIAKARLFAIPLYGNMLALS 138
Cdd:cd06551     3 YLLLNFFGFVRL-----EVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERGLrrdvygLMDEELLERYPFFTRLGAFS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 139 GYLPSNATGhladlmLQRMASMPGHLADGGN-LIIFPEGTRGRQG-RIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKP 216
Cdd:cd06551    78 VDRDSPRSA------AKSLKYVARLLSKPGSvVWIFPEGTRTRRDkRPLQFKPGVAHLAEKAGVPIVPVALRYTFELFEQ 151


                  .
gi 1981674398 217 G 217
Cdd:cd06551   152 F 152
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 90-243 1.26e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 51.07  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  90 RDVRASVVVSNHISYLDPILLISlYRRHTTIAKARLFAIPLYGNMLALSGYLP-----SNATGHLADLMLQR---MASMP 161
Cdd:cd07991    21 PPEAPRIIVANHTSFIDPLILFS-DLFPSIVAKKELGKLPFIGTILRALGCIFvdrsePKDRKKVVEEIKERatdPNWPP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 162 ghladggnLIIFPEGT--RGRQgrIGRLNKGAFKIAR-----LCRAPVKVLFISNTDKLFKPGRFLFD--TQRPNRIRVE 232
Cdd:cd07991   100 --------ILIFPEGTttNGKA--LIMFKKGAFEPGVpvqpvAIRYPNKFVDAFWNSSGYSSLMYLFRllTQPANVLEVE 169

                         170
                  ....*....|.
gi 1981674398 233 LLETIDPDYED 243
Cdd:cd07991   170 FLPVYTPSEEG 180
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 96-196 1.61e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 47.64  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  96 VVVSNHI-SYLDPILLISLYRRHTT-IAKARLFAIPLYGNMLALSGYLP-----SNATGHLADLMLQRM-ASMPGHLADG 167
Cdd:cd07992    31 IFLGNHPnALIDPLLLAATLRRPVRfLAKADLFKNPLIGWLLESFGAIPvyrpkDLARGGIGKISNAAVfDAVGEALKAG 110

                          90       100
                  ....*....|....*....|....*....
gi 1981674398 168 GNLIIFPEGTRGRQGRIGRLNKGAFKIAR 196
Cdd:cd07992   111 GAIGIFPEGGSHDRPRLLPLKAGAARMAL 139
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 95-178 8.69e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 45.31  E-value: 8.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  95 SVVVSNHISYLDPILLISLYRRHTT------IAKARLFAIPLYGNMLALSGYLPSNATG-----HLADlMLQRMASMPGH 163
Cdd:cd07990    26 ALIISNHRSEVDWLVLWMLADRFGRlgrlkiVLKDSLKYPPLGGWGWQLGEFIFLKRKWekdekTIKR-QLKRLKDSPEP 104

                          90
                  ....*....|....*
gi 1981674398 164 LAdggnLIIFPEGTR 178
Cdd:cd07990   105 FW----LLIFPEGTR 115
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
23-202 1.27e-05

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 46.50  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398   23 LIITLLLWAYYTLGFILFF-------APFYLLAyLFAKESDRR-FQHLNSLFYRVFFTLVRILIPACRwkidetvrdvrA 94
Cdd:PRK06814   388 IILALLQALGFSIPWIILFialanliVAILILR-LLPTNLLRDiFSILFRAFYRVEVKGLENLQKAGK-----------K 455

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398   95 SVVVSNHISYLDPILLISLYRR------HTTIAKA---RLFaiplygnmLALSGYLPSNATGHLAdlmlqrMASMPGHLA 165
Cdd:PRK06814   456 AVIAANHVSFLDGPLLAAYLPEeptfaiDTDIAKAwwvKPF--------LKLAKALPVDPTNPMA------TRTLIKEVQ 521

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1981674398  166 DGGNLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPV 202
Cdd:PRK06814   522 KGEKLVIFPEGRITVTGSLMKIYDGPGMIADKAGAMV 558
PTZ00261 PTZ00261
acyltransferase; Provisional
 98-176 3.91e-04

acyltransferase; Provisional


Pssm-ID: 240337  Cd Length: 355  Bit Score: 41.41  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  98 VSNHISYLDPILLISLY-RRHT----TIAKARLFAIPLYGNMLALSGYLP----SNATGHL---ADLMLQRMASMPGHLA 165
Cdd:PTZ00261  134 VGNHTSFWDVYAFIGLTpFRHLlntrTLMKSSLRKIPIFGGVFDRVGHFPvhfkSDSDGNFevdKEKQAQVQQAIDAHLR 213

                          90
                  ....*....|.
gi 1981674398 166 DGGNLIIFPEG 176
Cdd:PTZ00261  214 LGGSLAFFPEG 224
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 75-202 1.74e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 37.97  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  75 RILIPACRWKIDETVRDVRASVV-VSNHISYLDPILLISLY----RRHTTIAKARLFAIPLyGNMLALSGYLP---SNAT 146
Cdd:cd07988     2 RLLLRLSGWRIEGEPPNKPKFVViGAPHTSNWDFVLGLLAAfalgLKISFLGKHSLFKPPL-GPFMRWLGGIPvdrSRAG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1981674398 147 GhLADLMLQRMASmpghlADGGNLIIFPEGTRGRQGRIGRlnkGAFKIARLCRAPV 202
Cdd:cd07988    81 G-LVEQVVEEFRR-----REEFVLAIAPEGTRSKVDKWKT---GFYHIARGAGVPI 127
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 95-268 5.24e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 37.30  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  95 SVVVSNHISYLDPILLISLYRRHT-TIAKARLFAIPLYGNMLALSGYL----PSNATGHladlmlQRMASMPGHLADGG- 168
Cdd:PRK15018   67 AIYIANHQNNYDMVTASNIVQPPTvTVGKKSLLWIPFFGQLYWLTGNLlidrNNRTKAH------GTIAEVVNHFKKRRi 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398 169 NLIIFPEGTRGRQGRIGRLNKGAFKIARLCRAPVKVLFISNTDKLFKPGRFlfdtqRPNRIRVELLETIDPDyEDGSFSI 248
Cdd:PRK15018  141 SIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSTTSNKINLNRL-----HNGLVIVEMLPPIDVS-QYGKDQV 214

                         170       180
                  ....*....|....*....|
gi 1981674398 249 HSLMERVHTLLEKHSAALEE 268
Cdd:PRK15018  215 RELAAHCRSIMEQKIAELDK 234
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 24-202 7.08e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 37.60  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398   24 IITLLLWAYytlgfILFFAPFYLLaylfakesdrRFqhlnsLFYRVFFTLVRILIpacrwkidETVRDVRAS---VVVSN 100
Cdd:PRK08633   397 LVTLIGTLY-----TLLLLPDSLL----------RF-----LLLLLMHTRYRLRV--------EGRENIPAKggaLLLGN 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981674398  101 HISYLDPILL-ISLYRRHTTIAKARLFAIPLYGNMLALSGYLPSNATGHLADLMLQRMAsmpghLADGGNLIIFPEGTRG 179
Cdd:PRK08633   449 HVSWIDWALLqAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPISSGGSKESLEFIRKA-----LDDGEVVCIFPEGAIT 523

                          170       180
                   ....*....|....*....|...
gi 1981674398  180 RQGRIGRLNKGAFKIARLCRAPV 202
Cdd:PRK08633   524 RNGQLNEFKRGFELIVKGTDVPI 546
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH